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Results for "

PDHK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PDHK (9) Drug Derivative (1)
By Research Areas:	Cancer (8) Inflammation/Immunology (3) Metabolic Disease (3)

Inhibitors & Agonists

Screening Libraries

Recombinant Proteins

Antibodies

Targets Recommended: PDHK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16082

AZD7545 2 Publications Verification	PDHK	Metabolic Disease
AZD7545 is a potent, competitive, selective *PDHK2* (pyruvate dehydrogenase kinase 2) inhibitor with IC₅₀s of 36.8 nM, 6.4 nM for *PDHK1* and *PDHK2*, respectively .

HY-136882

TM-1	PDHK	Cancer
TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits *PDHK1* and *PDHK2* with IC₅₀s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation .

HY-146552

PDHK-IN-4	PDHK	Metabolic Disease Cancer
PDHK-IN-4 (Compound 30) is a potent inhibitor of *PDHK* with IC₅₀s of 0.0051 and 0.0122 μM for PDHK2 and PDHK4, repectively. Pyruvate dehydrogenase kinases (PDHKs) are fascinating agent targets for numerous diseases, including diabetes and cancers. PDHK-IN-4 has the potential for the research of cancer diseases .

HY-146554

PDHK-IN-5	PDHK	Cancer
PDHK-IN-5 (Compound 19) is a potent inhibitor of *PDHK* with IC₅₀s of 0.006 and 0.0329 μM for PDHK2 and PDHK4, repectively. Pyruvate dehydrogenase kinases (PDHKs) are fascinating agent targets for numerous diseases, including diabetes and cancers. PDHK-IN-5 has the potential for the research of cancer diseases .

HY-173301

PDHK1-IN-3	PDHK	Inflammation/Immunology Cancer
PDHK1-IN-3 (Compound 29) is a selective *PDHK1* inhibitor with an IC₅₀ of 0.028 μM against PDHK1 and an IC₅₀ of 0.120 μM against *PDHK2. PDHK1-IN-3 inhibits the activity of PDHK1* by forming a covalent bond with Lys299 in *PDHK1. PDHK*1-IN-3 can be used in the research of autoimmune diseases, inflammatory diseases, and cancer .

HY-146801

PDHK-IN-3	PDHK	Metabolic Disease Cancer
PDHK-IN-3 (compound 7) is a potent *PDHK* (pyruvate dehydrogenase kinase) inhibitor, with IC₅₀ values of 0.21 and 1.54 μM for *PDHK2* and *PDHK4*, respectively .

HY-173298

PDHK1-IN-2	PDHK	Inflammation/Immunology Cancer
PDHK1-IN-2 (Compound 24) is an ATP-competitive dual inhibitor of pyruvate dehydrogenase kinases 1/2 (PDHK1/2), with an IC₅₀ of 0.007 μM for *PDHK1* and an IC₅₀ of 0.015 μM for *PDHK2. PDHK*1-IN-2 can regulate immune cell metabolism and correct mitochondrial dysfunction, and is expected to be used in the research of autoimmune diseases, inflammatory diseases, cancers, and other conditions .

HY-170838

PDHK1-IN-1	PDHK	Cancer
PDHK1-IN-1 (compound 17) is a selective inhibitor of *PDHK1* (IC₅₀=1.5 μM) with anticancer activity. PDHK1 negatively regulates the pyruvate dehydrogenase complex (PDC), limiting the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. Overexpression of PDHK1 can shift the metabolism towards an increased glycolysis dependence (Warburg effect). PDHK1-IN-1 can inhibit the phosphorylation of the PDC E1α Ser232 recognition site of PDHK1 and the phosphorylation of Ser293 .

HY-162586

PDHK-IN-7	PDHK	Cancer
PDHK-IN-7 (compound 32) is an inhibitor of pyruvate dehydrogenase kinase with an IC₅₀ value of 17 nM.PDHK-IN-7 activates PDH in rat livers and has a glucose-lowering effect in Zucker fatty rats .

HY-176008

Lauric acid leelamide	Drug Derivative	Inflammation/Immunology
Lauric acid leelamide is the lauric acid (C-12) amide analog of Leelamine (HY-W005629). Leelamine exhibits inhibitory activity against pyruvate dehydrogenase kinase (PDHK) with an IC₅₀ value of 9.5 µM. Leelamine derivatives possess anti-inflammatory effects and can inhibit phospholipase A2 activity from various sources .

Cat. No.	Product Name

HY-L058

Glycolysis Compound Library	956 compounds
Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation. Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications. MCE provides a unique collection of 956 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

Glycolysis Compound Library

956 compounds

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 956 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

Species:	Human (2) Mouse (1)
Tag:	His (3) GST (2)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P73718

	PDK1 Protein, Human (sf9, His) Pyruvate dehydrogenase kinase isoform 1; PDK1; PDHK1	Human	Sf9 insect cells
	PDK1 protein is a key kinase that controls glucose and fatty acid metabolism by phosphorylating pyruvate dehydrogenase subunits PDHA1 and PDHA2. This molecular switch inhibits pyruvate dehydrogenase, fine-tunes metabolite flux and downregulates aerobic respiration. PDK1 Protein, Human (sf9, His) is the recombinant human-derived PDK1 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P703578

	PDK3 Protein, Human (Inactive, sf9, His, GST) PDHK3	Human	Sf9 insect cells
	PDK3 Protein, Human (Inactive, sf9, His, GST) is the recombinant human-derived PDK3, expressed by sf9 insect cells , with His, GST labeled tag. ,

HY-P74639

	PDK4 Protein, Mouse (sf9, His-GST) Pyruvate dehydrogenase kinase isoform 4; PDK4; PDHK4	Mouse	Sf9 insect cells
	PDK4 protein is a key kinase that regulates glucose and fatty acid metabolism by phosphorylating pyruvate dehydrogenase subunits PDHA1 and PDHA2.This inhibits pyruvate dehydrogenase activity, modulates metabolite flux and inhibits aerobic respiration.PDK4 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived PDK4 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

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HY-P81650

	PDK2 Antibody (YA1395) PDK2; PDHK2; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2; mitochondrial; Pyruvate dehydrogenase kinase isoform 2	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	PDK2 Antibody (YA1395) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1395), targeting PDK2, with a predicted molecular weight of 46 kDa (observed band size: 46 kDa). PDK2 Antibody (YA1395) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

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