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Results for "

Na -dependent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Na+/Ca2+ Exchanger (3) Na+/H+ Exchanger (NHE) (3) Na+/K+ ATPase (1) Sodium Channel (24) Adrenergic Receptor (1) Amino acid Transporter (2) Antibiotic (1) Apoptosis (9) Arp2/3 Complex (1) ASCT (1) Bacterial (2) Calcium Channel (3) Checkpoint Kinase (Chk) (1) EAAT (1) Endogenous Metabolite (4) ERK (1) Fungal (1) G protein-coupled Bile Acid Receptor 1 (2) GABA Receptor (8) GlyT (2) Guanylate Cyclase (1) HIV (4) IKK (3) Isotope-Labeled Compounds (3) MDM-2/p53 (2) Mitochondrial Metabolism (4) NF-κB (5) P2Y Receptor (1) Parasite (1) Phosphodiesterase (PDE) (3) PKA (1) PKC (1) Potassium Channel (3) Reference Standards (9)
By Research Areas:	Cancer (20) Cardiovascular Disease (12) Infection (8) Inflammation/Immunology (9) Metabolic Disease (5) Neurological Disease (28)

By Targets:

Na+/Ca2+ Exchanger (3)

Na+/H+ Exchanger (NHE) (3)

Na+/K+ ATPase (1)

Sodium Channel (24)

Adrenergic Receptor (1)

Amino acid Transporter (2)

Antibiotic (1)

Apoptosis (9)

Arp2/3 Complex (1)

ASCT (1)

Bacterial (2)

Calcium Channel (3)

Checkpoint Kinase (Chk) (1)

EAAT (1)

Endogenous Metabolite (4)

ERK (1)

Fungal (1)

G protein-coupled Bile Acid Receptor 1 (2)

GABA Receptor (8)

GlyT (2)

Guanylate Cyclase (1)

HIV (4)

IKK (3)

Isotope-Labeled Compounds (3)

MDM-2/p53 (2)

Mitochondrial Metabolism (4)

NF-κB (5)

P2Y Receptor (1)

Parasite (1)

Phosphodiesterase (PDE) (3)

PKA (1)

PKC (1)

Potassium Channel (3)

Reference Standards (9)

By Research Areas:

Cancer (20)

Cardiovascular Disease (12)

Infection (8)

Inflammation/Immunology (9)

Metabolic Disease (5)

Neurological Disease (28)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Na+/HCO3- Cotransporter Na+/Ca2+ Exchanger Na+/K+ ATPase Na+/H+ Exchanger (NHE) Apical Sodium-Dependent Bile Acid Transporter Sodium Channel NKCC CaMK CDK PKG SNIPERs DNA-PK VDAC SGLT CDKL PDK-1 Pyruvate Oxidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15515

SEA0400 Maximum Cited Publications 18 Publications Verification	Na+/Ca2+ Exchanger	Cardiovascular Disease
SEA0400 is a novel and selective inhibitor of the Na ⁺-Ca ²⁺ exchanger (NCX), inhibiting Na ⁺-dependent Ca ²⁺ uptake in cultured neurons, astrocytes, and microglia with IC₅₀s of from 5 to 33 nM.

HY-B0211

Riluzole 5+ Cited Publications PK 26124	Sodium Channel GABA Receptor	Neurological Disease Cancer
Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na ⁺ channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM.

HY-108504

Co 102862 V 102862	Sodium Channel	Neurological Disease
Co 102862 (V 102862) is a potent, broad-spectrum, state-dependent Na ⁺ channel blocker. Co 102862 is also an orally active anticonvulsant .

HY-B0211A

Riluzole hydrochloride 5+ Cited Publications PK 26124 hydrochloride	Sodium Channel GABA Receptor	Neurological Disease Cancer
Riluzole hydrochloride is an anticonvulsant agent and belongs to the family of use-dependent Na ⁺ channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM.

