SRC-1

By Targets:	Src (7) CDK (1) Endogenous Metabolite (1) Estrogen Receptor/ERR (1) FXR (1) Gap Junction Protein (1) GSK-3 (1) IGF-1R (1) Isotope-Labeled Compounds (1) LXR (1) Mineralocorticoid Receptor (1) Pim (1) PPAR (2) Progesterone Receptor (1) Prostaglandin Receptor (1) PROTACs (1) Raf (1) RET (1) Ribosomal S6 Kinase (RSK) (1) ROR (1) Small Interfering RNA (siRNA) (4)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Endocrinology (1) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (4)

Targets Recommended: Src SHP2 SHP1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123402

GSK3987 1 Publications Verification	LXR	Metabolic Disease
GSK3987 is a pan LXRα/β agonist with EC₅₀s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. GSK3987 increases the expression of ABCA1 and SREBP-1c. GSK3987 induces cellular cholesterol efflux and triglyceride accumulation ^[1].

HY-117819

TMP920	ROR	Inflammation/Immunology
TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC₅₀ of 0.03 μM ^[1].

HY-RS29186

Ncoa1 Rat Pre-designed siRNA Set A SRC-1	Small Interfering RNA (siRNA)	Others
Ncoa1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ncoa1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ncoa1 Rat Pre-designed siRNA Set A Ncoa1 Rat Pre-designed siRNA Set A

HY-RS22672

Ncoa1 Mouse Pre-designed siRNA Set A SRC1; NRC-1; SRC-1; SRC-a; KAT13A; NCoA-1; mNRC-1; bHLHe74	Small Interfering RNA (siRNA)	Others
Ncoa1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ncoa1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ncoa1 Mouse Pre-designed siRNA Set A Ncoa1 Mouse Pre-designed siRNA Set A

HY-RS09089

NCOA1 Human Pre-designed siRNA Set A SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74	Small Interfering RNA (siRNA)	Others
NCOA1 Human Pre-designed siRNA Set A contains three designed siRNAs for NCOA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NCOA1 Human Pre-designed siRNA Set A NCOA1 Human Pre-designed siRNA Set A

HY-RS13749

SRC Human Pre-designed siRNA Set A ASV; SRC1; THC6; c-SRC; p60-SRC	Small Interfering RNA (siRNA)	Others
SRC Human Pre-designed siRNA Set A contains three designed siRNAs for SRC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SRC Human Pre-designed siRNA Set A SRC Human Pre-designed siRNA Set A

HY-P5464

SRC-1 NR box peptide	Estrogen Receptor/ERR	Others
SRC-1 NR box peptide is a biological active peptide (This peptide is a 14-amino acid fragment from the steroid receptor cofactor SRC-1 NR II). SRC-1 NR box peptide can be used to study the regulatory mechanisms of estrogen receptor ligands ^[1].

HY-P5458

SRC-1 (686-700)	Mineralocorticoid Receptor	Others
SRC-1 (686-700) is a biological active peptide. (This peptide is amino acids 686 to 700 fragment containing the second LXXLL motif, derived from NR box II of steroid receptor coactivator (SRC1). Coactivator proteins interact with nuclear receptors in a ligand-dependent manner and augment transcription.)

HY-P5559

ND1-YL2	PROTACs	Cancer
ND1-YL2 is a PROTAC that selectively degrades *SRC-1* via the N-degron pathway. ND1-YL2 significantly inhibits cancer invasion and migration in vitro and in vivo. ND1-YL2 can be used in cancer research ^[1].

HY-139562

BMS-986318	FXR	Metabolic Disease
BMS-986318 is a potent nonbile acid FXR agonist with EC₅₀s of 53 and 350 nM in the FXR Gal4 and SRC-1 recruitment assays, respectively. BMS-986318 has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis.BMS-986318 can be used for the research of nonalcoholic steatohepatitis ^[1].

HY-15606

Tanaproget 1 Publications Verification NSP-989	Progesterone Receptor	Endocrinology
Tanaproget is an orally effective, selective nonsteroidal progesterone receptor (PR) agonist targeting human PR with an IC₅₀ of 1.7 nM. Tanaproget promotes the interaction between PR receptors and coactivators (such as SRC-1), thereby inhibiting the secretion of matrix metalloproteinases (MMP-3/MMP-7) and reducing endometrial tissue invasion and angiogenesis. Tanaproget can be used for contraception and endometriosis inhibition research ^[1] .

