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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

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P388 cells

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By Targets:	Aminopeptidase (1) Antibiotic (28) Apoptosis (3) Bacterial (44) DNA/RNA Synthesis (6) Drug Derivative (3) Endogenous Metabolite (3) Fungal (5) HIV (3) Insecticide (1) Parasite (1) Phospholipase (2) Reactive Oxygen Species (ROS) (1) Reference Standards (1) Serotonin Transporter (1) Topoisomerase (7) Virus Protease (1)
By Research Areas:	Cancer (78) Infection (54) Inflammation/Immunology (4)

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Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor Programmed Cell Death 4 (PDCD4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N8979

Kanshone A	Others	Inflammation/Immunology
Kanshone A is a sesquiterpene isolated from the roots of Nardostachys chinensis (Valerianaceae). Kanshone A shows cytotoxic with an IC₅₀ value of 7.0 µg/ml in P388 cells .

HY-136514

Tampramine	Serotonin Transporter	Cancer
Tampramine (47), a phenothiazine, could reverse multidrug resistance, with ED₅₀ values of 60 μM (P388 cells) and 60 μM (P388/ADR cells), respectively .

HY-113759

Saquayamycin A	Bacterial	Infection Cancer
Saquayamycin A has antimicrobial effect, but it has weaker effect against Gram-negative bacteria. Saquayamycin A has inhibitory effect on leukemia P388 cells and Adriamycin-resistant P388 cells .

HY-113771

Saquayamycin C	Bacterial	Infection Cancer
Saquayamycin C has antimicrobial effect, but it has weaker effect against Gram-negative bacteria. Saquayamycin C has inhibitory effect on leukemia P388 cells and Adriamycin-resistant P388 cells .

HY-126802

Saquayamycin B1	Bacterial	Infection Cancer
Saquayamycin B1 has antimicrobial effect, but it has weaker effect against Gram-negative bacteria. Saquayamycin B1 has inhibitory effect on leukemia P388 cells and Adriamycin-resistant P388 cells .

HY-N13870

Saquayamycin A1	Bacterial	Infection Cancer
Saquayamycin A1 has antimicrobial effect, but it has weaker effect against Gram-negative bacteria. Saquayamycin A1 has inhibitory effect on leukemia P388 cells and Adriamycin-resistant P388 cells .

HY-N13868

Saquayamycin C1	Bacterial	Infection Cancer
Saquayamycin C1 has antimicrobial effect, but it has weaker effect against Gram-negative bacteria. Saquayamycin C1 has inhibitory effect on leukemia P388 cells and Adriamycin-resistant P388 cells .

HY-N2835

Alboctalol	Others	Others
Alboctalol can be isolated from Morus australis. Alboctalol has weak cytotoxicity against P-388 cells .

HY-N7011

Epicorynoxidine	Others	Inflammation/Immunology
Epicorynoxidine, a natural alkaloid, shows cytotoxic effects P-388 cell line with an ED₅₀ of 25.53 μg/mL .

HY-12458

Pyrindamycin A	DNA/RNA Synthesis	Infection Cancer
Pyrindamycin A is an antibiotic that inhibits DNA synthesis. Pyrindamycin A shows antitumor activities against murine leukemia, exhibits stronger cytotoxic activities towards murine and human tumor cell lines and especially towards doxorubicin-resistant cells, inhibits P388 and P388/ADR cells with the same IC₅₀ of 3.9 μg/ml .

HY-120504

N-Acetyltyramine 1 Publications Verification	Bacterial	Infection Cancer
N-Acetyltyramine is a quorum-sensing inhibitor (QSI) compound produced by V. alginolyticus M3-10. N-Acetyltyramine is capable of inhibiting the QS of C. violaceum ATCC 12472. N-acetyltyramine reverses resistance in Doxorubicin-resistant leukemia P388 cells .

HY-167671

BE-10988	Topoisomerase	Cancer
BE-10988 is a DNA topoisomerase inhibitor. BE-10988 inhibits the growth of Doxorubicin (HY-15142A)-resistant and vincristine-resistant P388 mouse leukemia cell lines by increasing the formation of DNA topoisomerase complexes .

