Search Result

Isoforms Recommended:	TRPM

Results for "

TRPM3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (6) Autophagy (20) Cannabinoid Receptor (10) Endogenous Metabolite (10) Ferroptosis (9) GABA Receptor (3) Isotope-Labeled Compounds (7) Necroptosis (3) PPAR (10) Reference Standards (4) RIP kinase (3) Small Interfering RNA (siRNA) (3) Sodium Channel (3) TRP Channel (28)
By Research Areas:	Cancer (9) Inflammation/Immunology (13) Metabolic Disease (10) Neurological Disease (23)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110220

CIM0216 1 Publications Verification	TRP Channel	Neurological Disease
CIM0216, a synthetic *TRPM3* ligand, acts as a potent and selective agonist of TRPM3. CIM0216 exhibits selectivity for TRPM3 over TRPM1, TRPM2 and TRPM4-8. CIM0216 acts in a TRPM3-dependent manner to induce pain and evoke neuropeptide release from sensory nerve terminals in vitro. CIM0216 is a powerful tool for studies of the physiological functions of TRPM3, and can be used for neurogenic inflammation research .

HY-108451

Ononetin	TRP Channel	Neurological Disease
Ononetin, a natural deoxybenzoin, is a potent and selective TRPM3 channel blocker with an IC₅₀ of 0.3 μM .

HY-N2131

Isosakuranetin 3 Publications Verification	TRP Channel	Others
Isosakuranetin is a flavanone flavonoid which can be found in the fruit of Citrus bergamia. Isosakuranetin is a *TRPM3* blocker ^[3].

HY-W089922

D-erythro-Sphingosine hydrochloride 4 Publications Verification Erythrosphingosine hydrochloride; erythro-C18-Sphingosine hydrochloride; trans-4-Sphingenine hydrochloride	TRP Channel	Neurological Disease
D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific *TRPM3* activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation .

HY-N2131A

(R)-Isosakuranetin	TRP Channel	Others
(R)-Isosakuranetin is an isomer of Isosakuranetin (HY-N2131). Isosakuranetin is a flavanone flavonoid which can be found in the fruit of Citrus bergamia. Isosakuranetin is a *TRPM3* blocker ^[3].

HY-B0339

Primidone 2 Publications Verification	TRP Channel RIP kinase Sodium Channel GABA Receptor Necroptosis	Neurological Disease Inflammation/Immunology
Primidone is the orally active inhibitor for *TRPM3* (IC₅₀ = 0.6 μM), RIP kinase and voltage-gated sodium channel, and the antagonist for GABA receptor. Primidone can be used as the analgesic and anticonvulsant agent ^[3].

HY-B0339S

Primidone-d5	Isotope-Labeled Compounds RIP kinase TRP Channel Sodium Channel GABA Receptor Necroptosis	Neurological Disease Inflammation/Immunology
Primidone-d₅ is the deuterium labeled Primidone. Primidone is the orally active inhibitor for *TRPM3* (IC₅₀ = 0.6 μM), RIP kinase and voltage-gated sodium channel, and the antagonist for GABA receptor. Primidone can be used as the analgesic and anticonvulsant agent ^[3].

HY-RS16917

Trpm3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Trpm3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trpm3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Trpm3 Mouse Pre-designed siRNA Set A Trpm3 Mouse Pre-designed siRNA Set A

HY-RS15113

TRPM3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TRPM3 Human Pre-designed siRNA Set A contains three designed siRNAs for TRPM3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRPM3 Human Pre-designed siRNA Set A TRPM3 Human Pre-designed siRNA Set A

HY-RS23360

Trpm3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Trpm3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Trpm3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Trpm3 Rat Pre-designed siRNA Set A Trpm3 Rat Pre-designed siRNA Set A

HY-17386B

Rosiglitazone potassium BRL 49653 potassium	PPAR TRP Channel Autophagy Apoptosis Ferroptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Rosiglitazone (BRL 49653) potassium is an orally active selective PPARγ agonist (EC₅₀: 60 nM, K_d: 40 nM). Rosiglitazone potassium is a TRPC5 activator (EC₅₀: 30 μM) and *TRPM3* inhibitor. Rosiglitazone potassium can be used in the research of obesity and diabetes, senescence, ovarian cancer .

