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Results for "

Protein cross-linker

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (2) Drug-Linker Conjugates for ADC (1) E3 Ligase Ligand-Linker Conjugates (2) Antibiotic (5) Apoptosis (3) Bacterial (6) Beta-lactamase (2) Biochemical Assay Reagents (52) DNA Alkylator/Crosslinker (4) EAAT (1) Endogenous Metabolite (4) Eukaryotic Initiation Factor (eIF) (1) Fluorescent Dye (3) Reactive Oxygen Species (ROS) (1) Reference Standards (3) Ser/Thr Protease (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (2) Infection (6) Inflammation/Immunology (5) Metabolic Disease (6) Neurological Disease (3)
Click Chemistry:	PROTAC Synthesis (1) Azide (5) BCN (1) Alkynes (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

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Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: ADC Linker Target Protein Ligand-Linker Conjugates PROTAC-Linker Conjugates for PAC Drug-Linker Conjugates for ADC E3 Ligase Ligand-Linker Conjugates

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W041994

GMBS	Biochemical Assay Reagents	Others
GMBS is a heterobifunctional cross-linker. GMBS can be used in chemical cross-linking of proteins coupled with mass spectrometry (CXMS) to study protein folding and to map the interfaces between interacting proteins .

HY-157414

Azide-A-DSBSO crosslinker	Biochemical Assay Reagents	Others
Azide-A-DSBSO crosslinker is a mass spectrometry (MS) cleavable, membrane permeable, homobifunctional, azide-labeled, acid-cleavable crosslinking peptide. Azide-A-DSBSO crosslinker crosslinks proteins via NHS ester reaction with lysine residues. Azide-A-DSBSO crosslinker can be used to study protein-protein interactions by cross-linking mass spectrometry (XL-MS) ^{[1] .}

HY-123740

Disuccinimidyl sulfoxide DSSO	Biochemical Assay Reagents	Others
Disuccinimidyl sulfoxide (DSSO) is a mass spectrometry (MS)-cleavable cross-linker that is applicable for model peptides and proteins and a multisubunit protein complex. Disuccinimidyl sulfoxide contains two symmetric collision-induced dissociation (CID)-cleavable sites for identification of DSSO-cross-linked peptides based their distinct fragmentation patterns .

HY-107783

Sulfo-GMBS	Others	Cancer
Sulfo-GMBS is a cross-linking agent widely used in chemical modification and coupling reactions of proteins and peptides. Among the amine-sulfhydryl cross-linkers, Sulfo-GMBS generated the largest number of cross-links and covered most of the cross-links that were identified with AMAS and GMBS .

HY-W009034

Fmoc-Suberol	Eukaryotic Initiation Factor (eIF)	Others
Fmoc-Suberol is a protein cross-linking agent.

HY-159008

NHSF	Biochemical Assay Reagents	Others
NHSF is a protein cross-linking agent .

HY-137383

Sulfo-SANPAH	Biochemical Assay Reagents Reactive Oxygen Species (ROS)	Others
Sulfo-SANPAH is a primary amine-nitrobenzene azide cross-linker. Sulfo-SANPAH is widely used to crosslink ECM proteins to various substrates, including acrylic-based hydrogels, such as polyacrylamide hydrogels. Sulfo-SANPAH facilitates covalent binding through its negatively charged sulfonate group on its N-hydroxysuccinimide ester ring and a photoactivated phenyl azide group that is highly reactive with nucleophiles and free radicals .

HY-148140

Cross-linked dextran G 25 1 Publications Verification	Biochemical Assay Reagents	Others
Cross-linked dextran G 25 is a dextran chromatography medium. Cross-linked dextran G 25 separates from 1 to 5 kD (spherical proteins) and can be used for the separation of peptides as well as for the desalting and buffer replacement of large molecule proteins .

