Search Result

Results for "

TRPV1 agonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Adrenergic Receptor (2) Akt (3) Apoptosis (9) Autophagy (6) Bacterial (2) Bcl-2 Family (3) Cannabinoid Receptor (6) Caspase (3) Cholinesterase (ChE) (2) Endogenous Metabolite (11) HSV (2) Isotope-Labeled Compounds (4) Melatonin Receptor (2) Opioid Receptor (1) Oxytocin Receptor (1) P2X Receptor (2) PI3K (3) Potassium Channel (2) Reactive Oxygen Species (ROS) (3) Reference Standards (11) Sodium Channel (2) TRP Channel (51)
By Research Areas:	Cancer (11) Cardiovascular Disease (6) Inflammation/Immunology (8) Metabolic Disease (2) Neurological Disease (39)

By Targets:

5-HT Receptor (2)

Adrenergic Receptor (2)

Akt (3)

Apoptosis (9)

Autophagy (6)

Bacterial (2)

Bcl-2 Family (3)

Cannabinoid Receptor (6)

Caspase (3)

Cholinesterase (ChE) (2)

Endogenous Metabolite (11)

HSV (2)

Isotope-Labeled Compounds (4)

Melatonin Receptor (2)

Opioid Receptor (1)

Oxytocin Receptor (1)

P2X Receptor (2)

PI3K (3)

Potassium Channel (2)

Reactive Oxygen Species (ROS) (3)

Reference Standards (11)

Sodium Channel (2)

TRP Channel (51)

By Research Areas:

Cancer (11)

Cardiovascular Disease (6)

Inflammation/Immunology (8)

Metabolic Disease (2)

Neurological Disease (39)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2333

Resiniferatoxin 1 Publications Verification (+)-Resiniferatoxin	TRP Channel	Cardiovascular Disease Cancer
Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of *transient receptor potential vanilloid 1 (TRPV1) receptor* agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period .

HY-174344

TRPV1 agonist-1	TRP Channel	Others
TRPV1 agonist-1 (Compound 13) is an orally active non-irritating *TRPV1* agonist with EC₅₀ values of 4.5 and 0.57 nM for human and rat. TRPV1 agonist-1 can improve swallowing function in rats. TRPV1 agonist-1 can be used in the research of dysphagia .

HY-162908

TRPV1/CB2 agonist 1	TRP Channel Cannabinoid Receptor	Neurological Disease
TRPV1/CB2 agonist 1 (compound 41) is a *TRPV1/CB2* agonist, with an EC₅₀ of 26.8 μM for hTRPV1. TRPV1/CB2 agonist 1 can be used in nervous system related research .

HY-W747573

N-Linolenoylethanolamine 18:3 NAE; α-Linolenoyl ethanolamide	TRP Channel	Neurological Disease
N-Linolenoylethanolamine (18:3 NAE) is an endocannabinoid. N-Linolenoylethanolamine is a vanillin receptor (TRPV1) agonist .

HY-W790266

Polygodial pyridazine	TRP Channel	Cancer
Polygodial pyridazine (compound 7) is a polygodial analogue and a *TRPV1* agonist with a GI₅₀ of 72 μM against MCF-7. Polygodial pyridazine can be utilized in cancer research .

HY-128479

JYL-273	TRP Channel	Neurological Disease
JYL-273 is a *TRPV1* agonist, with the IC₅₀ of 361 nM in CHO-TRPV1 cell lines .

HY-176063

TRPV1 antagonist 11	TRP Channel Opioid Receptor	Neurological Disease
TRPV1 antagonist 11 (compound 2ac) is a potent *TRPV1* antagonist with an IC₅₀ of 29.3 nM. TRPV1 antagonist 11 is a potent μ-opioid receptor (MOR) agonist with a K_i of 60.3 nM. TRPV1 antagonist 11, a pyrimidine piperazine, exhibits pain relieving effects by antagonizing TRPV1 and stimulating MOR. TRPV1 antagonist 11 shows a potent, dose-dependent anti-nociceptive effect in a Formalin-induced pain model in mice .

HY-150030

CB1/2 agonist 4	Cannabinoid Receptor	Neurological Disease
CB1/2 agonist 4 is a full CB1 agonist and CB2 partial agonist with EC₅₀ values of 15.09 nM and 1.16 nM, respectively. CB1/2 agonist 4 also has hCB1 and hCB2 receptor affinities with K_i values of 1.1 nM and 4.2 nM, respectively. CB1/2 agonist 4 has a significant antinociceptive activity, and also can activate cannabinoid and *TRPV1* receptor with values of IC₅₀ and EC₅₀ is 0.8 μM and 0.12 μM, respectively .

