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Results for "

SMARCA4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Epigenetic Reader Domain (46) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (1) Oxidative Phosphorylation (1) Pregnane X Receptor (PXR) (1) PROTACs (45) Small Interfering RNA (siRNA) (3) SWI/SNF Complex (3)
By Research Areas:	Cancer (58)
Click Chemistry:	Azide (10)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144897

FHT-1204	Epigenetic Reader Domain	Cancer
FHT-1204 is a potent SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor with IC₅₀s of ≤10 nM (WO2020160180A1; compound 70) .

HY-153361

YD23	PROTACs Epigenetic Reader Domain	Cancer
YD23 is a selective SMARCA2 PROTAC degrader with DC₅₀ values of 64 nM and 297 nM in H1792 cells and H1975 cells. YD23 induces degradation of SMARCA2, which is synthetic lethal to SMARCA4. YD23 reduces chromatin accessibility only in SMARCA4 deficient cells, including cell cycle and cell growth regulatory genes. YD23 selectively inhibits growth of SMARCA4 mutant lung cancer cells. YD23 has potent tumor growth inhibitory activity in SMARCA4-mutant xenografts. YD23 can be used for the study of non-small cell lung cancer (NSCLC) (Pink: SMARCA2 ligand (HY-44012); Blue: CRBN ligand (HY-41547); Black: Linker (HY-175566)) .

HY-149026

GNE-064	Epigenetic Reader Domain	Others
GNE-064 (compound 5) is a selective, orally active and highly soluble inhibitor of *SMARCA4, SMARCA2* and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC₅₀ of 0.035 μM and inhibits SMARCA2 with an EC₅₀ of 0.10 μM. GNE-064 possess K_ds with 0.01, 0.016, 0.018 and 0.049 μM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of agent synthesis .

HY-RS23244

Smarca4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Smarca4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Smarca4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Smarca4 Rat Pre-designed siRNA Set A Smarca4 Rat Pre-designed siRNA Set A

HY-RS13405

SMARCA4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMARCA4 Human Pre-designed siRNA Set A contains three designed siRNAs for SMARCA4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMARCA4 Human Pre-designed siRNA Set A SMARCA4 Human Pre-designed siRNA Set A

HY-RS16803

Smarca4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Smarca4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smarca4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Smarca4 Mouse Pre-designed siRNA Set A Smarca4 Mouse Pre-designed siRNA Set A

HY-174237

*PBRM1/SMARCA2,4 binder-1*	Epigenetic Reader Domain	Cancer
PBRM1/SMARCA2,4 binder-1 (Compound 17) is a binder of PBRM1, *SMARCA2, and SMARCA4* (IC₅₀: 0.083, 0.153, and 0.046 μM, respectively) .

HY-159607

PRT3789	PROTACs Epigenetic Reader Domain	Cancer
PRT3789 is a *SMARCA2* PROTAC degrader (DC₅₀ in HeLa cell: 0.72 nM for SMARCA2, 14 nM for SMARCA4). PRT3789 shows synergistic anti-proliferation effects with Adagrasib (HY-130149) in cancer cells. PRT3789 inhibits SMARCA4-mutated lung cancer proliferation. PRT3789 inhibits tumor growth in SMARCA4-deleted NSCLC models. Pink: SMARCA4 ligand (HY-44824) ; Blue: VHL ligand (HY-159465) ; Black: linker; VHL ligand+linker (HY-172738) .

HY-162835

*PROTAC SMARCA2/4-degrader-28*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-28 (PROTAC 1) is a PROTAC-based partial degrader of *SMARCA2* and *SMARCA4*(Bliue: CRL2 ^VHL ligand (S,R,S)-AHPC (HY-125845); Black: linker (HY-159680); Pink: a SMARCA-BD ligand (+)-JQ-1 (HY-13030)) .

HY-162834

*PROTAC SMARCA2/4-degrader-27*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-27 (PROTAC 2) is a PROTAC-based degrader of *SMARCA2* and *SMARCA4. (Blue: CRL2 ^VHL ligand VH032-cyclopropane-F (HY-125905); Black: linker (HY-159678);Pink: a SMARCA*-BD ligand 1 for PROTAC (HY-44012)) .

