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PG analog

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (3) Drug Intermediate (1) Endogenous Metabolite (1) Eukaryotic Initiation Factor (eIF) (2) Melanocortin Receptor (2) OGT (1) Prostaglandin Receptor (7) Reference Standards (2)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Endocrinology (1) Inflammation/Immunology (4) Neurological Disease (1)
Oligonucleotides:	Cap Analogs (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Oligonucleotides

Targets Recommended: Nucleoside Antimetabolite/Analog

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1208

PG-931	Melanocortin Receptor	Inflammation/Immunology
PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R (IC₅₀=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-148113

PG 34	OGT	Others
PG 34 is a weak O-GlcNAc transferase (OGT) inhibitor (IC₅₀=68 μM), and a close structural analog of OSMI-1 (HY-119738) .

HY-113756A

Latanoprost acid 1 Publications Verification	Prostaglandin Receptor	Inflammation/Immunology
Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor . Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes .

HY-118414

20-Ethyl prostaglandin E2	Prostaglandin Receptor	Neurological Disease Cancer
20-Ethyl prostaglandin E2 (compound 62) is a PG analog that stimulates Nurr1-dependent transcriptional activity .

HY-169495

ent-Corey PG-lactone diol	Drug Intermediate	Others
ent-Corey PG-lactone diol is a versatile, chiral intermediate used in the preparation of PGs and PG analogs.

HY-P1208A

PG-931 TFA	Melanocortin Receptor	Inflammation/Immunology
PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R(IC₅₀=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-168802

9-Keto tafluprost	Prostaglandin Receptor	Cardiovascular Disease
9-Keto tafluprost is a derivative of Tafluprost (HY-B0600). Tafluprost is an anti-glaucoma prostaglandin (PG) analog .

HY-167938

(E/Z)-PG-11047 (E/Z)-CGC-11047	Endogenous Metabolite	Cancer
(E/Z)-PG-11047 ((E/Z)-CGC-11047) is a polyamine analog with potential application in lung cancer inhibition. (E/Z)-PG-11047 effectively inhibited the growth of non-small cell and small cell lung cancer cells. (E/Z)-PG-11047 exhibits significant biochemical effects in non-small cell lung cancer cells, resulting in significant downregulation of polyamine synthetase activity. (E/Z)-PG-11047 induces polyamine metabolism, resulting in a significant reduction in polyamine levels .

HY-158819

m7(3'OMeG)(5')ppp(5')m6(2'OMeA)pG trisodium	DNA/RNA Synthesis	Others
m7(3'OMeG)(5')ppp(5')m6(2'OMeA)pG trisodium is a cap analog that can be used for in vitro transcription of mRNA.

HY-113756AR

Latanoprost acid (Standard)	Reference Standards Prostaglandin Receptor	Inflammation/Immunology
Latanoprost acid (Standard) is the analytical standard of Latanoprost acid. This product is intended for research and analytical applications. Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor . Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes .

HY-113778

15-keto-17-phenyl trinor Prostaglandin F2α 15-keto-17-phenyl trinor PGF2α	Prostaglandin Receptor	Endocrinology
15-keto-17-phenyl trinor Prostaglandin F2α (15-keto-17-phenyl trinor PGF2α) is an F-series prostaglandin (PG) analog. The potential metabolite of 15-keto-17-phenyl trinor Prostaglandin F2α in animals is 15-keto PG. 15-keto PG can slightly reduce the intraocular pressure (1 mm Hg) in normal cynomolgus monkeys when administered at a dose of 1 μg/eye. 15-keto-17-phenyl trinor Prostaglandin F2α is a miotic agent in cats, reducing the pupil diameter by 8 mm at a dose of 5 μg/eye.

HY-B0600

Tafluprost AFP-168; MK2452	Prostaglandin Receptor	Cardiovascular Disease Others
Tafluprost (AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Tafluprost can inhibit the apoptosis of retinal ganglion cells (RGCs) and rat RGCs cells. Tafluprost promotes axon regeneration by regulating Zn ²⁺-mTORpathway, inhibits intracellular lipid accumulation in human preorbital adipocytes. Tafluprost can be used in the study of optic nerve injury in glaucoma .

