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Results for "

Specific uptake

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PSMA (2) Adrenergic Receptor (2) Amino acid Transporter (2) Apoptosis (2) Autophagy (2) Biochemical Assay Reagents (3) Caspase (2) DNA/RNA Synthesis (1) Dopamine Receptor (2) Dopamine Transporter (1) FAAH (1) FAP (2) GLUT (1) Histone Methyltransferase (1) iGluR (1) Integrin (1) Interleukin Related (4) LPL Receptor (1) MDM-2/p53 (2) NF-κB (2) NO Synthase (2) Notch (1) Parasite (3) PD-1/PD-L1 (1) Phosphodiesterase (PDE) (1) Radionuclide-Drug Conjugates (RDCs) (1) RANKL/RANK (2) Reference Standards (2) Sodium Channel (1) TNF Receptor (2) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (11) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (9)
Oligonucleotides:	CpG ODNs (2)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: PSMA SNIPERs BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3436

WLSEAGPVVTVRALRGTGSW	Apoptosis	Cardiovascular Disease
WLSEAGPVVTVRALRGTGSW is a cardiomyocyte specific peptide. WLSEAGPVVTVRALRGTGSW-expressing exosomes can improve specific uptake by cardiomyocytes, decrease cardiomyocyte apoptosis, and enhance cardiac retention following intramyocardial injection in vivo .

HY-115853A

Pyclen dihydrochloride	Biochemical Assay Reagents	Others
Pyclen dihydrochloride is a compound used for liver-specific MRI. Related compounds are synthesized as ligands of manganese (II) and have certain relaxivity and hepatocyte uptake ability. Pyclen dihydrochloride is a potential liver-specific contrast agent .

HY-14560C

Reboxetine mesylate 2 Publications Verification FCE20124 mesylate; PNU155950E mesylate	Adrenergic Receptor	Neurological Disease
Reboxetine mesylate (FCE20124 mesylate) is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) for the research of depression. Reboxetine mesylate inhibits the uptake of norepinephrine, with a K_i of 8 nM .

HY-134452

MeAIB 2 Publications Verification α-(Methylamino)isobutyric acid	Amino acid Transporter	Cancer
MeAIB (α-(Methylamino)isobutyric acid) is a specific?substrate for amino acid transport system A (ATA1). ATA mediate the uptake of short-chain neutral amino acids in a Na ⁺-dependent manner .

HY-100968

GBR 12783 dihydrochloride	Dopamine Receptor	Neurological Disease
GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [ ³H]dopamine uptake by rat and mice striatal synaptosomes with IC₅₀s of 1.8 nM and 1.2 nM, respectively. GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats .

HY-175014

LGT-1	PD-1/PD-L1 Biochemical Assay Reagents	Cancer
LGT-1 is a PD-L1 ligand. LGT-1 labeled with ¹⁸F has an excellent specific uptake in B16-F10 tumor cells, and shows a high tumor uptake but a low liver uptake with good stability in B16-F10 tumor-bearing mice model. LGT-1 can be used as a radiotracer for PET imaging of PD-L1 expression in tumors .

HY-115853

Pyclen	Biochemical Assay Reagents	Others
Pyclen is a compound used for liver-specific MRI. Related compounds were synthesized as ligands of manganese (II) and have certain relaxivity and hepatocyte uptake ability. It is a potential liver-specific contrast agent.

HY-P3436A

WLSEAGPVVTVRALRGTGSW TFA	Apoptosis	Cardiovascular Disease
WLSEAGPVVTVRALRGTGSW TFA is a cardiomyocyte specific peptide. WLSEAGPVVTVRALRGTGSW-expressing exosomes can improve specific uptake by cardiomyocytes, decrease cardiomyocyte apoptosis, and enhance cardiac retention following intramyocardial injection in vivo .

HY-119141

RH 3421	Sodium Channel	Neurological Disease
RH 3421, an insecticidal dihydropyrazole, acts as an inhibitor of sodium channel-specific sodium uptake, blocking the uptake stimulated by Veratridine (HY-N6691), Vatrachotoxin (HY-12549), crude scorpion .