HY-169278

*PROTAC SMARCA2 degrader-26*	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2 degrader-26 (compound 45) is a potent *SMARCA2* PROTAC degrader. PROTAC SMARCA2 degrader-26 induces SMARCA2 and SMARCA4 degradation in VCaP cells with the percent degradation of 94% and 57% for SMARCA2 and SMARCA4, respectively. PROTAC SMARCA2 degrader-26 shows antiproliferative activity .

HY-125905

VH032-cyclopropane-F 1 Publications Verification VHL ligand 3; E3 ligase Ligand 19	Ligands for E3 Ligase	Cancer
VH032-cyclopropane-F is the VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4 .

HY-170824

SMD-3236	PROTACs Epigenetic Reader Domain	Cancer
SMD-3236 is a SMARCA2-targeted PRAOTAC degrader designed based on SMARCA ligands and VHL-1 ligands, with long-lasting antitumor activity in vivo. SMARCA2 is a synthetic lethal target in SMARCA4-deficient cancer cells, and SMD-3236 has a 2000-fold selectivity for degradation of SMARCA2 over SMARCA4, with a DC₅₀< 1 nM and a D_max>95%. SMD-3236 can induce SMARCA2 loss in tumor tissues while retaining SMARCA4 protein, and inhibit tumor growth in the H838 smarca4-deficient human cancer xenograft model. SMD-3236 is composed of target protein ligand (red part) SMI-1074 (HY-170817), PROTAC linker (black part) (trans-4-Ethynylcyclohexyl)methyl methanesulfonate (HY-170825), and E3 ligase ligand (blue part) SMARCA2 ligand-14 (HY-170826), of which the E3 ligase ligand and linker form a conjugate E3 Ligase Ligand-linker Conjugate 159 (HY-170827) .

HY-149458

FHT-2344	Epigenetic Reader Domain	Cancer
FHT-2344, a chemical probe, is a SMARCA4/SMARCA2 ATPase inhibitor with IC₅₀ values of 0.026 μM and 0.013 μM, respectively. FHT-2344 has anticancer activity .

HY-145388

AU-15330 5+ Cited Publications	PROTACs Epigenetic Reader Domain	Cancer
AU-15330 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, *SMARCA2* and *SMARCA4*. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide. AU-15330 induces disease remission in castration-resistant prostate cancer (CRPC) models without toxicity .

HY-161884

SMARCA2/4-IN-1	Epigenetic Reader Domain	Cancer
SMARCA2/4-IN-1 (compound 1) is a potent *SMARCA2* inhibitor with IC₅₀ values of 3.8, 1.7 µM for SMARCA2, SMARCA4, respectively .

HY-171774

*PBRM1/SMARCA2,4-ligand-1*	Ligands for Target Protein for PROTAC Epigenetic Reader Domain	Cancer
PBRM1/SMARCA2,4-ligand-1 (Compound 4) is a Ligand for Target Protein for PROTAC that binds to PBRM1, *SMARCA2, and SMARCA4. PBRM1/SMARCA2,4-ligand-1 is a potent SMARCA4* bromodomain inhibitor. PBRM1/SMARCA2,4-ligand-1 can be used to synthesize PROTAC AU-24118 (HY-163410) .

HY-144896

FHT-1015 2 Publications Verification	Epigenetic Reader Domain	Cancer
FHT-1015 is a selective *SMARCA4* (IC₅₀ = 4 nM) and *SMARCA2* (IC₅₀ = 5 nM) (also known as BRG1 and BRM) inhibitor. FH-1015 is an allosteric inhibitor that causes conformation change in the BRG1/BRM protein upon interaction with an allosteric site, inhibiting ATPase activity. FH-1015 interferes with tumor cell growth and migration. FH-1015 can be studied in research for uveal melanoma and hematologic cancer ^[4].

HY-144835

Camibirstat 2 Publications Verification FHD-286	Oxidative Phosphorylation Epigenetic Reader Domain	Cancer
FHD-286 is a selective, oral inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor. FHD-286 has the potential for the research of BAF (BRG1/BRM-associated factor)-related disorders such as acute myeloid leukemia .

HY-163871

*PROTAC SMARCA2/4-degrader-18*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-18 (Compound I-348) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-18 degrades SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159531); Black: Linker (HY-76547); Blue: Ligand for E3 Ligase (HY-125845))

HY-163870

*PROTAC SMARCA2/4-degrader-17*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-17 (Compound I-345) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-17 degrades SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-W053507); Blue: Ligand for E3 Ligase (HY-125845))

HY-162743

*PROTAC SMARCA2/4-degrader-29*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-29 (Compound I-279) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-29 degrades SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: ligand for target protein (HY-163926); Black: linker (HY-159682); Blue: ligand for E3 ligase (HY-W382038)) .

