Search Result
Results for "
Streptomyces sp
" in MedChemExpress (MCE) Product Catalog:
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-N12787
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Others
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Others
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T-Muurolol is a sesquiterpene and can be isolated from Streptomyces sp. M491 .
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- HY-P2936
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Phospholipase
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Metabolic Disease
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Sphingomyelin phosphodiesterase, Streptomyces sp., a hydrolase, is involved in the sphingomyelin metabolism process. Sphingomyelin phosphodiesterase hydrolyzes the conversion of sphingomyelin to phosphocholine and ceramide. Sphingomyelin phosphodiesterase also plays an important role in cellular differentiation, various immune and inflammatory responses, and intracellular cholesterol trafficking and metabolism .
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- HY-E70328
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Endogenous Metabolite
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Others
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Alkalophilic Proteinase, Streptomyces sp is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
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- HY-113945
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Antibiotic
Bacterial
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Infection
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Abbeymycin is an antibiotic derived from the actinobacterium Streptomyces sp. AB-999F-52. Abbeymycin is a specifically acting antibiotic with antimicrobial activity, primarily targeting anaerobic bacteria. Abbeymycin is employed in research concerning antibiotic discovery and screening .
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- HY-124163
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- HY-N13149
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- HY-N13017
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- HY-108993
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SNA-8073A; Rubiginone A2
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Others
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Others
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Fujianmycin B (SNA-8073A) is found in the strain of Streptomyces sp .
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- HY-N14403
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Cathepsin
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Infection
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6-Hydroxytetrangulol is a CPP32 protease inducer found in Streptomyces sp .
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- HY-N14778
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Others
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Others
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N-Acetylisopenicillin N is isolated from the culture broth of Streptomyces tokunonensis sp. nov .
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- HY-114585A
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Glutathione S-transferase
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Others
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Sperabillin A (dihydrochloride)is new inhibitors ofglutathione S-transferaseisolated from the culture broth ofStreptomyces sp .
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- HY-N11620
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Proteasome
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Others
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Sadopeptins A is a nature product that could be isolated from Streptomyces sp. Sadopeptins A is a potent proteasome inhibitor .
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- HY-125458
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NO Synthase
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Others
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Iromycin A is a potent inhibitor of nitric oxide synthases (NO synthase) that can be isolated from Streptomyces sp. .
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- HY-N15078
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Herbicide
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Others
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4-Chlorothreonine is found in the strain of Streptomyces sp. OH-5093 with herbicidal activity .
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- HY-N14811
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Others
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Others
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Gibbestatin C is found in the strain of Streptomyces sp. C39. Gibbestatin C is a bioactive substance .
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- HY-119246
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- HY-119025
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- HY-131054
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- HY-N14766
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GLUT
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Metabolic Disease
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Mumbaistatin is a glucose-3-phosphate translocase inhibitor found in Streptomyces sp. DSM 11641 .
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- HY-N13975
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Others
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Cancer
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Belactosin A is found in the strain of Streptomyces sp. that inhibits HeLa S3 cells with the IC50 of 51 μM .
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- HY-129669
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Antibiotic
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Infection
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Landomycin A is a notable antibiotic belonging to the angucycline class, characterized by its hexasaccharide structure, and is derived from Streptomyces sp.
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- HY-N11621
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Proteasome
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Others
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Sadopeptins B is a nature product that could be isolated from Streptomyces sp. Sadopeptins B is a potent proteasome inhibitor .
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- HY-125410
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Endogenous Metabolite
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Infection
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Promothiocin A is a thiopeptide with tipA promoter inducing activity. Promothiocin A can be extracted from Streptomyces sp. SF2741 .
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- HY-N13976
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Others
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Cancer
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Belactosin C is found in the strain of Streptomyces sp. that inhibits HeLa S3 cells with the IC50 of 200 μM .
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- HY-N14989A
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Dipeptidyl Peptidase
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Others
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Fluostatin A sodium is a dipeptidyl peptidaseIII inhibitor with an IC50 of 0.44 μg/mL. Fluostatin A can be extracted from Streptomyces sp. TA-3391 .
