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Pyridoxal phosphate

" in MedChemExpress (MCE) Product Catalog:

25

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11

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4

Isotope-Labeled Compounds

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1744
    Pyridoxal phosphate
    1 Publications Verification

    Pyridoxal 5′-phosphate; Pyridoxyl phosphate

    		 Reverse Transcriptase Endogenous Metabolite ERK Amyloid-β Neurological Disease Metabolic Disease Cancer
    Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia.
    Pyridoxal phosphate
  • HY-B1744S
    Pyridoxal phosphate-d5

    		Isotope-Labeled Compounds Reverse Transcriptase Endogenous Metabolite Neurological Disease
    Pyridoxal phosphate-d5 is the deuterium labeled Pyridoxal phosphate. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia .
    Pyridoxal phosphate-d5
  • HY-W011727
    Pyridoxal 5'-phosphate hydrate
    1 Publications Verification

    Pyridoxal phosphate hydrate

    		 Endogenous Metabolite Amyloid-β ERK Neurological Disease Metabolic Disease Cancer
    Pyridoxal 5'-phosphate hydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate hydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) .
    Pyridoxal 5'-phosphate hydrate
  • HY-W011727A
    Pyridoxal 5'-​phosphate monohydrate
    1 Publications Verification

    Pyridoxal phosphate monohydrate

    		 Endogenous Metabolite Amyloid-β ERK Neurological Disease Metabolic Disease Cancer
    Pyridoxal 5'-phosphate monohydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate monohydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′‐phosphate (PMP) .
    Pyridoxal 5'-​phosphate monohydrate
  • HY-W011727S
    Pyridoxal Phosphate-d3

    Pyridoxal 5'-phosphate-d3

    		 Endogenous Metabolite Amyloid-β ERK Neurological Disease Metabolic Disease Cancer
    Pyridoxal Phosphate-d3 is the deuterium labeled Pyridoxal 5'-phosphate. Pyridoxal 5'-phosphate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) .
    Pyridoxal Phosphate-d3
  • HY-107469
    Pyridoxal

    Pyridoxaldehyde

    		 Endogenous Metabolite Neurological Disease Metabolic Disease
    Pyridoxal is a neuroprotectant. Pyridoxal is one of the main forms of vitamin B6. Pyridoxal is phosphorylated by pyridoxal kinase to pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-pyridoxic acid (HY-113493) and excreted in the urine. Pyridoxal has shown promise in the study of carpal tunnel syndrome (CTS) .
    Pyridoxal
  • HY-W027446
    Pyridoxal hydrochloride

    		Endogenous Metabolite Neurological Disease Metabolic Disease
    Pyridoxal hydrochloride, the hydrochloride form of Pyridoxal (HY-107469), is a newly developed neuroprotective agent. Pyridoxal hydrochloride is one of the major forms of vitamin B6. Pyridoxal hydrochloride is solvolyzed in methanol to form pyridoxal monomethylacetal. Pyridoxal is phosphorylated by pyridoxal kinase to Pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-Pyridoxic acid (HY-113493) which is excreted in the urine. Pyridoxal hydrochloride is proming for research of carpal tunnel syndrome (CTS) .
    Pyridoxal hydrochloride
  • HY-B1744R
    Pyridoxal phosphate (Standard)

    		Reverse Transcriptase Endogenous Metabolite Neurological Disease
    Pyridoxal phosphate (Standard) is the analytical standard of Pyridoxal phosphate. This product is intended for research and analytical applications. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia.
    Pyridoxal phosphate (Standard)
  • HY-W011727AR
    Pyridoxal 5'-?phosphate monohydrate (Standard)

    Pyridoxal phosphate monohydrate (Standard)

    		 Endogenous Metabolite Amyloid-β ERK Neurological Disease Metabolic Disease Cancer
    Pyridoxal 5'-​phosphate (monohydrate) (Standard) is the analytical standard of Pyridoxal 5'-​phosphate (monohydrate). This product is intended for research and analytical applications. Pyridoxal 5'-phosphate monohydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate monohydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) .
    Pyridoxal 5'-?phosphate monohydrate (Standard)
  • HY-107469R
    Pyridoxal (Standard)