HY-162744

*PROTAC SMARCA2/4-degrader-31*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-31 (Compound I-280) is a degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-31 degrades SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-163926); Black: Linker (HY-159682); Blue: Ligand for E3 ligase (HY-W382038)) .

HY-163868

*PROTAC SMARCA2/4-degrader-15*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-15 (Compound I-335) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-15 degrades SMARCA2* in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-N3024); Blue: Ligand for E3 Ligase (HY-125845))

HY-163410

AU-24118 1 Publications Verification	PROTACs Epigenetic Reader Domain	Cancer
AU-24118 is a selective and orally bioavailable PROTAC degrader of mSWI-SNF ATPases (SMARCA2 and SMARCA4) and PBRM1. AU-24118 integrates a bait moiety binding to the bromodomains of SMARCA2 and SMARCA4, along with a ligand moiety for CRBN ligase. AU-24118 demonstrates tumor regression in prostate cancer model. AU-24118 can be studied to combat prostate cancer. (Pink: PBRM1/SMARCA2,4 ligand (HY-171774); Blue: CRBN ligand (HY-171775)) .

HY-163877

*PROTAC SMARCA2/4-degrader-19*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-19 (Compound I-412) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-19 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for Target Protein (HY-163949); Black: Linker (HY-W006635); Blue: Ligand for E3 Ligase (HY-125845))

HY-159461

*PROTAC SMARCA2/4-degrader-9*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2 degrader-9 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM . (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-162748

*PROTAC SMARCA2/4-degrader-30*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-30 (Compound I-291) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-30 degrades SMARCA2* in A549 and in MV411 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: ligand for target protein (HY-163926); Black: linker (HY-159684); Blue: ligand for E3 ligase (HY-W382038)) .

HY-159455

*PROTAC SMARCA2/4-degrader-4*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-4 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159456

*PROTAC SMARCA2/4-degrader-5*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-5 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ of 100-500 nM. (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-159557); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-153425

*PROTAC SMARCA2 degrader-2*	PROTACs	Cancer
PROTAC SMARCA2 degrader-2 is a potent and selective SMARCA2/4 PROTAC degrader with an IC₅₀ of <0.1 μΜ in HeLa HiBiT assay. PROTAC SMARCA2 degrader-2 is extracted from patent WO2023287787A1 and has the potential for SMARCA4-related or deficient cancer research .

HY-128359

ACBI1 5+ Cited Publications	PROTACs Epigenetic Reader Domain Apoptosis	Cancer
ACBI1 is a potent and cooperative *SMARCA2, SMARCA4* and PBRM1 degrader with DC₅₀s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosis .

HY-169275

*PROTAC SMARCA2 degrader-24*	PROTACs SWI/SNF Complex	Cancer
PROTAC SMARCA2 degrader-24 (Compound 34) is a PROTAC degrader for *SMARCA2* with a DC₅₀ < 0.1 µM in HeLa. PROTAC SMARCA2 degrader-24 degrades *SMARCA4* with a DC₅₀ > 10 μM in HeLa .

HY-169272

*PROTAC SMARCA2 degrader-21*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-21 (Compound I-5) is a PROTAC degrader for *SMARCA, that degrades SMARCA2* with a DC₅₀ of 10-50 nM in A549 cell, and degrades *SMARCA2* and *SMARCA4* in MV411 with DC₅₀ of <1 nM and >100 nM, respectively .

HY-122645

SMARCA2-IN-4	Epigenetic Reader Domain	Cancer
SMARCA2-IN-4 (Compound 26) is an inhibitor for SWI/SNF chromatin remodeling complexe *SMARCA* by targeting the bromodomains. SMARCA2-IN-4 exhibits high affinity for PB1(5), *SMARCA2B* and *SMARCA4* with K_d of 124, 262 and 417 nM .

HY-144720

BRG1-IN-1	SWI/SNF Complex	Cancer
BRG1-IN-1 (Compound 11d) is a potent inhibitor of *SMARCA4/BRG1*. BRG1-IN-1 shows better efficacy than PFI-3 in sensitizing GBM cells to the antiproliferative and cell death inducing effects of Temozolomide in vitro. BRG1-IN-1 enhances the inhibitor effect of Temozolomide on the growth of subcutaneous GBM tumors .