HY-17386

Rosiglitazone Maximum Cited Publications 123 Publications Verification BRL 49653	PPAR TRP Channel Autophagy Ferroptosis Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC₅₀: 60 nM, K_d: 40 nM). Rosiglitazone is an TRPC5 activator (EC₅₀: 30 μM) and TRPM3 inhibitor. Rosiglitazone can be used in the research of obesity and diabetes, senescence, ovarian cancer .

HY-17386A

Rosiglitazone hydrochloride Maximum Cited Publications 123 Publications Verification BRL 49653 hydrochloride	PPAR TRP Channel Autophagy Ferroptosis Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Rosiglitazone (BRL 49653) hydrochloride is an orally active selective PPARγ agonist (EC₅₀: 60 nM, K_d: 40 nM). Rosiglitazone hydrochloride is a TRPC5 activator (EC₅₀: 30 μM) and *TRPM3* inhibitor. Rosiglitazone hydrochloride can be used in the research of obesity and diabetes, senescence, ovarian cancer .

HY-B0339R

Primidone (Standard) 2 Publications Verification	Reference Standards TRP Channel RIP kinase Sodium Channel GABA Receptor Necroptosis	Neurological Disease Inflammation/Immunology
Primidone (Standard) is the analytical standard of Primidone. This product is intended for research and analytical applications. Primidone is the orally active inhibitor for *TRPM3* (IC₅₀ = 0.6 μM), RIP kinase and voltage-gated sodium channel, and the antagonist for GABA receptor. Primidone can be used as the analgesic and anticonvulsant agent ^[3].

HY-17386AR

Rosiglitazone hydrochloride (Standard)	PPAR TRP Channel Autophagy Ferroptosis Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Rosiglitazone (hydrochloride) (Standard) is the analytical standard of Rosiglitazone (hydrochloride). This product is intended for research and analytical applications. Rosiglitazone (BRL 49653) hydrochloride is an orally active selective PPARγ agonist (EC50: 60 nM, Kd: 40 nM). Rosiglitazone hydrochloride is a TRPC5 activator (EC50: 30 μM) and TRPM3 inhibitor. Rosiglitazone hydrochloride can be used in the research of obesity and diabetes, senescence, ovarian cancer .

HY-17386S1

Rosiglitazone-d4 BRL 49653-d₄	TRP Channel Autophagy PPAR Ferroptosis Apoptosis Isotope-Labeled Compounds	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Rosiglitazone-d₄ is deuterated labeled Rosiglitazone (HY-17386). Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC₅₀: 60 nM, K_d: 40 nM). Rosiglitazone is an TRPC5 activator (EC₅₀: 30 μM) and TRPM3 inhibitor. Rosiglitazone can be used in the research of obesity and diabetes, senescence, ovarian cancer .

HY-17386R

Rosiglitazone (Standard) BRL 49653 (Standard)	Reference Standards PPAR TRP Channel Autophagy Ferroptosis Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Rosiglitazone (Standard) is the analytical standard of Rosiglitazone. This product is intended for research and analytical applications. Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC₅₀: 60 nM, K_d: 40 nM). Rosiglitazone is an TRPC5 activator (EC₅₀: 30 μM) and TRPM3 inhibitor. Rosiglitazone can be used in the research of obesity and diabetes, senescence, ovarian cancer .

HY-B0700

Rosiglitazone sodium BRL 49653 sodium	PPAR TRP Channel Autophagy	Metabolic Disease Inflammation/Immunology
Rosiglitazone sodium is a potent and selective activator of PPARγ, with EC₅₀s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a K_d of appr 40 nM for PPARγ; Rosiglitazone sodium is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5).

HY-14600

Rosiglitazone maleate Maximum Cited Publications 123 Publications Verification BRL 49653C	PPAR TRP Channel Autophagy Ferroptosis	Metabolic Disease Inflammation/Immunology Cancer
Rosiglitazone maleate (BRL 49653C) is a potent and selective activator of PPARγ, with EC₅₀s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a K_d of appr 40 nM for PPARγ; Rosiglitazone maleate is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5).

