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Results for "

Reproductive development

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Androgen Receptor (5) Arginase (1) Atg8/LC3 (1) Autophagy (1) Biochemical Assay Reagents (2) Drug Intermediate (1) Drug Metabolite (3) Endogenous Metabolite (1) ERK (1) Estrogen Receptor/ERR (1) Ferroptosis (2) Fungal (2) Gap Junction Protein (1) iGluR (1) Integrin (1) Kisspeptin Receptor (1) mTOR (1) p62 (1) Parasite (1) PI3K (1) Reactive Oxygen Species (ROS) (4) Reference Standards (3) RET (1) TGF-beta/Smad (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (4) Endocrinology (4) Infection (3) Inflammation/Immunology (3) Metabolic Disease (4) Neurological Disease (3)
Oligonucleotides:	Antioxidants (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P10489

Kisspeptin-14 human	Kisspeptin Receptor	Cancer
Kisspeptin-14 human is a peptide hormone encoded by the KiSS-1 gene. Kisspeptin-14 human, along with several other similar peptide hormones, is produced from a common precursor protein by cleavage by different proteases. Kisspeptin-14 human is an endogenous ligand of KISS1R. Kisspeptin-14 human has the same receptor binding efficiency and potency as full-length kisspeptin. Kisspeptin-14 human binds to its receptor GPR54 and is able to activate this G protein-coupled receptor and activate multiple intracellular signaling pathways. Kisspeptin-14 human can be used to study reproductive development and tumor metastasis .

HY-W013272

Hydroxyflutamide HFT	Androgen Receptor Drug Metabolite Akt PI3K Gap Junction Protein Integrin	Cancer
Hydroxyflutamide (HFT) is the active metabolite of Flutamide (HY-B0022) and exhibits oral activity. Hydroxyflutamide is a potent androgen receptor antagonist with an IC₅₀ of 700 nM. Hydroxyflutamide can affect embryonic development and reproductive tract development in mice. Additionally, Hydroxyflutamide can enhance the efficacy of Bacillus Calmette-Guérin (BCG) to better inhibit the progression of bladder cancer. Hydroxyflutamide can be used in research related to tumors and reproductive diseases .

HY-B1066

Butylhydroxyanisole 5 Publications Verification Butylated hydroxyanisole; E320	Reactive Oxygen Species (ROS) Ferroptosis	Neurological Disease Inflammation/Immunology
Butylhydroxyanisole (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative. Butylhydroxyanisole mediates liver toxicity, retardation in reproductive organ development and learning, and sleep deficit. Butylhydroxyanisole exerts neurotoxic effects and leads to disruption of the brain and nerve development . Butylhydroxyanisole is a ferroptosis inducer .

HY-W583749

6:2 Cl-PFAES	Estrogen Receptor/ERR	Endocrinology
6:2 Cl-PFAES is reproductively toxic. 6:2 Cl-PFAES can cause elevated serum estradiol and vitellogenin levels in adult males and impair embryonic development in offspring .

HY-21191

Perfluorobutanesulfonic acid PFBS	Biochemical Assay Reagents Parasite	Infection Metabolic Disease
Perfluorobutanesulfonic acid is a surfactant that can disrupt the development of pancreatic organs and lipid metabolism regulation in zebrafish. Perfluorobutanesulfonic acid can harm the reproductive ability of nematodes (Caenorhabditis elegans) and alter the physiological functions of their offspring .

HY-B1978

Iprodione	Fungal Reactive Oxygen Species (ROS) Androgen Receptor	Infection
Iprodione is an orally active diformimide fungicide. Iprodione can specifically cause oxidative damage by producing free radicals (ROS). Iprodione is also an antiandrogen agent that delays adolescent development in rats and reduces sexual behavior and reproductive ability in rats .

HY-W585856

Bisphenol A (3-chloro-2-hydroxypropyl)glycidyl ether	Drug Intermediate	Others
Bisphenol A (3-chloro-2-hydroxypropyl) glycidyl ether is a chlorinated derivative that is released during heat treatment of food cans, bulk storage containers, and food containers. Bisphenol A (3-chloro-2-hydroxypropyl) glycidyl ether is an endocrine disruptor that affects reproductive organs and brain development.

HY-N12634

Pregnant mare serum gonadotropin PMSG	Endogenous Metabolite	Endocrinology
Pregnant mare serum gonadotropin (PMSG) is a gonadotropin used to promote follicular development and ovulation in animals. PMSG exerts its regulatory effects by stimulating changes in blood hormones, gonadotropins, and cytoplasmic estradiol receptors in the anterior pituitary and hypothalamus. PMSG is commonly used in livestock to improve reproductive efficiency and can also be utilized for research on estrous cycle regulation .

HY-B1066R

Butylhydroxyanisole (Standard) Butylated hydroxyanisole (Standard); E320 (Standard)	Reference Standards Reactive Oxygen Species (ROS) Ferroptosis	Neurological Disease Inflammation/Immunology
Butylhydroxyanisole (Standard) is the analytical standard of Butylhydroxyanisole. This product is intended for research and analytical applications. Butylhydroxyanisole (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative. Butylhydroxyanisole mediates liver toxicity, retardation in reproductive organ development and learning, and sleep deficit. Butylhydroxyanisole exerts neurotoxic effects and leads to disruption of the brain and nerve development . Butylhydroxyanisole is a ferroptosis inducer .