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- HY-N11415
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Antibiotic
Bacterial
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Infection
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Aurachin SS is a nature product that could be isolated from Streptomyces sp. NA04227. Aurachin SS is an antibiotic and has antibacterial activity .
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- HY-N12322
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Antibiotic
Bacterial
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Infection
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Dihydrotetrodecamycin is an antibiotic that can be isolated from the fermentation broth of Streptomyces nashvillensis MJ885-mF8. Dihydrotetrodecamycin has MIC values of 50 mg/mL against both Pasteurella piscicida sp. 639 and P. piscicida sp. 6356 .
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- HY-N14363
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- HY-N13962
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Bacterial
Fungal
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Infection
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Bagremycin A is found in the strain of Streptomyce sp. Tu 4128. Bagremycin A has weak activity against Gram-positive bacteria, Saccharomyces cerevisiae and Candida albicans .
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- HY-106338
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Bacterial
ADC Cytotoxin
Parasite
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Infection
Cancer
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Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities .
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- HY-111264
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Antibiotic
Bacterial
Fungal
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Infection
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Naphthomycin B is an antibiotic, which is initially isolated from Streptomyces sp. Naphthomycin B exhibits antimicrobial activities against gram positive bacteria and many fungis .
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- HY-125653
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Antibiotic
Bacterial
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Infection
Cancer
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Kapurimycin A2 is an antitumor antibiotic that can be found in the culture of Streptomyces sp.. Kapurimycin A2 is an active against bacteria, particularly Gram-positive organisms .
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- HY-N14113
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Insecticide
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Infection
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Cytosaminomycin D is an anticoccidial agent that can be isolated from Streptomyces sp. Cytosaminomycin D shows anticoccidial activity at 2.5 μg/mL with a 100% inhibition rate .
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- HY-N13963
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Bacterial
Fungal
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Infection
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Bagremycin B is found in the strain of Streptomyce sp. Tu 4128. Bagremycin B has weak activity against Gram-positive bacteria, Saccharomyces cerevisiae and Candida albicans .
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- HY-119736
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Others
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Others
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Leptolstatin is an inhibitor of the progression of G1 and G2 phases of the mammalian cell cycle. Leptolstatin can be extracted from the fermentation broth of Streptomyces sp. SAM1595 .
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- HY-12450
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Lomondomycin
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Antibiotic
Bacterial
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Infection
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Lomofungin is a novel antibiotic produced by Streptomyces lomondensis sp.N . Lomofungin can inhibit MBNL1-CUG RNA binding. Lomofungin has antibacterial activity .
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- HY-129558
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HCV
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Infection
Cancer
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UK-1 is a cytotoxic metabolite from Streptomyces sp. 517-02 and exerts a wide spectrum of potent anticancer activities . UK-1 also inhibits HCV replication .
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- HY-N14993
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Others
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Cancer
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3'-Deoxytalopiericidin is found in the strain of Streptomyces sp.DO-100. 3'-Deoxytalopiericidin inhibited the activity of 26 cell in rectal cancer than L1210 cell in leukemia .
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- HY-125637
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Aabomycin A2
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Antibiotic
Fungal
ATP Synthase
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Infection
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Venturicidin B (Aabomycin A2) is a macrolide antibiotic isolated from Streptomyces sp., used as an antifungal agent, a potent inhibitor of the mitochondrial F0-ATP synthase complex .
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- HY-N14601
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Bacterial
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Cancer
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Respinomycin A1 is an antibiotic. Respinomycin A1 can be found in Streptomyces sp. RK-483. Respinomycin A1 causes the differentiation of leukemic K-562 cells .
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- HY-121452
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nAChR
Calcium Channel
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Cancer
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Migrastatin is a typical Fascin1 inhibitor. Migrastatin is isolated from a cultured broth of Streptomyces sp. MK929-43F1. Migrastatin inhibits tumor cell migration .
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- HY-N14350
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Bacterial
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Hydroxychlorothricin is an antibiotic of the chlorothricin group. Hydroxychlorothricin can be found in Streptomyces sp. K818. Hydroxychlorothricin has anti-tumor effect and can prolong the survival period of ICR mice inoculated with Ehrlich cancer cells .
