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Results for "

Pancreatic Lipase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Lipase (30) Amylases (1) Apoptosis (5) Autophagy (1) Bacterial (2) Biochemical Assay Reagents (2) Carboxylesterase (CES) (1) Drug Metabolite (2) Endogenous Metabolite (2) Fatty Acid Synthase (FASN) (3) Fluorescent Dye (1) Glycosidase (1) Isotope-Labeled Compounds (1) MMP (1)
By Research Areas:	Cancer (4) Infection (2) Inflammation/Immunology (3) Metabolic Disease (34)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Lipase DAGL MAGL ATGL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144809

Pancreatic lipase/Carboxylesterase 1-IN-1	Carboxylesterase (CES)	Metabolic Disease
Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) is a potent dual inhibitor of pancreatic lipase (PL) and human carboxylesterase 1A (hCES1A) with IC₅₀ values of 2.13 µM and 0.055 µM against PL and hCES1A .

HY-Y1422A

Lipase, Human Pancreas Pancreatic Triacylglycerol Lipase, PL, PTL, Pancreatic Lipase	Lipase	Others
Lipase, Human Pancreas (Pancreatic Triacylglycerol Lipase, PL, PTL, Pancreatic Lipase) is a biological material or organic compound that can be used in life science research .

HY-157313

Pancreatic lipase-IN-1	Lipase	Metabolic Disease
Pancreatic lipase-IN-1 (compound 8) ia a **pancreatic lipase inhibitor with the K_i** of 1.288 μM .

HY-157534

Pancreatic lipase-IN-2	Lipase	Metabolic Disease
Pancreatic lipase-IN-2 (compound 7r) is a potent inhibitor of pancreatic lipase (PL), with the IC₅₀ value of 2.67 μM, that has anti-obesity effect .

HY-N12294

Ciwujianoside D2	Lipase	Metabolic Disease
Ciwujianoside D2, a saponin compound, can enhance **pancreatic lipase** activity in vitro .

HY-N12296

Ciwujianoside C4	Lipase	Metabolic Disease
Ciwujianoside C4, a saponin compound, can enhance pancreatic lipase activity in vitro .

HY-N12297

Ciwujianoside C2	Lipase	Others
Ciwujianoside C2 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C2 enhances pancreatic lipase activity in vitro .

HY-N12292

Acanthopanaxoside A	Lipase	Metabolic Disease
Acanthopanaxoside A, a triterpenoid saponin, has pancreatic *lipase* inhibitory action .

HY-N8362

1-Isomangostin	Lipase	Metabolic Disease
1-Isomangostin is an inhibitor of **pancreatic lipase*. 1-Isomangostin inhibits porcine pancreatic* lipase with an IC₅₀ of 34.5 μM. 1-Isomangostin has anti-obesity activity .

HY-N12298

Ciwujianoside C1	Lipase	Others
Ciwujianoside C1 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C1 inhibits pancreatic lipase activity in vitro .

HY-14471

Cetilistat ATL-962	Lipase	Metabolic Disease
Cetilistat (ATL-962), an inhibitor of **pancreatic lipase*, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic* lipase activity with IC₅₀s of 54.8 nM, and 5.95 nM, respectively .

HY-136124

Cetilistat impurity 1	Drug Metabolite	Others
Cetilistat impurity 1 is an impurity of Cetilistat. Cetilistat, an inhibitor of **pancreatic lipase*, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic* lipase activity with IC₅₀s of 54.8 nM, and 5.95 nM, respectively .

HY-Y0606

(+)-Camphor-10-sulfonic acid (+)-10-Camphorsulfonic acid	Lipase	Metabolic Disease
(+)-Camphor-10-sulfonic acid ((+)-10-Camphorsulfonic acid) is an effective pancreatic lipase (PL) inhibitor. (+)-Camphor-10-sulfonic acid is promising for research of obesity .

HY-14471R

Cetilistat (Standard)	Lipase	Metabolic Disease
Cetilistat (Standard) is the analytical standard of Cetilistat. This product is intended for research and analytical applications. Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM, and 5.95 nM, respectively .