HY-B0575

Triamterene 5 Publications Verification	Sodium Channel G protein-coupled Bile Acid Receptor 1	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Triamterene blocks epithelial Na ⁺ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene is an inhibitor of the TGR5 receptor .

HY-P10811

Na2+ - Ca2+ Exchanger inhibitory peptide XIP	Na+/Ca2+ Exchanger	Neurological Disease
Na ⁺-Ca ²⁺ Exchanger inhibitory peptide (XIP) is a Na ⁺-Ca ²⁺ exchanger inhibitor with a K_i of 200 nM. Na ⁺-Ca ²⁺ Exchanger inhibitory peptide inhibits the Na ⁺-dependent Ca ²⁺ uptake and the Na ⁺-dependent Ca ²⁺ efflux of sarcolemmal vesicles in a noncompetitive manner .

HY-169688

NA-17	MDM-2/p53 Apoptosis	Cancer
NA-17 is a naphthalimide compound with anti-tumor activity and lower toxicity to normal cells like HL-7702 and WI-38. NA-17 exhibits a *p53*-dependent selective inhibition in various NSCLC cells, inducing the accumulation of active p53 in the mitochondria and nuclei of NSCLC cells. NA-17 can cause cell cycle arrest in the G1 phase, leading to apoptosis and cell death .

HY-101334

MPDC	GlyT	Neurological Disease
MPDC is a potent and competitive inhibitor of the Na ⁺-dependent high-affinity glutamate transporter in forebrain synaptosomes .

HY-101334A

MPDC hydrochloride	GlyT	Neurological Disease
MPDC hydrochloride is a potent and competitive inhibitor of the Na ⁺-dependent high-affinity glutamate transporter in forebrain synaptosomes .

HY-135412

N-Methyl Duloxetine hydrochloride	Sodium Channel	Neurological Disease
N-Methyl Duloxetine hydrochloride is an analgesic. N-Methyl Duloxetine (hydrochloride) elicits both tonic and use-dependent block of neuronal Na ⁺ channels .

HY-B0575S

Triamterene-d5	Sodium Channel	Metabolic Disease
Triamterene-d₅ is deuterium labeled Triamterene, which can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic.

HY-15515R

SEA0400 (Standard)	Na+/Ca2+ Exchanger	Cardiovascular Disease
SEA0400 (Standard) is the analytical standard of SEA0400. This product is intended for research and analytical applications. SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger (NCX), inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50s of from 5 to 33 nM.

HY-N6745

Citreoviridin	Na+/K+ ATPase Apoptosis	Infection Cardiovascular Disease
Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na ⁺/K ⁺-ATPase whereas in microsomes, both Na ⁺/K ⁺-ATPase and Mg ²⁺-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .

HY-B0161C

(R)-Duloxetine (R)-LY248686	Sodium Channel	Neurological Disease
(R)-Duloxetine is a isomer of Duloxetine (HY-B0161) that causes tonic and usage-dependent impairment of neuronal Na ⁺ channels. (R)-Duloxetine can be used in pain research .

HY-134452

MeAIB 2 Publications Verification α-(Methylamino)isobutyric acid	Amino acid Transporter	Cancer
MeAIB (α-(Methylamino)isobutyric acid) is a specific?substrate for amino acid transport system A (ATA1). ATA mediate the uptake of short-chain neutral amino acids in a Na ⁺-dependent manner .

HY-W011391

GPNA hydrochloride 5+ Cited Publications	Apoptosis ASCT	Cancer
GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na ⁺-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na ⁺-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells .

HY-100080

A-887826	Sodium Channel	Neurological Disease
A-887826 is a potent, selective, oral bioavailable and voltage-dependent Na(v)1.8 sodium channel blocker with an IC₅₀ of 11 nM . A-887826 attenuates neuropathic tactile allodynia in vivo .

HY-B0575R

Triamterene (Standard) 5 Publications Verification	Reference Standards Sodium Channel G protein-coupled Bile Acid Receptor 1	Metabolic Disease
Triamterene (Standard) is the analytical standard of Triamterene. This product is intended for research and analytical applications. Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene as an inhibitor of the TGR5 receptor.