HY-W096122

DTSSP Crosslinker disodium	Biochemical Assay Reagents	Others
DTSSP Crosslinker disodium is a protein cross-linker containing a disulfide bond. DTSSP Crosslinker disodium can react with sidechains of amino acids that are within close proximity .

HY-137251

Sulfo-MBS sodium	Biochemical Assay Reagents	Others
Sulfo-MBS sodium is a heterobifunctional crosslinker with a maleimide group and an N-hydroxysuccinimide (NHS) ester group, which can react with cysteine residues and lysine residues on proteins. Sulfo-MBS sodium be used for protein cross-linking studies .

HY-W040113

6-(N-Boc)caproic acid NHS	Biochemical Assay Reagents	Others
6-(N-Boc)caproic acid NHS is a protein cross-linking agent.

HY-156045C

Cross-linked dextran G 200	Biochemical Assay Reagents	Others
Cross-linked dextran G 200 is a hydrophilic gel based on molecular size exclusion and targeted macromolecular separation. Cross-linked dextran G 200 works through the gel permeation mechanism, and the cross-linked structure forms a three-dimensional network with a specific pore size, achieving separation based on the molecular hydrodynamic volume. Cross-linked dextran G 200 can be used to adjust the osmotic solute distribution coefficient and the ability to maintain osmotic equilibrium, such as in gel filtration chromatography for purification and analysis of biomacromolecules such as proteins and nucleic acids . Cross-linked dextran G 200 can also be used as a gel filtration filler (particle size range: 40-120 μm; globular protein separation range: 5-600 kDa) .

HY-W013538

1,2-Bis(maleimido)ethane N,N'-Ethylenedimaleimide	Biochemical Assay Reagents	Others
1,2-Bis(maleimido)ethane (N,N'-Ethylenedimaleimide) is a protein cross-linking agent.

HY-76214

Dibenzyl hydrazodicarboxylate Dibenzyl hydrazine-1,2-dicarboxylate	Others	Others
Dibenzyl hydrazodicarboxylate (Dibenzyl hydrazine-1,2-dicarboxylate) is a protein cross-linking agent.

HY-W012166

N-Succinimidyl bromoacetate NHS-Bromoacetate	Biochemical Assay Reagents	Others
N-Succinimidyl bromoacetate is a heterobifunctional cross-linking reagent can be used to prepare peptide-protein immunogens .

HY-122429

Lysinonorleucine LNL	Biochemical Assay Reagents	Others
Lysinonorleucine (LNL) is a Schiff base-type protein cross-link. Lysinonorleucine could be used as a potential and specific biomarker to indicate the level of protein oxidation .

HY-135066

Triallyl pentaerythritol Pentaerythritol triallyl ether	Biochemical Assay Reagents	Others
Triallyl pentaerythritol (PEATA), a crosslinker, decreases the protein rejection compared to membranes functionalized with MBAA or without any crosslinker .

HY-W074785

Carboxyl diazirine alkyne	Biochemical Assay Reagents	Others
Carboxyl diazirine alkyne is a protein cross-linking compound. Carboxyl diazirine alkyne plays a crucial role in the research on the inhibition and labeling of FTO protein by fluorescein derivatives .

HY-W008575

N-Fmoc-N-methoxy-3-aminopropionic acid	Biochemical Assay Reagents	Others
N-Fmoc-N-methoxy-3-aminopropionic acid, a Weinreb amide linker, is a protein cross-linking agent .

HY-W264744

3-Maleimidobenzoic acid	Biochemical Assay Reagents	Others
3-Maleimidobenzoic acid is a protein crosslinker .

HY-138560A

Cross-linked dextran G 50, medium	Biochemical Assay Reagents	Others
Cross-linked dextran G 50, medium is a gel filtration medium. Cross-linked dextran G 50, medium can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da). Cross-linked dextran G 50, medium are microspheres with an average particle size of D50 = 220-250 μm .

