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Norepinephrine hydrochloride (Standard)

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32

Inhibitors & Agonists

12

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13715R
    Norepinephrine (Standard)

    Levarterenol (Standard); L-Noradrenaline (Standard)

    		 Endogenous Metabolite Adrenergic Receptor Autophagy Cardiovascular Disease Endocrinology Cancer
    Norepinephrine (Standard) is the analytical standard of Norepinephrine. This product is intended for research and analytical applications. Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors .
    Norepinephrine (Standard)
  • HY-B0196AR
    Venlafaxine hydrochloride (Standard)
    1 Publications Verification

    Wy 45030 hydrochloride (Standard)

    		 Serotonin Transporter Neurological Disease Cancer
    Venlafaxine (hydrochloride) (Standard) is the analytical standard of Venlafaxine (hydrochloride). This product is intended for research and analytical applications. Venlafaxine hydrochloride (Wy 45030 hydrochloride) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant .
    Venlafaxine hydrochloride (Standard)
  • HY-113121R
    Vanillylmandelic acid (Standard)

    		Drug Metabolite Endogenous Metabolite Cardiovascular Disease
    Vanillylmandelic acid (Standard) is the analytical standard of Vanillylmandelic acid. This product is intended for research and analytical applications. Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM .
    Vanillylmandelic acid (Standard)
  • HY-13715AR
    Norepinephrine hydrochloride (Standard)

    Levarterenol hydrochloride (Standard); L-Noradrenaline hydrochloride (Standard)

    		 Adrenergic Receptor Autophagy Endogenous Metabolite Cardiovascular Disease Endocrinology Cancer
    Norepinephrine (hydrochloride) (Standard) is the analytical standard of Norepinephrine (hydrochloride). This product is intended for research and analytical applications. Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors[1][2][3][4].
    Norepinephrine hydrochloride (Standard)
  • HY-13715BR
    Norepinephrine bitartrate monohydrate (Standard)

    		Adrenergic Receptor Autophagy Endogenous Metabolite Cardiovascular Disease Endocrinology Cancer
    Norepinephrine (bitartrate monohydrate) (Standard) is the analytical standard of Norepinephrine (bitartrate monohydrate). This product is intended for research and analytical applications. Norepinephrine (Levarterenol; L-Noradrenaline) bitartrate monohydrate is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors .
    Norepinephrine bitartrate monohydrate (Standard)
  • HY-W008794R
    Normetanephrine (hydrochloride) (Standard)

    		Endogenous Metabolite Metabolic Disease
    Normetanephrine (hydrochloride) (Standard) is the analytical standard of Normetanephrine (hydrochloride). This product is intended for research and analytical applications. Normetanephrine ((±)-Normetanephrine) hydrochloride is the O-methylated metabolite of norepinephrine (NE) .
    Normetanephrine (hydrochloride) (Standard)
  • HY-113474R
    3,4-Dihydroxymandelic acid (Standard)

    		Drug Metabolite Endogenous Metabolite Metabolic Disease
    3,4-Dihydroxymandelic acid (Standard) is the analytical standard of 3,4-Dihydroxymandelic acid. This product is intended for research and analytical applications. 3,4-Dihydroxymandelic acid is a metabolite of norepinephrine.
    3,4-Dihydroxymandelic acid (Standard)
  • HY-14560CR
    Reboxetine (mesylate) (Standard)

    		Adrenergic Receptor Neurological Disease
    Reboxetine (mesylate) (Standard) is the analytical standard of Reboxetine (mesylate). This product is intended for research and analytical applications. Reboxetine mesylate (FCE20124 mesylate) is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) for the research of depression. Reboxetine mesylate inhibits the uptake of norepinephrine, with a Ki of 8 nM .
    Reboxetine (mesylate) (Standard)
  • HY-B1272R
    Desipramine (hydrochloride) (Standard)

    		Dopamine Transporter Serotonin Transporter Neurological Disease Cancer
    Desipramine (hydrochloride) (Standard) is the analytical standard of Desipramine (hydrochloride). This product is intended for research and analytical applications. Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively.
    Desipramine (hydrochloride) (Standard)
  • HY-B0161AR
    Duloxetine (hydrochloride) (Standard)

    (S)-Duloxetine hydrochloride (Standard); LY-248686 hydrochloride (Standard)

    		 Serotonin Transporter Neurological Disease Cancer
    Duloxetine (hydrochloride) (Standard) is the analytical standard of Duloxetine (hydrochloride). This product is intended for research and analytical applications. Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .
    Duloxetine (hydrochloride) (Standard)
  • HY-B1308R
    Adrenalone (hydrochloride) (Standard)