HY-B0211AR

Riluzole hydrochloride (Standard)	Sodium Channel GABA Receptor	Neurological Disease Cancer
Riluzole hydrochloride (Standard) is the analytical standard of Riluzole hydrochloride. This product is intended for research and analytical applications. Riluzole hydrochloride is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.

HY-B0211R

Riluzole (Standard) PK 26124 (Standard)	Reference Standards Sodium Channel GABA Receptor	Neurological Disease Cancer
Riluzole (Standard) is the analytical standard of Riluzole. This product is intended for research and analytical applications. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na ⁺ channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM.

HY-W015912S

2-Acetylfuran-d3 2-Furyl methyl ketone-d₃	Isotope-Labeled Compounds	Others
2-Acetylfuran-d₃ is deuterated labeled Citreoviridin (HY-N6745). Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na ⁺/K ⁺-ATPase whereas in microsomes, both Na ⁺/K ⁺-ATPase and Mg ²⁺-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .

HY-16923

Crobenetine BIII-890; BIII-890 CL free acid	Sodium Channel	Neurological Disease
Crobenetine (BIII-890), a benzomorphan derivative, is a potent, selective, and highly use-dependent Na ⁺ channel blocker. Crobenetine displaces ^[3H]BTX from site 2 of the Na ⁺ channel (IC₅₀=49 nM) in rat brain synaptosomes, yet exhibits only low binding affinity for other receptors and ion channels. Crobenetine protects brain tissue from the deleterious effects of focal cerebral ischemia in rodents .

HY-B0211S1

Riluzole-13C6 PK 26124-¹³C₆	Isotope-Labeled Compounds Sodium Channel GABA Receptor	Neurological Disease Cancer
Riluzole- ¹³C₆ (PK 26124- ¹³C₆) is ¹³C labeled Riluzole. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na ⁺ channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM.

HY-B0211S

Riluzole-13C,15N2 PK 26124-¹³C,¹⁵N₂	GABA Receptor Sodium Channel	Neurological Disease
Riluzole- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Riluzole . Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM .

HY-105064C

Zoniporide dihydrochloride CP-597396 dihydrochloride	Na+/H+ Exchanger (NHE)	Cancer
Zoniporide dihydrochloride (CP-597396 dihydrochloride) is a potent and selective inhibitor of highly water-soluble sodium hydrogen exchange type 1 (NHE-1). Zoniporide dihydrochloride inhibits NHE1 dependent 22Na ⁺ uptake in vitro with an IC₅₀ of 14 nM. Zoniporide has antitumor activity .

HY-134452R

MeAIB (Standard)	Amino acid Transporter	Cancer
MeAIB (Standard) is the analytical standard of MeAIB. This product is intended for research and analytical applications. MeAIB (α-(Methylamino)isobutyric acid) is a specific substrate for amino acid transport system A (ATA1). ATA mediate the uptake of short-chain neutral amino acids in a Na+-dependent manner .

HY-100616

cis-ACBD cis-1-Aminocyclobutane-1,3-dicarboxylic acid	Sodium Channel	Neurological Disease
cis-ACBD is a potent and selective inhibitor of the high-affinity, Na ⁺-dependent plasma membrane glutamate transporter. cis-ACBD is a glutamate reuptake inhibitor. cis-ACBD also acts as linear competitive inhibitor of the uptake of D-[3H]aspartate .

HY-B0161CR

(R)-Duloxetine (Standard) (R)-LY248686 (Standard)	Reference Standards Sodium Channel	Neurological Disease
(R)-Duloxetine (Standard) is the analytical standard of (R)-Duloxetine. This product is intended for research and analytical applications. (R)-Duloxetine is a form of Duloxetine (HY-B0161) that causes tonic and usage-dependent impairment of neuronal Na+ channels. (R)-Duloxetine can be used in pain research .

