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OHCs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1) Biochemical Assay Reagents (7) Drug Intermediate (1) E3 Ligase Ligand-Linker Conjugates (1) EBI2/GPR183 (4) Endogenous Metabolite (8) Estrogen Receptor/ERR (2) iGluR (1) Isotope-Labeled Compounds (2) Ligands for Target Protein for PROTAC (1) LXR (3) PROTAC Linkers (1) ROR (1) Smo (1)
By Research Areas:	Cancer (8) Infection (1) Inflammation/Immunology (7) Metabolic Disease (2) Neurological Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2371

27-Hydroxycholesterol 5 Publications Verification 27-OHC	Estrogen Receptor/ERR LXR Endogenous Metabolite	Cancer
27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor.

HY-W414548

7α,27-Dihydroxycholesterol	Others	Neurological Disease Metabolic Disease
7α,27-Dihydroxycholesterol is an oxysterol characterized by its oxidized side chains and is produced through the hydroxylation of 27-Hydroxycholesterol (27-OHC); it serves as a metabolite of interest in lipidomic analyses of various pathological conditions, including neurological diseases, Smith-Lemli-Opitz syndrome, obesity metabolic syndrome, and diabetes. Notably, levels of 7α,27-di-OHC decrease following lipopolysaccharide activation, and it also functions as a ligand for Epstein-Barr virus-induced gene 2 (EBI2). Additionally, 7α,27-di-OHC exists as a structural isomer of 7α,25-dihydroxycholesterol (7α25-OHC).

HY-N2371R

27-Hydroxycholesterol (Standard) 27-OHC (Standard)	Estrogen Receptor/ERR LXR Endogenous Metabolite	Cancer
27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor.

HY-W1048574E

OHC-PEG-COOH (MW 20000) OHC-PEG-carboxyl (MW 20000)	Biochemical Assay Reagents	Others
OHC-PEG-COOH (MW 20000) (OHC-PEG-carboxyl (MW 20000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 20000) can be used for drug delivery .

HY-W1048574J

OHC-PEG-COOH (MW 40000) OHC-PEG-carboxyl (MW 40000)	Biochemical Assay Reagents	Others
OHC-PEG-COOH (MW 40000) (OHC-PEG-carboxyl (MW 40000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 40000) can be used for drug delivery .

HY-W1048574H

OHC-PEG-COOH (MW 1000) OHC-PEG-carboxyl (MW 1000)	Biochemical Assay Reagents	Others
OHC-PEG-COOH (MW 1000) (OHC-PEG-carboxyl (MW 1000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 1000) can be used for drug delivery .

HY-W1048574I

OHC-PEG-COOH (MW 3400) OHC-PEG-carboxyl (MW 3400)	Biochemical Assay Reagents	Others
OHC-PEG-COOH (MW 3400) (OHC-PEG-carboxyl (MW 3400)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 3400) can be used for drug delivery .

HY-W1048574A

OHC-PEG-COOH (MW 2000) OHC-PEG-carboxyl (MW 2000)	Biochemical Assay Reagents	Others
OHC-PEG-COOH (MW 2000) (OHC-PEG-carboxyl (MW 2000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 2000) can be used for drug delivery .

HY-W1048574D

OHC-PEG-COOH (MW 10000) OHC-PEG-carboxyl (MW 10000)	Biochemical Assay Reagents	Others
OHC-PEG-COOH (MW 10000) (OHC-PEG-carboxyl (MW 10000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 10000) can be used for drug delivery .

HY-W1048574C

OHC-PEG-COOH (MW 5000) OHC-PEG-carboxyl (MW 5000)	Biochemical Assay Reagents	Others
OHC-PEG-COOH (MW 5000) (OHC-PEG-carboxyl (MW 5000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 5000) can be used for drug delivery .

HY-113134

25-Hydroxycholesterol Maximum Cited Publications 25 Publications Verification 25-OHC	Endogenous Metabolite	Inflammation/Immunology
25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC₅₀≈65 nM) and selective suppressor of IgA production by B cells.

HY-133974

7-keto-25-Hydroxycholesterol 7-keto-25-OHC	Smo	Cancer
7-keto-25-Hydroxycholesterol (7-keto-25-OHC), a oxysterol, is a Smoothened (Smo) activator. 7-keto-25-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo .

HY-16940

24(S)-Hydroxycholesterol 24S-OHC; 24S-HC; Cerebrosterol	LXR iGluR Endogenous Metabolite	Metabolic Disease
24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators .

HY-16940A

24(R)-Hydroxycholesterol 24R-OHC; 24R-HC; 24(R)-Cerebrosterol	Drug Intermediate	Others
24(R)-Hydroxycholesterol (24R-OHC) is a key intermediate of Tacalcitol (HY-32337) .

HY-113134R

25-Hydroxycholesterol (Standard)	Endogenous Metabolite	Inflammation/Immunology
25-Hydroxycholesterol (Standard) is the analytical standard of 25-Hydroxycholesterol. This product is intended for research and analytical applications. 25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

HY-113962S

7α,25-Dihydroxycholesterol-d6 7α,25-OHC-d₆	Isotope-Labeled Compounds EBI2/GPR183 Endogenous Metabolite	Inflammation/Immunology
7α,25-Dihydroxycholesterol-d₆ is deuterium labeled 7α,25-Dihydroxycholesterol. 7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly

HY-400897

7α,25-Dihydroxycholesterol intermediate-1	Ligands for Target Protein for PROTAC EBI2/GPR183	Cancer
7α,25-Dihydroxycholesterol intermediate-1 is an intermediate in the synthesis of 7α,25-Dihydroxycholesterol (HY-113962). 7α,25-Dihydroxycholesterol (7α,25-OHC) can be used as a ligand to target the orphan GPCR receptor EBI2 (GPR183). body, used to synthesize the corresponding PROTEACs .

HY-138115

7ß,27-Dihydroxycholesterol 7β, 27-OHC	ROR	Inflammation/Immunology
7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (K_i=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4 ⁺ Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1 .

HY-163903

OH-C2-PEG3-NHCO-C3-COOH	PROTAC Linkers	Cancer
OH-C2-PEG3-NHCO-C3-COOH is a PROTAC linker that can be used in the synthesis of PROTACs .

HY-174087

Thalidomide-4-OH-C11-OH	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-4-OH-C11-OH is an E3 Ligase Ligand-Linker Conjugate, which is composed of Thalidomide-4-OH (HY-103596) and the corresponding Linker. Thalidomide-4-OH-C11-OH can be used as a Cereblon ligand to recruit CRBN protein and as a key intermediate for the synthesis of complete PROTACs molecules, such as PROTAC GPX4 degrader-4 (HY-174086) .

HY-113962

7α,25-Dihydroxycholesterol 3 Publications Verification 7α,25-OHC	EBI2/GPR183 Endogenous Metabolite	Inflammation/Immunology
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC₅₀=140 pM; K_d=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells .

HY-147222

SAE-14 1 Publications Verification GPR183 antagonist-1	EBI2/GPR183	Neurological Disease Inflammation/Immunology
SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC₅₀ value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC₅₀ value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice .

HY-113134S

25-Hydroxycholesterol-d6 25-OHC-d₆	Isotope-Labeled Compounds Endogenous Metabolite	Inflammation/Immunology
25-Hydroxycholesterol-d₆ (25-OHC-d₆) is the deuterium labeled 25-Hydroxycholesterol. 25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC₅₀≈65 nM) and selective suppressor of IgA production by B cells .

HY-158730

N-3-Hydroxybutyryl-L-homoserine lactone 3-OH-C4-HSL; N-3-Hydroxybutanoyl-L-homoserine lactone; N-3-Hydroxybutyryl-L-HSL	Bacterial	Infection
N-3-Hydroxybutyryl-L-homoserine lactone (3-OH-C4-HSL) is an acyl-homoserine lactone, that can be isolated from Vibrionaceae. N-3-Hydroxybutyryl-L-homoserine lactone is a signaling molecule that is involved in bacterial quorum sensing (QS). N-3-Hydroxybutyryl-L-homoserine lactone senses the density of bacterial population, regulates the cellular process, such as bioluminescence, biofilm formation, and exo-enzyme production .

Cat. No.	Product Name	Type

HY-W1048574E

OHC-PEG-COOH (MW 20000) OHC-PEG-carboxyl (MW 20000)	Drug Delivery
OHC-PEG-COOH (MW 20000) (OHC-PEG-carboxyl (MW 20000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 20000) can be used for drug delivery .