HY-138560B

Cross-linked dextran G 50, fine	Biochemical Assay Reagents	Others
Cross-linked dextran G 50, fine is a gel filtration medium. Cross-linked dextran G 50, fine can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da). Cross-linked dextran G 50, fineThe average particle size is D50=110-130 μmof microspheres .

HY-138560

Cross-linked dextran G 50 1 Publications Verification	Biochemical Assay Reagents	Others
Cross-linked dextran G 50 is a gel filtration medium. Cross-linked dextran G 50 can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da) .

HY-W075885

trans-Platinum(II)diammine dichloride trans-platinumdiamminedichloride	DNA Alkylator/Crosslinker	Others
trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links .

HY-W332335

Sulfosuccinimidyl-6-(biotinamido)hexanoate sodium	Biochemical Assay Reagents	Others
Sulfosuccinimidyl-6-(biotinamido)hexanoate sodium is a protein crosslinker, and is a biotinylation reagentcan for labeling cell surface proteins .

HY-156045

Cross-linked dextran G 15	Biochemical Assay Reagents	Others
Cross-linked dextran G 15 is a hydrophilic gel that can be used as a gel filter filler (Sphere protein separation range: >1500 Da; Polysaccharide separation range: >1500 Da) .

HY-148139

Cross-linked dextran G 75	Biochemical Assay Reagents	Others
Cross-linked dextran G 75 is a Gel-filtration media. Cross-linked dextran G 75 also is a dextran-based matrix and used for Gel-filtration chromatography (Particle size range: 40-120 μm; Sphere protein separation range: 3K-80K Da; Polysaccharide separation range: 1K-50K Da) .

HY-D0853A

DiAzKs hydrochloride 1 Publications Verification H-L-Photo-lysine hydrochloride	Fluorescent Dye	Others
DiAzKs (H-L-Photo-lysine) hydrochloride is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs hydrochloride can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs hydrochloride acts as a UV light-activated photo-crosslinking probe .

HY-D0853

DiAzKs 1 Publications Verification H-L-Photo-lysine	Fluorescent Dye	Others
DiAzKs (H-L-Photo-lysine) is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs acts as a UV light-activated photo-crosslinking probe .

HY-W104848

4-Maleimidobenzoic acid	Biochemical Assay Reagents	Others
4-Maleimidobenzoic acid is a protein crosslinker. 4-Maleimidobenzoic acid can be used to synthesis maleimidobenzoyl spacers .

HY-W123005

Dimethyl pimelimidate dihydrochloride 1 Publications Verification	Biochemical Assay Reagents	Others
Dimethyl pimelimidate dihydrochloride (DMP) is a protein crosslinker that can be used in chromatin immunoprecipitation experiments (ChIP) to enhance signal .

HY-129380A

Fructosyl-lysine dihydrochloride 1 Publications Verification Fructoselysine dihydrochloride	Endogenous Metabolite	Metabolic Disease
Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection .

HY-129380

Fructosyl-lysine 1 Publications Verification Fructoselysine	Endogenous Metabolite	Metabolic Disease
Fructosyl-lysine (Fructoselysine) is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes?detection .

HY-156045A

Cross-linked dextran G 10	Biochemical Assay Reagents	Others
Cross-linked dextran G 10 is a weak cation exchanger and a hydrophilic gel that can be used as a gel filter filler (Sphere protein separation range: >700 Da; Polysaccharide separation range: >700 Da) .

HY-42360

SMCC	ADC Linker	Cancer
SMCC is a protein crosslinker. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses .

HY-48999A

FSK hydrochloride	Others	Cancer
FSK hydrochloride is fluorosulfonyloxybenzoyl-l-lysine, with a long and flexible aryl fluorosulfate-containing side chain that can reach protein sites that are difficult to reach by covalent linkage. FSK hydrochloride is a modified nanomolecule that targets the epidermal growth factor receptor (EGFR), creating a covalent binding that results in irreversible binding. FSK hydrochloride captures unknown enzyme-substrate interactions in living cells through genetically encoded chemical cross-linking, targeting residues beyond Cys, and cross-linking at the binding periphery. FSK hydrochloride enables the construction of bioreactive SuFEx systems for creating covalent bonds in different proteins in vitro and in vivo .