HY-N13941

Baciphelacin	Bacterial	Infection Cancer
Baciphelacin is mainly resistant to gram-positive bacteria and has the activity of inhibiting Newcastle disease virus and leukemia P-388 cells .

HY-N10206

11-epi-Chaetomugilin I	Endogenous Metabolite	Cancer
11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .

HY-N14621

Harzialacton A	Others	Cancer
Harzialacton A has weak cytotoxicity to P388 leukemia cells with ED₅₀ of > 100 μg/mL .

HY-N7321A

(R)-Eucomol	Bacterial	Infection Cancer
(R)-Eucomol, a flavonoid derivative, displays marginal antibacterial activity. (R)-Eucomol shows cytotoxic activity against KB and P-388 cells .

HY-125321

Lychnostatin 2	Others	Cancer
Lychnostatin 2 exhibits cytotoxicity in cell P-388 with an ED₅₀ of 0.19 µg/ml. Lychnostatin 2 can be used in research abour leukemia .

HY-N13878

Anguinomycin B	Antibiotic Bacterial	Infection
Anguinomycin B is an antitumor antibiotic that shows highly cytotoxic to murine P388 leukemia cells .

HY-N1649

2,3,2'',3''-Tetrahydroochnaflavone	Others	Cancer
2,3,2'',3''-Tetrahydroochnaflavone is a biflavonoid, which can be isolated from the leaves of Quintinia acutifolia. 2,3,2'',3''-Tetrahydroochnaflavone shows some cytotoxicity against P388 murine lymphocytic leukemia cells, with an IC₅₀ of 8.2 µg/mL .

HY-N15047

Barminomycin II	Others	Cancer
Barminomycin II shows a strong inhibition of P388 leukemia cells with IC₅₀ of about 0.00002 g/mL .

HY-N15046

Barminomycin I	Others	Cancer
Barminomycin I shows a strong inhibition of P388 leukemia cells with IC₅₀ of about 0.00001 g/mL .

HY-129752

Piperafizine B	Antibiotic	Cancer
Piperafizine B exhibits slightly cytotoxicity in moser cells, P388 cells and Vincristine (VCR) (HY-N0488)-resistant P388 cells (IC₅₀s is 23.8, 22.6 and 23.7 μg/mL, respectively). Piperafizine B exhibits synergistic effects with Vincristine, enhances the VCR-induced cytotoxicity and ameliorates the leukemia in mouse model .

HY-N6955

Eupalinilide B	Others	Cancer
Eupalinilide B is a guaiane type sesquiterpene lactone that can be found in Eupatorium lindleyanum. Eupalinilide B shows potent cytotoxicity against P-388 and A-549 tumor cell lines .

HY-N14522

Gilvocarcin E	Bacterial	Infection Cancer
Gilvocarcin E has anti-Gram-positive bacterial activity and can inhibit sarcoma 180 and P388 leukemia cells .

HY-N9210

1,2,3-Tri-O-methyl-7,8-methyleneflavellagic acid	Others	Cancer
1,2,3-Tri-O-methyl-7,8-methyleneflavellagic acid, a ellagic acid derivative of Agrostistachys hookeri, exhibits activity against cultured P-388 lymphocytic leukemia cells .

HY-118726

Luotonin F	Topoisomerase	Cancer
Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II .

HY-N12151

Chaparrinone	Parasite	Infection
Chaparrinone is a quassinoid that can be isolated from the root of Eurycoma harmandiana. Chaparrinone has antimalarial and cytotoxic activities against Plasmodium falciparum and P-388 cells (IC₅₀: 0.037 and 0.34 μg/mL respectively) .

HY-N3123

Oxychelerythrine Dihydrooxochelerythrine	Others	Cancer
Oxychelerythrine is an alkaloid that can be isolated from Zanthoxylum integrifoliolum. Oxychelerythrine exhibits cytotoxicity against P-388 and HT-29 cell lines with ED₅₀s of 3.25 and 5.48 μg/mL, respectively .