HY-14600R

Rosiglitazone maleate (Standard) BRL 49653C (Standard)	Reference Standards PPAR TRP Channel Autophagy Ferroptosis	Metabolic Disease Inflammation/Immunology Cancer
Rosiglitazone (maleate) (Standard) is the analytical standard of Rosiglitazone (maleate). This product is intended for research and analytical applications. Rosiglitazone maleate (BRL 49653C) is a potent and selective activator of PPARγ, with EC₅₀s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a K_d of appr 40 nM for PPARγ; Rosiglitazone maleate is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5).

HY-17386S

Rosiglitazone-d3	Isotope-Labeled Compounds PPAR TRP Channel Autophagy Ferroptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Rosiglitazone-d₃ is the deuterium labeled Rosiglitazone. Rosiglitazone (BRL 49653) is a selective, orally active PPARγ agonist with EC₅₀s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively. Rosiglitazone binds to PPARγ with a Kd of approximately 40 nM. Rosiglitazone is also an activator of TRPC5 (EC₅₀=~30 μM) and an inhibitor of TRPM3 ^[3] .

HY-B0151

Pregnenolone 5 Publications Verification 3β-Hydroxy-5-pregnen-20-one	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

HY-B0151S1

Pregnenolone-13C2,d2 3β-Hydroxy-5-pregnen-20-one-¹³C₂,d₂	Isotope-Labeled Compounds Autophagy Cannabinoid Receptor Endogenous Metabolite TRP Channel	Neurological Disease
Pregnenolone- ¹³C₂,d₂ is the deuterium and ¹³C labeled Pregnenolone (HY-B0151). Pregnenolone is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3] .

HY-B0151S

Pregnenolone-d4 3β-Hydroxy-5-pregnen-20-one-d₄	Isotope-Labeled Compounds Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone-d₄ is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

HY-B1739

Pregnenolone monosulfate 5 Publications Verification 3β-Hydroxy-5-pregnen-20-one monosulfate	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate can protect the brain from cannabis intoxication . Pregnenolone monosulfate is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

HY-B0151S2

Pregnenolone-d4-1 3β-Hydroxy-5-pregnen-20-one-d₄-1	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone-d₄-1 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

HY-110189

Pregnenolone monosulfate sodium 5 Publications Verification 3β-Hydroxy-5-pregnen-20-one monosulfate sodium	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication . Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

HY-B0151R

Pregnenolone (Standard) 4 Publications Verification 3β-Hydroxy-5-pregnen-20-one (Standard)	Reference Standards Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone (Standard) is the analytical standard of Pregnenolone. This product is intended for research and analytical applications. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

HY-110189S1

Pregnenolone monosulfate-d4 sodium 3β-Hydroxy-5-pregnen-20-one monosulfate-d₄ sodium	Isotope-Labeled Compounds Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate-d₄ (sodium) is the deuterium labeled Pregnenolone monosulfate. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication . Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

HY-110189R

Pregnenolone monosulfate sodium (Standard)	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate (sodium) (Standard) is the analytical standard of Pregnenolone monosulfate (sodium). This product is intended for research and analytical applications. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication . Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

HY-110189S

Pregnenolone monosulfate sodium-13C2,d2 3β-Hydroxy-5-pregnen-20-one monosulfate sodium-¹³C₂,d₂	Isotope-Labeled Compounds Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy	Neurological Disease
Pregnenolone monosulfate (sodium)- ¹³C₂,d₂ is the ¹³C- and deuterium labeled Pregnenolone monosulfate sodium. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication . Pregnenolone monosulfate sodium salt is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-108451

Ononetin	Structural Classification Leguminosae Source classification Phenols Polyphenols Plants Ononis arvensis Linn.	TRP Channel
Ononetin, a natural deoxybenzoin, is a potent and selective TRPM3 channel blocker with an IC₅₀ of 0.3 μM .

HY-N2131

Isosakuranetin 3 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavanols Rutaceae Other Diseases Plants Citrus bergamia Disease Research Fields	TRP Channel
Isosakuranetin is a flavanone flavonoid which can be found in the fruit of Citrus bergamia. Isosakuranetin is a *TRPM3* blocker ^[3].

