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Results for "

TPPS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (5) Bacterial (1) Biochemical Assay Reagents (4) DNA Stain (1) Drug Derivative (1) Endogenous Metabolite (2) Fluorescent Dye (2) Fungal (2) HSP (5) Liposome (1) Mitochondrial Metabolism (3) PD-1/PD-L1 (2) PDHK (1) Pyroptosis (1) Reactive Oxygen Species (3) Ser/Thr Protease (3) Small Interfering RNA (siRNA) (6)
By Research Areas:	Cancer (17) Infection (3) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) Cholesterol (1) siRNAs (6)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W075353

*TPPS*	Fluorescent Dye	Cancer
TPPS can be used as a non-cytotoxic probe for detecting tumor location .

HY-135868

Mito-apocynin (C2)	Mitochondrial Metabolism	Neurological Disease
Mito-apocynin (C2), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP ⁺ cation. Mito-apocynin (C2) exhibits antineuroinflammatory effect .

HY-P3139

TPP-1	PD-1/PD-L1	Cancer
TPP-1 is a potent inhibitor of the?PD-1/PD-L1 interaction. TPP-1 binds specifically to PD-L1 with a high affinity (K_D=95 nM). TPP-1 inhibits human tumor growth in vivo via reactivating T-cell function .

HY-107759

Butabindide oxalate UCL-1397 oxalate	Ser/Thr Protease	Neurological Disease
Butabindide (UCL-1397) oxalate is a potent, selective *tripeptidvl peptidase II (TPP* II) inhibitor with K_i** values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation .

HY-W127806

TPPS dihydrochloride	Biochemical Assay Reagents	Others
TPPS dihydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-158189

TPP-Ce6	Biochemical Assay Reagents Apoptosis Reactive Oxygen Species	Others Cancer
Tpp-ce6 is a mitochondria-targeting photosensitizer formed by binding chlorophyll e6 (Ce6) to triphenylphosphine (TPP) via an ester bond. TPP-Ce6 can produce ROS under light irradiation, especially singlet oxygen, which can induce oxidative stress, leading to mitochondrial dysfunction and apoptosis. TPP-Ce6 can be used in the study of mitochondria in apoptosis and energy metabolism as well as cancer therapy .

HY-151342

*Ser@TPP@CUR*	Drug Derivative	Others
Ser@TPP@CUR is a Curcumin (HY-N0005) derivative. Ser@TPP@CUR effectively ameliorates injured renal tubular epithelial cells and improves renal functions of acute kidney injury (AKI) mice. Ser@TPP@CUR can be used for the research of AKI .

HY-157933

SF-C5-TPP	Mitochondrial Metabolism	Infection
SF-C5-TPP is an potent mitochondria-targeted protonophoric uncoupler. SF-C5-TPP has significant proton transfer activity on model planar bilayer lipid membranes. SF-C5-TPP inhibits the growth of Bacillus subtilis with a MIC of 2 μM ^>[1].

HY-P3139A

TPP-1 TFA	PD-1/PD-L1	Cancer
TPP-1 TFA is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 TFA binds specifically to PD-L1 with a high affinity (K_D=95 nM). TPP-1 TFA inhibits human tumor growth in vivo via reactivating T-cell function .

HY-150070

Butabindide UCL-1397	Ser/Thr Protease	Neurological Disease
Butabindide (UCL-1397) is a potent, selective *tripeptidvl peptidase II (TPP* II) inhibitor with K_i** values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation .

HY-159734

TPP-resveratrol	Apoptosis	Cancer
TPP-resveratrol is a conjugate of Resveratrol (HY-16561) and triphenylphosphine (TPP) with anticancer activity. TPP-resveratrol increases the potency of Resveratrol through mitochondrial-targeted delivery and induces mitochondria-mediated apoptosis .

HY-144831

6BrCaQ-C10-TPP	HSP	Cancer
6BrCaQ-C10-TPP is a potent mitochondrial heat shock protein TRAP1 inhibitor, with antiproliferative activity in various human cancer cells (IC₅₀=0.008-0.30 μM). 6BrCaQ-C10-TPP can also induces mitochondrial membrane disturbance .

HY-P10656

Ac-DEVDD-TPP	Apoptosis Pyroptosis	Cancer
Ac-DEVDD-TPP is a porphyrin derivative that can be converted into D-TPP by caspase-3 cleavage and laser irradiation. The formed porphyrin nanofibers can effectively induce Apoptosis and Pyroptosis. Ac-DEVDD-TPP has antitumor activity .

