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Results for "

SARM1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (1) Ceramidase (1) Reference Standards (1) Small Interfering RNA (siRNA) (3) Toll-like Receptor (TLR) (9) TRP Channel (3)
By Research Areas:	Inflammation/Immunology (1) Neurological Disease (12)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145917

SARM1-IN-2	Toll-like Receptor (TLR)	Neurological Disease
SARM1-IN-2 (Example 82) is a *SARM1* inhibitor (IC₅₀ <1 μM) that inhibits axon regeneration. Axon regeneration refers to the process by which neuronal axons attempt to restore their structure and function after axonal degeneration. SARM1-IN-2 inhibits axon regeneration by reducing or inhibiting the binding of SARM1 to NAD+. SARM1-IN-2 can be used to study axonal degeneration ^{^[1]} .

HY-Z0816

Dehydronitrosonisoldipine 3 Publications Verification	Calcium Channel	Others
Dehydronitrosonisoldipine, a derivative of Nisoldipine (HY-17402), is an irreversible and cell-permeant sterile alpha and TIR motif-containing 1 (SARM1) inhibitor. Dehydronitrosonisoldipine acts mainly by blocking SARM1 activation but not its enzymatic activities. Dehydronitrosonisoldipine inhibits SARM1 and axon degenration (AxD) by covalently modifying cysteines, also inhibits the Vincristine-activated cADPR production in neurons. Dehydronitrosonisoldipine can be used for researching neurodegenerative disorders ^[1].

HY-RS23158

Sarm1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sarm1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sarm1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sarm1 Rat Pre-designed siRNA Set A Sarm1 Rat Pre-designed siRNA Set A

HY-RS16722

Sarm1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sarm1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sarm1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sarm1 Mouse Pre-designed siRNA Set A Sarm1 Mouse Pre-designed siRNA Set A

HY-RS12446

SARM1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SARM1 Human Pre-designed siRNA Set A contains three designed siRNAs for SARM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SARM1 Human Pre-designed siRNA Set A SARM1 Human Pre-designed siRNA Set A

HY-161918

SARM1-IN-3	Toll-like Receptor (TLR)	Neurological Disease
SARM1-IN-3 (Example 30) is a *SARM1* inhibitor. SARM1-IN-3 can be used in the study of chemotherapy induced peripheral neuropathy (CIPN) ^[1].

HY-176487

SARM1-IN-6	Toll-like Receptor (TLR)	Neurological Disease
SARM1-IN-6 (Compound 22b) is a brain-permeable *SARM1* orthosteric inhibitor, the IC₅₀ of SARM1-IN-6 against NAM is 0.069 μM ^[1].

HY-172967

SARM1-IN-5	Toll-like Receptor (TLR)	Neurological Disease
SARM1-IN-5 (compound 1-23-a) is a *SARM1* inhibitor. SARM1-IN-5 can be used in the study of axonal degeneration related diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) ^[1].

HY-173276

SARM1-IN-4	Toll-like Receptor (TLR)	Neurological Disease
SARM1-IN-4 (Compound 7) is an orally active *SARM1* inhibitor. After being orally administered at a dose of 50 mg/kg in a mouse model, it can reduce the level of plasma neurofilament light chain (NfL). SARM1-IN-4 prevents programmed axonal degeneration by inhibiting the NAD+ hydrolase activity of *SARM1*, and it can be used in research related to neurodegenerative diseases and neurological disorders (such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathies, etc.).

HY-176783

GNE-5152	Toll-like Receptor (TLR)	Neurological Disease
GNE-5152 is an orthosteric *SARM1* base-exchange (BE) inhibitor. GNE-5152 sustainably activates SARM1 at subinhibitory concentrations under mildly activating conditions, and this synergistic adverse effect increases NAD consumption, induces axon degradation and neurodegeneration and releases neurofilament-light (NfL) in cortical neurons. GNE-5152 can be used for neurodegenerative diseases research ^[1].