HY-169270

*PROTAC SMARCA2 degrader-19*	Epigenetic Reader Domain PROTACs	Cancer
PROTAC SMARCA2 degrader-19 (Compound 46) is a PROTAC degrader for *SMARCA2, that degrades SMARCA2* in cell A549 and MV411 with a DC₅₀ < 100 nM. PROTAC SMARCA2 degrader-19 degrades *SMARCA4* in cell MV411 with a DC₅₀ > 1000 nM .

HY-163875

*PROTAC SMARCA2/4-degrader-22*	PROTACs	Cancer
SMARCA2 degrader-14 (compound I-408) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163876

*PROTAC SMARCA2/4-degrader-23*	PROTACs	Cancer
SMARCA2 degrader-15 (compound I-409) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-168215

YDR1	PROTACs Epigenetic Reader Domain	Cancer
YDR1 is a potent PROTAC SMARCA2 degrader, with the DC₅₀ of 7.7 nM. YDR1 plays an important role in SMARCA4 mutant cancers(Sturcture Note:(Blue: Cereblon ligand (HY-W087383), Black: linker；Pink: SMARCA2 ligand (HY-44012B)) .

HY-159459

*PROTAC SMARCA2/4-degrader-32*	PROTACs	Cancer
PROTAC SMARCA2/4-degrader-32 (compound I-446) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-163869

*PROTAC SMARCA2/4-degrader-16*	PROTACs	Cancer
PROTAC SMARCA2/4-degrader-16 (compound I-337) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159458

*PROTAC SMARCA2/4-degrader-7*	PROTACs	Cancer
SMARCA2/4-degrader-7 (compound I-439) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159452

*PROTAC SMARCA2/4-degrader-1*	PROTACs	Cancer
SMARCA2/4-degrader-1 (compound I-430) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159453

*PROTAC SMARCA2/4-degrader-2*	PROTACs	Cancer
SMARCA2/4-degrader-2 (compound I-431) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-162741

*PROTAC SMARCA2/4-degrader-33*	PROTACs	Cancer
PROTAC SMARCA2/4-degrader-33 (compound I-277) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-119374

BRM/BRG1 ATP Inhibitor-1 Maximum Cited Publications 33 Publications Verification	Epigenetic Reader Domain	Cancer
BRM/BRG1 ATP Inhibitor-1 (compound 14) is an orally active allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 *(SMARCA2)* and brahma related gene 1 *(BRG1)/SMARCA4* ATPase activity inhibitor, both IC₅₀s are below 0.005 µM. BRM/BRG1 ATP Inhibitor-1 has anticancer activity .

HY-122573

Bromodomain inhibitor-13	Epigenetic Reader Domain	Cancer
Bromodomain inhibitor-13 (Compound 1) is an analog of PFI-3 (HY-12409). Bromodomain inhibitor-13 is a bromodomain-containing protein (BCP) inhibitor. Bromodomain inhibitor-13 targets SMARCA2, SMARCA4, PB1(5), and second bromodomain of PB1 (PB1(2)) with K_D values of 37, 53, 30, and 190 nM, respectively .

HY-161885

SMARCA2-IN-6	Epigenetic Reader Domain	Cancer
SMARCA2-IN-6 is a *SMARCA2* (also known as BRM) inhibitor, with IC₅₀s less than 5 nM for SMARCA2 and SMARCA4. SMARCA2-IN-6 inhibits KRT80 gene expression in H1299 cells (IC₅₀: 26 nM). SMARCA2-IN-6 inhibits proliferation in BRG1-mutant SKMEL5 cells (IC₅₀: 13 nM) .

HY-159449

*PROTAC SMARCA2 degrader-5*	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC SMARCA2 degrader-5 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* with DC₅₀ of 100-500 nM . (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

Cat. No.	Compare	Product Name	Species	Source

HY-P71784

	SMARCA4 Protein, Human (P.pastoris, His) ATP dependent helicase SMARCA4; ATP-dependent helicase SMARCA4; Brahma protein like 1; BRG1; BRG1 protein; BRG1-associated factor 190A; MRD16	Human	P. pastoris
	The SMARCA4 protein is a multifaceted regulator of chromatin remodeling that dynamically alters DNA nucleosome topology through ATP-dependent enzymatic activity. As part of the SWI/SNF complex and the CREST-BRG1 complex, it regulates transcriptional processes, coordinating the release and activating recruitment of calcium-dependent repressor complexes. SMARCA4 Protein, Human (P.pastoris, His) is the recombinant human-derived SMARCA4 protein, expressed by P. pastoris , with N-6*His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80575