HY-116028

15-deoxy-Δ12,14-Prostaglandin D2 15-Deoxy-Δ12,14-PGD2	Endogenous Metabolite Prostaglandin Receptor PPAR Src	Cardiovascular Disease
15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2), a metabolite of PGD2 (HY-101988), is an agonist of prostaglandin receptor 2 (DP2). 15-deoxy-Δ12,14-Prostaglandin D2 binds to DP2 (Ki=50 nM) and induces eosinophil activation (EC₅₀=8 nM). 15-deoxy-Δ12,14-Prostaglandin D2 also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ), inducing PPARγ-mediated transcription. 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) is cytotoxic to L1210 murine leukemia cells (IC₅₀=0.3 μg/ml) and inhibits ADP-induced platelet aggregation (IC₅₀=320 ng/mL).

HY-18507A

AD57 hydrochloride	RET Src Ribosomal S6 Kinase (RSK) Raf	Cancer
AD57 hydrochloride is an orally active multikinase inhibitor, inhibits RET, BRAF, S6K and *Src* .

HY-116699

CP-868388 free base	PPAR	Neurological Disease Metabolic Disease Inflammation/Immunology
CP-868388 free base is a potent, selective and orally active PPARα agonist with a K_i value of 10.8 nM. CP-868388 free base has little or no affinity for PPARβ (K_i of 3.47 μM) and PPARγ. CP-868388 free base has hypolipidemic and anti-inflammatory actions ^[1].

HY-P3773

*p60c-src* substrate II**	Src	Cancer
p60c-src substrate II is an efficient pentapeptide substrate for the tyrosine kinase *pp60c-src* .

HY-156914

*IGF-1R/SRC-IN-1*	IGF-1R Src	Cancer
IGF-1R/SRC-IN-1 (Compound 3b) is an inhibitor for *IGF-1R* (IC₅₀ is 63 μM) and *SRC* .

HY-153833

PDS-0330 KVA-E-23A	Gap Junction Protein	Cancer
PDS-0330 is a specific and potent *Claudin-1* inhibitor. PDS-0330 interferes with claudin-1/Src association and inhibits colorectal cancer (CRC) progression and metastasis ^[1].

HY-169670

Protein kinase inhibitor 13	Pim CDK GSK-3 Src	Cancer
Protein kinase inhibitor 13 (Compound I-90) is the inhibitor for protein kinase that exhibits inhibitory effects on kinases such as PIM-1, CDK-2, GSK-3 and SRC .

HY-112096

eCF506 3 Publications Verification NXP900	Src	Cancer
eCF506 (NXP900) is a highly potent and orally active *YES1/SRC* kinase inhibitor with an IC₅₀ of 0.47 nM. eCF506 locks its target into its native “closed” conformation, thereby inhibiting both kinase activity and complex formation with protein partners. eCF506 can be used for the study of esophageal squamous cancer and breast cancer ^[1].

HY-112096S

eCF506-d5 NXP900-d₅	Src Isotope-Labeled Compounds	Cancer
eCF506-d₅ (NXP900-d₅) is deuterated labeled eCF506 (HY-112096). eCF506 is a highly potent and orally active *YES1/SRC* kinase inhibitor with an IC₅₀ of 0.47 nM. eCF506 locks its target into its native “closed” conformation, thereby inhibiting both kinase activity and complex formation with protein partners. eCF506 can be used for the study of esophageal squamous cancer and breast cancer ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-P5464

SRC-1 NR box peptide	Estrogen Receptor/ERR	Others
SRC-1 NR box peptide is a biological active peptide (This peptide is a 14-amino acid fragment from the steroid receptor cofactor SRC-1 NR II). SRC-1 NR box peptide can be used to study the regulatory mechanisms of estrogen receptor ligands ^[1].

HY-P5458

SRC-1 (686-700)	Mineralocorticoid Receptor	Others
SRC-1 (686-700) is a biological active peptide. (This peptide is amino acids 686 to 700 fragment containing the second LXXLL motif, derived from NR box II of steroid receptor coactivator (SRC1). Coactivator proteins interact with nuclear receptors in a ligand-dependent manner and augment transcription.)

HY-P5559

ND1-YL2	PROTACs	Cancer
ND1-YL2 is a PROTAC that selectively degrades *SRC-1* via the N-degron pathway. ND1-YL2 significantly inhibits cancer invasion and migration in vitro and in vivo. ND1-YL2 can be used in cancer research ^[1].

HY-P3773

*p60c-src* substrate II**	Src	Cancer
p60c-src substrate II is an efficient pentapeptide substrate for the tyrosine kinase *pp60c-src* .