    Pyridoxaldehyde (Standard)

    		 Endogenous Metabolite Neurological Disease Metabolic Disease
    Pyridoxal (Standard) is the analytical standard of Pyridoxal. This product is intended for research and analytical applications. Pyridoxal is a neuroprotectant. Pyridoxal is one of the main forms of vitamin B6. Pyridoxal is phosphorylated by pyridoxal kinase to pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-pyridoxic acid (HY-113493) and excreted in the urine. Pyridoxal has shown promise in the study of carpal tunnel syndrome (CTS)[1][2][3].
    Pyridoxal (Standard)
  • HY-W027446R
    Pyridoxal hydrochloride (Standard)

    		Endogenous Metabolite Neurological Disease Metabolic Disease
    Pyridoxal hydrochloride (Standard) is the analytical standard of Pyridoxal hydrochloride. This product is intended for research and analytical applications. Pyridoxal hydrochloride, the hydrochloride form of Pyridoxal (HY-107469), is a newly developed neuroprotective agent. Pyridoxal hydrochloride is one of the major forms of vitamin B6. Pyridoxal hydrochloride is solvolyzed in methanol to form pyridoxal monomethylacetal. Pyridoxal is phosphorylated by pyridoxal kinase to Pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-Pyridoxic acid (HY-113493) which is excreted in the urine. Pyridoxal hydrochloride is proming for research of carpal tunnel syndrome (CTS) .
    Pyridoxal hydrochloride (Standard)
  • HY-114758
    Pyridoxal isonicotinoyl hydrazone
    4 Publications Verification

    		 Biochemical Assay Reagents Ferrochelatase Cardiovascular Disease
    Pyridoxal isonicotinoyl hydrazone is an orally active and lipophilic iron-specific chelator that acts as a non-competitive inhibitor of ferrochelatase (FECH) by binding iron ions. Pyridoxal isonicotinoyl hydrazone disrupts heme biosynthesis, leading to reduced FECH stability and increased protoporphyrin IX (PPIX) accumulation. Pyridoxal isonicotinoyl hydrazone is promising for research of iron-overload diseases (e.g., β-thalassemia) .
    Pyridoxal isonicotinoyl hydrazone
  • HY-107469S1
    Pyridoxal-d3

    Pyridoxaldehyde-d3

    		 Endogenous Metabolite Others
    Pyridoxal-d3 is the deuterium labeled Pyridoxal .
    Pyridoxal-d3
  • HY-107469S
    Pyridoxal-d3 hydrochloride

    Pyridoxaldehyde-d3 hydrochloride

    		 Isotope-Labeled Compounds Others
    Pyridoxal-d3 (hydrochloride) is the deuterium labeled Pyridoxal hydrochloride .
    Pyridoxal-d3 hydrochloride
  • HY-N3394
    Lecanoric acid

    		Others Infection
    Lecanoric acid is a histidine-decarboxylase inhibitor isolated from fungus. The inhibition by lecanoric acid is competitive with histidineand noncompetitive with pyridoxal phosphate. Lecanoric acid did not inhibit aromatic amino acid decarboxylase .
    Lecanoric acid
  • HY-116073
    L-Penicillamine

    		Biochemical Assay Reagents Metabolic Disease
    L-Penicillamine is a mechanism-based inhibitor of serine palmitoyltransferase by forming a pyridoxal-5 '-phosphate-thiazolidine adduct. L-Penicillamine is a metal chelating agent of intermediate strength .
    L-Penicillamine
  • HY-B1746
    Pyridoxamine 5′-phosphate

    		Endogenous Metabolite Neurological Disease
    Pyridoxamine 5′-phosphate is the active form of vitamin B6 bound to phosphoric acid. Pyridoxamine 5′-phosphate is the aminated form of pyridoxal 5'-phosphate hydrate (HY-W011727A) and as co-factor of a variety of enzymes central metabolite, potent antioxidant, vitamin B6 vitamer and enzyme substrate. Pyridoxamine 5′-phosphate can be interconverted with pyridoxal 5'-phosphate hydrate .
    Pyridoxamine 5′-phosphate
  • HY-123202
    MRS2603