	BRG1 Antibody (YA817) SMARCA4; BAF190A; BRG1; SNF2B; SNF2L4; Transcription activator BRG1; ATP-dependent helicase SMARCA4; BRG1-associated factor 190A; BAF190A; Mitotic growth and transcription activator; Protein BRG-1; Protein brahma homolog 1; SNF2-beta; SWI/S	WB, ICC/IF, IP	Human, Mouse
	BRG1 Antibody (YA817) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BRG1.

HY-P86425

	BRG1 Antibody (YA6117) SMARCA4; BAF190A; BRG1; SNF2B; SNF2L4; Transcription activator BRG1; ATP-dependent helicase SMARCA4; BRG1-associated factor 190A; BAF190A; Mitotic growth and transcription activator; Protein BRG-1; Protein brahma homolog 1; SNF2-beta; SWI/S	WB, IHC-P, ICC/IF, IP, ELISA	Mouse, Rat
	BRG1 Antibody (YA6117) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BRG1.

HY-P85601

	BRG1 Antibody (YA5293) ATP dependent helicase SMARCA4; ATP-dependent helicase SMARCA4; BAF 190; BAF190; BAF190A; Brahma protein homolog 1; Brahma protein like 1; BRG1; BRG1 associated factor 190A; BRG1 protein; BRG1-associated factor 190A; BRM/SWI2 related gene 1; Global transcription activator homologous sequence; global transcription activator snf2l4; Homeotic gene regulator; hSNF2b; Mitotic growth and transcription activator; MRD16; Nuclear protein GRB1; Protein brahma homolog 1; Protein BRG-1; Protein BRG1; RTPS2; SMARC A4; SMARCA4; SMCA4_HUMAN; SNF2; SNF2 beta; SNF2 like 4; SNF2-beta; SNF2B; SNF2L4; SNF2LB; Sucrose nonfermenting like 4; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; SWI2; Transcription activator BRG1.	WB, ICC/IF, IP	Human, Mouse
	BRG1 Antibody (YA5293) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to BRG1.

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Cat. No.	Product Name		Classification

HY-159461

*PROTAC SMARCA2/4-degrader-9*		Azide
PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2 degrader-9 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM . (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159455

*PROTAC SMARCA2/4-degrader-4*		Azide
PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-4 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159456

*PROTAC SMARCA2/4-degrader-5*		Azide
PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2* and *SMARCA4. PROTAC SMARCA2/4-degrader-5 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* in MV411 with DC₅₀ of 100-500 nM. (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-159557); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159459

*PROTAC SMARCA2/4-degrader-32*		Azide
PROTAC SMARCA2/4-degrader-32 (compound I-446) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159458

*PROTAC SMARCA2/4-degrader-7*		Azide
SMARCA2/4-degrader-7 (compound I-439) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159452

*PROTAC SMARCA2/4-degrader-1*		Azide
SMARCA2/4-degrader-1 (compound I-430) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159453

*PROTAC SMARCA2/4-degrader-2*		Azide
SMARCA2/4-degrader-2 (compound I-431) is a PROTAC degrader targeting *SMARCA2* and *SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC₅₀*s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .

HY-159449

*PROTAC SMARCA2 degrader-5*		Azide
PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC SMARCA2 degrader-5 degrades SMARCA2* in MV411 and in A549 with DC₅₀ <100 nM, degrades *SMARCA4* with DC₅₀ of 100-500 nM . (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159451

*PROTAC SMARCA2 degrader-7*		Azide
PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) *SMARCA2. PROTAC SMARCA2 degrader-7 degrades SMARCA2* and *SMARCA4* in MV411 with DC₅₀ of <100 and 100-500 nM. (Pink: Ligand for target protein (HY-159542); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

HY-159460

*PROTAC SMARCA2/4-degrader-8*		Azide
PROTAC SMARCA2/4-degrader-8 (Compound I-502) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex *SMARCA2. PROTAC SMARCA2/4-degrader-8 degrades SMARCA2* with DC₅₀ <100 nM in A549 and in MV411, degrades *SMARCA4* with DC₅₀<100 nM in MV411(Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W063924); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

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