HY-110209

AC4	TRP Channel	Others
AC4 is a trans antagonist upon voltageactivation of *TRPV1* and as cis antagonist of *TRPV1* currents upon stimulation with Capsaicin (HY-10448). AC4 demonstrates that a photoswitchable antagonist and an agonist can be used in concert .

HY-111038

Capsiconiate Coniferyl (E)-8-methyl-6-nonenoate	TRP Channel	Neurological Disease Inflammation/Immunology
Capsiconiate (Coniferyl (E)-8-methyl-6-nonenoate) is a *TRPV1* agonist (EC₅₀= 3.2 μM). Capsiconiate can be used to study TRPV1-mediated diseases such as pain, inflammation, and epilepsy(EC₅₀= 3.2 μM) .

HY-123428

MSK-195	TRP Channel	Cardiovascular Disease
MSK-195 is a potent agonist of *TRPV1*, with a potency of 120 nM and an efficacy of 71% in arteriolar response .

HY-114630

Protokylol Caytine; JB-251	TRP Channel Adrenergic Receptor	Cardiovascular Disease
Protokylol (Caytine; JB-251) is a beta-adrenergic receptor agonist and *TRPV1* agonist. Protokylol is used as a bronchodilator .

HY-108448

N-Oleoyldopamine OLDA	TRP Channel	Cardiovascular Disease
N-Oleoyldopamine (OLDA) is a product of condensation of oleic acid and dopamine (DA) and an endogenous *TRPV1* selective agonist. N-Oleoyldopamine (OLDA) can crosses the blood-brain barrier. N-oleoyl-dopamine protects the heart against ischemia-reperfusion injury via activation of TRPV1 .

HY-B1583

(Z)-Capsaicin Zucapsaicin; Civamide; cis-Capsaicin	TRP Channel HSV	Neurological Disease
(Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active *TRPV1* agonist, and is used in the research of neuropathic pain.

HY-124073

Dihydrocapsiate	TRP Channel	Metabolic Disease
Dihydrocapsiate, as a compound of capsinoid family, is an orally active *TRPV1* agonist. Dihydrocapsiate can be used for the research of metabolism disease .

HY-117922

JYL-79	TRP Channel	Neurological Disease
JYL-79 is a *TRPV1* agonist with the IC₅₀ of 3.9 nM. JYL-79 can be used for study of neuropathic pain .

HY-110018

N-Arachidonyldopamine	Cannabinoid Receptor TRP Channel	Neurological Disease
N-Arachidonyldopamine is a potent and selective endogenous *CB1 receptor agonist* with a K_i of 250 nM . N-Arachidonyldopamine is also a potent and selective *TRPV1* agonist an with EC₅₀ of ~ 50 nM .**

HY-118785

MSP-3	TRP Channel	Neurological Disease
MSP-3 is a potent *TRPV1* agonist, with an EC₅₀ of 0.87 μM. MSP-3 exhibits neuroprotective and antinociceptive effects .

HY-101323

Olvanil NE-19550; N-Vanillyloleamide	TRP Channel	Neurological Disease
Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC₅₀ of 0.7 nM .

HY-17568

Nonivamide 1 Publications Verification Pelargonic acid vanillylamide; Nonanoic acid vanillylamide; Pseudocapsaicin	TRP Channel	Neurological Disease
Nonivamide is a agonist, which exhibits 4d-EC₅₀ value of 5.1 mg/L in static toxicity tests.

HY-N8377

Capsiate 2 Publications Verification	TRP Channel	Inflammation/Immunology
Capsiate, as a capsaicin analogue extracted from a non-pungent cultivar of CH-19 sweet red pepper, is an orally active agonist of *TRPV1* .

HY-10448A

Capsaicin (Purity 65%) 20+ Cited Publications	TRP Channel Autophagy Apoptosis Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Capsaicin (Purity 65%) is a mixture of Capsaicin and Dihydrocapsaicin (Ratio >2:1). Capsaicin (Purity 65%) is an orally active capsaicin receptor (TRPV1) agonist .