HY-W008610

GBR 12783	Dopamine Receptor	Neurological Disease
GBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the [ ³H]dopamine uptake by rat and mice striatal synaptosomes with IC₅₀s of 1.8 nM and 1.2 nM, respectively. GBR 12783 can improve memory performance and increase hippocampal acetylcholine release in rats .

HY-163079

AlF-PD-FAPI	FAP	Cancer
AlF-PD-FAPI has affinity for FAP , with the IC₅₀ of 0.13 nM, and shows a specific uptake, high internalized fraction, and low cellular efflux in vitro. AlF-PD-FAPI can be used as FAP-targeting tracer .

HY-14560CR

Reboxetine mesylate (Standard) FCE20124 mesylate (Standard); PNU155950E mesylate (Standard)	Reference Standards Adrenergic Receptor	Neurological Disease
Reboxetine (mesylate) (Standard) is the analytical standard of Reboxetine (mesylate). This product is intended for research and analytical applications. Reboxetine mesylate (FCE20124 mesylate) is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) for the research of depression. Reboxetine mesylate inhibits the uptake of norepinephrine, with a K_i of 8 nM .

HY-D2281

FAP Ligand 2	FAP	Cancer
FAP Ligand 2, a FAPI-46 derivative, is a specific fibroblast activation protein (FAP)-targeted tracer. FAP Ligand 2 exhibits good tumor uptake and acts as a promising molecular tracer for FAP tumor imaging .

HY-150741A

Biotin-labeled ODN 2216 sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
Biotin-labeled ODN 2216 (sodium) is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. Biotin-labeled ODN 2216 (sodium) can be used to evaluate CpG ODN cellular uptake and localization using a biotin detection system and light microscopy.

HY-P5098

E(c(RGDfK))2	Integrin	Cancer
E(c(RGDfK)) is an αvβ3 integrin-specific binding moiety with tumor targeting properties. Increased uptake of E(c(RGDfK)) in human ovarian cancer OVCAR-3 xenograft tumors may be useful in cancer research .

HY-153612

MMV009085	GLUT Parasite	Infection Inflammation/Immunology
MMV009085 is a potent PfHT1 (Plasmodium falciparum hexose transporter)-specific inhibitor and a potential anti-malarial agent . MMV009085 is also a human glucose transporter inhibitor, it has high potency in inhibiting both glucose uptake (IC₅₀: 2.6 μM in glucose uptake assay) and growth of the parasites (EC₅₀: 1.23±0.04 μM against 3D7) .

HY-134452R

MeAIB (Standard)	Amino acid Transporter	Cancer
MeAIB (Standard) is the analytical standard of MeAIB. This product is intended for research and analytical applications. MeAIB (α-(Methylamino)isobutyric acid) is a specific substrate for amino acid transport system A (ATA1). ATA mediate the uptake of short-chain neutral amino acids in a Na+-dependent manner .

HY-N15726

Obtusichromoneside C	Others	Others
Obtusichromoneside C is a chromone C-glycoside found in the seeds of Cassia obtusifolia. Obtusichromoneside C regulates substance transport by inhibiting substrate uptake of specific transporters (e.g., OAT3, OATP1B3). Obtusichromoneside C is promising for research of drug transport .

HY-W194107

Antitumor agent-152	DNA/RNA Synthesis	Cancer
Antitumor agent-152 (Compound 5) is a specific substrate and inhibitor of deoxycytidine kinase (dCK) with anticancer activity. Antitumor agent-152 can inhibit the uptake of ³H-dC in L1210 leukemia cells with an IC₅₀ value of 1.12 μM .

HY-150741B

FITC-labeled ODN 2216 sodium	Toll-like Receptor (TLR) Interleukin Related	Inflammation/Immunology
FITC-labeled ODN 2216 (sodium) is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. FITC-labeled ODN 2216 (sodium) can be used to evaluate CpG ODN cellular uptake and localization by confocal laser-scanning microscopy (excitation 495 nm, emission 520 nm) or flow cytometry.