HY-B0245

Busulfan Maximum Cited Publications 16 Publications Verification	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-141522

Cross-linked dextran G 100	Biochemical Assay Reagents	Others
Cross-linked dextran G 100 is a gel filtration medium that can be used for protein purification (Sphere protein separation range: 4K-150K Da; Polysaccharide separation range: 1K-100K Da) .

HY-117080

Sulfo-EGS	Biochemical Assay Reagents	Others
Sulfo-EGS is a homobifunctional, amine-reactive chemical crosslinker. Sulfo-EGS is used to study protein-protein or protein-peptide interactions, which can determine the spatial proximity of amino acid residues in a protein complex, without relying on standards .

HY-P3026

Bowman-birk inhibitor	Ser/Thr Protease Endogenous Metabolite	Cancer
The Bowman-Birk inhibitor, a highly cross-linked protein featuring seven disulfide bridges, possesses spatially distinct domains specifically designed for the inhibition of both trypsin and chymotrypsin, showcasing its significant role as a plant protease inhibitor with anticarcinogenic properties.

HY-156045B

Cross-linked dextran G 150	Biochemical Assay Reagents	Others
Cross-linked dextran G 150 is a hydrophilic gel that can be used as a gel filter filler (Particle size range: 40-120 μm; Sphere protein separation range: 5k-300k Da) .

HY-W414754

2,5-Dioxopyrrolidin-1-yl methyl phthalate	Biochemical Assay Reagents	Others
2,5-Dioxopyrrolidin-1-yl methyl phthalate is a cross-linking agent used for modification of proteins and peptides. 2,5-Dioxopyrrolidin-1-yl methyl phthalate is a reagent for introducing succinimide-activated esters that react with primary amines in proteins and peptides to form stable amide bonds.

HY-W075885R

trans-Platinum(II)diammine dichloride (Standard) trans-platinumdiamminedichloride (Standard)	Biochemical Assay Reagents Reference Standards	Others
trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) (Standard) is an analytical standard for trans-Platinum(II)diammine dichloride (HY-W075885). This product is intended for research and analytical applications. trans-Platinum(II)diammine dichloride is a geometric isomer of Cisplatin (HY-17394). trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage but exhibits low cytotoxicity. trans-Platinum(II)diammine dichloride can be used to study DNA-protein cross-links.

HY-W319374

2-(Methylsulfonyl)ethyl n-succinimidyl carbonate	Biochemical Assay Reagents	Others
2-(Methylsulfonyl)ethyl n-succinimidyl carbonate is a protein crosslinker. 2-(Methylsulfonyl)ethyl n-succinimidyl carbonate has amino protective function .

HY-W800818

(Z)-Non-2-enyl 6-bromohexanoate	Biochemical Assay Reagents	Others
(Z)-Non-2-enyl 6-bromohexanoate is an analogue of Biotin and a protein cross-linking agent.(Z)-Non-2-enyl 6-bromohexanoate binds less tightly to biotin-binding proteins such as Avidin and is easily displaced by Biotin. It is used in the preparation of agarose matrices for affinity-based isolation of streptavidin-fluorophore conjugates.

HY-113033

Pentosidine	Others	Neurological Disease Metabolic Disease
Pentosidine is an advanced glycation end product (AGE) and cross-linked substance with fluorescent properties. Pentosidine is present in various human tissues and can serve as a biomarker for diabetes, aging, uremia, protein accumulation damage, and non-enzymatic modification of long-lived proteins in the Maillard reaction. It aids in gaining a deeper understanding of the overall role of the Maillard reaction in aging and disease .