HY-102007

Gamitrinib TPP	HSP	Cancer
Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.

HY-102007A

*Gamitrinib TPP* hexafluorophosphate** 10+ Cited Publications	HSP	Cancer
Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.

HY-W111141

BCN-OH endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne	Biochemical Assay Reagents	Others
BCN-OH (endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne) is a mitochondrial probe based on the lyophilic bidentate bicyclic ligand BCN and is a control reagent for BCN-TPP. The TPP group is a reactive sulfenic acid probe that targets mitochondria. BCN-TPP is known to affect mitochondrial energy, causing a sharp decrease in basal respiration, causing it to exhibit faster reaction kinetics with sulfonated proteins. BCN-OH does not contain hydrophobic triphenylphosphonium (TPP) ions. Using BCN-OH as a control allows the TPP group to be safely introduced when designing sulfenic acid traps .

HY-RS14942

TPP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TPP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TPP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TPP1 Human Pre-designed siRNA Set A TPP1 Human Pre-designed siRNA Set A

HY-RS25466

Tpp2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tpp2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tpp2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tpp2 Rat Pre-designed siRNA Set A Tpp2 Rat Pre-designed siRNA Set A

HY-RS14943

TPP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TPP2 Human Pre-designed siRNA Set A contains three designed siRNAs for TPP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TPP2 Human Pre-designed siRNA Set A TPP2 Human Pre-designed siRNA Set A

HY-RS24220

Tpp1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tpp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tpp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tpp1 Rat Pre-designed siRNA Set A Tpp1 Rat Pre-designed siRNA Set A

HY-RS18977

Tpp2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tpp2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tpp2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tpp2 Mouse Pre-designed siRNA Set A Tpp2 Mouse Pre-designed siRNA Set A

HY-RS17753

Tpp1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tpp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tpp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tpp1 Mouse Pre-designed siRNA Set A Tpp1 Mouse Pre-designed siRNA Set A

HY-P10707

Tpp-CAQK	Endogenous Metabolite	Inflammation/Immunology
Tpp-CAQK can bind to mitochondria, enabling the construction of an engineered mitochondrial compound, Mito-Tpp-CAQK, with excellent bioactivity. Mito-Tpp-CAQK can be internalized by macrophages, thereby enhancing the phagocytosis of myelin debris, alleviating mitochondrial dysfunction, and reducing proinflammatory profiles, ultimately facilitating tissue repair and functional recovery in mice after spinal cord injury .

HY-P10707A

Tpp-CAQK TFA	Endogenous Metabolite	Inflammation/Immunology
Tpp-CAQK TAF can bind to mitochondria, enabling the construction of an engineered mitochondrial compound, Mito-Tpp-CAQK TFA, with excellent bioactivity. Mito-Tpp-CAQK TFA can be internalized by macrophages, thereby enhancing the phagocytosis of myelin debris, alleviating mitochondrial dysfunction, and reducing proinflammatory profiles, ultimately facilitating tissue repair and functional recovery in mice after spinal cord injury .

HY-100116A

Mitoquinone mesylate Maximum Cited Publications 117 Publications Verification MitoQ mesylate; MitoQ10 mesylate	Reactive Oxygen Species	Metabolic Disease Cancer
Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant in order to protect against oxidative damage .

HY-135869

Mito-apocynin (C11) 3 Publications Verification	Mitochondrial Metabolism	Neurological Disease
Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP ⁺ cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function .

HY-144768

(R)-Chol-TPP	Liposome	Others
(R)-Chol-TPP a mitochondria targeting liposome ligand could be used in pH-redox responsive .

HY-W854649

*[Au(TPP)]Cl*	HSP	Cancer
[Au(TPP)]Cl inhibits the refolding activity of the Hsp60-Hsp10 complex with significant anticancer activities .

HY-161048

PDH E1-IN-1	PDHK	Others
PDH E1-IN-1 (compound 24) is a selective TPP-competitive PDH E1 with an IC₅₀ value of 0.99 μM .

HY-103656

Tetraphenylporphyrin TPP; Tetraphenylporphine; meso-Tetraphenylporphyrin	Others	Cancer
Tetraphenylporphyrin (TPP) is a symmetrically substituted porphyrin-based heterocyclic compound and used as a structural block for supramolecular synthesis. Tetraphenylporphyrin derivatives can be used for cancer research .

HY-151404

Antitumor agent-76	Apoptosis	Cancer
Antitumor agent-76 (Compound TP-P1) is an orally active, rapid-release and water-soluble Triptolide (HY-32735) proagent with antitumor activity .

