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PU.1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Apoptosis (7) ERK (2) HIV (1) Integrin (2) PI3K (2) PKC (2) PPAR (2) Reference Standards (1) Sirtuin (2) Small Interfering RNA (siRNA) (3) STAT (2) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W176171

PU.1-IN-1 1 Publications Verification	Others	Inflammation/Immunology
PU.1-IN-1 (compound A11) is a potent *PU.1* inhibitor with an IC₅₀ of 2 nM. PU.1-IN-1 has anti-inflammatory properties ^[1].

HY-124629

DB2313 4 Publications Verification	Apoptosis	Cancer
DB2313 is a potent inhibitor of transcription factor *PU.1. DB2313 inhibits PU.1*-dependent reporter gene transactivation with an IC₅₀ of 5 μM. DB2313 disrupts the interaction of *PU.1* with target gene promoters. DB2313 induces apoptosis in acute myeloid leukemia (AML) cells and has anticancer effects ^[1].

HY-124676A

DB2115 tertahydrochloride 1 Publications Verification	Apoptosis	Cancer
DB2115 tetrahydrochloride is a highly selective *PU.1* inhibitor that suppresses the binding of *PU.1* to DNA (IC₅₀: 2.3 nM). DB2115 tetrahydrochloride can inhibit tumor cell proliferation and induce apoptosis. DB2115 tetrahydrochloride can be used in the research of tumors such as leukemia ^[1].

HY-135797A

DB1976 dihydrochloride 5 Publications Verification	Apoptosis	Cancer
DB1976 dihydrochloride is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor *PU.1* inhibitor. DB1976 dihydrochloride potently inhibits *PU.1* binding (IC₅₀ of 10 nM) and strongly inhibits the *PU.1/DNA* complex (with high DB1976-λB affinity, K_D of 12 nM) in vitro. DB1976 dihydrochloride has apoptosis-inducing effect ^[1] .

HY-N2110

Phellopterin	Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV	Inflammation/Immunology
Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating *SIRT1, downregulating ICAM-1* (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the *PU.1/CLEC5A/PI3K-AKT* loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus ^[1] .

HY-124629A

DB2313 tetrahydrochloride	Apoptosis	Cancer
DB2313 tetrahydrochloride is a potent transcription factor *PU.1* inhibitor with an apoptosis of 14 nM. DB2313 tetrahydrochloride disrupts the interaction of *PU.1* with target gene promoters. DB2313 tetrahydrochloride induces apoptosis of acute myeloid leukemia (AML) cells, and has anticancer effects ^[1].

HY-135797

DB1976	Apoptosis	Cancer
DB1976 is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor *PU.1* inhibitor. DB1976 potently inhibits *PU.1* binding (IC₅₀ of 10 nM) and strongly inhibits the *PU.1/DNA* complex (with high DB1976-λB affinity, K_D of 12 nM) in vitro. DB1976 has apoptosis-inducing effect ^[1] .

HY-RS23645

Spi1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Spi1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Spi1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Spi1 Rat Pre-designed siRNA Set A Spi1 Rat Pre-designed siRNA Set A

HY-RS13671

SPI1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SPI1 Human Pre-designed siRNA Set A contains three designed siRNAs for SPI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SPI1 Human Pre-designed siRNA Set A SPI1 Human Pre-designed siRNA Set A

HY-N2110R

Phellopterin (Standard)	Reference Standards Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR)	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Phellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating *SIRT1, downregulating ICAM-1* (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the *PU.1/CLEC5A/PI3K-AKT* loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.

HY-RS17194

Spi1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Spi1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Spi1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Spi1 Mouse Pre-designed siRNA Set A Spi1 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2110

Phellopterin	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants Inflammation/Immunology Disease Research Fields	Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV
Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating *SIRT1, downregulating ICAM-1* (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the *PU.1/CLEC5A/PI3K-AKT* loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus ^[1] .

HY-N2110R

Phellopterin (Standard)	Structural Classification Source classification Coumarins Phenylpropanoids Umbelliferae Helogyne apaloidea Nutt. Plants	Reference Standards Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR)
Phellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating *SIRT1, downregulating ICAM-1* (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the *PU.1/CLEC5A/PI3K-AKT* loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81371

	PU.1/SPI1 Antibody (YA1116) SPI1; Transcription factor PU.1; 31 kDa-transforming protein	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Hamster
	PU.1/SPI1 Antibody (YA1116) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PU.1/SPI1.

HY-P80287

	PU.1/SPI1 Antibody (YA118) Dis1; PU.1; Dis-1; Sfpi1; Spi-1; Sfpi-1; Tcfpu1; TfPU.1	WB, IHC-P	Human
	PU.1/SPI1 Antibody (YA118) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PU.1/SPI1.

HY-P80288

	PU.1/SPI1 Antibody (YA117) PU.1,SPI1	WB, IHC-P, FC	Human
	PU.1/SPI1 Antibody (YA117) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PU.1/SPI1.

HY-P85920

	MUM1 Antibody (YA5612) Interferon regulatory factor 4; IRF 4; IRF-4; Irf4; IRF4_HUMAN; LSIRF; Lymphocyte specific interferon regulatory factor; Lymphocyte specific IRF; Lymphocyte-specific interferon regulatory factor; Multiple myeloma oncogene 1; MUM 1; MUM1; NF EM5; NF-EM5; NFEM5; PU.1 interaction partner; Sfpi1/PU.1 interaction partner; Transcriptional activator PIP	IHC-P, WB, ICC/IF, ELISA	Human
	MUM1 Antibody (YA5612) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MUM1.

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Spi1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Spi1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Spi1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

SPI1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SPI1 Human Pre-designed siRNA Set A contains three designed siRNAs for SPI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Spi1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Spi1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Spi1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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