    		Adrenergic Receptor Cardiovascular Disease Endocrinology
    Adrenalone (hydrochloride) (Standard) is the analytical standard of Adrenalone (hydrochloride). This product is intended for research and analytical applications. Adrenalone hydrochloride is an adrenergic agonist used as a topical vasoconstrictor and hemostatic. Adrenalone hydrochloride is an inhibitor of dopamine β oxidase. Adrenalone hydrochloride is chemically similar to known norepinephrine transporter (NET) ligands with an IC50 of 36.9 μM .
    Adrenalone (hydrochloride) (Standard)
  • HY-B0932R
    Levocarnitine propionate (hydrochloride) (Standard)

    		Integrin NADPH Oxidase Others
    Adrenalone (hydrochloride) (Standard) is the analytical standard of Adrenalone (hydrochloride). This product is intended for research and analytical applications. Adrenalone hydrochloride is an adrenergic agonist used as a topical vasoconstrictor and hemostatic. Adrenalone hydrochloride is an inhibitor of dopamine β oxidase. Adrenalone hydrochloride is chemically similar to known norepinephrine transporter (NET) ligands with an IC50 of 36.9 μM .
    Levocarnitine propionate (hydrochloride) (Standard)
  • HY-108256R
    Melitracen (hydrochloride) (Standard)

    		5-HT Receptor Neurological Disease
    Melitracen (hydrochloride) (Standard) is the analytical standard of Melitracen (hydrochloride). This product is intended for research and analytical applications. Melitracen hydrochloride is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space .
    Melitracen (hydrochloride) (Standard)
  • HY-135615AR
    Desmethyl Sibutramine (hydrochloride) (Standard)

    		Serotonin Transporter Neurological Disease Metabolic Disease
    Desmethyl Sibutramine (hydrochloride) (Standard) is the analytical standard of Desmethyl Sibutramine (hydrochloride). This product is intended for research and analytical applications. Desmethyl Sibutramine hydrochloride, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine hydrochloride can be used in the research of obesity and appetite suppressant .
    Desmethyl Sibutramine (hydrochloride) (Standard)
  • HY-121212R
    Icosabutate (Standard)

    		Aminotransferases (Transaminases) Metabolic Disease Inflammation/Immunology
    Desmethyl Sibutramine (hydrochloride) (Standard) is the analytical standard of Desmethyl Sibutramine (hydrochloride). This product is intended for research and analytical applications. Desmethyl Sibutramine hydrochloride, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine hydrochloride can be used in the research of obesity and appetite suppressant .
    Icosabutate (Standard)
  • HY-B0562R
    Methyclothiazide (Standard)

    		Carbonic Anhydrase Cardiovascular Disease Metabolic Disease
    Methyclothiazide (Standard) is the analytical standard of Methyclothiazide. This product is intended for research and analytical applications. Methyclothiazide is an orally active antihypertensive agent and a diuretic agent. Methyclothiazide leads to a reduction of the vascular response to the action of endogenous vasoconstricting stimuli, such as Norepinephrine (HY-13715). Methyclothiazide is against voltage-dependent Ca-channel (VDCC) activity in vitro .
    Methyclothiazide (Standard)
  • HY-131527R
    Wy-45494 (hydrochloride) (Standard)

    		Serotonin Transporter Metabolic Disease
    Wy-45494 (hydrochloride) (Standard) is the analytical standard of Wy-45494 (hydrochloride). This product is intended for research and analytical applications. Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.
    Wy-45494 (hydrochloride) (Standard)
  • HY-B0168AR
    Milnacipran hydrochloride (Standard)

    		Reference Standards Serotonin Transporter PERK Neurological Disease
    Milnacipran (hydrochloride) (Standard) is the analytical standard of Milnacipran hydrochloride (HY-B0168A). This product is intended for research and analytical applications. Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia) .
    Milnacipran hydrochloride (Standard)
  • HY-N0913R
    Manninotriose (Standard)

    		Endogenous Metabolite Others
    Wy-45494 (hydrochloride) (Standard) is the analytical standard of Wy-45494 (hydrochloride). This product is intended for research and analytical applications. Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.
    Manninotriose (Standard)
  • HY-129040AR
    Iobenguane (sulfate) (Standard)

    		Adrenergic Receptor Cancer
    Iobenguane (sulfate) (Standard) is the analytical standard of Iobenguane (sulfate). This product is intended for research and analytical applications. Iobenguane sulfate (MIBG sulfate) is an analogue of the neurotransmitter norepinephrine with antitumor activity. Radioiodinated Iobenguane sulfate is clinically used as a tumor-targeted radiopharmaceutical in the diagnosis and treatment of adrenergic tumors. Iobenguane sulfate is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation) .
    Iobenguane (sulfate) (Standard)
  • HY-17385R
    Atomoxetine (hydrochloride) (Standard)

