OH radical

By Targets:	Apoptosis (1) Biochemical Assay Reagents (2) DNA/RNA Synthesis (1) Drug Intermediate (1) Drug Metabolite (1) Ferroptosis (1) Fluorescent Dye (3) Opioid Receptor (1) PI3K (1) Reactive Oxygen Species (ROS) (5)
By Research Areas:	Cancer (5) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120976

DEPMPO	Biochemical Assay Reagents	Cancer
cDEPMPO is a potent anticancer proagent. High concentrations of DEPMPO spin-trap the ·OH radical together with aryl radicals arising from one-electron reduced BTO (benzotriazine 1,4-di-N-oxide) compounds .

HY-D1151

HKOH-1 2 Publications Verification	Reactive Oxygen Species (ROS) Fluorescent Dye	Others
HKOH-1 is a highly sensitive green fluorescent probe for the specific detection of ·OH in living cells with a maximum excitation wavelength and emission wavelength of 500 nm and 520 nm, respectively .

HY-W027951

N,N'-Dimethylthiourea 1 Publications Verification DMTU	Reactive Oxygen Species (ROS)	Inflammation/Immunology
N,N'-Dimethylthiourea (DMTU), isolated from Allium sativum, is an orally active scavenger of hydroxyl radical (•OH) and blocks •OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including •OH scavenging and anti-inflammatory action .

HY-129109

NBD-Pen	Fluorescent Dye	Inflammation/Immunology Cancer
NBD-Pen is the first fluorescence probe for lipid radicals with high selectivity and sensitivity (λ_ex: 470 nm, λ_em: 530 nm). NBD-Pen specifically detects lipid derived radicals over other reactive species present in biological systems, including H₂O₂, ClO ^-, O₂ ^-∙, and ∙OH. NBD-Pen directly detects lipid radicals in living cells by turn-on fluorescence. NBD-Pen decreases inflammation, apoptosis, and oxidative stress markers. NBD-Pen can be studied in various disease models such as hepatic carcinoma .

HY-W587960

Hercynine Histidine-betaine	Drug Metabolite Drug Intermediate	Metabolic Disease
Hercynine (Histidine-betaine) is an intermediate (precursor) and a redox metabolite of Ergothioneine (HY-N1914), which is found in the fine leaf algae, Schizosaccharomyces cerevisiae and honey bees. Hercynine has no effect on scavenging •OH radicals .

HY-111314

NZ 419 5-Hydroxy-1-methylhydantoin	Reactive Oxygen Species (ROS)	Inflammation/Immunology
NZ 419 (5-Hydroxy-1-methylhydantoin) is a metabolite of creatinine and an antioxidant with oral activity, which has the ability to scavenge hydroxyl radicals (•OH). NZ 419 can inhibit the progression of chronic kidney disease (CKD) in rats .

HY-145779

H-Glu(Met-OH)-OH γ-Glu-Met	Biochemical Assay Reagents	Metabolic Disease
H-Glu(Met-OH)-OH (γ-Glu-Met) could induce oxidation of hydroxyl radical .

HY-117457

BPIC	DNA/RNA Synthesis	Cancer
BPIC is a DNA intercalator agent and also an anti-cancer agent. BPIC scavenge ∙OH, ∙O2(-), and NO free radicals .

HY-P4531

H-Ser-Tyr-OH	Opioid Receptor	Neurological Disease
H-Ser-Tyr-OH is a dipeptide consisting of glutamic acid, glycine and histidine. H-Ser-Tyr-OH can form a copper(II) complex with copper ions to form a strong free radical scavenging activity. H-Ser-Tyr-OH also increases the intracellular uptake of the delta opioid receptor ligand deltorphin .

HY-172333

HCy-Lyso	Fluorescent Dye	Others
HCy-Lyso is a lysosome-targeting turn-on fluorescent probe based on hydrocyanine. HCy-Lyso integrates a hydrocyanine moiety for selective recognition of hydroxyl radicals (•OH) and a morpholine group for lysosome targeting. Upon reacting with •OH, HCy-Lyso undergoes an extension of its π-conjugation system, producing a strong fluorescence signal at 598 nm when excited at 510 nm .

