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Results for "

RPE65

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

2

Antibodies

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-149325
    RPE65-IN-1

    		Others Others
    RPE65-IN-1(Compound 16e) is a potent RPE65 inhibitor, with an IC50 value of 0.29 μM. which can be used in retinopathy-related research .
    RPE65-IN-1
  • HY-19720
    Emixustat

    ACU-4429

    		 RPE65 Metabolic Disease
    Emixustat is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. Emixustat is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD) .
    Emixustat
  • HY-19720A
    Emixustat hydrochloride

    ACU-4429 hydrochloride

    		 Others Metabolic Disease
    Emixustat (ACU-4429) hydrochloride is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. Emixustat hydrochloride is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD) .
    Emixustat hydrochloride
  • HY-RS22780
    Rpe65 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Rpe65 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rpe65 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Rpe65 Mouse Pre-designed siRNA Set A
    Rpe65 Mouse Pre-designed siRNA Set A
  • HY-RS12151
    RPE65 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    RPE65 Human Pre-designed siRNA Set A contains three designed siRNAs for RPE65 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    RPE65 Human Pre-designed siRNA Set A
    RPE65 Human Pre-designed siRNA Set A
  • HY-RS29294
    Rpe65 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others
    Rpe65 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rpe65 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Rpe65 Rat Pre-designed siRNA Set A
    Rpe65 Rat Pre-designed siRNA Set A
  • HY-175663
    EYE-002

    		RPE65 Metabolic Disease
    EYE-002 is a RPE65 inhibitor with an IC50 of 69 nM. EYE-002 promotes recovery of scotopic ERG a-/b-wave amplitudes. EYE-002 regulates the visual cycle in mice by reducing 11-cis-retinal (11cRAL) (HY-116711) synthesis and increasing all-trans-retinyl esters (atREs). EYE-002 exerts protective effects against photic retinal damage in mice. EYE-002 can be used for the study of visual cycle-associated retinopathies, such as Stargardt disease type 1 (STGD1) .
    EYE-002
  • HY-175664
    EYE-003

    		RPE65 Metabolic Disease
    EYE-003 is an orally active RPE65 inhibitor with an IC50 of 102 nM. EYE-003 regulates the visual cycle in mice by reducing 11-cis-retinal (11cRAL) (HY-116711) synthesis and increasing all-trans-retinyl esters (atREs). EYE-003 suppresses scotopic ERG b-wave amplitude and exerts protective effects against retinal degeneration in Abca4 ⁻/⁻ Rdh8 ⁻/⁻ mice (a STGD1 model) by reducing retinal autofluorescent puncta and preserving outer nuclear layer (ONL) thickness in a dose-dependent manner. EYE-003 can be used for the study of visual cycle-associated retinopathies, such as Stargardt disease type 1 (STGD1) .
    EYE-003

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