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P2Y14R antagonist 5

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-176739
    P2Y14R antagonist 5

    		P2Y Receptor Inflammation/Immunology
    P2Y14R antagonist 5 (Compound A) is a novel P2Y14R antagonist based on a benzisoxazole skeleton (IC50: 23.60 nM, KD: 7.26 μM). P2Y14R antagonist 5 reduces the levels of proinflammatory cytokines (IL-1β, IL-6, TNF-α) and myeloperoxidase (MPO). P2Y14R antagonist 5 has anti-inflammatory activity in a mouse model of LPS-induced acute lung injury .
    P2Y14R antagonist 5

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