HY-173473

Anticancer agent 272	Reactive Oxygen Species (ROS) Apoptosis Ferroptosis	Cancer
Anticancer agent 272 (Compound 2) is an anticancer agent. Anticancer agent 272 has significant anti-bladder cancer cell (T-24) activity (IC₅₀: 2.81 μM). Anticancer agent 272 consumes glutathione (GSH) through Fenton-like reaction, produces reactive oxygen species (ROS) and hydroxyl radicals (•OH), and induces apoptosis and ferroptosis. Anticancer agent 272 can enhance chemodynamic therapy (CDT) and promote tumor cell death through mitochondrial dysfunction and autophagy. Anticancer agent 272 has potential in the study of bladder cancer .

HY-172892

PI3K-IN-59	PI3K Reactive Oxygen Species (ROS)	Cancer
PI3K-IN-59 (Compound 3d) is a PI3K inhibitor (IC₅₀: 17.44 μM). PI3K-IN-59 has significant antiproliferative activity and exhibits potent inhibitory effects on breast cancer 4T1 cells (IC₅₀: 3.70 μM) and colon cancer CT26 cells (IC₅₀: 1.98 μM) as well as human breast cancer cells (IC₅₀: 19.72 μM). PI3K-IN-59 exerts a dual anti-tumor mechanism by inhibiting PI3Kα enzymatic activity and triggering the Fenton reaction to generate hydroxyl radicals (•OH). PI3K-IN-59 shows promising anti-4T1 tumor effects and is suitable for synergistic targeting studies in breast and colon cancers .

Cat. No.	Product Name	Type

HY-D1151

HKOH-1 2 Publications Verification	Fluorescent Dyes/Probes
HKOH-1 is a highly sensitive green fluorescent probe for the specific detection of ·OH in living cells with a maximum excitation wavelength and emission wavelength of 500 nm and 520 nm, respectively .

HY-129109

NBD-Pen	Fluorescent Dyes/Probes
NBD-Pen is the first fluorescence probe for lipid radicals with high selectivity and sensitivity (λ_ex: 470 nm, λ_em: 530 nm). NBD-Pen specifically detects lipid derived radicals over other reactive species present in biological systems, including H₂O₂, ClO ^-, O₂ ^-∙, and ∙OH. NBD-Pen directly detects lipid radicals in living cells by turn-on fluorescence. NBD-Pen decreases inflammation, apoptosis, and oxidative stress markers. NBD-Pen can be studied in various disease models such as hepatic carcinoma .

NBD-Pen

Fluorescent Dyes/Probes

NBD-Pen is the first fluorescence probe for lipid radicals with high selectivity and sensitivity (λ_ex: 470 nm, λ_em: 530 nm). NBD-Pen specifically detects lipid derived radicals over other reactive species present in biological systems, including H₂O₂, ClO ^-, O₂ ^-∙, and ∙OH. NBD-Pen directly detects lipid radicals in living cells by turn-on fluorescence. NBD-Pen decreases inflammation, apoptosis, and oxidative stress markers. NBD-Pen can be studied in various disease models such as hepatic carcinoma .

Cat. No.	Product Name	Target	Research Area

HY-145779A

H-Glu(Met-OH)-OH TFA γ-Glu-Met TFA	Peptides	Metabolic Disease
H-Glu(Met-OH)-OH TFA (γ-Glu-Met TFA) could induce oxidation of hydroxyl radical .

HY-145779

H-Glu(Met-OH)-OH γ-Glu-Met	Biochemical Assay Reagents	Metabolic Disease
H-Glu(Met-OH)-OH (γ-Glu-Met) could induce oxidation of hydroxyl radical .

HY-P4531

H-Ser-Tyr-OH	Opioid Receptor	Neurological Disease
H-Ser-Tyr-OH is a dipeptide consisting of glutamic acid, glycine and histidine. H-Ser-Tyr-OH can form a copper(II) complex with copper ions to form a strong free radical scavenging activity. H-Ser-Tyr-OH also increases the intracellular uptake of the delta opioid receptor ligand deltorphin .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W027951

N,N'-Dimethylthiourea 1 Publications Verification DMTU	Structural Classification Natural Products Liliaceae Classification of Application Fields Source classification Allium sativum Linn. Plants Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species (ROS)
N,N'-Dimethylthiourea (DMTU), isolated from Allium sativum, is an orally active scavenger of hydroxyl radical (•OH) and blocks •OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including •OH scavenging and anti-inflammatory action .

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