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By Targets:	BCL6 (1) Biochemical Assay Reagents (2) Drug Metabolite (1) Endogenous Metabolite (8) Endothelin Receptor (2) Fluorescent Dye (2) Histone Acetyltransferase (1) iGluR (1) Isotope-Labeled Compounds (1) MDM-2/p53 (1) Molecular Glues (1) Nucleoside Antimetabolite/Analog (1) PD-1/PD-L1 (1) Prion Protein (2) Ras (1) Ser/Thr Kinase (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (3) Endocrinology (4) Infection (2) Inflammation/Immunology (1) Metabolic Disease (6) Neurological Disease (2)

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Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113367

Suberylglycine	Endogenous Metabolite	Metabolic Disease
Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid.

HY-113085

3-Hydroxyhippuric acid	Endogenous Metabolite	Others
3-Hydroxyhippuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids.

HY-17551

NMDA Maximum Cited Publications 22 Publications Verification N-Methyl-D-aspartic acid	iGluR Endogenous Metabolite	Neurological Disease
NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.

HY-113367S

Suberylglycine-d4	Endogenous Metabolite	Metabolic Disease
Suberylglycine-d₄ is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid .

HY-129738

I942	Ras	Cardiovascular Disease
I942 is a first in class, selective non-cyclic nucleotide (NCN) EPAC1 agonist. I942 can attenuate proinflammatory cytokine signalling normally associated with cardiovascular diseases .

HY-N2514

α-Lactose α-D-Lactose	Others	Others
α-Lactose (α-D-Lactose) is the major sugar present in milk. Lactose exists in the form of two anomers, α and β. The α form normally crystallizes as a monohydrate .

HY-113367S1

Suberylglycine-d2	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Suberylglycine-d₂ is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid .

HY-124003

Phytomonic acid	Endogenous Metabolite	Inflammation/Immunology
Phytomonic acid is a long-chain fatty acid containing a cyclopropane ring produced by Lactobacillus reuteri. Lactobacilli that normally produce Lactobacillic acid also have the ability to resist TNF-α .

HY-124375

IND81	Prion Protein	Infection
IND81 is an orally active antiprion with IC₅₀ value of 1.95 μM. IND81 reduces abnormal, misfolded, disease-causing forms of benign prion proteins that are normally present on or within cells .

HY-113085R

3-Hydroxyhippuric acid (Standard)	Endogenous Metabolite	Others
3-Hydroxyhippuric acid (Standard) is the analytical standard of 3-Hydroxyhippuric acid. This product is intended for research and analytical applications. 3-Hydroxyhippuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids.

HY-N9457R

Norcholic acid (Standard)	Endogenous Metabolite	Metabolic Disease Endocrinology
Ethambutol (dihydrochloride) (Standard) is the analytical standard of Ethambutol (dihydrochloride). This product is intended for research and analytical applications. 0

HY-N9457

Norcholic acid 1 Publications Verification	Others	Metabolic Disease Endocrinology
Norcholic acid is a normal minorbile C23 bile acid having four side chain and exsits in human urine and meconium. Norcholic acid can become prominent under certain pathological conditions. Norcholic acid is efficiently absorbed from intestine and quickly excreted into the bile but not into urine .

HY-157549

Brivoligide AYX1	Nucleoside Antimetabolite/Analog	Neurological Disease
Brivoligide (AYX1) is a double-stranded, unprotected, 23 base-pair oligonucleotide. Brivoligide can reduce acute post-surgical pain. Brivoligide mimics the DNA sequence normally bound by EGR1 on chromosomes .

HY-117856

IND24	Prion Protein	Infection
IND24 is a potent antiprion agent with an EC₅₀ value of 1.27 µM. IND24 decreases abnormal, misfolded, pathogenic forms of benign normally occurring prion protein on the cell surface or inside the cell .

HY-136886

IR-820 1 Publications Verification New Indocyanine Green	Fluorescent Dye	Cancer
IR-820 (New Indocyanine Green) is an infrared blood pool contrast agent. IR-820 also is normally used as a laser and near-infrared dye to detect and quantify diseased tissue in live animals .