HY-144830

6BrCaQ	HSP	Cancer
6BrCaQ is a potent mitochondrial heat shock protein TRAP1 inhibitor, with antiproliferative activity. 6BrCaQ can be used in the synthesis of 6BrCaQ-TPP conjugates .

HY-P4470

Phe-Pro-Ala-pNA	Ser/Thr Protease	Cancer
Phe-Pro-Ala-pNA is a chromogenic substrate of tripeptidyl peptidase. Phe-Pro-Ala-pNA can be used to test tripeptidyl peptidase activity .

HY-158918

*4-CF3-TPP-DC* 4-CF3-Triphenylphosphonium-DC	Biochemical Assay Reagents	Others
4-CF3-TPP-DC (4-CF3-Triphenylphosphonium-DC) is an inert mitochondrial targeting carrier, that delivers target drugs and probes to mitochondria without causing mitochondrial depolarization and cytotoxicity in cell C2C12 .

HY-W582504

Chlorotris(triphenylphosphine)copper CuCl(TPP)3	DNA Stain Bacterial Fungal	Infection Cancer
Chlorotris(triphenylphosphine)copper (CuCl(TPP)₃) is a DNA-targeted metal complex. Chlorotris(triphenylphosphine)copper involves non-covalent interactions (such as groove binding mode) through the copper(I) center to affect DNA function, showing inhibitory activity against bacteria, fungi, and tumor cells. Chlorotris(triphenylphosphine)copper is promising for research of antibacterial, antitumor, and antioxidant agents .

HY-144825

Chol-CTPP	Apoptosis Reactive Oxygen Species	Cancer
Chol-CTPP is a ligand with dual targeting effect on blood-brain barrier (BBB) and glioma cells. Lip-CTPP can be gained by Chol-CTPP and another mitochondria targeting ligand (Chol-TPP). Lip-CTPP is a promising potential carrier to exert the anti-glioma effect of doxorubicin (DOX) and lonidamine (LND) collaboratively. Lip-CTPP elevates the inhibition rate of tumor cell proliferation, migration and invasion, promote apoptosis and necrosis, and interfere with mitochondrial function .

HY-151556

Antifungal agent 45	Fungal	Infection
Antifungal agent 45 is with fungicidal activities. Antifungal agent 45 shows excellent characteristics superior to Kresoxim-methyl (HY-125776), in which the activity enhancement against Phytophthora capsici was the most remarkable, with an EC₅₀ value of about 5 μM .

HY-125623

MitoPerOx	Fluorescent Dye	Others
MitoPerOx is a mitochondrial-targeted, lipid peroxidation-indicating fluorescent probe with BODIPY581/591 fluorophores. The triphenylphosphine cation (TPP+) of MitoPerOx can be selectively enriched in mitochondria (depending on membrane potential) and can be used to detect lipid peroxidation in the inner mitochondrial membrane. Under the action of lipid peroxides, the BODIPY581/591 fluorophores of MitoPerOx shift their emission wavelength from 590 nm (reduced state) to 520 nm (oxidized state), and ratiometric detection can be performed at an excitation wavelength of 488 nm. MitoPerOx can specifically monitor the peroxidation of mitochondrial phospholipids (especially cardiolipin) and is used in the study of oxidative stress-related diseases (such as aging, neurodegenerative diseases, and mitochondrial dysfunction)[1][2].

Cat. No.	Product Name	Type

HY-125623

MitoPerOx	Fluorescent Dyes/Probes
MitoPerOx is a mitochondrial-targeted, lipid peroxidation-indicating fluorescent probe with BODIPY581/591 fluorophores. The triphenylphosphine cation (TPP+) of MitoPerOx can be selectively enriched in mitochondria (depending on membrane potential) and can be used to detect lipid peroxidation in the inner mitochondrial membrane. Under the action of lipid peroxides, the BODIPY581/591 fluorophores of MitoPerOx shift their emission wavelength from 590 nm (reduced state) to 520 nm (oxidized state), and ratiometric detection can be performed at an excitation wavelength of 488 nm. MitoPerOx can specifically monitor the peroxidation of mitochondrial phospholipids (especially cardiolipin) and is used in the study of oxidative stress-related diseases (such as aging, neurodegenerative diseases, and mitochondrial dysfunction)[1][2].

