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Results for "

Pseudomonas aeruginosa quorum sensing

" in MedChemExpress (MCE) Product Catalog:

29

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1

Biochemical Assay Reagents

1

Peptides

6

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W007390
    Methyl 2-amino-5-bromobenzoate
    1 Publications Verification

    		 Bacterial Drug Intermediate Infection
    Methyl 2-amino-5-bromobenzoate (Compound 8/12) is a biochemical reagent. Methyl 2-amino-5-bromobenzoate can be used to synthesize 2-benzamidobenzoic acid, a known FabH inhibitor. Derivatives of methyl 2-amino-5-bromobenzoate also inhibit PqsD, the pqs quorum sensing (QS) system, of Pseudomonas aeruginosa .
    Methyl 2-amino-5-bromobenzoate
  • HY-W104758
    Elastase-IN-3

    		Elastase Antibiotic Bacterial Others
    Elastase-IN-3 (Compound 2i) is an Elastase inhibitor of Pseudomonas aeruginosa. Elastase-IN-3 inhibits the quorum sensing system of Pseudomonas aeruginosa by targeting the LasR protein (KD value of 7.04 M), thereby preventing food spoilage caused by Pseudomonas aeruginosa .
    Elastase-IN-3
  • HY-128200
    Pseudomonas quinolone signal
    1 Publications Verification

    PQS

    		 Bacterial Infection Inflammation/Immunology
    Pseudomonas quinolone signal (PQS) is a quorum-sensing signaling molecule produced by Pseudomonas aeruginosa. The synthesis of Pseudomonas quinolone signal relies on the las quorum-sensing system, and its biological activity is associated with the rhl system. Pseudomonas quinolone signal regulates the expression of the virulence gene lasB. Additionally, Pseudomonas quinolone signal plays roles in iron acquisition, cytotoxicity, outer-membrane vesicle biogenesis, and host immune modulation .
    Pseudomonas quinolone signal
  • HY-163508
    Antibacterial agent 210

    		Bacterial Infection
    Antibacterial agent 210 (compound A9), an amide derivative, is a Pseudomonas aeruginosa quorum sensing inhibitor (QSI). Antibacterial agent 210 inhibits the quorum sensing systems by binding with LasR and PqsR, especially PqsR .
    Antibacterial agent 210
  • HY-158193
    N-Decanoyl cyclopentylamide

    C10-CPA

    		 Bacterial Infection
    N-Decanoyl cyclopentylamide (C10-CPA) is a potent inhibitor of quorum sensing in Pseudomonas aeruginosa. N-Decanoyl cyclopentylamide interferes with expression of Pseudomonas aeruginosa virulence factors regulated by the las and rhl quorum-sensing systems. N-Decanoyl cyclopentylamide inhibits production of elastase, pyocyanin, and rhamnolipid and biofilm formation .
    N-Decanoyl cyclopentylamide
  • HY-162957
    LasR-IN-5

    		Bacterial Antibiotic Infection
    LasR-IN-5 (compound 3C) is a LasR antagonist with an IC50 of 1.37 μM, demonstrating a 77% inhibition of biofilm formation in Pseudomonas aeruginosa. LasR-IN-5 also exhibits quorum sensing (QS) inhibition activity and has potential applications in Pseudomonas aeruginosa infection research .
    LasR-IN-5
  • HY-146304
    YXL-13

    		Bacterial Infection
    YXL-13 is a potent Pseudomonas aeruginosa (PAO1) inhibitor with an IC50 value of 3.686 μM. YXL-13 can inhibit virulence factors and biofilm formation of PAO1. YXL-13 reduces the pathogenicity and agent resistance of PAO1 by inhibition of the quorum sensing (QS) system. YXL-13 can be used for researching anti-bacteria .
    YXL-13
  • HY-149479
    Quorum sensing-IN-3

    		Bacterial Infection
    Quorum sensing-IN-3 (Compound 3a) is a quorum sensing inhibitor against pseudomonas aeruginosa. Quorum sensing-IN-3 inhibits biofilm formation .
    Quorum sensing-IN-3
  • HY-168948
    Quorum sensing-IN-9

    		Bacterial Infection
    Quorum sensing-IN-9 (Compound 7d) inhibits quorum sensing in Pseudomonas aeruginosa by binding PqsR proteins. Quorum sensing-IN-9 inhibits the expression of quorum sensing systems related genes lasB, rhlA and pqsA, blocks the generation of virulence factors elastase, pyocyanin and rhamnolipid. Quorum sensing-IN-9 destorys the motility of P. aeruginosa, inhibits the biofilm formation, decreasing the virulence and pathogenicity of P. aeruginosa. Quorum sensing-IN-9 exhibits anti-infectious activity in Galleria mellonella larval model .
    Quorum sensing-IN-9
  • HY-172895
    Quorum sensing-IN-10