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- HY-N14365
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Bacterial
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Infection
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Sannamycin J is an aminoglycoside antibiotic. Sannamycin J can be found in Streptomyces sannanensis sp. KC-7038. Sannamycin J has weak antibacterial activity against Gram-positive bacteria and Gram-negative bacteria .
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- HY-N10605
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SARS-CoV
Influenza Virus
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Infection
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Maniwamycin E is a maniwamycin derivative isolated from the culture extract of thermotolerant Streptomyces sp. JA74. Maniwamycin E shows antiviral activity against SARS-CoV-2 and influenza (H1N1) virus .
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- HY-118331
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PD 124895; CL-1957E
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Antibiotic
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Infection
Cancer
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Kazusamycin B is an antibiotic that could be isolated from the fermentation broth of Streptomyces sp. No. 81-484. Kazusamycin B inhibits cell growth and arrests cell cycle at G1 phase. Kazusamycin B can be used in research of cancer .
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- HY-119604
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Antibiotic
Bacterial
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Infection
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Cafamycin is a polyether antibiotic active against gram-positive bacteria, including Staphylococcus aureus. Cafamycin also demonstrates insecticidal and antiprotozoal activities. Cafamycin is isolated from the culture fluid of Streptomyces sp., an organism producing the anthracycline antibiotic galtamycin .
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- HY-N11699
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Glutathione S-transferase
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Inflammation/Immunology
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Bequinostatin A is a benzo[a]naphthacenequinone metabolite that can be isolated from Streptomyces sp. MI384-DF12. Bequinostatin A shows considerable inhibitory activity against human pi class glutathione S-transferase (GST pi) .
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- HY-125747
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Actinomycin V
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Bacterial
Antibiotic
Apoptosis
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Infection
Cancer
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Actinomycin X2 (Actinomycin V),produced by many Streptomyces sp.,shows strong inhibition of MRSA with a minimum inhibitory concentration (MIC) value of 0.25 μg/mL. Actinomycin X2 can be used for cancer and bacterial infection .
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- HY-N14594
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GLCB
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Bacterial
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Infection
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Glucoallosamidin B is a glycoside antibiotic. Glucoallosamidin B can be found in Streptomyces sp. SA-684. Glucoallosamidin B inhibits Chitinase activity. Glucoallosamidin B inhibits candida albicans ATCC 10231 chitinase with an IC50 of 0.8 μg/mL .
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- HY-N14558
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Others
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Neurological Disease
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3',8-Dihydroxy-4',6,7-trimethoxyisoflavone is found in the strain of Streptomyces sp. 3',8-Dihydroxy-4',6,7-trimethoxyisoflavone is a catechole-O-methyltransferase inhibitor (IC50 is 0.2 g/mL) .
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- HY-163113
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Endogenous Metabolite
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Cancer
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Anticancer agent 180 (compound 4) is a secondary metabolite present in fungal strains and extracted through physical interaction with Streptomyces sp. Anticancer agent 180 has potential anti-tumor activity and can inhibit the migration of MDA-MB-231 breast cancer cells .
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- HY-N15194A
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Antibiotic
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Cancer
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Inostamycin A sodium is an antibiotic, which can be found in Streptomyces sp. MH816-AF15. Inostamycin A sodium blocks the phosphatidylinositol turnover, exhibits antimicrobial and cytotoxic activities through inhibition of CDP-DG:inositol transferase. Inostamycin A sodium is promising for research of cancers .
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- HY-123095
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JBIR 100
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Antibiotic
Bacterial
Proton Pump
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Infection
Inflammation/Immunology
Endocrinology
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TS 155-2 (JBIR 100), an antimicrobial agent, is a Bafilomycin analogue and an antibiotic. TS 155-2 can be isolated from a culture of Streptomyces sp. TS 155-2 inhibits V-ATPase activity. V-ATPase is correlated with an increasing number of diseases such as osteopetrosis, male infertility and renal acidosis .
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- HY-N15005
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Others
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Neurological Disease
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Espicufolin is a neuroprotective substance that can be found in Streptomyces sp:cu39. Espicufolin can inhibit glutamate toxicity, thereby reducing or overcoming cerebral ischemic damage, with a toxicity EC50 value of 40 nM for N18-RE-105 cells. Espicufolin can be used in the study of neurodegenerative diseases .
