Search Result

Results for "

RPEs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	RPE65 (3) Amino Acid Derivatives (2) Apolipoprotein (2) Apoptosis (4) Autophagy (2) Bacterial (1) Caspase (1) Complement System (2) DNA Stain (1) Ferroptosis (1) Fluorescent Dye (2) Fungal (1) HDAC (1) Histone Demethylase (2) Interleukin Related (1) Mitochondrial Metabolism (1) Phospholipase (1) PKC (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) ROCK (1) Small Interfering RNA (siRNA) (6) VEGFR (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (4) Infection (5) Inflammation/Immunology (8) Metabolic Disease (5) Neurological Disease (1)
Click Chemistry:	Alkynes (2)
Oligonucleotides:	Aptamers (1) Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) siRNAs (6)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Click Chemistry

Oligonucleotides

Targets Recommended: RPE65

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-149325

RPE65-IN-1	Others	Others
RPE65-IN-1(Compound 16e) is a potent *RPE65* inhibitor, with an IC₅₀ value of 0.29 μM. which can be used in retinopathy-related research .

HY-22024

5-Hydroxyflavone 1 Publications Verification	Others	Cancer
5-Hydroxyflavone, a flavonoid ligand, shows no cytotoxic activity against MCF-7, FaDU, MDA-MB-435S, U87, RPE-1, and HEK293 cells .

HY-N11499

Myricetin 3-O-α-L-arabinopyranoside	Bacterial	Infection Inflammation/Immunology
Myricetin 3-O-α-L-arabinopyranoside is a quercetin derivative and plant flavonoid with antioxidant, antibacterial and antiurease effects. Myricetin 3-O-α-L-arabinopyranoside inhibits A2E photooxidation-induced RPE cell death. Myricetin 3-O-α-L-arabinopyranoside is protective against retinal degeneration and protects against blue light (BL)-induced damage in RPE cells and mouse models .

HY-162904

BPU17	Mitochondrial Metabolism	Cardiovascular Disease
BPU17 binds to PHB1 and causes mild defects in mitochondrial function by defects in the PHB1-PHB2 interaction. This impairment inhibits the SRF/CArG-box-dependent transcription, resulting in the suppression of epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells (RPEs). BPU17 exhibits antifibrotic activity in vivo. BPU17 is promising for research of anti-neovascular age-related macular degeneration (nAMD) agent .

HY-RS16987

Rpe Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Rpe Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rpe gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rpe Mouse Pre-designed siRNA Set A Rpe Mouse Pre-designed siRNA Set A

HY-RS12150

RPE Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RPE Human Pre-designed siRNA Set A contains three designed siRNAs for RPE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RPE Human Pre-designed siRNA Set A RPE Human Pre-designed siRNA Set A

HY-RS23430

Rpe Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Rpe Rat Pre-designed siRNA Set A contains three designed siRNAs for Rpe gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rpe Rat Pre-designed siRNA Set A Rpe Rat Pre-designed siRNA Set A

HY-RS22780

Rpe65 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Rpe65 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rpe65 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rpe65 Mouse Pre-designed siRNA Set A Rpe65 Mouse Pre-designed siRNA Set A

HY-RS12151

RPE65 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RPE65 Human Pre-designed siRNA Set A contains three designed siRNAs for RPE65 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RPE65 Human Pre-designed siRNA Set A RPE65 Human Pre-designed siRNA Set A

HY-RS29294

Rpe65 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Rpe65 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rpe65 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rpe65 Rat Pre-designed siRNA Set A Rpe65 Rat Pre-designed siRNA Set A

HY-163684

Zoracopan	Complement System	Inflammation/Immunology
Zoracopan is a selective complement factor D (CFD) inhibitor. When administered systemically (orally or intravenously), Zoracopan accumulates and is sustained-released in ocular tissues, primarily in the choroid-retinal pigment epithelium (C-RPE) and/or iridociliary body (I-CB) .

HY-N0428

Obacunone 3 Publications Verification	Apoptosis	Cancer
Obacunone is a highly oxidized triterpenoid limonoid isolated from citrus plants. Obacunone exerts its anticancer effects by inducing apoptosis. Obacunone also protects retinal pigment epithelial (RPE) cells from ultraviolet (UV) radiation (UVR)-induced oxidative damage .

