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Ral

" in MedChemExpress (MCE) Product Catalog:

By Targets:	COX (1) JNK (1) p38 MAPK (1) Ras (4)
By Research Areas:	Cancer (4) Inflammation/Immunology (1)

5

Inhibitors & Agonists

3

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

RBC10	Ras	Cancer
RBC10 is an anti-cancer agent. RBC10 inhibits the binding of Ral to its effector RALBP1. RBC10 also inhibits Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines .

RBC6	Ras	Cancer
RBC6 is an inhibitor of GTPases RalA. RBC6 inhibits binding of Ral to its effector RALBP1. RBC6 also inhibits Ral-mediated cell spreading of murine embryonic fibroblasts, as well as anchorage-independent growth of human cancer celllines .

RBC8	Ras p38 MAPK JNK	Cancer
RBC8 is a selective and allosteric RALA and RALB inhibitor. RBC8 stabilizes the inactive GDP-bound state of Ral, preventing its activation. RBC8 promotes the phosphorylation of proteins related to the MAPK/JNK pathway. RBC8 has the activity of inhibiting tumor cell proliferation, migration and invasion. RBC8 is used in the study of various cancers such as lung cancer, gastric cancer, and multiple myeloma .

BQU57	Ras	Cancer
BQU57 is a selective inhibitor of RalA/RalB small GTPases, with a binding potency (Kb) of 7.7 μM for RalB-GDP. BQU57 can block its interaction with effector proteins (such as SEC5 and EXO84), inhibiting tumor cell migration, invasion and non-adherent growth. BQU57 downregulates the NF-κB signaling pathway, reduces the expression of IL-6, IL-8 and MMP-13, and inhibits apoptosis by regulating the Bcl-2/Bax balance. BQU57 also protects the extracellular matrix by inhibiting the *Ral/NF-κB* pathway and can be used for the study of degenerative diseases. BQU57 exhibits significant antitumor activity in triple-negative breast cancer (TNBC) models, inhibiting orthotopic tumor growth and lung metastasis and enhancing paclitaxel chemotherapy sensitivity .

AL-8417 (2R)-AL-5898	COX	Inflammation/Immunology
AL-8417 ((2R)-AL-5898) is a potent inhibitor of Cyclooxygenase (COX), with IC₅₀ of 120 μM, that plays an important role in inflammatory response .

Cat. No.	Compare	Product Name	Application	Reactivity

	RAP1 Antibody (YA1824) Ras-related protein Rap-1b; K-REV; Ral1B	WB, IP	Human, Mouse, Rat
	RAP1 Antibody (YA1824) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1824), targeting RAP1, with a predicted molecular weight of 21 kDa (observed band size: 21 kDa). RAP1 Antibody (YA1824) can be used for WB, IP experiment in human, mouse, rat background.

	RALA Antibody (YA3752) Ral	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey

	RALB Antibody (YA1816) Ras-related protein Ral-B	WB, IP	Human, Mouse
	RALB Antibody (YA1816) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1816), targeting RALB, with a predicted molecular weight of 23 kDa (observed band size: 23 kDa). RALB Antibody (YA1816) can be used for WB, IP experiment in human, mouse background.

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