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Results for "

ROR1

" in MedChemExpress (MCE) Product Catalog:

18

Inhibitors & Agonists

1

Peptides

3

Inhibitory Antibodies

19

Recombinant Proteins

3

Antibodies

5

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99201
    Zilovertamab
    1 Publications Verification

    UC-961; Cirmtuzumab

    		 ROR Wnt Cancer
    Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling [1].
    Zilovertamab
  • HY-139534
    ARI-1

    		ROR Apoptosis Akt mTOR PARP Cancer
    ARI-1 is a receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitor. ARI-1 blocks the PI3K/AKT/mTOR signaling pathway in a ROR1-dependent manner. ARI-1 upregulates cleaved-PARP and p-P38. ARI-1 induces Apoptosis. ARI-1 has anticancer activity against non-small cell lung cancer [1].
    ARI-1
  • HY-170996
    ROR1 ligand-1

    		ROR Cancer
    ROR1 ligand-1 (9-1) is a ligand for PROTACT ROR1 degrader-1 (HY-170995). ROR1 ligand-1 connects with VHL-type or CRBN ligand to design and synthesize the first selective and potent of ROR1 PROTACs [1].
    ROR1 ligand-1
  • HY-RS16801
    Ror1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Ror1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ror1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ror1 Mouse Pre-designed siRNA Set A
    Ror1 Mouse Pre-designed siRNA Set A
  • HY-RS23242
    Ror1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Ror1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ror1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ror1 Rat Pre-designed siRNA Set A
    Ror1 Rat Pre-designed siRNA Set A
  • HY-RS12124
    ROR1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ROR1 Human Pre-designed siRNA Set A contains three designed siRNAs for ROR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ROR1 Human Pre-designed siRNA Set A
    ROR1 Human Pre-designed siRNA Set A
  • HY-174382
    ROR1-IN-3

    		Akt mTOR NF-κB ROR Apoptosis Cancer
    ROR1-IN-3 (Compound 24d) is a potent and highly selective ROR1 kinase inhibitor (IC50 = 17.6 nM). ROR1-IN-3 demonstrates robust antitumor activity and inhibitory effect against ROR1 both in vitro and in vivo. ROR1-IN-3 has robust antiproliferative efficacy in vitro and in vivo. ROR1-IN-3 induces apoptosis in cancer cell lines. ROR1-IN-3 inhibits ROR1 downstream AKT/mTOR and NF-κB signaling pathway. ROR1-IN-3 can be studied in antitumor research [1].
    ROR1-IN-3
  • HY-176190
    ROR1-IN-2

    		ROR Cancer
    ROR1-IN-2 (compound 9I) is a potent and selective ROR1 inhibitor. ROR1-IN-2 exhibits antiproliferative activity in multiple cancer cells. ROR1-IN-2 significantly suppresses tumor growth in vivo [1].
    ROR1-IN-2
  • HY-170995
    PROTAC ROR1 degrader-1

    		PROTACs ROR Apoptosis Cancer
    PROTAC ROR1 degrader-1 (Compound 11d) is a PROTAC degrader for pseudokinase ROR1 that degrades ROR1 in NSCLC cells with a DC50s of 40-80 nM. PROTAC ROR1 degrader-1 causes the cleavage of PARP and induces apoptosis in NCI-H23 [1]. (Pink: ligand for target protein ROR1 ligand-1 (HY-170996); Black: linker (HY-W014787); Blue: ligand for VHL E3 ligase (S,R,S)-AHPC (HY-125845))
    PROTAC ROR1 degrader-1
  • HY-P991209
    Nebratamig

    GNC-035

    		 ROR CD3 PD-1/PD-L1 Inflammation/Immunology Cancer
    Nebratamig (GNC-035) is an anti-ROR1/anti-CD3/anti-PD-L1/anti-4-1BB tetra-specific antibody with potential immunostimulatory and antineoplastic activities [1].
    Nebratamig
  • HY-139534A
    (S)-ARI-1

    		Drug Isomer Others
    (S)-ARI-1 is an S-enantiomer of ARI-1. ARI-1 is a ROR1 inhibitor and apoptosis inducer, used in NSCLC research [1].
    (S)-ARI-1
  • HY-161096
    Antitumor agent-127

    		ROR Cancer
    Antitumor agent-127 (compound 1) is a parent macrocyclic peptide. Antitumor agent-127 displays nanomolar cell-based binding to ROR1 and relatively good internalization in 786-O and MDA-MB-231 tumor cell lines [1].
    Antitumor agent-127
  • HY-P99956
    Zilovertamab vedotin

    VLS-101; MK-2140

    		 Antibody-Drug Conjugates (ADCs) Apoptosis Cancer
    Zilovertamab vedotin (VLS-101) is a novel antibody-drug conjugate comprising the humanized monoclonal antibody zilovertamab and and the anti-microtubule cytotoxin monomethyl vedotin. Zilovertamab vedotin binding to tumor cell ROR1 results in rapid internalization, trafficking to lysosomes, antibody–agent conjugate cleavage, and monomethyl vedotin release. Zilovertamab vedotin induces apoptosis. Zilovertamab vedotin can be used in research of cancer [1].
    Zilovertamab vedotin
  • HY-160790
    β-Glu-PNP

    		ADC Linker Cancer
    β-Glu-PNP is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
    β-Glu-PNP
  • HY-162640
    LDR102

    		ROR Cancer
    LDR102 (Compound 19h) is an inhibitor for receptor tyrosine kinase-like orphan receptor 1 (ROR 1) with Ki of 0.10 μM. LDR102 inhibits proliferation of cancer cells H1975, A549 and MDA-MB-231, with IC50 of 0.36 μM, 1.37 μM and 0.47 μM. LDR102 exhibits antitumor efficacy in mice and good pharmacokinetic characteristics in rat models [1].
    LDR102
  • HY-RS12126
    RORA Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) ROR Others

    RORA Human Pre-designed siRNA Set A contains three designed siRNAs for RORA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    RORA Human Pre-designed siRNA Set A
    RORA Human Pre-designed siRNA Set A
  • HY-RS12127
    Rora Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) ROR Others

    Rora Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rora gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Rora Mouse Pre-designed siRNA Set A
    Rora Mouse Pre-designed siRNA Set A
  • HY-117947
    (R)-OR-S1

    		Histone Methyltransferase Cancer
    (R)-OR-S1 is an isomer of OR-S1. The dual ZH1/2 inhibitors OR-S1 and OR-S2 exhibit strong inhibitory activity against both EZH1 and EZH2. OR-S1 and OR-S2 are highly selective methyltransferase inhibitors against EZH1 and EZH2, and they have very similar molecular features. Therefore, we investigated the effect of OR-S1 on acute myeloid leukemia (AML). We found that OR-S1 was able to induce cell differentiation and apoptosis in AML cells. These findings encouraged us to investigate whether functional LT-HSCs could survive PRC2-targeted therapy with OR-S1 or OR-S1 combined with cytarabine. The results showed that OR-S1 did not cause significant myelosuppression, and BM cells treated with the combination therapy were able to undergo normal hematopoiesis even 4 months after treatment. Therefore, temporary inhibition of EZH1 and EZH2 is clinically tolerable, making this combination therapy suitable for AML patients. AML is generally believed to originate from myeloid progenitor cells that inherit a large number of biological properties.
    (R)-OR-S1

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