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Isoforms Recommended:	PRMT3

Results for "

PRMT3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Derivative (1) E3 Ligase Ligand-Linker Conjugates (1) Histone Methyltransferase (17) PROTACs (1) Small Interfering RNA (siRNA) (3) WDR5 (1)
By Research Areas:	Cancer (18) Metabolic Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19714

XY1 1 Publications Verification	Drug Derivative	Cancer
XY1 is an analog of SGC707 (HY-19715), a potent and selective *PRMT3* inhibitor with an IC₅₀ of 31 nM. XY1 is completely inactive against PRMT3. XY1 and SGC707 represent an excellent pair of tools for further elucidating the biological functions and disease relevance of PRMT3 .

HY-110158

UNC2327	Histone Methyltransferase	Cancer
UNC2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).

HY-19715

SGC707 5+ Cited Publications	Histone Methyltransferase	Metabolic Disease
SGC707, a chemical probe, is a potent, selective, and non-competitive *PRMT3* (protein arginine methyltransferase 3) inhibitor (IC₅₀=31 nM, K_d=53 nM).

HY-RS11173

Prmt3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Prmt3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Prmt3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Prmt3 Rat Pre-designed siRNA Set A Prmt3 Rat Pre-designed siRNA Set A

HY-RS11171

PRMT3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRMT3 Human Pre-designed siRNA Set A contains three designed siRNAs for PRMT3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRMT3 Human Pre-designed siRNA Set A PRMT3 Human Pre-designed siRNA Set A

HY-RS11172

Prmt3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Prmt3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prmt3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Prmt3 Mouse Pre-designed siRNA Set A Prmt3 Mouse Pre-designed siRNA Set A

HY-171132

PRMT3-IN-5	Histone Methyltransferase
PRMT3-IN-5 (Compound 14) is an allosteric *PRMT3* inhibitor (IC₅₀: 291 nM). PRMT3-IN-5 can be used for investigating PRMT3's biological functions and disease associations .

HY-159732

PRMT3-IN-4	Histone Methyltransferase	Cancer
PRMT3-IN-4 (intermediate 15) is a protein arginine methyltransferase 3 (PRMT3) inhibitor. PRMT3-IN-4 is an active control for HY-19715. PRMT3-IN-4 can be used to synthesize PROTACs targeting PRMT3. PRMT3-IN-4 can be used in leukemia-related research .

HY-159728

*PROTAC PRMT3* degrader 1**	Histone Methyltransferase PROTACs	Cancer
PROTAC PRMT3 degrader 1 (compound 11) is a PROTAC degrader targeting *PRMT3. PROTAC PRMT3* degrader 1 can inhibit the growth of acute leukemia cells .

HY-159733

E3 Ligase Ligand-linker Conjugate 120	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 120 is a conjugate of the E3 ubiquitin ligase ligand and linker of PROTAC PRMT3 degrader 1 (HY-159728) .

HY-162003

DCPT1061	Histone Methyltransferase	Cancer
DCPT1061 potently inhibits PRMT1, PRMT6 and PRMT8 in vitro with less inhibitory effect on PRMT3, PRMT4, and PRMT5 or other epigenetic enzymes. DCPT1061 has antitumor effect .

HY-162003A

DCPT1061 hydrochloride	Histone Methyltransferase	Cancer
DCPT1061 hydrochloride has a strong inhibitory effect on *PRMT1, PRMT6, and PRMT8* in vitro, The epigenetic enzymes such as *PRMT3, PRMT4* and *PRMT5* had little inhibitory effect. DCPT1061 hydrochloride has antitumor effects .

HY-155154

PRMT4-IN-2	Histone Methyltransferase	Cancer
PRMT4-IN-2 (compound 55) is a pan-inhibitor of protein arginine methyltransferase (PRMT) with IC₅₀s of 92 nM (PRMT4), 436 nM (PRMT6), 460 nM (PRMT1), 823 nM ( PRMT8), 1.386 μM (PRMT3) .