HY-142102

T988C (+)-T988C	Others	Cancer
T988C is a heptacyclic epidithiodioxopiperazine (ETP) natural product. T988C shows strong cytotoxicity to cultured P388 leukemia cells .

HY-106843

Phospholine	Antibiotic Bacterial	Infection
Phospholine is an antibiotic. The IC₅₀ (μg/mL) of Ll 210, P388 and EL-4 cells are 3.37, 2.20 and 1.99, respectively .

HY-N10208

Aspericin C	Endogenous Metabolite	Cancer
Aspericin C is a pyran derivative found in the marine-derived fungus Rhizopus sp. 2-PDA-61. Aspericin C shows cytotoxic activities against P388, A549, HL-60, and BEL-7420 cell lines (IC₅₀=14.6, 7.1, 61.4, and 24.2 μM, respectively) .

HY-N15058

Chlorogentisylquinone	Phospholipase	Cancer
Chlorogentisylquinone is found in the strain of FOM-8108. The IC₅₀ of inhibitory rat meningeal nSMase is 1.2 μM, and the IC₅₀ of P388 cells is 7.6 μM .

HY-N3308

Medicarpin 1 Publications Verification	Apoptosis	Cancer
Medicarpin is a flavonoid isolated from Medicago sativa. Medicarpin induces apoptosis and overcome multidrug resistance in leukemia P388 cells by modulating P-gp-mediated efflux of agents .

HY-N8025

Nephthenol	Others	Cancer
Nephthenol is a terpenoid that can be isolated from Nephthea brassica. Nephthenol exhibits cytotoxicity in cells A549, HT-29, KB and P-388 with IC₅₀s of 2.72, 3.01, 1.84, and 0.42 µg/mL, respectively .

HY-N14303

16-Methyloxazolomycin	Antibiotic Bacterial	Infection Cancer
16-Methyloxazolomycin is an antibiotic. 16-Methyloxazolomycin has the effect of resisting bacteria and algae. 16-Methyloxazolomycin against leukemia P388 and human lung adenocarcinoma cells .

HY-126954

13-Deoxycarminomycin	Antibiotic Bacterial	Infection Cancer
13-Deoxycarminomycin is an antibiotic with antibacterial activity. 13-Deoxycarminomycin also exhibits cytotoxicity against tumor cells such as HeLa and P388, and can play an anti-tumor role .

HY-12459

Pyrindamycin B	Bacterial	Infection
Pyrindamycin B is an antibiotic, actives against gram-positive and gram-negative bacterias, and exhibits strong therapeutic effects against both agent-sensitive and resistant cells of P388 leukemia in mice .

HY-N14019

Glidobactin B	Antibiotic Bacterial	Infection Cancer
Glidobactin B is an anti-tumor antibiotic. Glidobactin B has the activity against pathogenic fungi and yeast. Glidobactin B also extends the survival of mice inoculated with leukemia P388 cells .

HY-N3041

Plumieride Agoniadin; NSC 609065	Fungal	Infection Cancer
Plumieride is an antifungal agent. Plumieride has strong fungitoxicity against some dermatophytes. Plumieride has little cytotoxic activity against the P388 leukaemia cell line with an IC₅₀ of 85 μg/mL .

HY-N14023

Glidobactin G	Antibiotic Fungal	Infection Cancer
Glidobactin G is an anti-tumor antibiotic. Glidobactin G has the activity against pathogenic fungi and yeast. Glidobactin G also extends the survival of mice inoculated with leukemia P388 cells .

HY-N14022

Glidobactin F	Antibiotic Fungal	Infection Cancer
Glidobactin F is an anti-tumor antibiotic. Glidobactin F has the activity against pathogenic fungi and yeast. Glidobactin F also extends the survival of mice inoculated with leukemia P388 cells .