HY-108576

Linopirdine dihydrochloride DuP 996 dihydrochloride	TRP Channel	Neurological Disease
Linopirdine dihydrochloride is a agonist of capsaicin receptor *TRPV1*. Linopirdine increases the intracellular calcium concentration in HEK293 cells. Linopirdine dihydrochloride exerts an excitatory action on mammalian nociceptors .

HY-137459

Vocacapsaicin CA-008	TRP Channel	Neurological Disease
Vocacapsaicin (CA-008), a proagent of Capsaicin, is a first-in-class non-opioid *TRPV1* agonist. Vocacapsaicin can provide meaningful and long-lasting pain relief .

HY-137459A

Vocacapsaicin hydrochloride CA-008 hydrochloride	TRP Channel	Neurological Disease
Vocacapsaicin (CA-008) hydrochloride, a proagent of Capsaicin, is a first-in-class non-opioid *TRPV1* agonist. Vocacapsaicin hydrochloride can provide meaningful and long-lasting pain relief .

HY-101389

(R)-Methanandamide AM-356	Cannabinoid Receptor TRP Channel	Neurological Disease
(R)-Methanandamide (AM-356), an analog of the endocannabinoid ligand Anandamide, is a potent CB1 agonist with a K_i of 20 nM. (R)-Methanandamide also activates *vanilloid (TRPV1) receptors* .

HY-10448

Capsaicin Maximum Cited Publications 54 Publications Verification (E)-Capsaicin	TRP Channel Autophagy Apoptosis Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a *TRPV1* agonist. Capsaicin has pain-relieving, antioxidant, anti-inflammatory, anti-cancer and certain neurotoxic effects .

HY-124073R

Dihydrocapsiate (Standard)	Reference Standards TRP Channel	Metabolic Disease
Dihydrocapsiate (Standard) is the analytical standard of Dihydrocapsiate. This product is intended for research and analytical applications. Dihydrocapsiate, as a compound of capsinoid family, is an orally active TRPV1 agonist. Dihydrocapsiate can be used for the research of metabolism disease .

HY-16413

Protokylol hydrochloride Caytine hydrochloride; JB-251 hydrochloride	TRP Channel Adrenergic Receptor	Others
Protokylol hydrochloride (Caytine hydrochloride; JB-251 hydrochloride) is the hydrochloride salt form of Protokylol (HY-114630). Protokylol hydrochloride is an agonist for β2-adrenergic receptor and *TRPV1*. Protokylol hydrochloride exhibits activity as a bronchodilator .

HY-B1583R

(Z)-Capsaicin (Standard) Zucapsaicin (Standard); Civamide (Standard); cis-Capsaicin (Standard)	Reference Standards TRP Channel HSV	Neurological Disease
(Z)-Capsaicin (Standard) is the analytical standard of (Z)-Capsaicin. This product is intended for research and analytical applications. (Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active *TRPV1* agonist, and is used in the research of neuropathic pain.

HY-N7536

Voacangine	TRP Channel	Others
Voacangine is an antagonist for *TRPV1* and TRPM8 but as an agonist for TRPA1 (EC₅₀=8 μM). Voacangine competitively blockes capsaicin binding to *TRPV1* (IC₅₀=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC₅₀=9 μM) and it shows noncompetitive inhibition against icilin (IC₅₀=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana .

HY-101323R

Olvanil (Standard) NE-19550 (Standard); N-Vanillyloleamide (Standard)	Reference Standards TRP Channel	Neurological Disease
Olvanil (Standard) is the analytical standard of Olvanil. This product is intended for research and analytical applications. Olvanil (NE-19550) is an analgesic and an agonist of transient receptor potential vanilloid type 1 (TRPV1) channels with an EC50 of 0.7 nM .

HY-17568R

Nonivamide (Standard) Pelargonic acid vanillylamide (Standard); Nonanoic acid vanillylamide (Standard); Pseudocapsaicin (Standard)	Reference Standards TRP Channel	Neurological Disease
Nonivamide (Standard) is the analytical standard of Nonivamide. This product is intended for research and analytical applications. Nonivamide is a TRPV1 agonist, which exhibits 4d-EC50 value of 5.1 mg/L in static toxicity tests.

HY-10448S1

Capsaicin-d3 (E)-Capsaicin-d₃	Isotope-Labeled Compounds TRP Channel Autophagy Apoptosis Endogenous Metabolite	Cancer
Capsaicin-d₃ is the deuterium labeled Capsaicin. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects[1][2].

