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Results for "

OATP1B1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (2) Bacterial (1) BCRP (3) Biochemical Assay Reagents (2) CaSR (2) Cytochrome P450 (1) Drug Metabolite (2) Endogenous Metabolite (2) HCV (4) HMG-CoA Reductase (HMGCR) (1) Isotope-Labeled Compounds (1) OAT (3) P-glycoprotein (1) PPAR (1) URAT1 (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Endocrinology (2) Infection (7) Inflammation/Immunology (2) Metabolic Disease (9)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W002438

6-Hydroxyindole	Biochemical Assay Reagents Endogenous Metabolite	Inflammation/Immunology
6-Hydroxyindole is a biochemical reagent. 6-hydroxyindole is an endogenous long-lasting *OATP1B1* inhibitor, and is elevated plasma of the renal failure patients .

HY-125348

6α-Hydroxy paclitaxel	Drug Metabolite	Cancer
6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion–transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of *OATP1B3*. 6α-Hydroxy paclitaxel can be used for the research of cancer .

HY-108347

CP-100356 hydrochloride 5+ Cited Publications	P-glycoprotein BCRP	Metabolic Disease
CP-100356 hydrochloride is an orally active dual MDR1 (P-gp)/BCRP inhibitor, with an IC₅₀s of 0.5 and 1.5 µM for inhibiting MDR1-mediated Calcein-AM transport and BCRP-mediated Prazosin transport, respectively. CP-100356 hydrochloride is also a weak inhibitor of *OATP1B1* (IC₅₀=∼66 µM). CP-100356 hydrochloride is devoid of inhibition against MRP2 and major human P450 enzymes (IC₅₀>15 µM) .

HY-125348S

6α-Hydroxy Paclitaxel-d5	Isotope-Labeled Compounds	Cancer
6α-Hydroxy Paclitaxel-d₅ is the deuterium labeled 6α-Hydroxy paclitaxel. 6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion-transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer .

HY-N8497

Leoidin	Bacterial	Infection
Leoidin is an *OATP1B1* and *OATP1B3* inhibitor with K_i values of 0.08 and 1.84 μM，respectively. Leoidin inhibits sodium fluorescein uptake in CHO cells expressing the human OATP1B1 and OATP1B3. Leoidin is an antibacterial agent against both Gram-positive and Gram-negative pathogens. Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) (IC₅₀= 42 μM) and inhibits protein synthesis in bacterial. Leoidin can be isolated from L. gangaleoides .

HY-138142

Euphol acetate	OAT	Metabolic Disease
Euphol acetate is a triterpene that can be isolated from Euphorbia broteri. Euphol acetate is an inhibitor of hepatic transport proteins organic anion-transporting polypeptide 1/3 (OATP1B1/3) .

HY-W002438R

6-Hydroxyindole (Standard)	Biochemical Assay Reagents Endogenous Metabolite	Inflammation/Immunology
6-Hydroxyindole (Standard) is the analytical standard of 6-Hydroxyindole. This product is intended for research and analytical applications. 6-Hydroxyindole is a biochemical reagent. 6-hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor, and is elevated plasma of the renal failure patients .

HY-155668

HMG-CoA Reductase-IN-1	HMG-CoA Reductase (HMGCR)	Metabolic Disease
HMG-CoA Reductase-IN-1 is a HMG-CoA reductase inhibitor. HMG-CoA Reductase-IN-1has high HMGR inhibitory activity and *OATP1B1* affinity with pIC₅₀ and pKm values of 8.54 and 1.98, respectively. HMG-CoA Reductase-IN-1 can be used for the research of hypercholesterolemia .

HY-173231

hURAT1 inhibitor 2	URAT1	Metabolic Disease
hURAT1 inhibitor 2 (Compound 5) is an inhibitor of hURAT1 (uric acid transporter 1, SLC22A12) with an IC₅₀ of 18 nM. hURAT1 inhibitor 2 also has a certain inhibitory effect on *OATP1B1, with an IC₅₀* value of 0.73 μM. hURAT1 inhibitor 2 can be used in the research of diseases related to abnormal uric acid metabolism, such as hyperuricemia and gout .

HY-16278A

Pradigastat sodium LCQ 908 sodium	Acyltransferase BCRP OAT	Infection Metabolic Disease
Pradigastat sodium (LCQ 908 sodium) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC₅₀ at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited *BCRP, OATP1B1, OATP1B3 and OAT3* activities with IC₅₀ of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro .

HY-16278

Pradigastat 2 Publications Verification LCQ-908	Acyltransferase BCRP OAT	Infection Metabolic Disease
Pradigastat (LCQ-908) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC₅₀ at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited *BCRP, OATP1B1, OATP1B3 and OAT3* activities with IC₅₀ of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro .

HY-14752

Ronacaleret SB 751689	CaSR	Metabolic Disease Endocrinology
Ronacaleret (SB 751689) is an orally active, potent, and selective calcium-sensing receptor (CaSR) antagonist that stimulates endogenous parathyroid hormone release from the parathyroid glands. Ronacaleret (SB 751689) is used for the study of postmenopausal osteoporosis .