HY-W021879

DSRM-3716 Maximum Cited Publications 7 Publications Verification 5-Iodoisoquinoline	Toll-like Receptor (TLR)	Neurological Disease
DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC₅₀ of 75 nM. DSRM-3716 is selective against other NAD ⁺-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection ^[1].

HY-129522

Sulfo-ara-F-NMN 5 Publications Verification CZ-48	Toll-like Receptor (TLR)	Neurological Disease
Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating *SARM1* but inhibiting CD38 (IC₅₀ around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production ^[1].

HY-W008341

5-Chloroisoquinoline	Toll-like Receptor (TLR)	Neurological Disease
5-Chloroisoquinoline (compound 42) is an inhibitor of *SARM1* (Sterile alpha and toll/interleukin receptor (TIR) motif containing protein 1), an enzyme involved in axon degeneration that catalyzes multiple activities through a ternary complex mechanism. 5-Chloroisoquinoline can be used in the study of neurodegenerative diseases or axon degeneration ^[1].

HY-B0985A

Phenazopyridine 2 Publications Verification	TRP Channel	Neurological Disease
Phenazopyridine is a competitive *SARM1* inhibitor, with IC₅₀ 145 μM. Phenazopyridine is a TRPM8 antagonist. Phenazopyridine has a local anesthetic/analgesic effect. Phenazopyridine is used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine can promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases ^[1] .

HY-B0985

Phenazopyridine hydrochloride 2 Publications Verification	TRP Channel	Neurological Disease
Phenazopyridine hydrochlorideis a competitive *SARM1* inhibitor, with IC₅₀ 145 μM. Phenazopyridine hydrochlorideis a TRPM8 antagonist. Phenazopyridine hydrochloride has a local anesthetic/analgesic effect. Phenazopyridine hydrochlorideis used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine hydrochloridecan promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases ^[1] .

HY-B0985R

Phenazopyridine hydrochloride (Standard)	Reference Standards TRP Channel	Neurological Disease
Phenazopyridine (hydrochloride) (Standard) is the analytical standard of Phenazopyridine (hydrochloride). This product is intended for research and analytical applications. Phenazopyridine hydrochlorideis a competitive *SARM1* inhibitor, with IC₅₀ 145 μM. Phenazopyridine hydrochlorideis a TRPM8 antagonist. Phenazopyridine hydrochloride has a local anesthetic/analgesic effect. Phenazopyridine hydrochlorideis used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine hydrochloridecan promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases ^[1] .

HY-175496

Acid Ceramidase-IN-3	Ceramidase	Inflammation/Immunology
Acid Ceramidase-IN-3 is a acid ceramidase (aCDase) inhibitor. Acid Ceramidase-IN-3 inhibits the enzymatic activity of aCDase with a pIC ₅₀ of 8.5 in enzymatic assays and 6.8 in A375 melanoma cellular assays. Acid Ceramidase-IN-3 promotes HSC inactivation, as measured by a dose-dependent reduction in COL1A1 and ACTA2. Acid Ceramidase-IN-3 inhibits aCDase activity in HSCs, promotes HSC inactivation and suppresses YAP/TAZ nuclear localization. Acid Ceramidase-IN-3 increases Dynein/Kinesin (NDE1, NDEL1. KIF3B, KIF15) while decreases several proteins involved with signaling pathway (SARM1, RGAP1, PDGF-D,PDGFR-B). Acid Ceramidase-IN-3 can be used for the study of fibrotic diseases ^[1].

Cat. No.	Compare	Product Name	Species	Source

HY-P702882

	SARM1 Protein, Human (HEK293, Flag) KIAA0524; SAMD2; SARM	Human	HEK293
	SARM1 Protein, Human (HEK293, Flag) is the recombinant human-derived SARM1, expressed by HEK293 , with N-Flag labeled tag. ,

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Sarm1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Sarm1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sarm1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sarm1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Sarm1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sarm1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

SARM1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SARM1 Human Pre-designed siRNA Set A contains three designed siRNAs for SARM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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