HY-W654381

N-Vanillylnonanamide-d3	Isotope-Labeled Compounds TRP Channel	Neurological Disease
N-Vanillylnonanamide-d₃ is the deuterium labeled Nonivamide (HY-17568). Nonivamide is a TRPV1 agonist, which exhibits 4d-EC₅₀ value of 5.1 mg/L in static toxicity tests.

HY-N0285

Imperatorin 2 Publications Verification Ammidin	Cholinesterase (ChE) TRP Channel	Neurological Disease
Imperatorin is an effective of NO synthesis inhibitor (IC₅₀=9.2 μmol), which also is a BChE inhibitor (IC₅₀=31.4 μmol). Imperatorin is a weak agonist of *TRPV1* with EC₅₀ of 12.6±3.2 μM.

HY-10448S4

Capsaicin-d7 (E)-Capsaicin-d₇	TRP Channel Autophagy Endogenous Metabolite Apoptosis Isotope-Labeled Compounds	Cancer
Capsaicin-d₇ is deuterated labeled Capsaicin (HY-10448). Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a *TRPV1* agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects .

HY-10448R

Capsaicin (Standard) Maximum Cited Publications 54 Publications Verification (E)-Capsaicin (Standard)	Reference Standards TRP Channel Autophagy Apoptosis Endogenous Metabolite	Cancer
Capsaicin (Standard) is the analytical standard of Capsaicin. This product is intended for research and analytical applications. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a *TRPV1* agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects .

HY-N6825

Hydroxy-α-sanshool 3 Publications Verification	TRP Channel Endogenous Metabolite	Neurological Disease
Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC₅₀s of 69 and 1.1 μM, respectively. Hydroxy-α-sanshool can be used for pain research .

HY-10448AR

Capsaicin (Purity 65%) (Standard)	Reference Standards TRP Channel Autophagy Apoptosis Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
Capsaicin (Purity 65%) (Standard) is the analytical standard of Capsaicin (Purity 65%). This product is intended for research and analytical applications. Capsaicin (Purity 65%) is a mixture of Capsaicin and Dihydrocapsaicin (Ratio >2:1).Capsaicin (Purity 65%) is an orally active capsaicin receptor (TRPV1) agonist .

HY-W020468

Linopirdine 1 Publications Verification DuP 996	Potassium Channel TRP Channel	Neurological Disease
Linopirdine (DuP 996) is an orally active, selective M-type K ⁺ current (IM; Kv7; KCNQ Channels) inhibitor with an IC₅₀ of 2.4 μM. Linopirdine is a *TRPV1* agonist. Linopirdine, a putative cognition enhancing agent, increases acetylcholine release in rat brain tissue .

HY-P3467

(Thr4,Gly7)-Oxytocin 1 Publications Verification	Oxytocin Receptor Potassium Channel	Neurological Disease
(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K ⁺ channels. .

HY-147707

CB2 receptor antagonist 1	Cannabinoid Receptor	Others
Hexyl resorcinol derivative 29 has been proved to be a CB2 selective competitive antagonist / reverse agonist with good potency. Olivanol and 5- (2-methyloctane-2-yl) resorcinol derivatives 23 and 24 showed significant antinociceptive activity. Compound 24 was shown to activate cannabinoid and TRPV1 receptors.

HY-135882

OMDM-6	TRP Channel Cannabinoid Receptor Endogenous Metabolite	Neurological Disease
OMDM-6 is a hybrid agonist of vanilloid receptor type 1 (VR1, TRPV1) (EC₅₀=75 nM) and cannabinoid receptor type 1 (CB1) (K_i=3.2 μM). OMDM-6 inhibits anandamide cellular uptake (ACU) with a K_i of 7.0 μM .

HY-N0285R

Imperatorin (Standard) Ammidin (Standard)	Reference Standards Cholinesterase (ChE) TRP Channel	Neurological Disease
Imperatorin (Standard) is the analytical standard of Imperatorin. This product is intended for research and analytical applications. Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol). Imperatorin is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM.

HY-136363

MDR-652	TRP Channel	Neurological Disease
MDR-652 is a highly specific and efficacious transient receptor potential vanilloid 1 (TRPV1) ligand with agonist activity. The K_is are 11.4 and 23.8 nM for hTRPV1 and rTRPV1, respectively. The EC₅₀s are 5.05 and 93 nM for hTRPV1 and rTRPV1, respectively. Potent topical analgesic activity .