HY-16928R

Cytochalasin B (Standard) Phomin (Standard)	Reference Standards Arp2/3 Complex	Cancer
(R)-Duloxetine (Standard) is the analytical standard of (R)-Duloxetine. This product is intended for research and analytical applications. (R)-Duloxetine is a form of Duloxetine (HY-B0161) that causes tonic and usage-dependent impairment of neuronal Na+ channels. (R)-Duloxetine can be used in pain research .

HY-147377

N-Salicyloyltryptamine	Calcium Channel ERK Potassium Channel Guanylate Cyclase NF-κB	Cardiovascular Disease Neurological Disease Inflammation/Immunology
N-Salicyloyltryptamine acts on voltage-dependent Na ⁺, Ca ²⁺, and K ⁺ ion channels inhibitor. N-Salicyloyltryptamine inhibits K ⁺ currents with an IC₅₀ value of 34.6 μM (I_to). N-Salicyloyltryptamine also exhibits anticonvulsant, anti-inflammatory, analgesic, and vasorelaxation effect ^- .

HY-117572

MRS2567	P2Y Receptor	Others
MRS2567 is a P2Y receptor antagonist with the activity of inhibiting contraction of mouse mesenteric arteries. MRS2567 can inhibit the sustained contraction caused by UTP and UDP, and inhibit the Na ⁺, K ⁺, 2Cl ^- co-transport-dependent signaling pathway, thereby affecting the myogenic tone of mouse mesenteric arteries.

HY-W685943

Heptaminol	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
Heptaminol is a fatty amine with pressor properties and a potential antihypotension agent. Heptaminol is also a competitive inhibitor of norepinephrine uptake and an inhibitor of nicotine-induced catecholamine release (IC₅₀: 650 μM). Heptaminol does not inhibit norepinephrine release induced by 59 mM K ⁺ but rather inhibits high-affinity Na ⁺-dependent norepinephrine uptake .

HY-173567

WJM664	Parasite	Infection
WJM664 is a potent Plasmodium falciparum PfATP4 inhibitor. WJM664 shows strong activity against malaria parasites. WJM664 blocks gamete development and transmission to mosquitoes by inhibiting PfATP4-mediated Na ⁺-dependent ATPase activity, and acts on multiple stages of the malaria parasite life cycle .

HY-105064

Zoniporide 1 Publications Verification CP-597396	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Zoniporide (CP-597396) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits ²²Na ⁺ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC₅₀=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC₅₀ of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease .

HY-106017

Nerispirdine	Potassium Channel Sodium Channel	Neurological Disease
Nerispirdine is an ion channel inhibitor with IC₅₀s of 3.6, 3.7 and 11.9 μM against K(v)1.1, K(v)1.2 and voltage-dependent *Na(+)* channel, respectively. Nerispirdine is a 4-aminopyridine (4-AP, HY-B0604) derivative and can be utilized in research on neurological disorders .

HY-P10228

S-Thanatin	Fungal Bacterial	Infection
S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity. S-Thanatin can inhibit the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, without cytotoxicity. The antibacterial activity of S-Thanatin is not affected by PH value, but monovalent cations (Na ⁺/K ⁺) can reduce its antibacterial activity against Gram-negative bacteria in a dose-dependent manner .

HY-100838

cis-α-(Carboxycyclopropyl)glycine L-CCG III	EAAT	Neurological Disease
cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC₅₀: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na ⁺-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes .

HY-115839

Detajmium Tachmalcor free base	Sodium Channel	Others
Detajmium (Tachmalcor free base) is a Na?-channel blocker with activity to inhibit ventricular conduction and refractoriness. Detajmium (0.3μM) prolongs intraventricular conduction time comparable to propafenone (0.3μM) during sinus rhythm, but the time constant for reaching steady state during rapid ventricular pacing is significantly longer for Detajmium, indicating a unique temporal profile for its heart rate-dependent effects.