HY-B0245S

Busulfan-d8	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-113033A

Pentosidine TFA	Biochemical Assay Reagents	Neurological Disease Metabolic Disease
Pentosidine TFA is an advanced glycation end product (AGE) and cross-linked substance with fluorescent properties. Pentosidine TFA is present in various human tissues and can serve as a biomarker for diabetes, aging, uremia, protein accumulation damage, and non-enzymatic modification of long-lived proteins in the Maillard reaction. It aids in gaining a deeper understanding of the overall role of the Maillard reaction in aging and disease .

HY-174358C

HOOC-PEG-COOH (MW 5000)	Biochemical Assay Reagents	Others
HOOC-PEG-COOH (MW 5000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 5000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .

HY-174358

HOOC-PEG-COOH (MW 1000)	Biochemical Assay Reagents	Others
HOOC-PEG-COOH (MW 1000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 1000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .

Cat. No.	Product Name

HY-L060

Cytoskeleton Compound Library

1,844 compounds

The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases.

MCE designs a unique collection of 1,844 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Cat. No.	Product Name	Type

HY-D0853A

DiAzKs hydrochloride 1 Publications Verification H-L-Photo-lysine hydrochloride	Fluorescent Dyes/Probes
DiAzKs (H-L-Photo-lysine) hydrochloride is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs hydrochloride can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs hydrochloride acts as a UV light-activated photo-crosslinking probe .

HY-D0853

DiAzKs 1 Publications Verification H-L-Photo-lysine	Fluorescent Dyes/Probes
DiAzKs (H-L-Photo-lysine) is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs acts as a UV light-activated photo-crosslinking probe .

HY-D2396

Sulfo SMCC R-phycoerythrin Sulfo SMCC R-PE	Dyes
Sulfo SMCC R-phycoerythrin is a conjugate composed of the protein crosslinker SMCC (HY-42360) and R-PE (R-Phycoerythrin) (HY-D0988) that can be used to label proteins to make them carry red fluorescence. Among them, SMCC is able to engage antigen-coupled spleen cells to induce antigen-specific immune responses .

Cat. No.	Product Name	Type

HY-156045C

Cross-linked dextran G 200

Filter Medium

Cross-linked dextran G 200 is a hydrophilic gel based on molecular size exclusion and targeted macromolecular separation. Cross-linked dextran G 200 works through the gel permeation mechanism, and the cross-linked structure forms a three-dimensional network with a specific pore size, achieving separation based on the molecular hydrodynamic volume. Cross-linked dextran G 200 can be used to adjust the osmotic solute distribution coefficient and the ability to maintain osmotic equilibrium, such as in gel filtration chromatography for purification and analysis of biomacromolecules such as proteins and nucleic acids . Cross-linked dextran G 200 can also be used as a gel filtration filler (particle size range: 40-120 μm; globular protein separation range: 5-600 kDa) .

HY-W074785

Carboxyl diazirine alkyne	Biochemical Assay Reagents
Carboxyl diazirine alkyne is a protein cross-linking compound. Carboxyl diazirine alkyne plays a crucial role in the research on the inhibition and labeling of FTO protein by fluorescein derivatives .

HY-138560

Cross-linked dextran G 50 1 Publications Verification	Filter Medium
Cross-linked dextran G 50 is a gel filtration medium. Cross-linked dextran G 50 can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da) .

HY-W075885

trans-Platinum(II)diammine dichloride trans-platinumdiamminedichloride	Cell Assay Reagents
trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links .

HY-148139

Cross-linked dextran G 75	Filter Medium
Cross-linked dextran G 75 is a Gel-filtration media. Cross-linked dextran G 75 also is a dextran-based matrix and used for Gel-filtration chromatography (Particle size range: 40-120 μm; Sphere protein separation range: 3K-80K Da; Polysaccharide separation range: 1K-50K Da) .