HY-W099648

4-Methylumbelliferyl octanoate	Lipase	Others
4-Methylumbelliferyl octanoate is a octoate. 4-Methylumbelliferyl octanoate can be used as a s ubstrate of hog pancreatic lipase .

HY-135297

Mono-and diglycerides	Biochemical Assay Reagents	Others
Mono-and diglycerides is formed by triglycerides being broken down by pancreatic lipase in the gastrointestinal lumen. Mono-and diglycerides is a food additive used as a nonionic emulsifier and mainly present in food fats .

HY-N11999

5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl	Glycosidase	Others
5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl (compound 8) can be isolated from Dendrobium infundibulum (D. infundibulum). 5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl has no inhibitory activity against α-glucosidase and pancreatic lipase .

HY-N3797A

Echitamine chloride Ditaine chloride	Apoptosis	Cancer
Echitamine (Ditaine) chloride is the major monoterpene indole alkaloid present in Alstonia scholaris with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits **pancreatic lipase with an IC₅₀** of 10.92 μM .

HY-B0218

Orlistat Maximum Cited Publications 18 Publications Verification Tetrahydrolipstatin; Ro-18-0647	Fatty Acid Synthase (FASN) Apoptosis	Metabolic Disease Cancer
Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric *lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN*), is used orally for long-term research of obesity . Anti-atherosclerotic effect .

HY-N13198

4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside	Endogenous Metabolite	Metabolic Disease
4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside is a **pancreatic lipase inhibitor, with an IC₅₀** value of 2.91 μM. 4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside can effectively reduce lipid absorption and regulate obesity-related metabolic disorders, making it useful for research on obesity .

HY-N14641

Panclicin A	Lipase	Metabolic Disease
Panclicin A is a potent **pancreatic lipase** inhibitor .

HY-N14643

Panclicin C	Lipase	Metabolic Disease
Panclicin C is a potent **pancreatic lipase** inhibitor .

HY-N14647

Panclicin E	Lipase	Metabolic Disease
Panclicin E is a potent **pancreatic lipase** inhibitor .

HY-N14646

Panclicin D	Lipase	Metabolic Disease
Panclicin D is a potent **pancreatic lipase** inhibitor .

HY-N14642

Panclicin B	Lipase	Metabolic Disease
Panclicin B is a potent **pancreatic lipase** inhibitor .

HY-N7668

Neotheaflavin	Lipase	Metabolic Disease
Neotheaflavin, from black tea, inhibits pancreatic lipase .

HY-149506

1,3-Didecanoylglycerol 1,3-Dicaprin	Lipase	Others
1,3-Didecanoylglycerol (1,3-Dicaprin) is a triglyceride analog that can be used as a substrate in pancreatic *lipase* hydrolysis reactions .

HY-N7072

Grape seed extract 1 Publications Verification	Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells .

HY-117095

4-Methylumbelliferyl oleate	Fluorescent Dye	Metabolic Disease
4-Methylumbelliferyl oleate is a fluorogenic substrate for acid and alkaline lipases. 4-Methylumbelliferyl oleate is cleaved by lipases, liberating 4-Methylumbelliferyl (Ex/Em=320/450 nm) .

HY-155836

hPL-IN-1	Lipase	Metabolic Disease
hPL-IN-1 (compound 2t) is a reversible inhibitor of pancreatic lipase (PL) (IC₅₀=1.86 μM) for anti-obesity research .

HY-W709047

Orlistat impurity-M3	Drug Metabolite	Metabolic Disease
Orlistat impurity-M3 is a Orlistat (HY-B0218) degradation product. Orlistat is a well-known irreversible inhibitor of pancreatic and gastric lipases .

HY-N0555

Escin IB	Lipase	Metabolic Disease
Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on **pancreatic lipase** activity .