HY-148457

Avacincaptad pegol Izervay	Complement System	Infection Inflammation/Immunology
Avacincaptad pegol, which is a pegylated aptamer, has garnered significant attention as a C5 complement inhibitor that may reduce inflammation-related retinal pigment epithelium (RPE) damage. Avacincaptad pegol caqn be used for the research of stargardt macular dystrophy (STGD1) and geographic atrophy (GA) .

HY-19720

Emixustat ACU-4429	RPE65	Metabolic Disease
Emixustat is an orally active *RPE65* inhibitor with an IC₅₀ value of 4.4 nM. Emixustat is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD) .

HY-19720A

Emixustat hydrochloride ACU-4429 hydrochloride	Others	Metabolic Disease
Emixustat (ACU-4429) hydrochloride is an orally active *RPE65* inhibitor with an IC₅₀ value of 4.4 nM. Emixustat hydrochloride is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD) .

HY-D2396

Sulfo SMCC R-phycoerythrin Sulfo SMCC R-PE	Fluorescent Dye	Cancer
Sulfo SMCC R-phycoerythrin is a conjugate composed of the protein crosslinker SMCC (HY-42360) and R-PE (R-Phycoerythrin) (HY-D0988) that can be used to label proteins to make them carry red fluorescence. Among them, SMCC is able to engage antigen-coupled spleen cells to induce antigen-specific immune responses .

HY-N0428R

Obacunone (Standard)	Reference Standards Apoptosis	Cancer
Obacunone (Standard) is the analytical standard of Obacunone. This product is intended for research and analytical applications. Obacunone is a highly oxidized triterpenoid limonoid isolated from citrus plants. Obacunone exerts its anticancer effects by inducing apoptosis. Obacunone also protects retinal pigment epithelial (RPE) cells from ultraviolet (UV) radiation (UVR)-induced oxidative damage .

HY-101293

VU0359595 1 Publications Verification CID-53361951; ML-270	Phospholipase Fungal	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
VU0359595 (CID-53361951; ML-270) is a potent and selective pharmacological phospholipase D1 (PLD1) inhibitor with an IC₅₀ of 3.7 nM. VU0359595 is >1700-fold selective for PLD1 over PLD2 (IC₅₀ of 6.4 μM). VU0359595 can be used for the research of cancer, diabetes, neurodegenerative and inflammatory diseases .

HY-D1742

DRAQ5	Fluorescent Dye DNA Stain	Others
DRAQ5 is a novel cell permeant and far red-fluorescing DNA probe. DRAQ5 excites at a wavelength of 647 nm, close to the Ex, and produces a fluorescence spectrum extending from 665 nm out to beyond 780 nm wavelengths. DRAQ5 fluorescence reflects cellular DNA content. DRAQ5 can be used in combination with FITC and RPE-labelled antibodies, without the need for fluorescence compensation .

HY-125639

(rac)-AR-13503 (rac)-AR-13324 M1 metabolite	PKC ROCK	Cardiovascular Disease
(rac)-AR-13503 ((rac)-AR-13324 M1 metabolite) is the isoform of AR-13503 (HY-12798C). AR-13503 a ROCK/PKC inhibitor, inhibiting angiogenesis and enhancing retinal pigment epithelium (RPE) permeability. AR-13503 also inhibits the formation of aberrant neovascularization (NV) in oxygen-induced retinopathy (OIR) model in mice .

HY-134928

Pyridinium bisretinoid A2E A2E	Apoptosis Autophagy Reactive Oxygen Species (ROS)	Cancer
Pyridinium bisretinoid A2E (A2E) is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E can be used in the study of retinal degenerative diseases .

HY-134928A

Pyridinium bisretinoid A2E TFA A2E TFA; N-retinylidene-N-retinylethanolamine TFA	Apoptosis Autophagy Reactive Oxygen Species (ROS)	Cancer
Pyridinium bisretinoid A2E (A2E) TFA is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E TFA is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E TFA mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E TFA can be used in the study of retinal degenerative diseases .

HY-P4253A

Arginyl-Glutamine TFA	VEGFR	Cardiovascular Disease
Arginyl-Glutamine TFA is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy .

HY-P4253

Arginyl-Glutamine	VEGFR	Cardiovascular Disease
Arginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy .

HY-P5169

LVGRQLEEFL (mouse)	Apolipoprotein Amino Acid Derivatives	Inflammation/Immunology
LVGRQLEEFL (mouse) can be named as G * peptide, corresponding to amino acids 113 to 122 in apolipoprotein J ([113,122] apoJ)}. LVGRQLEEFL (mouse) exhibits anti-inflammatory and anti-atherogenic properties. LVGRQLEEFL (mouse) can be added to an apoJ mimetic, to form HM-10/10 peptide, which is a mimetic peptide and a novel chimeric high density lipoprotein. HM-10/10 peptide protects retinal pigment epithelium (RPE) and photoreceptors from oxidant induced cell death .