HY-114231

Exaluren ELX-02; NB-124	Others	Others
Exaluren (ELX-02) is an synthetic eukaryotic ribosome-selective glycoside that induces read through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren is used for the research of cystic fibrosis caused by nonsense mutations .

HY-P1235A

Carperitide acetate 3 Publications Verification Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate	Endothelin Receptor	Cardiovascular Disease Endocrinology
Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide acetate inhibits endothelin-1 secretion in a dose-dependent way.

HY-120972

Pentafluorobenzenesulfonyl fluorescein	Fluorescent Dye	Others
Pentafluorobenzenesulfonyl fluorescein is a H₂O₂-selective sensor that can be used to detect H₂O₂ levels in cells. Pentafluorobenzenesulfonyl fluorescein is normally non-fluorescent but fluoresces upon perhydrolysis of the sulfonyl linkage by H₂O₂ .

HY-138054

Cjoc42	MDM-2/p53	Cancer
Cjoc42 is a compound capable of binding to gankyrin. Cjoc42 inhibits gankyrin activity in a dose-dependent manner. Cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin. Cjoc42 restores p53-dependent transcription and sensitivity to DNA damage .

HY-P1235

Carperitide Atrial Natriuretic Peptide (ANP) (1-28), human, porcine	Endothelin Receptor	Cardiovascular Disease Endocrinology
Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) inhibits endothelin-1 secretion in a dose-dependent way.

HY-P5435

LKBtide	Ser/Thr Kinase	Others
LKBtide is a biological active peptide. (This is a peptide substrate that is phosphorylated by Serine/Threonine kinase 11 (STK11), also known as LKB1. LKBtide is derived from sucrose non-fermenting 1 (SNF1) protein kinase, which is normally activated by the LKB1/AMP-activated protein kinase (AMPK) signaling pathway.)

HY-P9902A

Pembrolizumab (anti-PD-1) 2 Publications Verification MK-3475 (anti-PD-1); Lambrolizumab (anti-PD-1)	PD-1/PD-L1	Cancer
Pembrolizumab (anti-PD-1) is a humanized IgG4 antibody and PD-1 inhibitor. Pembrolizumab produces PD-1 blockade, preventing PD-L1 and PD-L2 from connecting to PD-1. This avoids the uncontrolled regulation of T cells on cells that normally express PD-1 .

HY-173552

TCIP3	Molecular Glues Histone Acetyltransferase BCL6	Cancer
TCIP3 is a bivalent molecular glue with with dual binding to p300/CBP and BCL6. TCIP3 redirects p300 and CBP to activate programmed cell death genes normally repressed by the oncogenic driver, BCL6. TCIP3 can be used for the study of diffuse large B cell lymphomas (DLBCLs). TCIP3 exhibits no toxicity in non-transformed tonsillar lymphocytes or fibroblasts .

HY-157053

[Ru(dppn)2phen](PF6)2	Biochemical Assay Reagents	Cancer
[Ru(dppn)2phen](PF6)2 (compound 4) is a polypyridylruthenium compound used in photodynamic therapy (PDT). [Ru(dppn)2phen](PF6)2 is normally nontoxic under dark conditions and induces mitochondrial respiratory damage upon light exposure. [Ru(dppn)2phen](PF6)2 exhibits high levels of singlet oxygen quantum yield and phototoxicity against cancer cells .

HY-N13366

3-Methylcrotonyl CoA	Drug Metabolite	Metabolic Disease
3-Methylcrotonyl CoA is a key metabolic intermediate in the leucine degradation pathway, converted to 3-Methylglutaconyl CoA by 3-Methylcrotonyl CoA Carboxylase. Normally, 3-Methylglutaconyl CoA is catalyzed by 3-Methylglutaconyl-CoA Hydratase into 3-Hydroxy-3-methylglutaryl-CoA (HMG CoA). However, mutations in 3-Methylglutaconyl-CoA Hydratase lead to the accumulation of 3-Methylglutaconyl CoA, causing metabolic disorders associated with 3MGA-uria. 3-Methylcrotonyl CoA is useful for research into metabolic diseases related to the leucine degradation pathway .

