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PZ-671

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-174876
    PZ671

    		PROTACs Bcl-2 Family Apoptosis Cancer
    PZ671 is a potent Bcl-xL PROTAC degrader with an IC50 of 1.3 nM (MOLT-4 cells) and a DC50 of 0.9 nM (Bcl-xL). PZ671 induces apoptosis in MOLT-4 cells. PZ671 effectively inhibits tumor growth and rapidly reverses transient platelet counts reduction in MOLT-4 xenograft mice. PZ671 can be used for the research of cancer, such as small cell lung cancer (SCLC) . (Structure Note: Pink: Bcl-xL ligand (HY-174878); Blue: E3 ligase Ligand (HY-138793); Black: linker; E3-linker (HY-174879))
    PZ671
  • HY-174878
    BCL-xL ligand 2

    		Ligands for Target Protein for PROTAC Bcl-2 Family Cancer
    BCL-xL ligand 2 is a ligand for BCL-xL. BCL-xL ligand 2 can be conjugated with E3 ligase Ligand (HY-138793) and linker to synthesize Bcl-xL PROTAC degrader PZ671 (HY-174876) .
    BCL-xL ligand 2
  • HY-174879
    Dioxopiperidin-phthalimidine-PEG3-NBoc

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Dioxopiperidin-phthalimidine-PEG3-NBoc is a conjugate of the E3 ligase ligand (HY-138793) and the linker (E3 Ligase Ligand-Linker Conjugate). Dioxopiperidin-phthalimidine-PEG3-NBoc can be used for synthesizing Bcl-xL PROTAC degrader PZ671 (HY-174876) .
    Dioxopiperidin-phthalimidine-PEG3-NBoc

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