HY-P5169A

LVGRQLEEFL (mouse) TFA	Apolipoprotein Amino Acid Derivatives	Inflammation/Immunology
LVGRQLEEFL (mouse) TFA can be named as G * peptide, corresponding to amino acids 113 to 122 in apolipoprotein J ([113,122] apoJ)}. LVGRQLEEFL (mouse) TFA exhibits anti-inflammatory and anti-atherogenic properties. LVGRQLEEFL (mouse) TFA can be added to an apoJ mimetic, to form HM-10/10 peptide, which is a mimetic peptide and a novel chimeric high density lipoprotein. HM-10/10 peptide protects retinal pigment epithelium (RPE) and photoreceptors from oxidant induced cell death .

HY-175663

EYE-002	RPE65	Metabolic Disease
EYE-002 is a *RPE65* inhibitor with an IC₅₀ of 69 nM. EYE-002 promotes recovery of scotopic ERG a-/b-wave amplitudes. EYE-002 regulates the visual cycle in mice by reducing 11-cis-retinal (11cRAL) (HY-116711) synthesis and increasing all-trans-retinyl esters (atREs). EYE-002 exerts protective effects against photic retinal damage in mice. EYE-002 can be used for the study of visual cycle-associated retinopathies, such as Stargardt disease type 1 (STGD1) .

HY-12462

WS3	Others	Inflammation/Immunology
WS3?is a novel proliferative molecule that promotes pancreatic β cell proliferation in rodent and human primary islets. WS3?can be used for the research of type 1 diabetes .

HY-101019

Ossirene 2 Publications Verification AS101	Interleukin Related Caspase	Inflammation/Immunology Cancer
Ossirene (AS101), an immunomodulatory tellurium compound, is a potent IL-1β inhibitor . Ossirene abolishes phosphorylation of STAT3 by inhibiting IL-10. Ossirene potently inhibits Caspase-1 and is used for the autoimmune diseases and certain malignancies .

HY-175664

EYE-003	RPE65	Metabolic Disease
EYE-003 is an orally active *RPE65* inhibitor with an IC₅₀ of 102 nM. EYE-003 regulates the visual cycle in mice by reducing 11-cis-retinal (11cRAL) (HY-116711) synthesis and increasing all-trans-retinyl esters (atREs). EYE-003 suppresses scotopic ERG b-wave amplitude and exerts protective effects against retinal degeneration in Abca4 ^⁻/⁻ Rdh8 ^⁻/⁻ mice (a STGD1 model) by reducing retinal autofluorescent puncta and preserving outer nuclear layer (ONL) thickness in a dose-dependent manner. EYE-003 can be used for the study of visual cycle-associated retinopathies, such as Stargardt disease type 1 (STGD1) .

HY-151872

HDAC-IN-48	HDAC Ferroptosis	Cancer
HDAC-IN-48 is a potent HDAC inhibitor. HDAC-IN-48 is a hybrid molecule with great cytotoxic profile (GI₅₀~20 nM). HDAC-IN-48 consists of harmacophores of SAHA and CETZOLE molecules. HDAC-IN-48 induces ferroptosis and inhibits HDAC proteins . HDAC-IN-48 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-175184

LSD1-IN-44	Histone Demethylase	Infection
LSD1-IN-44 (Compound 19) is a LSD1 inhibitor with an IC₅₀ of 0.02  μM for LSD1-CoREST enzymatic complex. LSD1-IN-44 has significant antischistosomal activity against transformed schistosomula (NTS) and Schistosoma mansoni adult worms while showing a delayed onset of action towards juvenile forms. LSD1-IN-44 has no significant toxicity to human cells. LSD1-IN-44 can be used for schistosomiasis research .

HY-175185

MC3935	Histone Demethylase	Infection
MC3935 is a LSD1 inhibitor with an IC₅₀ of 0.52  μM for LSD1-CoREST enzymatic complex. MC3935 has significant antischistosomal activity against transformed schistosomula (NTS) and Schistosoma mansoni adult worms while showing a delayed onset of action towards juvenile forms. MC3935 has no significant toxicity to human cells. MC3935 can be used for schistosomiasis research .

Cat. No.	Product Name	Type