HY-120174

SU200	Endogenous Metabolite	Others
SU200 is a TRPV1 agonist with the activity of regulating intracellular calcium ion concentration. SU200 can induce different calcium ion response modes, showing significant reaction potential and maximum reaction effect. There is obvious response delay and variability in the effects of SU200 in different cells. The use of SU200 may provide pharmacological development opportunities .

HY-135881

OMDM-5	TRP Channel Endogenous Metabolite	Neurological Disease
OMDM-5 is a selective inhibitor of anandamide cellular uptake (ACU), with a K_i of 4.8 μM. OMDM-5 is also a potent vanilloid receptor type 1 (VR1, TRPV1) agonist, with an EC₅₀ of 75 nM, and shows weakly active as cannabinoid receptor type 1 (CB1) ligand (K_i=4.9 μM) .

HY-N6825R

Hydroxy-α-sanshool (Standard)	Reference Standards TRP Channel Endogenous Metabolite	Neurological Disease
Hydroxy-α-sanshool (Standard) is the analytical standard of Hydroxy-α-sanshool. This product is intended for research and analytical applications. Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC50s of 69 and 1.1 μM, respectively. Hydroxy-α-sanshool can be used for pain research .

HY-N8264

Moringin 1 Publications Verification	TRP Channel	Neurological Disease Inflammation/Immunology Cancer
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .

Cat. No.	Product Name	Target	Research Area

HY-P3467

(Thr4,Gly7)-Oxytocin 1 Publications Verification	Oxytocin Receptor Potassium Channel	Neurological Disease
(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K ⁺ channels. .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2333

Resiniferatoxin 1 Publications Verification (+)-Resiniferatoxin	Cardiovascular Disease Euphorbia resinifera O. Berg Classification of Application Fields Source classification Euphorbiaceae Plants Disease Research Fields	TRP Channel
Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of *transient receptor potential vanilloid 1 (TRPV1) receptor* agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period .

HY-124073

Dihydrocapsiate	Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Source classification Phenols Metabolic Disease Plants Solanaceae Disease Research Fields	TRP Channel
Dihydrocapsiate, as a compound of capsinoid family, is an orally active *TRPV1* agonist. Dihydrocapsiate can be used for the research of metabolism disease .

HY-17568

Nonivamide 1 Publications Verification Pelargonic acid vanillylamide; Nonanoic acid vanillylamide; Pseudocapsaicin	Alkaloids Structural Classification Monophenols Capsicum annuum L. Other Alkaloids Source classification Phenols Solanaceae Plants	TRP Channel
Nonivamide is a agonist, which exhibits 4d-EC₅₀ value of 5.1 mg/L in static toxicity tests.

HY-N8377

Capsiate 2 Publications Verification	Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Source classification Phenols Solanaceae Plants Inflammation/Immunology Disease Research Fields	TRP Channel
Capsiate, as a capsaicin analogue extracted from a non-pungent cultivar of CH-19 sweet red pepper, is an orally active agonist of *TRPV1* .

HY-10448A

Capsaicin (Purity 65%) 20+ Cited Publications	Structural Classification Monophenols Capsicum annuum L. Neurological Disease Classification of Application Fields Source classification Phenols Solanaceae Plants Inflammation/Immunology Disease Research Fields	TRP Channel Autophagy Apoptosis Endogenous Metabolite
Capsaicin (Purity 65%) is a mixture of Capsaicin and Dihydrocapsaicin (Ratio >2:1). Capsaicin (Purity 65%) is an orally active capsaicin receptor (TRPV1) agonist .

HY-10448

Capsaicin Maximum Cited Publications 54 Publications Verification (E)-Capsaicin	Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Source classification Phenols Solanaceae Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	TRP Channel Autophagy Apoptosis Endogenous Metabolite
Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a *TRPV1* agonist. Capsaicin has pain-relieving, antioxidant, anti-inflammatory, anti-cancer and certain neurotoxic effects .

HY-N7536

Voacangine	Alkaloids Structural Classification other families Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields Indole Alkaloids	TRP Channel
Voacangine is an antagonist for *TRPV1* and TRPM8 but as an agonist for TRPA1 (EC₅₀=8 μM). Voacangine competitively blockes capsaicin binding to *TRPV1* (IC₅₀=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC₅₀=9 μM) and it shows noncompetitive inhibition against icilin (IC₅₀=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana .

HY-111038

Capsiconiate Coniferyl (E)-8-methyl-6-nonenoate	Structural Classification Monophenols Source classification Phenols Plants Solanaceae Capsicum baccatum L.	TRP Channel
Capsiconiate (Coniferyl (E)-8-methyl-6-nonenoate) is a *TRPV1* agonist (EC₅₀= 3.2 μM). Capsiconiate can be used to study TRPV1-mediated diseases such as pain, inflammation, and epilepsy(EC₅₀= 3.2 μM) .

HY-124073R

Dihydrocapsiate (Standard)	Structural Classification Monophenols Capsicum annuum L. Source classification Phenols Solanaceae Plants	Reference Standards TRP Channel
Dihydrocapsiate (Standard) is the analytical standard of Dihydrocapsiate. This product is intended for research and analytical applications. Dihydrocapsiate, as a compound of capsinoid family, is an orally active TRPV1 agonist. Dihydrocapsiate can be used for the research of metabolism disease .

HY-17568R

Nonivamide (Standard) Pelargonic acid vanillylamide (Standard); Nonanoic acid vanillylamide (Standard); Pseudocapsaicin (Standard)	Alkaloids Structural Classification Monophenols Capsicum annuum L. Other Alkaloids Source classification Phenols Solanaceae Plants	Reference Standards TRP Channel
Nonivamide (Standard) is the analytical standard of Nonivamide. This product is intended for research and analytical applications. Nonivamide is a TRPV1 agonist, which exhibits 4d-EC50 value of 5.1 mg/L in static toxicity tests.

HY-N0285

Imperatorin 2 Publications Verification Ammidin	Structural Classification Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants	Cholinesterase (ChE) TRP Channel
Imperatorin is an effective of NO synthesis inhibitor (IC₅₀=9.2 μmol), which also is a BChE inhibitor (IC₅₀=31.4 μmol). Imperatorin is a weak agonist of *TRPV1* with EC₅₀ of 12.6±3.2 μM.

HY-10448R

Capsaicin (Standard) Maximum Cited Publications 54 Publications Verification (E)-Capsaicin (Standard)	Structural Classification Capsicum annuum L. Classification of Application Fields Source classification Phenols Solanaceae Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Reference Standards TRP Channel Autophagy Apoptosis Endogenous Metabolite
Capsaicin (Standard) is the analytical standard of Capsaicin. This product is intended for research and analytical applications. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a *TRPV1* agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects .

HY-N6825

Hydroxy-α-sanshool 3 Publications Verification	Zanthoxylum bungeanum Maxim. Alkaloids Structural Classification Other Alkaloids Source classification Rutaceae Plants Endogenous metabolite	TRP Channel Endogenous Metabolite
Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC₅₀s of 69 and 1.1 μM, respectively. Hydroxy-α-sanshool can be used for pain research .

HY-10448AR

Capsaicin (Purity 65%) (Standard)	Structural Classification Monophenols Capsicum annuum L. Source classification Phenols Solanaceae Plants	Reference Standards TRP Channel Autophagy Apoptosis Endogenous Metabolite
Capsaicin (Purity 65%) (Standard) is the analytical standard of Capsaicin (Purity 65%). This product is intended for research and analytical applications. Capsaicin (Purity 65%) is a mixture of Capsaicin and Dihydrocapsaicin (Ratio >2:1).Capsaicin (Purity 65%) is an orally active capsaicin receptor (TRPV1) agonist .

HY-135882

OMDM-6	Structural Classification Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields	TRP Channel Cannabinoid Receptor Endogenous Metabolite
OMDM-6 is a hybrid agonist of vanilloid receptor type 1 (VR1, TRPV1) (EC₅₀=75 nM) and cannabinoid receptor type 1 (CB1) (K_i=3.2 μM). OMDM-6 inhibits anandamide cellular uptake (ACU) with a K_i of 7.0 μM .

HY-N0285R

Imperatorin (Standard) Ammidin (Standard)	Structural Classification Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants	Reference Standards Cholinesterase (ChE) TRP Channel
Imperatorin (Standard) is the analytical standard of Imperatorin. This product is intended for research and analytical applications. Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol). Imperatorin is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM.

