Search Result

Results for "

Protective groups

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Adenosine Receptor (1) Amino Acid Derivatives (7) Antibody-Drug Conjugates (ADCs) (2) Apoptosis (2) Biochemical Assay Reagents (4) CCR (1) Drug-Linker Conjugates for ADC (4) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (1) Interleukin Related (1) Ligands for E3 Ligase (2) Microtubule/Tubulin (5) Nucleoside Antimetabolite/Analog (1) Reactive Oxygen Species (1) Sodium Channel (1) TNF Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (2) Inflammation/Immunology (1)

By Targets:

ADC Cytotoxin (1)

Adenosine Receptor (1)

Amino Acid Derivatives (7)

Antibody-Drug Conjugates (ADCs) (2)

Apoptosis (2)

Biochemical Assay Reagents (4)

CCR (1)

Drug-Linker Conjugates for ADC (4)

E3 Ligase Ligand-Linker Conjugates (1)

Endogenous Metabolite (1)

Interleukin Related (1)

Ligands for E3 Ligase (2)

Microtubule/Tubulin (5)

Nucleoside Antimetabolite/Analog (1)

Reactive Oxygen Species (1)

Sodium Channel (1)

TNF Receptor (1)

Toll-like Receptor (TLR) (1)

By Research Areas:

Cancer (10)

Cardiovascular Disease (2)

Inflammation/Immunology (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W007056

Fmoc-N-me-Trp(Boc)-OH	Amino Acid Derivatives	Others
Fmoc-N-me-Trp(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptide antibiotics with antibacterial activity against Pseudomonas aeruginosa .

HY-W008024

Fmoc-Dab(Boc)-OH	Amino Acid Derivatives	Others
Fmoc-Dab(Boc)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize somatostatin analogs that inhibit neointima formation induced by balloon injury in rats without altering growth hormone release .

HY-W004864

Fmoc-(S)-2-(4-pentenyl)Ala-OH	Amino Acid Derivatives	Others
Fmoc-(S)-2-(4-pentenyl)Ala-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize biologically active secretin analogs .

HY-W006937

Boc-D-(4-fmoc)-aminophenylalanine Boc-p-amino-D-Phe(Fmoc)-OH; Boc-D-phe(4-NH-fmoc)-OH	Amino Acid Derivatives	Others
Boc-D-(4-fmoc)-aminophenylalanine (Boc-p-amino-D-Phe(Fmoc)-OH) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptides with gonadotropin-releasing hormone antagonist activity .

HY-W006886

Fmoc-(R)-2-(7-octenyl)Ala-OH	Amino Acid Derivatives	Others
Fmoc-(R)-2-(7-octenyl)Ala-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize inhibitor peptides that combinatorially inactivate ErbB1, ErbB2, and ErbB3 .

HY-15740

Mc-MMAD	Microtubule/Tubulin Drug-Linker Conjugates for ADC	Cancer
Mc-MMAD is a protective group (maleimidocaproyl)-conjugated MMAD. MMAD is a potent tubulin inhibitor. Mc-MMAD is a agent-linker conjugate for ADC.

HY-141253

N-Boc-Tris	Biochemical Assay Reagents	Others
N-Boc-Tris is a protective reagent. N-Boc-Tris can utilize the Boc protecting group to protect amino groups in fields such as organic synthesis and pharmaceutical research and development, thereby avoiding unnecessary side reactions.

HY-15741

Mc-MMAE Maleimidocaproyl-monomethylauristatin E	Microtubule/Tubulin Drug-Linker Conjugates for ADC	Cancer
Mc-MMAE is a protective group (maleimidocaproyl)-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Mc-MMAE is a agent-linker conjugate for ADC.

HY-78933

Fmoc-MMAE	Microtubule/Tubulin ADC Cytotoxin	Cancer
Fmoc-MMAE is a protective group-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Fmoc-MMAE can be used in the synthesis of ADC .

HY-157248

Fmoc-3-Me-Glu(OtBu)-OH	Amino Acid Derivatives	Others
Fmoc-3-Me-Glu(OtBu)-OH is an amino acid derivative with a protective group .

HY-148339

Fmoc-VAP-MMAE	Drug-Linker Conjugates for ADC	Others
Fmoc-VAP-MMAE is a agent-linker conjugates for ADC. Fmoc-VAP-MMAE consists of an ADC linker and a tubulin inhibitor MMAE (HY-15162), with a protective Fmoc group .

HY-W008034

Fmoc-L-Trp(Boc)-OH	Amino Acid Derivatives	Cancer
Fmoc-L-Trp(Boc)-OH is an amino acid derivative with a protective group, which has the ability to self-assemble and form nanoparticles. Fmoc-L-Trp(Boc)-OH can be used in the study of anticancer drug delivery .