HY-19615A

MS023 trihydrochloride	Histone Methyltransferase	Cancer
MS023 trihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for *PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8*, respectively .

HY-19615B

MS023 dihydrochloride Maximum Cited Publications 19 Publications Verification	Histone Methyltransferase	Cancer
MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for *PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8*, respectively .

HY-19615

MS023 Maximum Cited Publications 19 Publications Verification	Histone Methyltransferase	Cancer
MS023, a chemical probe, is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for *PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8*, respectively .

HY-10929

UNC0224 2 Publications Verification	Histone Methyltransferase	Cancer
UNC0224 is a potent and selective histone methyltransferase G9a inhibitor with a K_i of 2.6 nM, an IC₅₀ of 15 nM and a K_d of 23 nM. UNC0224 also potently inhibits b>GLP with assay-dependent IC₅₀ values of 20-58 nM. UNC0224 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E .

HY-128717C

GSK3368715 hydrochloride EPZ019997 hydrochloride	Histone Methyltransferase	Cancer
GSK3368715 (EPZ019997) hydrochloride is an orally active, reversible, SAM-noncompetitive type I protein arginine methyltransferase (PRMT) inhibitor with IC₅₀ values of 3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), and 1.7 nM (PRMT8). GSK3368715 hydrochloride induces a shift in arginine methylation states, alters exon usage, and exhibits potent anticancer activity .

HY-13807

UNC0646 1 Publications Verification	Histone Methyltransferase	Cancer
UNC0646 is a potent and selective histone methyltransferase G9a inhibitor with an IC₅₀ of 6 nM. UNC0646 is also a potent GLP inhibitor (IC₅₀ <15 nM) and highly selective for G9a/GLP over SETD7, SUV39H2, SETD8 and PRMT3. UNC0646 reduces *H3K9me2* levels in MDA-MB-231 cells with an IC₅₀ of 26 nM .

HY-128717B

GSK3368715 trihydrochloride EPZ019997 trihydrochloride	Histone Methyltransferase	Cancer
GSK3368715 trihydrochloride (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 trihydrochloride (EPZ019997) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity .

HY-128717A

GSK3368715 dihydrochloride 15+ Cited Publications EPZ019997 dihydrochloride	Histone Methyltransferase	Cancer
GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity .

HY-128717

GSK3368715 15+ Cited Publications EPZ019997	Histone Methyltransferase	Cancer
GSK3368715 (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 (EPZ019997) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity .

HY-148817

WDR5-0102	WDR5	Cancer
WDR5-0102 is an inhibitor targeting WDR5-MLL1 interface (K_dis=7 μM, K_d=4 μM). WDR5-0102 suppresses MLL1 HMT activity, but not human H3K4 methyltransferase SETD7 and six other HMTs: G9a, EHMT1, SUV39H2, SETD8, PRMT3, and PRMT5 .

Cat. No.	Compare	Product Name	Species	Source

HY-P76551

	PRMT3 Protein, Human (His) Protein arginine N-methyltransferase 3; PRMT3; HRMT1L3	Human	E. coli
	PRMT3 protein is a multifunctional protein arginine N-methyltransferase. As a type I methyltransferase, it catalyzes monomethylation and asymmetric dimethylation of arginine residues in target proteins. In addition to its methyltransferase role, PRMT3 may also regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity. PRMT3 Protein, Human (His) is the recombinant human-derived PRMT3 protein, expressed by E. coli , with N-10*His labeled tag.

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HY-P81986

	PRMT3 Antibody (YA1731) HRMT1L3	WB, IHC-P, IP	Human, Mouse, Rat
	PRMT3 Antibody (YA1731) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PRMT3.

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Prmt3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Prmt3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Prmt3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRMT3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PRMT3 Human Pre-designed siRNA Set A contains three designed siRNAs for PRMT3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Prmt3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Prmt3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prmt3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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