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Results for "

SARM1

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

2

Recombinant Proteins

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-145917
    SARM1-IN-2

    		Toll-like Receptor (TLR) Neurological Disease
    SARM1-IN-2 (Example 82) is a SARM1 inhibitor (IC50 <1 μM) that inhibits axon regeneration. Axon regeneration refers to the process by which neuronal axons attempt to restore their structure and function after axonal degeneration. SARM1-IN-2 inhibits axon regeneration by reducing or inhibiting the binding of SARM1 to NAD+. SARM1-IN-2 can be used to study axonal degeneration [1] .
    SARM1-IN-2
  • HY-Z0816
    Dehydronitrosonisoldipine
    3 Publications Verification

    		 Calcium Channel Others
    Dehydronitrosonisoldipine, a derivative of Nisoldipine (HY-17402), is an irreversible and cell-permeant sterile alpha and TIR motif-containing 1 (SARM1) inhibitor. Dehydronitrosonisoldipine acts mainly by blocking SARM1 activation but not its enzymatic activities. Dehydronitrosonisoldipine inhibits SARM1 and axon degenration (AxD) by covalently modifying cysteines, also inhibits the Vincristine-activated cADPR production in neurons. Dehydronitrosonisoldipine can be used for researching neurodegenerative disorders [1].
    Dehydronitrosonisoldipine
  • HY-W021879
    DSRM-3716
    5 Publications Verification

    5-Iodoisoquinoline

    		 Toll-like Receptor (TLR) Neurological Disease
    DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. DSRM-3716 is selective against other NAD +-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection [1].
    DSRM-3716
  • HY-129522
    Sulfo-ara-F-NMN
    4 Publications Verification

    CZ-48

    		 Toll-like Receptor (TLR) Neurological Disease
    Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC50 around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production [1].
    Sulfo-ara-F-NMN
  • HY-RS23158
    Sarm1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Sarm1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sarm1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Sarm1 Rat Pre-designed siRNA Set A
    Sarm1 Rat Pre-designed siRNA Set A
  • HY-RS16722
    Sarm1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Sarm1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sarm1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Sarm1 Mouse Pre-designed siRNA Set A
    Sarm1 Mouse Pre-designed siRNA Set A
  • HY-RS12446
    SARM1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SARM1 Human Pre-designed siRNA Set A contains three designed siRNAs for SARM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SARM1 Human Pre-designed siRNA Set A
    SARM1 Human Pre-designed siRNA Set A
  • HY-161918
    SARM1-IN-3

    		Toll-like Receptor (TLR) Neurological Disease
    SARM1-IN-3 (Example 30) is a SARM1 inhibitor. SARM1-IN-3 can be used in the study of chemotherapy induced peripheral neuropathy (CIPN) [1].
    SARM1-IN-3
  • HY-172967
    SARM1-IN-5

    		Toll-like Receptor (TLR) Neurological Disease
    SARM1-IN-5 (compound 1-23-a) is a SARM1 inhibitor. SARM1-IN-5 can be used in the study of axonal degeneration related diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) [1].
    SARM1-IN-5
  • HY-173276
    SARM1-IN-4

    		Toll-like Receptor (TLR) Neurological Disease
    SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor. After being orally administered at a dose of 50 mg/kg in a mouse model, it can reduce the level of plasma neurofilament light chain (NfL). SARM1-IN-4 prevents programmed axonal degeneration by inhibiting the NAD+ hydrolase activity of SARM1, and it can be used in research related to neurodegenerative diseases and neurological disorders (such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathies, etc.).
    SARM1-IN-4
  • HY-W008341
    5-Chloroisoquinoline

    		Toll-like Receptor (TLR) Neurological Disease
    5-Chloroisoquinoline (compound 42) is an inhibitor of SARM1 (Sterile alpha and toll/interleukin receptor (TIR) motif containing protein 1), an enzyme involved in axon degeneration that catalyzes multiple activities through a ternary complex mechanism. 5-Chloroisoquinoline can be used in the study of neurodegenerative diseases or axon degeneration [1].
    5-Chloroisoquinoline
  • HY-B0985A
    Phenazopyridine
    2 Publications Verification

    		 TRP Channel Neurological Disease
    Phenazopyridine is a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine is a TRPM8 antagonist. Phenazopyridine has a local anesthetic/analgesic effect. Phenazopyridine is used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine can promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases [1] .
    Phenazopyridine
  • HY-B0985
    Phenazopyridine hydrochloride
    2 Publications Verification

    		 TRP Channel Neurological Disease
    Phenazopyridine hydrochlorideis a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine hydrochlorideis a TRPM8 antagonist. Phenazopyridine hydrochloride has a local anesthetic/analgesic effect. Phenazopyridine hydrochlorideis used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine hydrochloridecan promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases [1] .
    Phenazopyridine hydrochloride
  • HY-B0985R
    Phenazopyridine (hydrochloride) (Standard)

    		TRP Channel Neurological Disease
    Phenazopyridine (hydrochloride) (Standard) is the analytical standard of Phenazopyridine (hydrochloride). This product is intended for research and analytical applications. Phenazopyridine hydrochlorideis a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine hydrochlorideis a TRPM8 antagonist. Phenazopyridine hydrochloride has a local anesthetic/analgesic effect. Phenazopyridine hydrochlorideis used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine hydrochloridecan promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases [1] .
    Phenazopyridine (hydrochloride) (Standard)

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