    		Adrenergic Receptor Serotonin Transporter Sodium Channel Neurological Disease Cancer
    Atomoxetine (hydrochloride) (Standard) is the analytical standard of Atomoxetine (hydrochloride). This product is intended for research and analytical applications. Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research .
    Atomoxetine (hydrochloride) (Standard)
  • HY-13458R
    Droxidopa (Standard)

    		Adrenergic Receptor Neurological Disease
    Droxidopa (Standard) is the analytical standard of Droxidopa. This product is intended for research and analytical applications. Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder) .
    Droxidopa (Standard)
  • HY-W438378
    4-Hydroxy-3-methoxyphenylglycol piperazine

    HMPG piperazine

    		 Biochemical Assay Reagents Others
    4-Hydroxy-3-methoxyphenylglycol piperazine (HMPG piperazine) is a salt of HMPG combined with piperazine. HMPG is a metabolite of adrenaline and norepinephrine and is an important marker of catecholamine hormone metabolism in the body. 4-Hydroxy-3-methoxyphenylglycol piperazine is used as a standard in clinical laboratories to accurately measure the HMPG content in urine .
    4-Hydroxy-3-methoxyphenylglycol piperazine
  • HY-N0740R
    Jatrorrhizine chloride (Standard)

    		Cholinesterase (ChE) 5-HT Receptor Bacterial Neurological Disease Inflammation/Immunology
    Jatrorrhizine (chloride) (Standard) is the analytical standard of Jatrorrhizine (chloride). This product is intended for research and analytical applications. Jatrorrhizine chloride is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .
    Jatrorrhizine chloride (Standard)
  • HY-14258AR
    Escitalopram (oxalate) (Standard)

    (S)-Citalopram (oxalate) (Standard); (S)-(+)-Citalopram (oxalate) (Standard)

    		 Serotonin Transporter Neurological Disease Cancer
    Escitalopram (oxalate) (Standard) is the analytical standard of Escitalopram (oxalate). This product is intended for research and analytical applications. Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression .
    Escitalopram (oxalate) (Standard)
  • HY-B0991R
    Amoxapine (Standard)

    CL-67772 (Standard)

    		 Autophagy Bacterial Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
    Amoxapine (Standard) is the analytical standard of Amoxapine. This product is intended for research and analytical applications. Amoxapine (CL-67772) is a norepinephrine reuptake blocker and a 5-HT2/5-HT3 antagonist. Amoxapine can be used for the research of depression. Amoxapine has antibacterial activity. Amoxapine can enhance the killing effect of macrophages on mycobacterium by inducing autophagy, while protecting the cells from death .
    Amoxapine (Standard)
  • HY-B0602R
    Desvenlafaxine (Standard)

    		Serotonin Transporter Neurological Disease
    Desvenlafaxine (Standard) is the analytical standard of Desvenlafaxine. This product is intended for research and analytical applications. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .
    Desvenlafaxine (Standard)
  • HY-N2426R
    Clerodendrin (Standard)

    		Interleukin Related Inflammation/Immunology
    Desvenlafaxine (Standard) is the analytical standard of Desvenlafaxine. This product is intended for research and analytical applications. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .
    Clerodendrin (Standard)
  • HY-B0193AR
    Prazosin hydrochloride (Standard)

    		Adrenergic Receptor Autophagy Cardiovascular Disease Endocrinology Cancer
    Prazosin (hydrochloride) (Standard) is the analytical standard of Prazosin (hydrochloride). This product is intended for research and analytical applications. Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders . Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM .Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8, and 13 μM, respectively .
    Prazosin hydrochloride (Standard)
  • HY-N0126R
    Xanthone (Standard)
    1 Publications Verification

    		 Reference Standards Monoamine Oxidase Calcium Channel Cardiovascular Disease Neurological Disease
    Xanthone (Standard) is the analytical standard of Xanthone (HY-N0126). This product is intended for research and analytical applications. Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC50 of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K +-induced vasoconstriction with IC50 values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca 2+ channels. Xanthone is the scaffold of several pharmacologically active compounds .
    Xanthone (Standard)
  • HY-B0725R
    Doxepin (Hydrochloride) (Standard)

    		Histamine Receptor Cytochrome P450 Neurological Disease Cancer
    Doxepin (Hydrochloride) (Standard) is the analytical standard of Doxepin (Hydrochloride). This product is intended for research and analytical applications. Doxepin hydrochloride is an orally active tricyclic antidepressant agent. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2 . Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant .
    . Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system .
    . Doxepin has also been proposed as a protective factor against oxidative stress .
    .
    Doxepin (Hydrochloride) (Standard)
  • HY-128483R
    Fusaric acid (Standard)

    		TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor Cardiovascular Disease Endocrinology Cancer
    Fusaric acid (Standard) is the analytical standard of Fusaric acid (HY-128483). This product is intended for research and analytical applications. Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β1/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .
    Fusaric acid (Standard)

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