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NiRAN

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-139165A
    AT-9010 tetrasodium
    1 Publications Verification

    		 SARS-CoV Infection
    AT-9010 tetrasodium, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 tetrasodium can inhibit SARS-CoV-2 replication .
    AT-9010 tetrasodium
  • HY-156597
    Arbemnifosbuvir

    AT-752 free base

    		 SARS-CoV Infection
    Arbemnifosbuvir is a nidovirus DdRp-associated nucleotidyltransferase (NiRAN) domain of non-structural protein 12 (nsp12)-interfering drugs. Arbemnifosbuvir can be used for SARS-CoVs infection research .
    Arbemnifosbuvir
  • HY-139165
    AT-9010

    		SARS-CoV Infection
    AT-9010, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 can inhibit SARS-CoV-2 replication .
    AT-9010
  • HY-139165B
    AT-9010 triethylamine

    		SARS-CoV Infection
    AT-9010 triethylamine，a triphosphate active metabolite of AT-527，is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 triethylamine can inhibit SARS-CoV-2 replication .
    AT-9010 triethylamine
  • HY-170649
    RdRP-IN-9

    		SARS-CoV Infection
    RdRP-IN-9 (Compound 6b) is a reversible covalent allosteric inhibitor of RdRp. RdRP-IN-9 demonstrates high anti-coronavirus activity, with an EC50 value of 0.68 μM against HCoV-OC43 RdRP-IN-9 exerts a more prolonged antiviral effect by reversibly acylating Cys12 in the NiRAN domain of non-structural protein 12 (nsp 12) and exhibits synergistic anti-coronavirus activity with Molnupiravir (HY-135853) .
    RdRP-IN-9

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