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TH 10184

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-176262
    TH10184

    		Ligands for Target Protein for PROTAC Cancer
    TH10184 is a NUDT5 inhibitor. TH10184 can be conjugated with VH032 (HY-125845) and linker (HY-W001958) to synthesize PROTAC NUDT5 degrader DDD2 (HY-176261) .
    TH10184
  • HY-176263
    TH10184-octanedioic acid

    		Target Protein Ligand-Linker Conjugates Cancer
    TH10184-octanedioic acid is a conjugate of the NUDT5 ligand (HY-176262) and the linker (HY-W001958). TH10184-octanedioic acid can be used for synthesizing PROTAC NUDT5 degrader DDD2 (HY-176261) .
    TH10184-octanedioic acid
  • HY-176261
    DDD2

    		PROTACs Cancer
    DDD2 is a selective and potent VHL-mediated PROTAC NUDT5 degrader. DDD2 induces robust NUDT5 degradation. DDD2 consists of the warhead TH10184 connected to the VHL recruiting ligand, VH032, through a saturated aliphatic eight carbon linker. DDD2 can be used in cancer research, such as lymphocytic leukemia and osteosarcoma . (Structure Note: Blue: NUDT5 inhibitor (HY-176262); Pink: E3 (HY-125845); Black: linker (HY-W001958))
    DDD2

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