MitoPerOx

Fluorescent Dyes/Probes

MitoPerOx is a mitochondrial-targeted, lipid peroxidation-indicating fluorescent probe with BODIPY581/591 fluorophores. The triphenylphosphine cation (TPP+) of MitoPerOx can be selectively enriched in mitochondria (depending on membrane potential) and can be used to detect lipid peroxidation in the inner mitochondrial membrane. Under the action of lipid peroxides, the BODIPY581/591 fluorophores of MitoPerOx shift their emission wavelength from 590 nm (reduced state) to 520 nm (oxidized state), and ratiometric detection can be performed at an excitation wavelength of 488 nm. MitoPerOx can specifically monitor the peroxidation of mitochondrial phospholipids (especially cardiolipin) and is used in the study of oxidative stress-related diseases (such as aging, neurodegenerative diseases, and mitochondrial dysfunction)[1][2].

Cat. No.	Product Name	Type

HY-W111141

BCN-OH endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne	Biochemical Assay Reagents
BCN-OH (endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne) is a mitochondrial probe based on the lyophilic bidentate bicyclic ligand BCN and is a control reagent for BCN-TPP. The TPP group is a reactive sulfenic acid probe that targets mitochondria. BCN-TPP is known to affect mitochondrial energy, causing a sharp decrease in basal respiration, causing it to exhibit faster reaction kinetics with sulfonated proteins. BCN-OH does not contain hydrophobic triphenylphosphonium (TPP) ions. Using BCN-OH as a control allows the TPP group to be safely introduced when designing sulfenic acid traps .

BCN-OH

endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne

Biochemical Assay Reagents

BCN-OH (endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne) is a mitochondrial probe based on the lyophilic bidentate bicyclic ligand BCN and is a control reagent for BCN-TPP. The TPP group is a reactive sulfenic acid probe that targets mitochondria. BCN-TPP is known to affect mitochondrial energy, causing a sharp decrease in basal respiration, causing it to exhibit faster reaction kinetics with sulfonated proteins. BCN-OH does not contain hydrophobic triphenylphosphonium (TPP) ions. Using BCN-OH as a control allows the TPP group to be safely introduced when designing sulfenic acid traps .

HY-144768

(R)-Chol-TPP	Drug Delivery
(R)-Chol-TPP a mitochondria targeting liposome ligand could be used in pH-redox responsive .

HY-W127806

TPPS dihydrochloride	Biochemical Assay Reagents
TPPS dihydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name	Target	Research Area

HY-P3139

TPP-1	PD-1/PD-L1	Cancer
TPP-1 is a potent inhibitor of the?PD-1/PD-L1 interaction. TPP-1 binds specifically to PD-L1 with a high affinity (K_D=95 nM). TPP-1 inhibits human tumor growth in vivo via reactivating T-cell function .

HY-P10707A

Tpp-CAQK TFA	Endogenous Metabolite	Inflammation/Immunology
Tpp-CAQK TAF can bind to mitochondria, enabling the construction of an engineered mitochondrial compound, Mito-Tpp-CAQK TFA, with excellent bioactivity. Mito-Tpp-CAQK TFA can be internalized by macrophages, thereby enhancing the phagocytosis of myelin debris, alleviating mitochondrial dysfunction, and reducing proinflammatory profiles, ultimately facilitating tissue repair and functional recovery in mice after spinal cord injury .

HY-P4470

Phe-Pro-Ala-pNA	Ser/Thr Protease	Cancer
Phe-Pro-Ala-pNA is a chromogenic substrate of tripeptidyl peptidase. Phe-Pro-Ala-pNA can be used to test tripeptidyl peptidase activity .

HY-P3139A

TPP-1 TFA	PD-1/PD-L1	Cancer
TPP-1 TFA is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 TFA binds specifically to PD-L1 with a high affinity (K_D=95 nM). TPP-1 TFA inhibits human tumor growth in vivo via reactivating T-cell function .

HY-P10656

Ac-DEVDD-TPP	Apoptosis Pyroptosis	Cancer
Ac-DEVDD-TPP is a porphyrin derivative that can be converted into D-TPP by caspase-3 cleavage and laser irradiation. The formed porphyrin nanofibers can effectively induce Apoptosis and Pyroptosis. Ac-DEVDD-TPP has antitumor activity .

HY-P10707

Tpp-CAQK	Endogenous Metabolite	Inflammation/Immunology
Tpp-CAQK can bind to mitochondria, enabling the construction of an engineered mitochondrial compound, Mito-Tpp-CAQK, with excellent bioactivity. Mito-Tpp-CAQK can be internalized by macrophages, thereby enhancing the phagocytosis of myelin debris, alleviating mitochondrial dysfunction, and reducing proinflammatory profiles, ultimately facilitating tissue repair and functional recovery in mice after spinal cord injury .

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