HY-15104

Ronacaleret hydrochloride SB 751689A	CaSR	Metabolic Disease Endocrinology
Ronacaleret hydrochloride (SB 751689A) is an orally active, potent, and selective calcium-sensing receptor (CaSR) antagonist that stimulates endogenous parathyroid hormone release from the parathyroid glands. Ronacaleret hydrochloride (SB 751689A) is used for the study of postmenopausal osteoporosis .

HY-10465R

Daclatasvir (dihydrochloride) (Standard)	HCV	Infection
Daclatasvir (dihydrochloride) (Standard) is the analytical standard of Daclatasvir (dihydrochloride). This product is intended for research and analytical applications. Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is a potent and orally active HCV NS5A protein inhibitor with EC₅₀s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir dihydrochloride is also an organic anion transporting polypeptide 1B (OATP1B) and *OATP1B3* inhibitor with IC₅₀s of 1.5 µM and 3.27 µM, respectively .

HY-10466R

Daclatasvir (Standard) BMS-790052 (Standard); EBP 883 (Standard)	HCV	Infection
Daclatasvir (Standard) is the analytical standard of Daclatasvir. This product is intended for research and analytical applications. Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 µM and 3.27 µM, respectively .

HY-10466

Daclatasvir Maximum Cited Publications 46 Publications Verification BMS-790052; EBP 883	HCV	Infection
Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC₅₀s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and *OATP1B3* inhibitor with IC₅₀s of 1.5 µM and 3.27 µM, respectively .

HY-10465

Daclatasvir dihydrochloride Maximum Cited Publications 46 Publications Verification BMS-790052 dihydrochloride; EBP 883 dihydrochloride	HCV	Infection
Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is a potent and orally active HCV NS5A protein inhibitor with EC₅₀s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir dihydrochloride is also an organic anion transporting polypeptide 1B (OATP1B) and *OATP1B3* inhibitor with IC₅₀s of 1.5 μM and 3.27 μM, respectively .

HY-129993

Gemfibrozil 1-O-β-glucuronide	PPAR Cytochrome P450 Drug Metabolite	Cardiovascular Disease Metabolic Disease
Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC₅₀ of 4.07 μM .

Cat. No.	Product Name	Type

HY-W002438

6-Hydroxyindole	Biochemical Assay Reagents
6-Hydroxyindole is a biochemical reagent. 6-hydroxyindole is an endogenous long-lasting *OATP1B1* inhibitor, and is elevated plasma of the renal failure patients .

HY-W002438R

6-Hydroxyindole (Standard)	Biochemical Assay Reagents
6-Hydroxyindole (Standard) is the analytical standard of 6-Hydroxyindole. This product is intended for research and analytical applications. 6-Hydroxyindole is a biochemical reagent. 6-hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor, and is elevated plasma of the renal failure patients .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W002438

6-Hydroxyindole	Structural Classification Alkaloids Monophenols Classification of Application Fields Source classification Phenols Endogenous metabolite Inflammation/Immunology Disease Research Fields Indole Alkaloids	Biochemical Assay Reagents Endogenous Metabolite
6-Hydroxyindole is a biochemical reagent. 6-hydroxyindole is an endogenous long-lasting *OATP1B1* inhibitor, and is elevated plasma of the renal failure patients .

HY-N8497

Leoidin	Structural Classification Monophenols Microorganisms Source classification Phenols	Bacterial
Leoidin is an *OATP1B1* and *OATP1B3* inhibitor with K_i values of 0.08 and 1.84 μM，respectively. Leoidin inhibits sodium fluorescein uptake in CHO cells expressing the human OATP1B1 and OATP1B3. Leoidin is an antibacterial agent against both Gram-positive and Gram-negative pathogens. Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) (IC₅₀= 42 μM) and inhibits protein synthesis in bacterial. Leoidin can be isolated from L. gangaleoides .

HY-138142

Euphol acetate	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Metabolic Disease Plants Disease Research Fields	OAT
Euphol acetate is a triterpene that can be isolated from Euphorbia broteri. Euphol acetate is an inhibitor of hepatic transport proteins organic anion-transporting polypeptide 1/3 (OATP1B1/3) .

HY-W002438R

6-Hydroxyindole (Standard)	Structural Classification Alkaloids Monophenols Source classification Phenols Endogenous metabolite Indole Alkaloids	Biochemical Assay Reagents Endogenous Metabolite
6-Hydroxyindole (Standard) is the analytical standard of 6-Hydroxyindole. This product is intended for research and analytical applications. 6-Hydroxyindole is a biochemical reagent. 6-hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor, and is elevated plasma of the renal failure patients .

Cat. No.	Product Name	Chemical Structure

HY-125348S

6α-Hydroxy Paclitaxel-d5
6α-Hydroxy Paclitaxel-d₅ is the deuterium labeled 6α-Hydroxy paclitaxel. 6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion-transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer .

6α-Hydroxy Paclitaxel-d5

6α-Hydroxy Paclitaxel-d₅ is the deuterium labeled 6α-Hydroxy paclitaxel. 6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion-transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer .

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OATP1B1

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products