HY-132274

DMS(O)MT aminolink C6	Biochemical Assay Reagents	Others
DMS(O)MT aminolink C6 for oligonucleotide synthesis. DMS(O)MT is a special protective group similar to traditional MMT, but designed as an improved alternative to it. DMS(O)MT aminolink is fully compatible with standard coupling, deblock, and purification protocols.

HY-78574

N-Benzoylcytidine	Nucleoside Antimetabolite/Analog	Others
N-Benzoylcytidine is a substrate for uracil-cytidine kinase 1 (UCK1) and UCK2. N-Benzoylcytidine can be used to synthesize 2-OH protective groups for solid-phase RNA synthesis，as well as synthetic oligonucleotides for UV induction and targeted gene silencing in zebrafish embryos .

HY-W784557

O-DMT-2,2-di(ethoxycarbonyl)propan-1,3-diol	Biochemical Assay Reagents	Others
O-DMT-2,2-di(ethoxycarbonyl)propan-1,3-diol is a chemical phosphorylation reagent used for the synthesis of 5'-phosphorylated oligonucleotides. It contains the chemical protective group DMT in its structure, which allows for purification through C18 columns or reversed-phase chromatography .

HY-15578G

McMMAF Maleimidocaproyl monomethylauristatin F	Drug-Linker Conjugates for ADC	Cancer
McMMAF GMP is a GMP grade McMMAF (HY-15578). McMMAF is a protective group (maleimidocaproyl)-conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for antibody-drug conjugates (ADC). McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent .

HY-103174

MRS1334	Adenosine Receptor	Cardiovascular Disease
MRS1334 is a potent and selective human adenosine A₃ receptor antagonist with K_is of 2.69 nM, >100 nM, >100 nM for hA₃, rA₁, rA_2A, respectively. MRS1334 blocks the protective effect of Cl-IB-MECA leading to significant bradycardia and elevated ST segment . MRS1334 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W584528

VH032 analogue-2	Ligands for E3 Ligase	Cancer
VH032 analogue-2 is a VH032 (HY-120217) analog that acts as a ligand for VHL, recruiting von Hippel-Lindau (VHL) protein. VH032 analogue-2 will remove the protective group under acidic conditions, and can be directly used for the synthesis of PROTAC molecules. VH032 analogue-2 is a key intermediate for the synthesis of PROTACs based on VHL ligands.

HY-W584527

VH032 analogue-1	Ligands for E3 Ligase	Cancer
VH032 analogue-1 is a VH032 (HY-120217) analog that acts as a ligand for VHL, recruiting von Hippel-Lindau (VHL) protein. VH032 analogue-1 will remove the protective group under acidic conditions and be directly used for PROTAC molecular synthesis. VH032 analogue-1 is a key intermediate in the synthesis of PROTACs based on VHL ligands.

HY-77957

1-O-Methyl-2-deoxy-D-ribose	Biochemical Assay Reagents	Others
1-O-Methyl-2-deoxy-D-ribose is a ribose derivative that can be more conveniently obtained through a one-step reaction by introducing a methoxy protective group at the anomeric carbon position under acidic conditions. This facilitates the acquisition of 2-deoxy-D-ribose. 1-O-Methyl-2-deoxy-D-ribose can be utilized in research on the synthesis of chemical materials .

HY-171682

Anti-CCL2 (Carlumab)-McMMAF	Antibody-Drug Conjugates (ADCs) CCR Microtubule/Tubulin Apoptosis	Cancer
Anti-CCL2 (Carlumab)-McMMAF is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated to the protective group maleimidocaproyl and the tubulin inhibitor MMAF (HY-15579). The ADC toxic molecule and linker part are McMMAF (HY-15578). Anti-CCL2 (Carlumab)-McMMAF induces apoptosis and can be used in cancer research .

HY-W584535

VH032-C3-Boc	E3 Ligase Ligand-Linker Conjugates	Cancer
VH032-C3-Boc is a Boc-modified VH032 (HY-120217) that serves as a ligand for VHL and recruits von Hippel-Lindau (VHL) proteins. VH032-C3-Boc will remove the protective group under acidic conditions and be directly used for PROTAC molecular synthesis. VH032-C3-Boc is a key intermediate for the synthesis of PROTACs based on VHL ligands.

HY-171737

Anti-SLC34A2 (Lifastuzumab)-McMMAF	Antibody-Drug Conjugates (ADCs) Sodium Channel Microtubule/Tubulin Apoptosis	Cancer
Anti-SLC34A2 (Lifastuzumab)-McMMAF is an antibody-drug conjugate (ADC) consisting of the humanized anti-SLC34A2 (sodium-dependent phosphate transporter 2) antibody Lifastuzumab (HY-P99970) conjugated to the protective group maleimidocaproyl and the tubulin inhibitor MMAF (HY-15579). The ADC toxic molecule and linker part McMMAF (HY-15578). Anti-SLC34A2 (Lifastuzumab)-McMMAF induces apoptosis and can be used in cancer research .