    		Bacterial Infection Inflammation/Immunology
    Quorum sensing-IN-10 (10p), an antibacterial synergist, shows significant inhibition of P. aeruginosa virulence, biofilm, and motility, with low toxicity. Quorum sensing-IN-10 (10p) can be used in the research for drug-resistant Pseudomonas aeruginosa infections .
    Quorum sensing-IN-10
  • HY-158124
    LasR antagonist 1

    		Bacterial Infection
    LasR antagonist 1 (Compound 7) is an antagonist for LasR with an IC50 of 0.4 μM, that modulates the quorum sensing (QS) in the opportunistic pathogen Pseudomonas aeruginosa .
    LasR antagonist 1
  • HY-119808
    Terrein

    		Melanocortin Receptor Apoptosis Antibiotic Cancer
    Terrein is a melanogenesis inhibitor . Terrein induces apoptosis in breast cancer cell lines . Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa .
    Terrein
  • HY-146705
    PqsR-IN-1

    		Bacterial Infection
    PqsR-IN-1 (Compound 18) is a potent PqsR (Pseudomonas aeruginosa quorum sensing transcriptional regulator) inhibitor. PqsR-IN-1 attenuates pyocyanin production and has very low cytotoxicity .
    PqsR-IN-1
  • HY-146706
    PqsR-IN-2

    		Bacterial Infection
    PqsR-IN-2 (Compound 19) is a potent PqsR (Pseudomonas aeruginosa quorum sensing transcriptional regulator) inhibitor. PqsR-IN-1 attenuates pyocyanin production and has very low cytotoxicity .
    PqsR-IN-2
  • HY-118697
    N-dodecanoyl-L-Homoserine lactone
    1 Publications Verification

    C12-HSL

    		 Bacterial Infection
    N-dodecanoyl-L-Homoserine lactone (C12-HSL) is a quorum sensing (QS) signaling molecule. N-dodecanoyl-L-Homoserine lactone (C12-HSL) aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa .
    N-dodecanoyl-L-Homoserine lactone
  • HY-122143
    V-06-018

    		Bacterial Infection
    V-06-018 is a potent LasR antagonist with an IC50 value of 5.2 µM. V-06-018 can be used as chemical probes of quorum sensing (QS) in Pseudomonas aeruginosa .
    V-06-018
  • HY-156439
    Antibiofilm agent-2

    		Bacterial Infection
    Antibiofilm agent-2 (compound 4T) is a potent biofilm inhibitor with an IC50 of 3.6 μM. Antibiofilm agent-2 inhibits the quorum sensing system and iron homeostasis as antibacterial synergists against Pseudomonas aeruginosa .
    Antibiofilm agent-2
  • HY-111278
    Pyocyanin
    1 Publications Verification

    Pyocyanine; Sanazin; Sanasin

    		 Reactive Oxygen Species (ROS) Bacterial Drug Metabolite Endogenous Metabolite Infection Inflammation/Immunology
    Pyocyanin (Pyocyanine) is a toxic, quorum sensing (QS) controlled metabolite produced by Pseudomonas aeruginosa. Pyocyanin is a REDOX active compound that promotes the production of reactive oxygen species (ROS). Pyocyanin has antibacterial and anti-inflammatory activity .
    Pyocyanin
  • HY-163838
    Quorum sensing-IN-6

    		Bacterial Infection
    Quorum sensing-IN-6 (compound 27) is a quorum sensing (QS) inhibitor with IC50 values of 8 and 106 nM for E.coli and Pyocyanin, respectively .
    Quorum sensing-IN-6
  • HY-W040220
    N-(3-Hydroxyoctanoyl)-DL-homoserine lactone

    		Bacterial Infection
    N-(3-Hydroxyoctanoyl)-DL-homoserine lactone (Compound 40) is a competitive inhibitor of the quorum sensing receptor LuxR with an IC50 value of 4 μM. N-(3-Hydroxyoctanoyl)-DL-homoserine lactone shows selective inhibition toward quorum sensing systems in Gram-negative bacteria like Pseudomonas aeruginosa. N-(3-Hydroxyoctanoyl)-DL-homoserine lactone is promising for research of bacterial infections .
    N-(3-Hydroxyoctanoyl)-DL-homoserine lactone
  • HY-111278R
    Pyocyanin (Standard)

    Pyocyanine (Standard); Sanazin (Standard); Sanasin (Standard)