    		P2Y Receptor Cancer
    MRS2603 is a pyridoxal derivative. MRS2603 antagonized both P2Y1 and P2Y13 receptors .
    MRS2603
  • HY-P2985
    Alanine aminotransferase, Porcine heart

    		Endogenous Metabolite Metabolic Disease
    Alanine aminotransferase, Porcine heart is a pyridoxal enzyme that catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate .
    Alanine aminotransferase, Porcine heart
  • HY-15377
    DL-Gabaculine hydrochloride

    		GABA Receptor Neurological Disease
    DL-Gabaculine hydrochloride is a neurotoxin that irreversibly inhibits bacterial pyridoxal phosphate linked γ-aminobutyric acid-α-ketoglutaric acid transaminase with a Ki of 2.86 μM .
    DL-Gabaculine hydrochloride
  • HY-N2553
    4-Deoxypyridoxine 5'-phosphate

    		LPL Receptor Metabolic Disease
    4-Deoxypyridoxine 5'-phosphate is a Pyridoxal 5'-phosphate analogue and a sphingosine 1-phosphate (S1P) inhibitor. 4-Deoxypyridoxine 5'-phosphate inhibits ornithine decarboxylase activity with a Ki of 60 μM. 4-Deoxypyridoxine 5'-phosphate is a competitive inhibitor of the activation of glutamate apodecarboxylase by Pyridoxal 5'-phosphate (Ki of 0.27 μM) and strongly inhibits glutamate-dependent labeling of glutamate decarboxylase .
    4-Deoxypyridoxine 5'-phosphate
  • HY-P2825
    Tyrosine decarboxylase, Microorganism

    TDC; TyrDC

    		 Endogenous Metabolite Metabolic Disease Cancer
    Tyrosine decarboxylase, Microorganism (TDC) widely exists in plants, insects and different microorganisms, and is often used in biochemical research. Tyrosine decarboxylase is a pyridoxal 5'-phosphate (PLP)-dependent decarboxylase that catalyzes the removal of carboxyl groups from tyrosine to produce tyramine and carbon dioxide .
    Tyrosine decarboxylase, Microorganism
  • HY-P991210
    Efzimfotase alfa

    ALXN-1850

    		 Phosphatase Cardiovascular Disease
    Efzimfotase alfa (ALXN-1850) is enzyme replacement therapy agent targeting the deficiency of tissue-nonspecific alkaline phosphatase (TNSALP). Efzimfotase alfa functions by hydrolyzing the substrates of TNSALP, reducing the concentrations of substrates such as inorganic pyrophosphate (PPi) and pyridoxal 5′-phosphate (PLP). Efzimfotase alfa is promising for research of hypophosphatasia (HPP) .
    Efzimfotase alfa
  • HY-162508
    KSK-104

    		Bacterial Infection
    KSK-104 has potent antibacterial activity against Mycobacterium tuberculosis (MIC=0.78 μM). The role of KSK-104 is mainly involved in the synthesis and recovery pathways of pyridoxal 5'-phosphate (PLP), PLP-dependent enzymes and oxidative stress networks. KSK-104, as a candidate molecule for novel anti-tuberculosis drugs, can be used to develop research against drug-resistant mycobacterium tuberculosis .
    KSK-104
  • HY-162652
    HSR-IN-1

    		Serine Racemase (SR) Neurological Disease
    HSR-IN-1 (Compound 28) is an effective hSR (human serine racemase) inhibitor. In the presence of the cofactor Pyridoxal 5'-phosphate monohydrate (HY-W011727A), HSR-IN-1 has a Kd value of 5.4 μM and an IC50 of 18.3 μM for hSR, while the IC50 of HSR-IN-1 alone is 4.7 μM. HSR-IN-1 can be used for research on central nervous system diseases .
    HSR-IN-1

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