HY-116762

N-butyryl-L-Homocysteine thiolactone	Biochemical Assay Reagents	Others
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. The control of bacterial infection by quenching the quorum sensing system of bacteria is a promising research area. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR protein family, is coordinated by the synthesis of diffusible acyl homoserine lactone (AHL) molecules. N-butyryl-L-Homocysteine thio-lactone is an analog of N-butyryl-L-homoserine lactone, a small, diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and cellular metabolism . N-butyryl-L-homocysteine thiolactone induces violacein expression in Viola viola mutants that normally fail to produce AHL.

Cat. No.	Product Name

HY-L031

Small Molecule Immuno-Oncology Compound Library	630 compounds
Immuno-Oncology is a type of immunotherapy that has the specific purpose of treating cancer. It works by stimulating our immune system to fight back. Normally, our immune system is able to destroy cancer cells in our body, however sometimes cancer cells can adapt and mutate, effectively hiding from our immune system. This is when tumors can develop and become a threat to our health. Immuno-oncology involves mobilizing lymphocytes to recognize and eliminate cancer cells using the body’s immune system. There are several immuno-oncology treatments available, including Immune cell therapy (CAR-T), monoclonal antibodies (mABs) and checkpoint inhibitors, cytokines and cancer vaccines. MCE Small Molecule Immuno-Oncology Compound Library offers 630 bioactive tumor immunology compounds that target some important checkpoints such as PD1/PD-L1, CXCR, Sting, IDO, TLR, etc. This library is a useful tool for Immuno-oncology research.

Small Molecule Immuno-Oncology Compound Library

630 compounds

Immuno-Oncology is a type of immunotherapy that has the specific purpose of treating cancer. It works by stimulating our immune system to fight back. Normally, our immune system is able to destroy cancer cells in our body, however sometimes cancer cells can adapt and mutate, effectively hiding from our immune system. This is when tumors can develop and become a threat to our health. Immuno-oncology involves mobilizing lymphocytes to recognize and eliminate cancer cells using the body’s immune system. There are several immuno-oncology treatments available, including Immune cell therapy (CAR-T), monoclonal antibodies (mABs) and checkpoint inhibitors, cytokines and cancer vaccines.

MCE Small Molecule Immuno-Oncology Compound Library offers 630 bioactive tumor immunology compounds that target some important checkpoints such as PD1/PD-L1, CXCR, Sting, IDO, TLR, etc. This library is a useful tool for Immuno-oncology research.

Cat. No.	Product Name	Type

HY-136886

IR-820 1 Publications Verification New Indocyanine Green	Fluorescent Dyes/Probes
IR-820 (New Indocyanine Green) is an infrared blood pool contrast agent. IR-820 also is normally used as a laser and near-infrared dye to detect and quantify diseased tissue in live animals .

Cat. No.	Product Name	Type

HY-116762

N-butyryl-L-Homocysteine thiolactone	Microbial Culture
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. The control of bacterial infection by quenching the quorum sensing system of bacteria is a promising research area. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR protein family, is coordinated by the synthesis of diffusible acyl homoserine lactone (AHL) molecules. N-butyryl-L-Homocysteine thio-lactone is an analog of N-butyryl-L-homoserine lactone, a small, diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and cellular metabolism . N-butyryl-L-homocysteine thiolactone induces violacein expression in Viola viola mutants that normally fail to produce AHL.

N-butyryl-L-Homocysteine thiolactone

Microbial Culture

Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. The control of bacterial infection by quenching the quorum sensing system of bacteria is a promising research area. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR protein family, is coordinated by the synthesis of diffusible acyl homoserine lactone (AHL) molecules. N-butyryl-L-Homocysteine thio-lactone is an analog of N-butyryl-L-homoserine lactone, a small, diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and cellular metabolism . N-butyryl-L-homocysteine thiolactone induces violacein expression in Viola viola mutants that normally fail to produce AHL.

Cat. No.	Product Name	Target	Research Area

HY-P1235A

Carperitide acetate 3 Publications Verification Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate	Endothelin Receptor	Cardiovascular Disease Endocrinology
Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine acetate) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide acetate inhibits endothelin-1 secretion in a dose-dependent way.