HY-124750

NecroX-7	TNF Receptor Interleukin Related Toll-like Receptor (TLR) Reactive Oxygen Species	Cardiovascular Disease Inflammation/Immunology
NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research .

HY-134356

AICA-riboside, 5′-phosphate AICAR-5'-MP	Endogenous Metabolite	Others
AICA-riboside, 5′-phosphate is AICA riboside with a phosphate group. The functions of AICA riboside include: 1) conversion into AMP mimetic to selectively activate AMPK; 2) competition with adenosine for the uptake of nucleoside transporters, reversible blocking of adenosine reuptake, increasing extracellular adenosine concentration, and indirectly activating adenosine A1 receptors. AICA riboside is involved in metabolic regulation (promoting catabolism and inhibiting anabolism) and adenosine-dependent neuroprotection (inhibiting excitatory synaptic transmission). AICA riboside can be used in the study of metabolic diseases (such as diabetes and obesity) and neurological diseases (such as ischemia and epilepsy), and has central nervous system protective activity .

Cat. No.	Product Name	Type

HY-15578G

McMMAF (GMP) Maleimidocaproyl monomethylauristatin F (GMP)	Fluorescent Dye
McMMAF GMP is a GMP grade McMMAF (HY-15578). McMMAF is a protective group (maleimidocaproyl)-conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for antibody-drug conjugates (ADC). McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent .

Cat. No.	Product Name	Type

HY-W008034

Fmoc-L-Trp(Boc)-OH	Drug Delivery
Fmoc-L-Trp(Boc)-OH is an amino acid derivative with a protective group, which has the ability to self-assemble and form nanoparticles. Fmoc-L-Trp(Boc)-OH can be used in the study of anticancer drug delivery .

HY-77957

1-O-Methyl-2-deoxy-D-ribose	Biochemical Assay Reagents
1-O-Methyl-2-deoxy-D-ribose is a ribose derivative that can be more conveniently obtained through a one-step reaction by introducing a methoxy protective group at the anomeric carbon position under acidic conditions. This facilitates the acquisition of 2-deoxy-D-ribose. 1-O-Methyl-2-deoxy-D-ribose can be utilized in research on the synthesis of chemical materials .

HY-15578G

McMMAF (GMP) Maleimidocaproyl monomethylauristatin F (GMP)	Biochemical Assay Reagents
McMMAF GMP is a GMP grade McMMAF (HY-15578). McMMAF is a protective group (maleimidocaproyl)-conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for antibody-drug conjugates (ADC). McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent .

Cat. No.	Product Name	Target	Research Area

HY-W007056

Fmoc-N-me-Trp(Boc)-OH	Amino Acid Derivatives	Others
Fmoc-N-me-Trp(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptide antibiotics with antibacterial activity against Pseudomonas aeruginosa .

HY-W008024

Fmoc-Dab(Boc)-OH	Amino Acid Derivatives	Others
Fmoc-Dab(Boc)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize somatostatin analogs that inhibit neointima formation induced by balloon injury in rats without altering growth hormone release .

HY-W004864

Fmoc-(S)-2-(4-pentenyl)Ala-OH	Amino Acid Derivatives	Others
Fmoc-(S)-2-(4-pentenyl)Ala-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize biologically active secretin analogs .

HY-W006937

Boc-D-(4-fmoc)-aminophenylalanine Boc-p-amino-D-Phe(Fmoc)-OH; Boc-D-phe(4-NH-fmoc)-OH	Amino Acid Derivatives	Others
Boc-D-(4-fmoc)-aminophenylalanine (Boc-p-amino-D-Phe(Fmoc)-OH) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize peptides with gonadotropin-releasing hormone antagonist activity .

HY-W006886

Fmoc-(R)-2-(7-octenyl)Ala-OH	Amino Acid Derivatives	Others
Fmoc-(R)-2-(7-octenyl)Ala-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize inhibitor peptides that combinatorially inactivate ErbB1, ErbB2, and ErbB3 .

HY-157248

Fmoc-3-Me-Glu(OtBu)-OH	Amino Acid Derivatives	Others
Fmoc-3-Me-Glu(OtBu)-OH is an amino acid derivative with a protective group .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-134356

AICA-riboside, 5′-phosphate AICAR-5'-MP	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
AICA-riboside, 5′-phosphate is AICA riboside with a phosphate group. The functions of AICA riboside include: 1) conversion into AMP mimetic to selectively activate AMPK; 2) competition with adenosine for the uptake of nucleoside transporters, reversible blocking of adenosine reuptake, increasing extracellular adenosine concentration, and indirectly activating adenosine A1 receptors. AICA riboside is involved in metabolic regulation (promoting catabolism and inhibiting anabolism) and adenosine-dependent neuroprotection (inhibiting excitatory synaptic transmission). AICA riboside can be used in the study of metabolic diseases (such as diabetes and obesity) and neurological diseases (such as ischemia and epilepsy), and has central nervous system protective activity .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Protective groups

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Natural
Products