HY-135881

OMDM-5	Structural Classification Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields	TRP Channel Endogenous Metabolite
OMDM-5 is a selective inhibitor of anandamide cellular uptake (ACU), with a K_i of 4.8 μM. OMDM-5 is also a potent vanilloid receptor type 1 (VR1, TRPV1) agonist, with an EC₅₀ of 75 nM, and shows weakly active as cannabinoid receptor type 1 (CB1) ligand (K_i=4.9 μM) .

HY-N6825R

Hydroxy-α-sanshool (Standard)	Zanthoxylum bungeanum Maxim. Alkaloids Structural Classification Other Alkaloids Source classification Rutaceae Plants Endogenous metabolite	Reference Standards TRP Channel Endogenous Metabolite
Hydroxy-α-sanshool (Standard) is the analytical standard of Hydroxy-α-sanshool. This product is intended for research and analytical applications. Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC50s of 69 and 1.1 μM, respectively. Hydroxy-α-sanshool can be used for pain research .

HY-N8264

Moringin 1 Publications Verification	Structural Classification Natural Products Neurological Disease Classification of Application Fields Moringa oleifera Lam. Source classification Moringaceae Plants Inflammation/Immunology Disease Research Fields	TRP Channel
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .

HY-N0361

Dihydrocapsaicin 2 Publications Verification	Alkaloids Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Other Alkaloids Source classification Phenols Metabolic Disease Solanaceae Plants Disease Research Fields	TRP Channel Reactive Oxygen Species (ROS) Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin, a capsaicin, is a potent and selective *TRPV1* (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-N0361R

Dihydrocapsaicin (Standard)	Alkaloids Structural Classification Monophenols Capsicum annuum L. Other Alkaloids Source classification Phenols Solanaceae Plants	Reference Standards TRP Channel Reactive Oxygen Species (ROS) Apoptosis Caspase Bcl-2 Family Akt PI3K
Dihydrocapsaicin (Standard) is the analytical standard of Dihydrocapsaicin. This product is intended for research and analytical applications. Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-B1173

(+)-Camphor D-(+)-Camphor; (1R)-(+)-Camphor	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Source classification Other Diseases Plants Lauraceae Cinnamomum camphora Disease Research Fields	Bacterial
(+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as *TRPV1, TRPV3, TRPM8) and an inhibitor of TRPA1* channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation .

HY-B1173R

(+)-Camphor (Standard) D-(+)-Camphor (Standard); (1R)-(+)-Camphor (Standard)	Structural Classification Other Monoterpenes Terpenoids Source classification Plants Lauraceae Cinnamomum camphora	Reference Standards Bacterial
(+)-Camphor (Standard) is the analytical standard of (+)-Camphor. This product is intended for research and analytical applications. (+)-Camphor (D-(+)-Camphor; (1R)-(+)-Camphor) is an isomer of Camphor. Camphor is an agonist of monoterpenoid transient receptor potential (TRP) channels (such as *TRPV1, TRPV3, TRPM8) and an inhibitor of TRPA1* channels. Camphor's derivatives have multiple biological activities, including antibacterial, antiviral, antioxidant, analgesic and anticancer. Camphor can selectively activate cold-sensitive TRP channels and inhibit TRPA1-mediated nociceptive signals. Camphor stimulates the cold-sensing nerve endings in the skin and regulates the activity of ion channels to exert analgesic, anti-inflammatory and anti-itching effects. It also has anti-proliferative and anti-mutagenic activities on tumor cells, which may be related to inhibiting ribosome function or inducing cell apoptosis. Camphor can be absorbed through the skin and (+)-Camphor can be used in the study of muscle and joint pain and inflammation .

Cat. No.	Product Name	Chemical Structure

HY-N0361S

Dihydrocapsaicin-d3

Dihydrocapsaicin-d₃ is the deuterium labeled Dihydrocapsaicin (HY-N0361) . Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat .

HY-10448S1

Capsaicin-d3
Capsaicin-d₃ is the deuterium labeled Capsaicin. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects[1][2].

HY-W654381

N-Vanillylnonanamide-d3
N-Vanillylnonanamide-d₃ is the deuterium labeled Nonivamide (HY-17568). Nonivamide is a TRPV1 agonist, which exhibits 4d-EC₅₀ value of 5.1 mg/L in static toxicity tests.

HY-10448S4

Capsaicin-d7
Capsaicin-d₇ is deuterated labeled Capsaicin (HY-10448). Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a *TRPV1* agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

TRPV1 agonist

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products