Species:	Human (3) Mouse (1)
Tag:	His (4) GST (2) Flag (1)
Source:	Sf9 insect cells (2) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P701321

	Src Protein, Human (His) Proto-oncogene tyrosine-protein kinase SRC; Proto-oncogene c-SRC; pp60c-SRC (p60-SRC); SRC1	Human	E. coli
	Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. SRC Protein, Human (His) is the recombinant human-derived SRC protein, expressed by E. coli , with N-10*His labeled tag.

HY-P73422

	Src Protein, Human (sf9, His-GST) Proto-oncogene tyrosine-protein kinase SRC; SRC; p60-SRC; SRC1	Human	Sf9 insect cells
	Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. Src Protein, Human (sf9, His-GST) is the recombinant human-derived Src protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P73423

	Src Protein, Mouse (sf9, His-GST) Proto-oncogene tyrosine-protein kinase SRC; SRC; p60-SRC; SRC1	Mouse	Sf9 insect cells
	Src, a non-receptor protein tyrosine kinase, displays a unique ability to phosphorylate synaptophysin with high affinity.Src Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Src protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P702724

	Src Protein, Human (sf9, His, Flag) Proto-oncogene tyrosine-protein kinase SRC; SRC; p60-SRC; SRC1	Human	Sf9 insect cells
	Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. Src Protein, Human (sf9, His, Flag) is the recombinant human-derived Src, expressed by Sf9 insect cells , with His, Flag labeled tag. ,

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Cat. No.	Product Name	Chemical Structure

HY-112096S

eCF506-d5
eCF506-d₅ (NXP900-d₅) is deuterated labeled eCF506 (HY-112096). eCF506 is a highly potent and orally active *YES1/SRC* kinase inhibitor with an IC₅₀ of 0.47 nM. eCF506 locks its target into its native “closed” conformation, thereby inhibiting both kinase activity and complex formation with protein partners. eCF506 can be used for the study of esophageal squamous cancer and breast cancer ^[1] .

eCF506-d5

eCF506-d₅ (NXP900-d₅) is deuterated labeled eCF506 (HY-112096). eCF506 is a highly potent and orally active YES1/SRC kinase inhibitor with an IC₅₀ of 0.47 nM. eCF506 locks its target into its native “closed” conformation, thereby inhibiting both kinase activity and complex formation with protein partners. eCF506 can be used for the study of esophageal squamous cancer and breast cancer ^[1] .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80339

	SRC1 Antibody (YA060)	WB, IHC-P, IP	Human
	SRC1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 157 kDa, targeting to SRC1. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human.

HY-P81990

	KAT13A Antibody (YA1735) bHLHe74; mNRC 1; NCoA 1; RIP160; SRC 1	WB, IHC-P, IP	Human
	KAT13A Antibody (YA1735) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1735), targeting KAT13A, with a predicted molecular weight of 157 kDa (observed band size: 157 kDa). KAT13A Antibody (YA1735) can be used for WB, IHC-P, IP experiment in human background.

HY-P82911

	*Phospho-Src* (Tyr530) Antibody (YA2656)** SRC; SRC1; Proto-oncogene tyrosine-protein kinase SRC; Proto-oncogene c-SRC; pp60c-SRC; p60-SRC	WB, IP	Rat
	Phospho-Src (Tyr530) Antibody (YA2656) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2656), targeting Phospho-Src (Tyr530), with a predicted molecular weight of 60 kDa (observed band size: 60 kDa). Phospho-Src (Tyr530) Antibody (YA2656) can be used for WB, IP experiment in rat background.

HY-P86105

	*Phospho-Src* Family(Tyr416) Antibody (YA5797)** SRC; SRC1; Proto-oncogene tyrosine-protein kinase SRC; Proto-oncogene c-SRC; pp60c-SRC; p60-SRC; ASV	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

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HY-RS29186

Ncoa1 Rat Pre-designed siRNA Set A SRC-1		siRNAs Rat Pre-designed siRNA Sets
Ncoa1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ncoa1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS22672

Ncoa1 Mouse Pre-designed siRNA Set A SRC1; NRC-1; SRC-1; SRC-a; KAT13A; NCoA-1; mNRC-1; bHLHe74		siRNAs Mouse Pre-designed siRNA Sets
Ncoa1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ncoa1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09089

NCOA1 Human Pre-designed siRNA Set A SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74		siRNAs Human Pre-designed siRNA Sets
NCOA1 Human Pre-designed siRNA Set A contains three designed siRNAs for NCOA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS13749

SRC Human Pre-designed siRNA Set A ASV; SRC1; THC6; c-SRC; p60-SRC		siRNAs Human Pre-designed siRNA Sets
SRC Human Pre-designed siRNA Set A contains three designed siRNAs for SRC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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