HY-136659

Ro 04-5595	iGluR	Others
Ro 04-5595 is a selective antagonist with specific activity against the NR2B subunit of the NMDA receptor. Ro 04-5595 exhibits favorable pharmacokinetic properties in in vitro and in vivo studies, with rapid uptake and clearance. Ro 04-5595 exhibits strong binding in NR2B receptor-enriched regions and low binding in the cerebellum. Ro 04-5595 is able to effectively inhibit specific binding, showing high affinity for the NR2B receptor and a clear ranking of binding affinity with a variety of other compounds .

HY-121810

LBT-999	Dopamine Transporter	Others
LBT-999 is a phenyltropane derivative used for positron emission tomography (PET) exploration of the dopamine transporter (DAT). It has high affinity binding to DAT on rat striatal membranes and human postmortem brain slices in vitro, high uptake in the striatum in rat and baboon models in vivo, and its binding can be blocked by specific compounds.

HY-158266

DOTA-PSMA-EB-01 LNC1003	Radionuclide-Drug Conjugates (RDCs) PSMA	Cancer
DOTA-PSMA-EB-01 (Compound LNC1003) is a specific inhibitor of PSMA (IC₅₀= 10.77 nM).DOTA-PSMA-EB-01 enhances the uptake and retention time of ¹⁷⁷Lu in tumors . DOTA-PSMA-EB-01 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-161965

MK-3168 (12C)	FAAH	Neurological Disease
MK-3168 (12C) is a FAAH inhibitor with IC₅₀ values of 1.0, 5.5, 1.7 nM for human, rhesus, rat, respectively. MK-3168 shows good brain uptake and FAAH-specific signal. ¹¹C MK-3168 can be used as FAAH PET tracer .

HY-149210

S1PR1 ligand 1	LPL Receptor	Others
S1PR1 ligand 1 (compound 6 h) is a specific S1PR1 ligand with IC₅₀ = 8.7 nM. S1PR1 ligand 1 has good brain uptake. S1PR1 ligand 1 can be labeled with ¹⁸F to study the function of S1PR1 in brain diseases .

HY-P99925

Enoticumab REGN421	Notch	Metabolic Disease Cancer
Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human Dll4. DLL4 is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively .

HY-121659

DCFBC	PSMA	Cancer
DCFBC is a prostate-specific membrane antigen (PSMA) inhibitor that can be used for small animal positron emission tomography (PET) imaging. DCFBC labeled with F ¹⁸ ([18F]DCFBC) can images in severe combined immunodeficient mice. [18F]DCFBC uptake is higher in PIP tumors, but almost absent in FLU tumors. [18F]DCFBC uptake is also high in the kidney and bladder, but the radioactivity washout time is shorter than that in PIP tumors. Indicating that [18F]DCFBC can specifically localize to PSMA+ expressing tumors and is applicable to the study of prostate cancer .

HY-169071S

ATX-1905	Phosphodiesterase (PDE)	Others
ATX-1905 is a positron emission tomography (PET) tracer that demonstrates good autotaxin (ATX) binding specificity and achieves semiquantification of lung ATX expression levels, which are elevated in fibrotic lungs. ATX-1905 exhibits elevated uptake in Bleomycin (HY-108345)-induced pulmonary fibrosis (BPF) lungs. ATX-1905 is promising for research of idiopathic pulmonary fibrosis (IPF) .

HY-117542

D595	Histone Methyltransferase	Neurological Disease
D595 is a phenylethylamine calcium channel blocker with potent negative inotropic activity. D595 has shown significant efficacy in its corresponding pharmacological studies, especially in inhibiting the uptake of monoamine neurotransmitters. D595 has high affinity in binding to the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET). Structural adjustments of D595, especially changes in the hydroxyl stereochemistry, significantly affect its interaction with the transporters, showing a specific preference for stereoisomers .

