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Pathways Recommended: Neuronal Signaling JAK/STAT Signaling
Results for "

ST2/IL-33 signaling

" in MedChemExpress (MCE) Product Catalog:

2

Inhibitors & Agonists

1

Inhibitory Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99444
    Astegolimab
    2 Publications Verification

    MSTT 1041A; RG 6149

    		 Interleukin Related MDM-2/p53 NF-κB Cardiovascular Disease Inflammation/Immunology
    Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and MCP1. Astegolimab mitigates IL33-increased p-p65/p65 ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research .
    Astegolimab
  • HY-168532
    ST2-IN-1

    		Interleukin Related Inflammation/Immunology
    ST2-IN-1 (compound 31) is a Stimulation-2 (ST2) inhibitor, with an IC50 value of 7 μM in AlphaLISA assay, and 7.19 μM in HEK-Blue assay. ST2-IN-1 effectively attenuats the ST2/IL-33 signaling in human mast cells .
    ST2-IN-1

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