HY-B1978R

Iprodione (Standard)	Reference Standards Fungal Reactive Oxygen Species (ROS) Androgen Receptor	Infection
Iprodione (Standard) is the analytical standard of Iprodione. This product is intended for research and analytical applications. Iprodione is an orally active diformimide fungicide. Iprodione can specifically cause oxidative damage by producing free radicals (ROS). Iprodione is also an antiandrogen agent that delays adolescent development in rats and reduces sexual behavior and reproductive ability in rats .

HY-B1986

p,p'-DDE 1 Publications Verification 4,4'-DDE; p,p'-Dichlorodiphenyldichloroethylene	Androgen Receptor Drug Metabolite	Metabolic Disease Endocrinology
p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC₅₀ of 5 μM and a K_i of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women .

HY-143546

RET-IN-9	RET	Cancer
RET-IN-9 is a potent inhibitor of RET. RET kinase is a single-pass transmembrane receptor tyrosine kinase that plays an important role in the development of the kidney and enteric nervous system, and the maintenance of homeostasis in the nervous, endocrine, hematopoietic, and male reproductive systems. RET-IN-9 has the potential for the research of RET-related disease including non-small cell lung cancer and medullary thyroid cancer (extracted from patent WO2021115457A1, compound 29) .

HY-21197

Perfluoroenanthic acid Perfluoroheptanoic acid; Tridecafluoroheptanoic acid; PFHpA	iGluR	Neurological Disease
Perfluoroenanthic acid (Perfluoroheptanoic acid) is a type of perfluoroalkyl substance (PFAS) that can negatively impact the development of seminiferous tubules and m6A RNA methylation in the testes of offspring mice when exposed during pregnancy, consequently disrupting spermatogenesis and leading to reproductive toxicity. Perfluoroenanthic acid alters the morphology of dendritic spines and synaptic formation in primary cortical neuron cultures, enhancing neuronal activity and synaptic transmission, and increasing the expression of excitatory synapse-related proteins Synaptophysin and PSD95 .

HY-W142432

Perfluoroundecanoic acid	Biochemical Assay Reagents β-catenin Wnt Arginase TGF-beta/Smad mTOR Akt ERK Atg8/LC3 p62 Autophagy	Metabolic Disease Inflammation/Immunology Cancer
Perfluoroundecanoic acid is a perfluoroalkyl substance (PFAS). Perfluoroundecanoic acid is an orally active oxidative stress inducer. Perfluoroundecanoic acid promotes macrophage M2 polarization, activates Wnt/β-catenin signaling and enhances β-catenin nuclear accumulation. Perfluoroundecanoic acid -induced M2 phenotype macrophage accelerates tumor progression in vitro and in vivo. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy. Perfluoroundecanoic acid accelerates insulitis development in a mouse model of type 1 diabetes. Perfluoroundecanoic acid can be used for the study of ovarian cancer, type 1 diabetes and inflammation .

HY-B1986R

p,p'-DDE (Standard) 4,4'-DDE (Standard); p,p'-Dichlorodiphenyldichloroethylene (Standard)	Reference Standards Androgen Receptor Drug Metabolite	Metabolic Disease Endocrinology
p,p'-DDE (Standard) is the analytical standard of p,p'-DDE. This product is intended for research and analytical applications. p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC₅₀ of 5 μM and a K_i of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women .

Cat. No.	Product Name

HY-L197

Vitamin Compound Library	134 compounds
Vitamins are a category of trace organic compounds essential for maintaining normal physiological functions in living organisms. They are classified into fat-soluble and water-soluble vitamins. Fat-soluble vitamins play a role in maintaining vision, bone health, reproductive functions, and blood coagulation. Water-soluble vitamins are involved in energy metabolism, nervous system function, and cellular repair processes. Most vitamins cannot be synthesized by the organism and must be obtained through diet. In recent years, vitamins and their derivatives have become increasingly important in the field of drug development due to their extensive physiological activities. Additionally, vitamins and their derivatives can be used to construct research platforms for vitamin metabolism, which helps to delve into the metabolic pathways and dynamic changes of vitamins within the body and aids in identifying new biomarkers for certain diseases. MCE included 134 vitamins and their derivatives, including Vitamin A, Vitamin B, Vitamin D, etc., which is a good tool for studying vitamin metabolism.

Vitamin Compound Library

134 compounds

Vitamins are a category of trace organic compounds essential for maintaining normal physiological functions in living organisms. They are classified into fat-soluble and water-soluble vitamins. Fat-soluble vitamins play a role in maintaining vision, bone health, reproductive functions, and blood coagulation. Water-soluble vitamins are involved in energy metabolism, nervous system function, and cellular repair processes. Most vitamins cannot be synthesized by the organism and must be obtained through diet. In recent years, vitamins and their derivatives have become increasingly important in the field of drug development due to their extensive physiological activities. Additionally, vitamins and their derivatives can be used to construct research platforms for vitamin metabolism, which helps to delve into the metabolic pathways and dynamic changes of vitamins within the body and aids in identifying new biomarkers for certain diseases.

MCE included 134 vitamins and their derivatives, including Vitamin A, Vitamin B, Vitamin D, etc., which is a good tool for studying vitamin metabolism.

Cat. No.	Product Name	Target	Research Area