HY-P1235

Carperitide Atrial Natriuretic Peptide (ANP) (1-28), human, porcine	Endothelin Receptor	Cardiovascular Disease Endocrinology
Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. Carperitide (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine) inhibits endothelin-1 secretion in a dose-dependent way.

HY-P5435

LKBtide	Ser/Thr Kinase	Others
LKBtide is a biological active peptide. (This is a peptide substrate that is phosphorylated by Serine/Threonine kinase 11 (STK11), also known as LKB1. LKBtide is derived from sucrose non-fermenting 1 (SNF1) protein kinase, which is normally activated by the LKB1/AMP-activated protein kinase (AMPK) signaling pathway.)

Cat. No.	Product Name	Target	Research Area

HY-P9902A

Pembrolizumab (anti-PD-1) 2 Publications Verification MK-3475 (anti-PD-1); Lambrolizumab (anti-PD-1)	PD-1/PD-L1	Cancer
Pembrolizumab (anti-PD-1) is a humanized IgG4 antibody and PD-1 inhibitor. Pembrolizumab produces PD-1 blockade, preventing PD-L1 and PD-L2 from connecting to PD-1. This avoids the uncontrolled regulation of T cells on cells that normally express PD-1 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113367

Suberylglycine	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Metabolic Disease Endocrine diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid.

HY-113085

3-Hydroxyhippuric acid	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
3-Hydroxyhippuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids.

HY-17551

NMDA 20+ Cited Publications N-Methyl-D-aspartic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	iGluR Endogenous Metabolite
NMDA is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor.

HY-N2514

α-Lactose α-D-Lactose	Structural Classification Polysaccharides Animals Classification of Application Fields Source classification Other Diseases Disease Research Fields Saccharides	Others
α-Lactose (α-D-Lactose) is the major sugar present in milk. Lactose exists in the form of two anomers, α and β. The α form normally crystallizes as a monohydrate .

HY-N9457

Norcholic acid 1 Publications Verification	Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Others
Norcholic acid is a normal minorbile C23 bile acid having four side chain and exsits in human urine and meconium. Norcholic acid can become prominent under certain pathological conditions. Norcholic acid is efficiently absorbed from intestine and quickly excreted into the bile but not into urine .

HY-124003

Phytomonic acid	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Endogenous Metabolite
Phytomonic acid is a long-chain fatty acid containing a cyclopropane ring produced by Lactobacillus reuteri. Lactobacilli that normally produce Lactobacillic acid also have the ability to resist TNF-α .

HY-113085R

3-Hydroxyhippuric acid (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Endogenous Metabolite
3-Hydroxyhippuric acid (Standard) is the analytical standard of 3-Hydroxyhippuric acid. This product is intended for research and analytical applications. 3-Hydroxyhippuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids.

HY-N9457R

Norcholic acid (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Endogenous Metabolite
Ethambutol (dihydrochloride) (Standard) is the analytical standard of Ethambutol (dihydrochloride). This product is intended for research and analytical applications. 0

HY-N13366

3-Methylcrotonyl CoA	Structural Classification Natural Products Source classification Endogenous metabolite	Drug Metabolite
3-Methylcrotonyl CoA is a key metabolic intermediate in the leucine degradation pathway, converted to 3-Methylglutaconyl CoA by 3-Methylcrotonyl CoA Carboxylase. Normally, 3-Methylglutaconyl CoA is catalyzed by 3-Methylglutaconyl-CoA Hydratase into 3-Hydroxy-3-methylglutaryl-CoA (HMG CoA). However, mutations in 3-Methylglutaconyl-CoA Hydratase lead to the accumulation of 3-Methylglutaconyl CoA, causing metabolic disorders associated with 3MGA-uria. 3-Methylcrotonyl CoA is useful for research into metabolic diseases related to the leucine degradation pathway .

Cat. No.	Product Name	Chemical Structure

HY-113367S

Suberylglycine-d4
Suberylglycine-d₄ is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid .

HY-113367S1

Suberylglycine-d2
Suberylglycine-d₂ is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid .

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Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Natural
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