HY-W1048574J

OHC-PEG-COOH (MW 40000) OHC-PEG-carboxyl (MW 40000)	Drug Delivery
OHC-PEG-COOH (MW 40000) (OHC-PEG-carboxyl (MW 40000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 40000) can be used for drug delivery .

HY-W1048574H

OHC-PEG-COOH (MW 1000) OHC-PEG-carboxyl (MW 1000)	Drug Delivery
OHC-PEG-COOH (MW 1000) (OHC-PEG-carboxyl (MW 1000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 1000) can be used for drug delivery .

HY-W1048574I

OHC-PEG-COOH (MW 3400) OHC-PEG-carboxyl (MW 3400)	Drug Delivery
OHC-PEG-COOH (MW 3400) (OHC-PEG-carboxyl (MW 3400)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 3400) can be used for drug delivery .

HY-W1048574A

OHC-PEG-COOH (MW 2000) OHC-PEG-carboxyl (MW 2000)	Drug Delivery
OHC-PEG-COOH (MW 2000) (OHC-PEG-carboxyl (MW 2000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 2000) can be used for drug delivery .

HY-W1048574D

OHC-PEG-COOH (MW 10000) OHC-PEG-carboxyl (MW 10000)	Drug Delivery
OHC-PEG-COOH (MW 10000) (OHC-PEG-carboxyl (MW 10000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 10000) can be used for drug delivery .

HY-W1048574C

OHC-PEG-COOH (MW 5000) OHC-PEG-carboxyl (MW 5000)	Drug Delivery
OHC-PEG-COOH (MW 5000) (OHC-PEG-carboxyl (MW 5000)) is a PEG derivative with a linear heteroterminal bifunctional structure of aldehyde and carboxylic acid groups. OHC-PEG-COOH (MW 5000) can be used for drug delivery .

Cat. No.	Product Name	Target	Research Area

HY-P11350

A666 peptide	Peptides	Cancer
A666 peptide is a highly selective prestin ligand. A666 peptide enables active drug delivery (e.g., dexamethasone) to outer hair cells (OHCs). A666 peptide is promising for research of cisplatin-induced ototoxicity protection and sensorineural hearing loss interventions .

HY-P11350A

A666 peptide TFA	Peptides	Cancer
A666 peptide TFA is a highly selective prestin ligand. A666 peptide TFA enables active drug delivery (e.g., dexamethasone) to outer hair cells (OHCs). A666 peptide TFA is promising for research of cisplatin-induced ototoxicity protection and sensorineural hearing loss interventions .

27-Hydroxycholesterol 5 Publications Verification 27-OHC	Natural Products Classification of Application Fields Source classification Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder Cancer	Estrogen Receptor/ERR LXR Endogenous Metabolite
27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor.

25-Hydroxycholesterol Maximum Cited Publications 25 Publications Verification 25-OHC	Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Endogenous Metabolite
25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC₅₀≈65 nM) and selective suppressor of IgA production by B cells.

24(S)-Hydroxycholesterol 24S-OHC; 24S-HC; Cerebrosterol	Classification of Application Fields Source classification Disease markers Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Steroids	LXR iGluR Endogenous Metabolite
24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators .

7α,25-Dihydroxycholesterol 3 Publications Verification 7α,25-OHC	Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	EBI2/GPR183 Endogenous Metabolite
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC₅₀=140 pM; K_d=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells .

27-Hydroxycholesterol (Standard) 27-OHC (Standard)	Natural Products Source classification Disease markers Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder	Estrogen Receptor/ERR LXR Endogenous Metabolite
27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor.

25-Hydroxycholesterol (Standard)	Source classification Endogenous metabolite Steroids	Endogenous Metabolite
25-Hydroxycholesterol (Standard) is the analytical standard of 25-Hydroxycholesterol. This product is intended for research and analytical applications. 25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

Cat. No.	Product Name	Chemical Structure

HY-113134S

25-Hydroxycholesterol-d6
25-Hydroxycholesterol-d₆ (25-OHC-d₆) is the deuterium labeled 25-Hydroxycholesterol. 25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC₅₀≈65 nM) and selective suppressor of IgA production by B cells .

HY-113962S

7α,25-Dihydroxycholesterol-d6
7α,25-Dihydroxycholesterol-d₆ is deuterium labeled 7α,25-Dihydroxycholesterol. 7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly

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OHCs

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Isotope-Labeled Compounds

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