PDK3 Protein, Human (Inactive, sf9, His, GST)

PDK3 Protein, Human (Inactive, sf9, His, GST) is the recombinant human-derived PDK3, expressed by sf9 insect cells , with His, GST labeled tag. ,

PDK3, a pivotal player in metabolic regulation, exerts its influence by inhibiting pyruvate dehydrogenase activity through the phosphorylation of the E1 subunit PDHA1, thereby finely tuning glucose metabolism and aerobic respiration. Its capacity to phosphorylate PDHA2 adds another layer of control to these critical cellular processes. Under conditions of prolonged fasting or in response to a high-fat diet, PDK3 orchestrates a metabolic shift, reducing glucose utilization and enhancing fat metabolism. Beyond its role in nutrient adaptation, PDK3 emerges as a key contributor to glucose homeostasis, playing a crucial part in maintaining normal blood glucose levels. Additionally, its involvement in the generation of reactive oxygen species adds a layer of complexity to its multifaceted functions.

Human

Sf9 insect cells

His;GST

Q15120-1 (R2-Q406)

5165

Full Length of Isoform-1 Mature Protein

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.