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- HY-19828
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GEX1A
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DNA/RNA Synthesis
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Cancer
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Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome .
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- HY-121071
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Bacterial
Nucleoside Antimetabolite/Analog
Antibiotic
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Infection
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Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. Ascamycin has a selective antibacterial activity against Xanthomonas species with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Xanthomonas citri, Xanthomonas oryzae and Mycobacterium phlei, respectively .
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- HY-114798
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- HY-N15349
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Others
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Cancer
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Nocapyrone Q is a polyketide compound discovered in the karst cave mold Streptomyces sp. FD-2-6. At a dose of 100 μM, Nocapyrone Q exhibits inhibitory activity against human hepatocellular carcinoma HepG2 cells and human cervical cancer HeLa cells. Nocapyrone Q holds potential for research in the field of cancer therapy .
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- HY-N14111
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Bacterial
Fungal
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Infection
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Cuevaene A can be isolated from the strain of gdmAI-disrupted Streptomyces sp. LZ35 and. Cuevaene A displays moderate activity against Gram-positive bacteria (e.g., Bacillus subtilis strain ATCC 11060) and modest activity against fungi (e.g., Fusarium verticillioides strain S68 and Rhizoctonia solani strain GXE4) .
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- HY-W050151
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Bacterial
DNA/RNA Synthesis
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Infection
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2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent that defends the emerging antibacterial resistance, which is found in marine Streptomyces sp. VITVSK1. 2,5-Di-tert-butyl-1,4-benzoquinone is also a potent inhibitor of RNA polymerase .
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- HY-N14112
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Bacterial
Fungal
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Infection
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Cuevaene B can be isolated from the strain of gdmAI-disrupted Streptomyces sp. LZ35 and. Cuevaene B displays moderate activity against Gram-positive bacteria (e.g., Bacillus subtilis strain ATCC 11060) and modest activity against fungi (e.g., Fusarium verticillioides strain S68 and Rhizoctonia solani strain GXE4) .
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- HY-130173
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Bacterial
Fungal
Na+/K+ ATPase
Apoptosis
Antibiotic
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Infection
Cancer
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Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H +-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi . Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC) .
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- HY-N14056
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Bacterial
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Infection
Cancer
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Chrolactomycin is found in the strain of Streptomyces sp. 569N-3. The IC50 of Chrolactomycin for ACHN, A431, McF-7 and T24 cells are 1.2 μM, 1.6 μM, 0.69 μM and 0.45 μM, respectively. Chrolactomycin has only anti-Gram-positive bacteria activity with the MIC of 5.2-10.4 μg/mL .
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- HY-120721
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Lipoxygenase
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Cancer
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Lagunamycin is a 5-lipoxygenase inhibitor isolated from the culture medium of Streptomyces sp. AA0310. Lagunamycin has a significant inhibitory activity against rat 5-lipoxygenase with an IC50 value of 6.08 μM. Lagunamycin can effectively inhibit 5-lipoxygenase without causing lipid peroxidation, indicating that it has an effective inhibitory effect without causing side effects.
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- HY-105463
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Antibiotic
Bacterial
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Infection
Cancer
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Saptomycin D is an antibiotic with antitumor activity isolated from the Streptomyces sp. HP530 strain. Saptomycin D exhibits potent inhibitory effects against Gram-positive bacteria, while demonstrating weaker inhibitory activities against certain Gram-negative bacteria and yeasts. Saptomycin D also displays remarkable antitumor properties. Saptomycin D is applicable in research within the field of oncology .
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- HY-P1708
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BRN 537924; NSC 657143
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Bacterial
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Infection
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Enopeptin A, originally isolated from a culture broth of Streptomyces sp. RK-1051, is a depsipeptide antibiotic that contains two unusual amino acids (N-methylalanine and 4-methylproline) and features a pentaenone side chain. It is effective against Gram-positive bacteria, including methicillin-resistant S. aureus (MIC=25 μg/mL), and Gram-negative bacteria, including mutant forms of E. coli and P. aeruginosa (MICs=200 μg/mL); however, it is not inhibitory to fungi.