HY-145974

m7GpppAmpG m7G(5')ppp(5')(2'OMeA)PG	DNA/RNA Synthesis Eukaryotic Initiation Factor (eIF)	Others
m7GpppAmpG (m7G(5')ppp(5')(2'OMeA)pG) is a trinucleotide 5′ end cap analog. m7GpppAmpG binds to eIF4E with a K_D value of 45.6 nM. m7GpppAmpG caps RNA with a capping efficiency of 90%. m7GpppAmpG enhances mRNA stability and translation efficiency. m7GpppAmpG is used in mRNA therapeutic research .

HY-B0600R

Tafluprost (Standard) AFP-168 (Standard); MK2452 (Standard)	Prostaglandin Receptor Reference Standards	Cardiovascular Disease Others
Tafluprost (Standard) is the analytical standard of Tafluprost. This product is intended for research and analytical applications. Tafluprost (AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Tafluprost can inhibit the apoptosis of retinal ganglion cells (RGCs) and rat RGCs cells. Tafluprost promotes axon regeneration by regulating Zn2+-mTORpathway, inhibits intracellular lipid accumulation in human preorbital adipocytes. Tafluprost can be used in the study of optic nerve injury in glaucoma [4] .

HY-145974A

m7GpppAmpG ammonium m7G(5')ppp(5')(2'OMeA)PG ammonium	DNA/RNA Synthesis Eukaryotic Initiation Factor (eIF)	Others
m7GpppAmpG ammonium (m7G(5')ppp(5')(2'OMeA)pG ammonium) is a trinucleotide 5′ end cap analog. m7GpppAmpG ammonium binds to eIF4E with a K_D value of 45.6 nM. m7GpppAmpG ammonium caps RNA with a capping efficiency of 90%. m7GpppAmpG ammonium enhances mRNA stability and translation efficiency. m7GpppAmpG ammonium is used in mRNA therapeutic research .

Cat. No.	Product Name	Type

HY-145974A

m7GpppAmpG ammonium m7G(5')ppp(5')(2'OMeA)PG ammonium	Gene Sequencing and Synthesis
m7GpppAmpG ammonium (m7G(5')ppp(5')(2'OMeA)pG ammonium) is a trinucleotide 5′ end cap analog. m7GpppAmpG ammonium binds to eIF4E with a K_D value of 45.6 nM. m7GpppAmpG ammonium caps RNA with a capping efficiency of 90%. m7GpppAmpG ammonium enhances mRNA stability and translation efficiency. m7GpppAmpG ammonium is used in mRNA therapeutic research .

Cat. No.	Product Name	Target	Research Area

HY-P1208

PG-931	Melanocortin Receptor	Inflammation/Immunology
PG-931, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R (IC₅₀=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

HY-P1208A

PG-931 TFA	Melanocortin Receptor	Inflammation/Immunology
PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC₅₀=0.58 nM) agonist and is more selective than for the hMC3R (IC₅₀=55 nM) or the hMC5R(IC₅₀=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo .

Cat. No.	Product Name		Classification

HY-145974A

m7GpppAmpG ammonium m7G(5')ppp(5')(2'OMeA)PG ammonium		Cap Analogs
m7GpppAmpG ammonium (m7G(5')ppp(5')(2'OMeA)pG ammonium) is a trinucleotide 5′ end cap analog. m7GpppAmpG ammonium binds to eIF4E with a K_D value of 45.6 nM. m7GpppAmpG ammonium caps RNA with a capping efficiency of 90%. m7GpppAmpG ammonium enhances mRNA stability and translation efficiency. m7GpppAmpG ammonium is used in mRNA therapeutic research .

HY-158819

m7(3'OMeG)(5')ppp(5')m6(2'OMeA)pG trisodium		Cap Analogs
m7(3'OMeG)(5')ppp(5')m6(2'OMeA)pG trisodium is a cap analog that can be used for in vitro transcription of mRNA.

HY-145974

m7GpppAmpG m7G(5')ppp(5')(2'OMeA)PG		Cap Analogs
m7GpppAmpG (m7G(5')ppp(5')(2'OMeA)pG) is a trinucleotide 5′ end cap analog. m7GpppAmpG binds to eIF4E with a K_D value of 45.6 nM. m7GpppAmpG caps RNA with a capping efficiency of 90%. m7GpppAmpG enhances mRNA stability and translation efficiency. m7GpppAmpG is used in mRNA therapeutic research .

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