HY-P1848

Pep-1 (uncapped)	Interleukin Related	Cancer
Pep-1 (uncapped) is a specific ligand of IL-13Ra2. Pep-1 (uncapped) exerts cell penetrating activity through receptor-mediated endocytosis, can cross the blood-tumor barrier (BTB) and target glioma cells. Pep-1 (uncapped) can enhance the uptake of nanoparticles by tumor cells and enhance the cell penetration ability of nanoparticles, and can be used to develop targeted drug delivery systems for glioma .

HY-Y0148

10-Hydroxydecanoic acid NSC 15139; 10-HDAA	Parasite Autophagy NF-κB Interleukin Related NO Synthase MDM-2/p53 TNF Receptor RANKL/RANK Caspase	Infection Neurological Disease Inflammation/Immunology
10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 (IRF-1), which reduces the production of interleukin 6 (IL-6) and nitric oxide (NO) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells .

HY-Y0148R

10-Hydroxydecanoic acid (Standard) NSC 15139 (Standard); 10-HDAA (Standard)	Reference Standards Parasite Autophagy NF-κB Interleukin Related NO Synthase MDM-2/p53 TNF Receptor RANKL/RANK Caspase	Infection Neurological Disease Inflammation/Immunology
10-Hydroxydecanoic acid (Standard) is the analytical standard of 10-Hydroxydecanoic acid. This product is intended for research and analytical applications. 10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 (IRF-1), which reduces the production of interleukin 6 (IL-6) and nitric oxide (NO) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells[1][2][3][4][5].

Cat. No.	Product Name

HY-L214

Liposome Library	140 compounds
Liposomes are spherical or multilayered spherical vesicles formed by the self-assembly of diacyl chain phospholipids (lipid bilayers) in aqueous solutions, which can be made from natural or synthetic phospholipids and exhibit good biocompatibility and low toxicity. They can serve as delivery carriers for various bioactive substances (such as drugs, proteins, nucleic acids, etc.) and are widely used in biomedical and chemical research. The main advantages of liposomes include 1) Protective effect: Their bilayer structure can protect encapsulated molecules from enzymatic degradation, oxidation, and other influences, extending stability and activity; 2) Active targeting: Surface modifications enable active targeting, enhancing the concentration of drugs or molecules in specific tissues or cells; 3) Customizability: The composition and structure of liposomes can be adjusted according to needs, such as altering phospholipid types or adding targeting ligands. These properties make liposomes highly valuable in developing novel drug delivery systems, serving as nucleic acid carriers for gene transfection, studying cellular uptake mechanisms and drug release kinetics, as well as developing functional food additives to improve the bioavailability of nutritional components. MCE contains 140 liposome compounds, which is a good tool for lipidomic-related studies.

Liposome Library

140 compounds

Liposomes are spherical or multilayered spherical vesicles formed by the self-assembly of diacyl chain phospholipids (lipid bilayers) in aqueous solutions, which can be made from natural or synthetic phospholipids and exhibit good biocompatibility and low toxicity. They can serve as delivery carriers for various bioactive substances (such as drugs, proteins, nucleic acids, etc.) and are widely used in biomedical and chemical research. The main advantages of liposomes include 1) Protective effect: Their bilayer structure can protect encapsulated molecules from enzymatic degradation, oxidation, and other influences, extending stability and activity; 2) Active targeting: Surface modifications enable active targeting, enhancing the concentration of drugs or molecules in specific tissues or cells; 3) Customizability: The composition and structure of liposomes can be adjusted according to needs, such as altering phospholipid types or adding targeting ligands. These properties make liposomes highly valuable in developing novel drug delivery systems, serving as nucleic acid carriers for gene transfection, studying cellular uptake mechanisms and drug release kinetics, as well as developing functional food additives to improve the bioavailability of nutritional components.

MCE contains 140 liposome compounds, which is a good tool for lipidomic-related studies.

Cat. No.	Product Name	Type