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- HY-N15587
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Gostatine
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Aminotransferases (Transaminases)
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Metabolic Disease
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Gostatin is an inhibitor of aspartate aminotransferase (GOT). Gostatin is found in Streptomyces sumanensis nov. sp. NK-23. Gostatin has a strong inhibitory effect on pig heart GOT, a weak inhibitory effect on wheat germ GOT and GPT, and no significant effect on glutamate dehydrogenase and glutamine synthetase. The inhibitory mechanism of gostatin is similar to substrate competitive inhibition, and aspartate has a protective effect on its inhibitory effect. Gostatin can be used to study the catalytic mechanism of GOT and its role in nitrogen metabolism .
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- HY-118043
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Antibiotic
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Infection
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RK-1441B is an anti-phage antibiotic produced by Streptomyces sp. RK-1441 and belongs to the pyrrolo[1,4]benzodiazepine class. RK-1441B has antiphage activity but no significant antimicrobial activity against a supersusceptible E. coli strain to an antitumor antibiotic. RK-1441B is inactive in vitro and may be converted to the active form in the host organism. Its fellow antibiotic RK-1441A can form an adduct with guanine residues in the DNA chain to exert resistance .
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- HY-134090
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Antibiotic TS 885; NSC 248958
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Bacterial
VSV
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Infection
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9-Methylstreptimidone is a microbial metabolite originally isolated from Streptomyces sp. S-885 that has antifungal and antiviral activities. It is active against several fungi, including S. sake, S. fragilis, R. rubra, T. rubra, and C. albidus (MICs=4-20 μg/mL) and has antiviral activity against poliovirus, vesicular stomatitis virus (VSV), and Newcastle disease virus (NDV) in vitro (MIC=0.02 μg/mL for all). 9-Methylstreptimidone increases survival in mouse models of infection with influenza A2 (H2N2) or C. albicans when administered prior to infection.
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-125747
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Actinomycin V
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Bacterial
Antibiotic
Apoptosis
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Infection
Cancer
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Actinomycin X2 (Actinomycin V),produced by many Streptomyces sp.,shows strong inhibition of MRSA with a minimum inhibitory concentration (MIC) value of 0.25 μg/mL. Actinomycin X2 can be used for cancer and bacterial infection .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
- HY-120721
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Structural Classification
Natural Products
Microorganisms
Source classification
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Lipoxygenase
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Lagunamycin is a 5-lipoxygenase inhibitor isolated from the culture medium of Streptomyces sp. AA0310. Lagunamycin has a significant inhibitory activity against rat 5-lipoxygenase with an IC50 value of 6.08 μM. Lagunamycin can effectively inhibit 5-lipoxygenase without causing lipid peroxidation, indicating that it has an effective inhibitory effect without causing side effects.
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- HY-105463
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Quinones
Structural Classification
Microorganisms
Anthraquinones
Source classification
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Antibiotic
Bacterial
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Saptomycin D is an antibiotic with antitumor activity isolated from the Streptomyces sp. HP530 strain. Saptomycin D exhibits potent inhibitory effects against Gram-positive bacteria, while demonstrating weaker inhibitory activities against certain Gram-negative bacteria and yeasts. Saptomycin D also displays remarkable antitumor properties. Saptomycin D is applicable in research within the field of oncology .
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- HY-N15587
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Gostatine
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Structural Classification
Microorganisms
Ketones, Aldehydes, Acids
Source classification
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Aminotransferases (Transaminases)
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Gostatin is an inhibitor of aspartate aminotransferase (GOT). Gostatin is found in Streptomyces sumanensis nov. sp. NK-23. Gostatin has a strong inhibitory effect on pig heart GOT, a weak inhibitory effect on wheat germ GOT and GPT, and no significant effect on glutamate dehydrogenase and glutamine synthetase. The inhibitory mechanism of gostatin is similar to substrate competitive inhibition, and aspartate has a protective effect on its inhibitory effect. Gostatin can be used to study the catalytic mechanism of GOT and its role in nitrogen metabolism .
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