    		 Reference Standards Reactive Oxygen Species (ROS) Bacterial Drug Metabolite Endogenous Metabolite Infection Inflammation/Immunology
    Pyocyanin (Standard) is the analytical standard of Pyocyanin. This product is intended for research and analytical applications. Pyocyanin (Pyocyanine) is a toxic, quorum sensing (QS) controlled metabolite produced by Pseudomonas aeruginosa. Pyocyanin is a REDOX active compound that promotes the production of reactive oxygen species (ROS). Pyocyanin has antibacterial and anti-inflammatory activity[1][2][3][4].
    Pyocyanin (Standard)
  • HY-118697R
    N-Dodecanoyl-L-homoserine lactone (Standard)

    C12-HSL (Standard)

    		 Reference Standards Bacterial Infection
    N-dodecanoyl-L-Homoserine lactone (Standard) (C12-HSL (Standard)) is the analytical standard of N-dodecanoyl-L-Homoserine lactone (HY-118697). This product is intended for research and analytical applications. N-dodecanoyl-L-Homoserine lactone (C12-HSL) is a quorum sensing (QS) signaling molecule. N-dodecanoyl-L-Homoserine lactone (C12-HSL) aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa.
    N-Dodecanoyl-L-homoserine lactone (Standard)
  • HY-B0914
    10-Undecenoic acid,98% (stabilized with TBC)
    2 Publications Verification

    Undecylenic acid

    		 Fungal Amyloid-β Reactive Oxygen Species (ROS) Proteasome Bacterial Infection Neurological Disease Endocrinology Cancer
    10-Undecenoic acid (Undecylenic acid) is an antifungal agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .
    10-Undecenoic acid,98% (stabilized with TBC)
  • HY-114773
    N-Undecanoyl-L-homoserine lactone

    		Biochemical Assay Reagents Others
    Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C11-HSL has a rare odd-numbered acyl carbon chain and may be a minor quorum-sensing signaling molecule in Pseudomonas aeruginosa strains.
    N-Undecanoyl-L-homoserine lactone
  • HY-B0914A
    10-Undecenoic acid zinc salt
    2 Publications Verification

    Zinc undecylenate

    		 Fungal Bacterial Amyloid-β Reactive Oxygen Species (ROS) Proteasome Infection Neurological Disease Endocrinology Cancer
    10-Undecenoic acid zinc salt (Undecylenic acid zinc salt) is an antifungal agent. 10-Undecenoic acid zinc salt inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid zinc salt has neuroprotective effects. 10-Undecenoic acid zinc salt has anticancer effects on a variety of tumors. 10-Undecenoic acid zinc salt inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid zinc salt inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .
    10-Undecenoic acid zinc salt
  • HY-B0914B
    10-Undecenoic acid (copper)

    Undecylenic acid (copper)

    		 Fungal Bacterial Amyloid-β Reactive Oxygen Species (ROS) Proteasome Infection Neurological Disease Endocrinology Cancer
    10-Undecenoic acid copper (Undecylenic acid copper) is an antifungal agent. 10-Undecenoic acid copper inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid copper has neuroprotective effects. 10-Undecenoic acid copper has anticancer effects on a variety of tumors. 10-Undecenoic acid copper inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid copper inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .
    10-Undecenoic acid (copper)
  • HY-B0914R
    10-Undecenoic acid (Standard)

    Undecylenic acid (Standard)

    		 Reference Standards Fungal Amyloid-β Reactive Oxygen Species (ROS) Proteasome Bacterial Infection Neurological Disease Endocrinology Cancer
    10-Undecenoic acid (Standard) is the analytical standard of 10-Undecenoic acid. This product is intended for research and analytical applications. 10-Undecenoic acid (Undecylenic acid) is an antifungal agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .
    10-Undecenoic acid (Standard)
  • HY-B0914AR
    10-Undecenoic acid zinc salt (Standard)

    Zinc undecylenate (Standard)

    		 Reference Standards Fungal Amyloid-β Reactive Oxygen Species (ROS) Proteasome Bacterial Infection Neurological Disease Endocrinology Cancer
    10-Undecenoic acid (zinc salt) (Standard) is the analytical standard of 10-Undecenoic acid (zinc salt). This product is intended for research and analytical applications. 10-Undecenoic acid zinc salt (Undecylenic acid zinc salt) is an antifungal agent. 10-Undecenoic acid zinc salt inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid zinc salt has neuroprotective effects. 10-Undecenoic acid zinc salt has anticancer effects on a variety of tumors. 10-Undecenoic acid zinc salt inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid zinc salt inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .
    10-Undecenoic acid zinc salt (Standard)
  • HY-W141788
    N-Butyryl-DL-homocysteine thiolactone

    		Bacterial Infection
    N-Butyryl-DL-homocysteine thiolactone is an N-acyl homoserine lactone (AHL) analogue. AHLs are potent inhibitors of biofilm formation and virulence factors, and has been used for degrading microbial communities, reducing bacterial pathogenicity .
    N-Butyryl-DL-homocysteine thiolactone

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