HY-Y1422B

Lipase (MS grade)	Endogenous Metabolite	Metabolic Disease
Lipase (MS grade) catalyzes the hydrolysis of triacylglycerols to release long-chain fatty acids in a site-specific manner. Lipase (MS grade) is involved in a variety of biological processes, from fat metabolism to cell signaling and inflammation, and can be used to treat diseases such as pancreatic insufficiency, celiac disease and cystic fibrosis .

HY-155837

hPL-IN-2	Lipase	Metabolic Disease
hPL-IN-2 (compound 2u) is a potent, reversible, and non-competitive inhibitor of pancreatic lipase (IC₅₀: 1.63 μM) and can be used in anti-obesity research .

HY-119741

Salacinol	Lipase	Metabolic Disease
Salacinol can be isolated from the roots of the plant Salacia reticulata. Salacinol inhibits fat metabolizing enzymes, such as **pancreatic lipase (PL, IC₅₀*=12.6 mg/L), lipoprotein lipase* (LPL, IC₅₀=13.6 mg/L), and glycerophosphate dehydrogenase (GPDH), enhances the lipolysis, and exhibits antiobesity efficacy in rats .

HY-N2330

Lipstatin	Lipase	Metabolic Disease
Lipstatin is a pancreatic lipase inhibitor (IC₅₀=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM) .

HY-N4167

3-O-Methylgalangin Galangin 3-methyl ether; 3-Methylgalangin	Bacterial	Infection
3-O-Methylgalangin (Galangin 3-methyl ether) is a natural flavonoid compound from the rhizome of Alpinia officinarum (AO) with antibacterial activities, which also inhibits pancreatic lipase .

HY-N0618

Sanggenon D	Lipase	Inflammation/Immunology
Sanggenon D is a Diels-Alder-type adduct from Chinese crude agent root bark of mulberry ( Morus alba L.). Sanggenon D possesses antioxidant and inhibits Pancreatic lipase (PL) with the an IC50 of 0.77 μM.

HY-131999

3,4,5-Trihydroxycinnamic acid decyl ester	Lipase	Metabolic Disease
3,4,5-Trihydroxycinnamic acid decyl ester is an excellent inhibitor of lipid absorption and accumulation, with anti-obesity properties. 3,4,5-Trihydroxycinnamic acid decyl ester is a **pancreatic lipase inhibitor, with an EC₅₀** of approximately 0.9 μM .

HY-157733

1,2-Dioleoyl-3-behenoylglycerol	Lipase	Metabolic Disease
1,2-Dioleoyl-3-behenoylglycerol (BOO) inhibits pancreatic lipase activity. 1,2-Dioleoyl-3-behenoylglycerol prevents the deposition of visceral fat and hepatic triacylglycerol (TAG) .

HY-W013168

4-Nitrophenyl palmitate 4-Nitrophenyl hexadecanoate; p-Nitrophenyl Palmitate; pNpp	Bacterial	Infection
4-Nitrophenyl palmitate (4-Nitrophenyl hexadecanoate; p-Nitrophenyl Palmitate) is a colorimetric lipase and esterase substrate. Upon enzymatic hydrolysis of 4-Nitrophenyl palmitate, 4-nitrophenol is released, which can be quantified by colorimetric detection at 410 nm as a measure of enzyme activity. 4-Nitrophenyl palmitate has been used to characterize the activity of various bacterial and mammalian enzymes, including Burkholderia and porcine pancreatic lipase.

HY-N0555R

Escin IB (Standard)	Lipase	Metabolic Disease
Escin IB (Standard) is the analytical standard of Escin IB. This product is intended for research and analytical applications. Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity .

HY-B0218S

Orlistat-d3 Tetrahydrolipstatin-d₃; Ro-18-0647-d₃	Isotope-Labeled Compounds Fatty Acid Synthase (FASN) Apoptosis	Metabolic Disease
Orlistat-d3 is a deuterated labeled Orlistat . Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric *lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN*), is used orally for long-term research of obesity .?Anti-atherosclerotic?effect .

