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Isoforms Recommended: TRPML
Results for "

TRPML1

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

2

Recombinant Proteins

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-134818
    ML-SI1
    Maximum Cited Publications
    6 Publications Verification

    		 TRP Channel Neurological Disease
    ML-SI1, a racemic mixture of diastereomers, is a TRPML inhibitor with an IC50 value of 15 μM for TRPML1 [1].
    ML-SI1
  • HY-152182
    ML-SA5
    1 Publications Verification

    		 TRP Channel Cancer
    ML-SA5 is a potent TRPML1 cation channel agonist that activates the entire endosomal TRPML1 (ML1) current in DMD myocytes with an EC50 of 285 nM and is more potent than ML-SA1. ML-SA5 has anticancer activity and can inhibit tumour growth [1].
    ML-SA5
  • HY-110238
    MK6-83

    		TRP Channel Metabolic Disease
    MK6-83 is a new candidate agonist of TRPML1 with an improved efficacy and potency. MK6-83 has the potential for Mucolipidosis type IV study [1].
    MK6-83
  • HY-139426
    ML-SI3
    3 Publications Verification

    ML-SI3 (cis/trans mix)

    		 Parasite TRP Channel Cardiovascular Disease Neurological Disease
    ML-SI3 is a mixture of cis/trans ML-SI3 (HY-139426A), which is a TRPML1/2 channel inhibitor with IC50s of 4.7 μM and 1.7 μM, respectively. ML-SI3 also inhibits lysosomal calcium efflux and blocks downstream TRPML1-mediated autophagy. The cis/trans ML-SI3 (HY-139426A) components of ML-SI3 are TRPML2 activators with EC50s of 3.3 μM and 9.4 μM, respectively [1] .
    ML-SI3
  • HY-134819A
    (1R,2R)-ML-SI3
    1 Publications Verification

    (-)-trans-ML-SI3

    		 TRP Channel Neurological Disease
    (1R,2R)-ML-SI3 is an isomer of ML-SI3 and a potent inhibitor of three isoforms of TRPML. (1R,2R)-ML-SI3 inhibits TRPMLs with IC50s of 1.6 μM (TRPML1), 2.3 μM (TRPML2), and 12.5 μM (TRPML3), respectively [1].
    (1R,2R)-ML-SI3
  • HY-134819
    (1S,2S)-ML-SI3

    (+)-trans-ML-SI3

    		 TRP Channel Cancer
    (1S,2S)-ML-SI3 is a trans-isomer of ML-SI3 that targets all three isoforms of TRPML. (1S,2S)-ML-SI3 is an activator of TRPML2 and TRPML3 (EC50=2.7 μM/10.8 μM) and a potent inhibitor of TRPML1 (IC50=5.9 μM) [1].
    (1S,2S)-ML-SI3
  • HY-139426A
    (rel)-ML-SI3

    trans-ML-SI3

    		 TRP Channel Autophagy Cancer
    (rel)-ML-SI3 is one of the active ingredients of ML-SI3 (HY-139426) (another component is (cis)-ML-SI3) that targets three isoforms of TRPML. (rel)-ML-SI3 is an inhibitor of TRPML1 and TRPML3 (IC50=3.1 μM/28.5 μM), and a potent activator of TRPML2 (EC50=3.3 μM) [1] .
    (rel)-ML-SI3

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