HY-W089922

D-erythro-Sphingosine hydrochloride 4 Publications Verification Erythrosphingosine hydrochloride; erythro-C18-Sphingosine hydrochloride; trans-4-Sphingenine hydrochloride	Animals Source classification	TRP Channel
D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific *TRPM3* activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation .

HY-B0151

Pregnenolone 5 Publications Verification 3β-Hydroxy-5-pregnen-20-one	Structural Classification Microorganisms Neurological Disease Classification of Application Fields Anti-aging Source classification Endogenous metabolite Disease Research Fields Steroids	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

HY-B1739

Pregnenolone monosulfate 5 Publications Verification 3β-Hydroxy-5-pregnen-20-one monosulfate	Structural Classification Source classification Endogenous metabolite Steroids	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate can protect the brain from cannabis intoxication . Pregnenolone monosulfate is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

HY-110189

Pregnenolone monosulfate sodium 5 Publications Verification 3β-Hydroxy-5-pregnen-20-one monosulfate sodium	Structural Classification Source classification Endogenous metabolite Steroids	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication . Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

HY-B0151R

Pregnenolone (Standard) 4 Publications Verification 3β-Hydroxy-5-pregnen-20-one (Standard)	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Endogenous metabolite Disease Research Fields Steroids	Reference Standards Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone (Standard) is the analytical standard of Pregnenolone. This product is intended for research and analytical applications. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

HY-110189R

Pregnenolone monosulfate sodium (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Cannabinoid Receptor TRP Channel Endogenous Metabolite Autophagy
Pregnenolone monosulfate (sodium) (Standard) is the analytical standard of Pregnenolone monosulfate (sodium). This product is intended for research and analytical applications. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication . Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

Cat. No.	Product Name	Chemical Structure

HY-B0339S

Primidone-d5
Primidone-d₅ is the deuterium labeled Primidone. Primidone is the orally active inhibitor for *TRPM3* (IC₅₀ = 0.6 μM), RIP kinase and voltage-gated sodium channel, and the antagonist for GABA receptor. Primidone can be used as the analgesic and anticonvulsant agent ^[3].

HY-B0151S2

Pregnenolone-d4-1
Pregnenolone-d₄-1 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

Pregnenolone-d4-1

Pregnenolone-d₄-1 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

HY-17386S1

Rosiglitazone-d4
Rosiglitazone-d₄ is deuterated labeled Rosiglitazone (HY-17386). Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC₅₀: 60 nM, K_d: 40 nM). Rosiglitazone is an TRPC5 activator (EC₅₀: 30 μM) and TRPM3 inhibitor. Rosiglitazone can be used in the research of obesity and diabetes, senescence, ovarian cancer .

HY-17386S

Rosiglitazone-d3
Rosiglitazone-d₃ is the deuterium labeled Rosiglitazone. Rosiglitazone (BRL 49653) is a selective, orally active PPARγ agonist with EC₅₀s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively. Rosiglitazone binds to PPARγ with a Kd of approximately 40 nM. Rosiglitazone is also an activator of TRPC5 (EC₅₀=~30 μM) and an inhibitor of TRPM3 ^[3] .

HY-B0151S1

Pregnenolone-13C2,d2
Pregnenolone- ¹³C₂,d₂ is the deuterium and ¹³C labeled Pregnenolone (HY-B0151). Pregnenolone is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3] .

Pregnenolone-13C2,d2

Pregnenolone- ¹³C₂,d₂ is the deuterium and ¹³C labeled Pregnenolone (HY-B0151). Pregnenolone is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3] .

HY-B0151S

Pregnenolone-d4

Pregnenolone-d₄ is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication . Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

HY-110189S1

Pregnenolone monosulfate-d4 sodium

Pregnenolone monosulfate-d₄ (sodium) is the deuterium labeled Pregnenolone monosulfate. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication . Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

HY-110189S

Pregnenolone monosulfate sodium-13C2,d2

Pregnenolone monosulfate (sodium)- ¹³C₂,d₂ is the ¹³C- and deuterium labeled Pregnenolone monosulfate sodium. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication . Pregnenolone monosulfate sodium salt is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels ^[3].

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TRPM3

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Isotope-Labeled Compounds

Oligonucleotides

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