HY-141522

Cross-linked dextran G 100	Filter Medium
Cross-linked dextran G 100 is a gel filtration medium that can be used for protein purification (Sphere protein separation range: 4K-150K Da; Polysaccharide separation range: 1K-100K Da) .

HY-138560A

Cross-linked dextran G 50, medium	Filter Medium
Cross-linked dextran G 50, medium is a gel filtration medium. Cross-linked dextran G 50, medium can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da). Cross-linked dextran G 50, medium are microspheres with an average particle size of D50 = 220-250 μm .

HY-138560B

Cross-linked dextran G 50, fine	Filter Medium
Cross-linked dextran G 50, fine is a gel filtration medium. Cross-linked dextran G 50, fine can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da). Cross-linked dextran G 50, fineThe average particle size is D50=110-130 μmof microspheres .

HY-156045

Cross-linked dextran G 15	Filter Medium
Cross-linked dextran G 15 is a hydrophilic gel that can be used as a gel filter filler (Sphere protein separation range: >1500 Da; Polysaccharide separation range: >1500 Da) .

HY-156045A

Cross-linked dextran G 10	Filter Medium
Cross-linked dextran G 10 is a weak cation exchanger and a hydrophilic gel that can be used as a gel filter filler (Sphere protein separation range: >700 Da; Polysaccharide separation range: >700 Da) .

HY-156045B

Cross-linked dextran G 150	Filter Medium
Cross-linked dextran G 150 is a hydrophilic gel that can be used as a gel filter filler (Particle size range: 40-120 μm; Sphere protein separation range: 5k-300k Da) .

HY-W414754

2,5-Dioxopyrrolidin-1-yl methyl phthalate	Biochemical Assay Reagents
2,5-Dioxopyrrolidin-1-yl methyl phthalate is a cross-linking agent used for modification of proteins and peptides. 2,5-Dioxopyrrolidin-1-yl methyl phthalate is a reagent for introducing succinimide-activated esters that react with primary amines in proteins and peptides to form stable amide bonds.

HY-W075885R

trans-Platinum(II)diammine dichloride (Standard)

trans-platinumdiamminedichloride (Standard)

Cell Assay Reagents

trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) (Standard) is an analytical standard for trans-Platinum(II)diammine dichloride (HY-W075885). This product is intended for research and analytical applications. trans-Platinum(II)diammine dichloride is a geometric isomer of Cisplatin (HY-17394). trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage but exhibits low cytotoxicity. trans-Platinum(II)diammine dichloride can be used to study DNA-protein cross-links.

HY-174358C

HOOC-PEG-COOH (MW 5000)	Drug Delivery
HOOC-PEG-COOH (MW 5000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 5000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .

HY-174358

HOOC-PEG-COOH (MW 1000)	Drug Delivery
HOOC-PEG-COOH (MW 1000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 1000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .

HY-174358D

HOOC-PEG-COOH (MW 10000)	Drug Delivery
HOOC-PEG-COOH (MW 10000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 10000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .

HY-174358E

HOOC-PEG-COOH (MW 20000)	Drug Delivery
HOOC-PEG-COOH (MW 20000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 20000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .

HY-174358H

HOOC-PEG-COOH (MW 40000)	Drug Delivery
HOOC-PEG-COOH (MW 40000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 40000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .

HY-174358A

HOOC-PEG-COOH (MW 2000)	Drug Delivery
HOOC-PEG-COOH (MW 2000) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 2000) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .

HY-174358B

HOOC-PEG-COOH (MW 3400)	Drug Delivery
HOOC-PEG-COOH (MW 3400) has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG-COOH (MW 3400) is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .

HY-W127719

Photobiotin acetate

Biochemical Assay Reagents

Photobiotin (acetate)It is a biological probe used to study biochemical processes such as protein interactions and enzymatic reactions. It is a molecule containing a photosensitive group, which can be combined with specific target molecules (such as proteins, nucleic acids, etc.) through photochemical cross-linking technology, so as to realize the labeling and detection of these molecules. During the photosensitive crosslinking process, Photobiotin (acetate)Can participate in the formation of covalent bonds and form stable compounds. In addition, the compound also has high biocompatibility and biological activity, so it is widely used in the field of biomedical research, such as enzymatic research, proteomics, western blotting and other aspects. Photobiotin (acetate) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-Y0623

N-Hydroxysuccinimide

3 Publications Verification

HOSu; 1-Hydroxy-2,5-pyrrolidinedione

Biochemical Assay Reagents

N-Hydroxysuccinimide (HOSu; 1-Hydroxy-2,5-pyrrolidinedione) is a covalent crosslinker commonly used in bioconjugation technology with a primary amine group. N-Hydroxysuccinimide reacts with amino groups (-NH2) to form a stable amide bond, which can modify amino-containing biomolecules. N-Hydroxysuccinimide can be used, for example, for protein labeling with fluorescent dyes and enzymes, surface activation of chromatography supports, microbeads, nanoparticles and microarray slides, and chemical synthesis of peptides. N-Hydroxysuccinimide has a wide range of applications in biomaterial synthesis (such as collagen, chitosan crosslinking), drug delivery systems (such as hydrogel preparation) and tissue engineering .

Cat. No.	Product Name	Target	Research Area

HY-P6172

GCO-(GPO)10-GCOG	Bacterial	Infection
GCO-(GPO)10-GCOG is a GPO repeat-containing peptide with a single collagen triple helix structure similar to collagen. The cross-linked triple helix GCO-(GPO)10-GCOG can form a collagen-related peptide (CRP) mimetic that tightly binds to the Yersinia adhesin YadA. YadA mediates the adhesion of the human enteric pathogen Yersinia enterocolitica to collagen and other extracellular matrix components, potentially interfering with host processes mediated by endogenous collagen-binding proteins in vivo. GCO-(GPO)10-GCOG can be used to study YadA-associated infections .

Cat. No.	Product Name

HY-K0213

Protein A Agarose 4 Publications Verification
MCE Protein A Agarose, a 4% highly cross-linked agarose reagent coupled with recombinant Protein A, effectively purifies mammalian monoclonal and polyclonal antibodies, such as human IgG, IgE, IgM.

HY-K0215

Protein L Agarose
MCE Protein L Agarose, a 4% highly cross-linked agarose reagent coupled with recombinant Protein L, effectively purifies mammalian monoclonal and polyclonal antibodies which have kappa light chain.

HY-K0211

Glutathione Agarose 5+ Cited Publications
MCE Glutathione Agarose, a 4% highly cross-linked agarose reagent, enables high-yield, high-purity purification of GST-tagged proteins.

HY-K0214

Protein G Agarose 5+ Cited Publications
MCE Protein G Agarose, a 4% highly cross-linked agarose reagent coupled with recombinant Protein G, effectively purifies mammalian monoclonal and polyclonal antibodies, such as human IgG3 and rat IgG2a.

HY-K0210

Ni-NTA His-Tag Purification Agarose Maximum Cited Publications 23 Publications Verification
MCE Ni-NTA His-Tag Purification Agarose, a 6% highly cross-linked agarose reagent, enables high-yield, high-purity purification of his-tagged proteins.

HY-K0219

High-Affinity Iodoacetyl Agarose 1 Publications Verification
MCE High-Affinity Iodoacetyl Agarose, a 4% highly cross-linked agarose reagent coupled with a derivative of iodoacetic acid, is ideal for conjugating sulfhydryl-containing peptide or protein for subsequent affinity purification.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-129380A

Fructosyl-lysine dihydrochloride 1 Publications Verification Fructoselysine dihydrochloride	Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection .

HY-129380

Fructosyl-lysine 1 Publications Verification Fructoselysine	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Fructosyl-lysine (Fructoselysine) is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes?detection .

HY-113033

Pentosidine	Natural Products Source classification Disease markers Endogenous metabolite	Others
Pentosidine is an advanced glycation end product (AGE) and cross-linked substance with fluorescent properties. Pentosidine is present in various human tissues and can serve as a biomarker for diabetes, aging, uremia, protein accumulation damage, and non-enzymatic modification of long-lived proteins in the Maillard reaction. It aids in gaining a deeper understanding of the overall role of the Maillard reaction in aging and disease .

HY-129380AR

Fructosyl-lysine dihydrochloride (Standard)	Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
Fructosyl-lysine (dihydrochloride) (Standard) is the analytical standard of Fructosyl-lysine (dihydrochloride). This product is intended for research and analytical applications. Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine-arginine protein cross-link that can be an indicator in diabetes detection .

Cat. No.	Product Name	Chemical Structure

HY-B0245S

Busulfan-d8
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

Cat. No.	Product Name		Classification

HY-W074785

Carboxyl diazirine alkyne		Alkynes
Carboxyl diazirine alkyne is a protein cross-linking compound. Carboxyl diazirine alkyne plays a crucial role in the research on the inhibition and labeling of FTO protein by fluorescein derivatives .

HY-111434

UAA crosslinker 1		Azide
UAA crosslinker 1 hydrochloride is an amber codon used for non-canonical amino acids (ncAAs) incorporation. The ncAAs can be incorporated into proteins in vivo by making use of the promiscuous activity of certain wildtype and engineered aminoacyl-tRNA synthetases . UAA crosslinker 1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-111434A

UAA crosslinker 1 hydrochloride		Azide
UAA crosslinker 1 hydrochloride is an amber codon used for non-canonical amino acids (ncAAs) incorporation. The ncAAs can be incorporated into proteins in vivo by making use of the promiscuous activity of certain wildtype and engineered aminoacyl-tRNA synthetases . UAA crosslinker 1 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W035129

endo-BCN-NHS carbonate		BCN
endo-BCN-NHS carbonate is an elastin-like protein (ELP) modification reagent. endo-BCN-NHS carbonate can react with lysine residues in ELP to make ELP carry BCN groups, and then cross-link ELP through strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. endo-BCN-NHS carbonate promotes hydrogel formation. endo-BCN-NHS carbonate is mainly used in cell encapsulation related research .

HY-W127719

Photobiotin acetate		Azide
Photobiotin (acetate)It is a biological probe used to study biochemical processes such as protein interactions and enzymatic reactions. It is a molecule containing a photosensitive group, which can be combined with specific target molecules (such as proteins, nucleic acids, etc.) through photochemical cross-linking technology, so as to realize the labeling and detection of these molecules. During the photosensitive crosslinking process, Photobiotin (acetate)Can participate in the formation of covalent bonds and form stable compounds. In addition, the compound also has high biocompatibility and biological activity, so it is widely used in the field of biomedical research, such as enzymatic research, proteomics, western blotting and other aspects. Photobiotin (acetate) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-151792

Pomalidomid-C6-PEG3-butyl-N3		PROTAC Synthesis Azide
Pomalidomid-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. Pomalidomid-C6-PEG3-butyl-N3 also is a crosslinker-E3 ligase ligand conjugate, which be used in click reactive protein degrader building block for PROTAC research. Pomalidomid-C6-PEG3-butyl-N3 also can be used in the template for synthesis of targeted protein degrader . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151791

(S,R,S)-AHPC-C6-PEG3-butyl-N3		Azide
(S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. (S,R,S)-AHPC-C6-PEG3-butyl-N3 serves as crosslinker-E3 ligase ligand conjugate, Click reactive protein degrader building block for PROTAC research, Template for synthesis of targeted protein degrader, VH032 conjugate . (S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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Protein cross-linker

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