HY-B0218R

Orlistat (Standard) Maximum Cited Publications 18 Publications Verification Tetrahydrolipstatin (Standard); Ro-18-0647 (Standard)	Fatty Acid Synthase (FASN) Apoptosis	Metabolic Disease Cancer
Orlistat (Standard) is the analytical standard of Orlistat. This product is intended for research and analytical applications. Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric *lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN*), is used orally for long-term research of obesity . Anti-atherosclerotic effect .

HY-B0998

Dehydrocholate sodium Sodium dehydrocholate	Amylases Lipase Autophagy	Metabolic Disease
Dehydrocholate sodium is an orally active hydrocholeretic agent. Dehydrocholate sodium modulates Autophagy, reduces serum amylase and *lipase* levels. Dehydrocholate sodium has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholate sodium can be used in the study of acute biliary pancreatitis and obstructive jaundice .

HY-N4298

Epitheaflagallin 3-O-gallate	MMP	Metabolic Disease Inflammation/Immunology
Epitheaflagallin 3-O-gallate is a minor polyphenol in black tea. Epitheaflagallin 3-O-gallate exhibits versatile physiological functions in vivo and in vitro, including antioxidative activity, pancreatic lipase inhibition, Streptococcus sorbinusglycosyltransferase inhibition, and an inhibiting effect on the activity of matrix metalloprotease-1 and -3 and their synthesis by human gingival fibroblasts .

HY-W127391

1,2-Dilaurin (Rac)-1,2-Didodecanoylglycerol	Biochemical Assay Reagents	Others
1,2-Dilaurin is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions. It has been used as an internal standard for the quantification of diglycerides in rat desheathed sciatic nerves. [1] Monomolecular films containing 1,2-dilauroyl-rac-glycerol have been used as substrates to measure surface pressure and the effect of pancreatic procolipase and colipase on porcine pancreatic lipase activity. [2] References: [1]. Zhu, X. and Eichberg, J. 1,2-Diacylglycerol content and its arachidonyl-containing molecular species are reduced in the sciatic nerve of streptozotocin-induced diabetic rats. J. Neurochemistry. 55(3), 1087-1090 (1990).[2]. Wieloch, T., Borgstr m, B., Piéroni, G. et al. Porcine trypsinogen and its trypsin-activated form: lipid binding and lipase activation on monomolecular membranes. FEBS Express. 128(2), 217-220 (1981).

Cat. No.	Product Name	Type

HY-W013168

4-Nitrophenyl palmitate

4-Nitrophenyl hexadecanoate; p-Nitrophenyl Palmitate; pNpp

Dyes

4-Nitrophenyl palmitate (4-Nitrophenyl hexadecanoate; p-Nitrophenyl Palmitate) is a colorimetric lipase and esterase substrate. Upon enzymatic hydrolysis of 4-Nitrophenyl palmitate, 4-nitrophenol is released, which can be quantified by colorimetric detection at 410 nm as a measure of enzyme activity. 4-Nitrophenyl palmitate has been used to characterize the activity of various bacterial and mammalian enzymes, including Burkholderia and porcine pancreatic lipase.

Cat. No.	Product Name	Type

HY-W127391

1,2-Dilaurin

(Rac)-1,2-Didodecanoylglycerol

Drug Delivery

1,2-Dilaurin is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions. It has been used as an internal standard for the quantification of diglycerides in rat desheathed sciatic nerves. [1] Monomolecular films containing 1,2-dilauroyl-rac-glycerol have been used as substrates to measure surface pressure and the effect of pancreatic procolipase and colipase on porcine pancreatic lipase activity. [2] References: [1]. Zhu, X. and Eichberg, J. 1,2-Diacylglycerol content and its arachidonyl-containing molecular species are reduced in the sciatic nerve of streptozotocin-induced diabetic rats. J. Neurochemistry. 55(3), 1087-1090 (1990).[2]. Wieloch, T., Borgstr m, B., Piéroni, G. et al. Porcine trypsinogen and its trypsin-activated form: lipid binding and lipase activation on monomolecular membranes. FEBS Express. 128(2), 217-220 (1981).

Cat. No.	Product Name	Category	Target	Chemical Structure