HY-N10350

2,3-Dihydro-3-methoxywithaferin A	Others	Cancer
2,3-Dihydro-3-methoxywithaferin A is an analogue of 2,3-dihydrowithaferin-A. 2,3-Dihydro-3-methoxywithaferin A inhibits proiiferation of P388 cells[1].

HY-N0128R

Sclareol (Standard)	Apoptosis	Cancer
Sclareol (Standard) is the analytical standard of Sclareol. This product is intended for research and analytical applications. Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis .

HY-126617

Duclauxin NSC 258308	Others	Cancer
Duclauxin decreases proliferation of tumor cells in vitro and increases the lifespan of mice innoculated with Ehrlich ascitic tumor cells. Duclauxin (10-30 μg/mL) inhibits mitochondrial respiration of P-388 tumor cells and nucleic acid synthesis in cell culture of Ehrlich cancer, the lymphadenomas NK/LI and L 5178, and sarcoma 37. Duclauxin also inhibits growth of wheat coleoptile.

HY-N1631

1-Hydroxyrutecarpine 1-Hydroxyrutaecarpine	Drug Derivative	Others
1-Hydroxyrutaecarpine (compound 1a) is a hydroxy-derivative of rutaecarpine. 1-Hydroxyrutaecarpine shows cytotoxicities with ED₅₀s of 3.72, 7.44 µg/mL for P-388 and HT-29 cells, respectively. 1-Hydroxyrutaecarpine shows antiplatelet activity .

HY-N14095

Curromycin A	Bacterial HIV	Infection Cancer
Curromycin A has antibacterial activity against Gram-positive bacteria such as Bacillus subtilis. Curromycin A can inhibit the replication of human immunodeficiency virus (HIV), inhibit mouse melanoma B16 and leukemia P388 cells .

HY-23120

1-Hydroxyguanidine sulfate	Antibiotic Virus Protease	Infection Cancer
1-Hydroxyguanidine sulfate is an antitumor agent that inhibits mast cell P815, leukaemia P388, leukaemia L1210 and carcinosarcoma Walker 256 cells growth. 1-Hydroxyguanidine sulfate also has antiviral activity .

HY-W747504

TAN-420E Dihydroherbimycin A	Antibiotic Reactive Oxygen Species (ROS)	Infection Cancer
TAN-420E (Dihydroherbimycin A) is an antibiotic, that can be isolated from the fermentation product of Streptomyces hygroscopicus. TAN-420E exhibits cytotoxicity in cancer cells P-388 and KB. TAN-420E scavenges DPPH free radicals with an IC₅₀ of 1.3 μM .

HY-N14496

Nisamycin	Bacterial	Infection Cancer
Nisamycin has stronger anti-Gram-positive bacteria and weaker anti-fungal and individual Gram-negative bacteria activities. Nisamycin has weak cytotoxic effect. The IC₅₀ of mouse leukemia P388 cells is 4.8 μg/mL .

HY-N14110

Curromycin B	Bacterial HIV	Infection
Curromycin B has antibacterial activity against Gram-positive bacteria such as Bacillus subtilis. Curromycin B can inhibit the replication of human immunodeficiency virus (HIV), inhibit mouse melanoma B16 and leukemia P388 cells .

Cat. No.	Product Name	Target	Research Area

HY-N6689

Destruxin A 1 Publications Verification	Insecticide Bacterial	Infection Inflammation/Immunology Cancer
Destruxin A is a fungal cyclopeptide with insecticidal and antiviral activities. Destruxin A has a certain inhibitory effect on leukemia cells in vitro. Destruxin A can also specifically inhibit the innate immune response of Drosophila melanogaster, making the flies more susceptible to bacterial infections .

HY-P3116

Thiocoraline	Bacterial	Cancer
Thiocoraline is a depsipeptide that can be isolated by marine Micromonospora. Thiocoraline has antitumor activity with IC₅₀s of 0.002, 0.002, 0.01 and 0.002 μg/mL in P388, A549, HT-29 and MEL-28 cells, respectively. Thiocoraline also a strong antimicrobial activity against Gram-positive microorganisms .

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P388 cells

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