HY-13295

Vinpocetine 5+ Cited Publications Ethyl apovincamiNate	Sodium Channel IKK Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits *NF-κB*-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-B1671

(+)-Kavain	GABA Receptor Sodium Channel Calcium Channel	Neurological Disease Metabolic Disease
(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na ⁺ and Ca ²⁺ channels . (+)-Kavain is shown to bind at the α4β2δ GABA_A receptor and potentiate GABA efficacy . (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .

HY-105064R

Zoniporide (Standard) CP-597396 (Standard)	Reference Standards Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Zoniporide (Standard) is the analytical standard of Zoniporide. This product is intended for research and analytical applications. Zoniporide (CP-597396) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22Na+ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC50=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease .

HY-13295S

Vinpocetine-d5	Isotope-Labeled Compounds Sodium Channel IKK Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Vinpocetine-d₅ is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-B1671R

(+)-Kavain (Standard)	Reference Standards GABA Receptor Sodium Channel Calcium Channel	Neurological Disease Metabolic Disease
(+)-Kavain (Standard) is the analytical standard of (+)-Kavain. This product is intended for research and analytical applications. (+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels . (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy . (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .

HY-14183

Vernakalant Hydrochloride 3 Publications Verification RSD1235 hydrochloride	Potassium Channel	Cardiovascular Disease
Vernakalant hydrochloride is a mixed voltage- and frequency-dependent Na ⁺ and atria-preferred K ⁺ channel blocker. IC₅₀ for block by Vernakalant of wild-type and mutant Kv1.5 channels Fractional block is 13.35±0.93 μM, 0.61±0.03 μM, and 1.63±0.09 μM for Kv1.5 channel ^wt, Kv1.5 channel ^I508F, Kv1.5 channel ^T479A, respectively.

HY-162347

Nav1.7-IN-13	Sodium Channel	Neurological Disease
Nav1.7-IN-13 (compound 3g) is a sodium channel inhibitor that significantly inhibits Veratridine (HY-N6691)-induced neuronal activity. Nav1.7-IN-13 inhibits total Na+ current in DRG neurons in a concentration-dependent manner; slows down the activation of Navs. Nav1.7-IN-13 significantly alleviated mechanical pain behavior in a rat model of nerve injury (SNI) and had analgesic activity .

HY-13295R

Vinpocetine (Standard) Ethyl apovincamiNate (Standard)	Reference Standards Sodium Channel IKK Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Vinpocetine (Standard) is the analytical standard of Vinpocetine. This product is intended for research and analytical applications. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits *NF-κB*-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-N0492

α-Lipoic Acid 5+ Cited Publications Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits *NF-κB*-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N6791

KT5823 5+ Cited Publications	PKA PKC Bacterial Apoptosis Antibiotic	Infection Inflammation/Immunology
KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an K_i value of 0.23 μM, it also inhibits PKA and PKC with K_i values of 10 μM and 4 μM, respectively. KT5823 is a Staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na ⁺/I ^- symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation .

HY-N0492A

α-Lipoic Acid sodium 5+ Cited Publications Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Infection Inflammation/Immunology Cancer
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits *NF-κB*-dependent HIV-1 LTR activation . α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-172915

p53 Stabilizer 2	MDM-2/p53 Apoptosis Checkpoint Kinase (Chk)	Cancer
p53 Stabilizer 2 (Compound 17a16) is a p53 stabilizer. p53 Stabilizer 2 induces S-phase arrest and apoptosis in both p53-proficient and p53-deficient cancer cells. p53 Stabilizer 2 induces mitochondrial stress and activates two checkpoint pathways: NA-PKcs-dependent p53 stabilization and ATR-Chk1 axis activation. p53 Stabilizer 2 inhibits tumor growth in p53-deficient xenograft model .

Cat. No.	Product Name

HY-L118

Sodium Channel Blocker Library

161 compounds

Sodium channels conduct sodium ions (Na+) through a cell's plasma membrane that are the source of excitatory currents for the nervous system and muscle. Na channels are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). Dysfunction in voltage-gated sodium channels correlates with neurological and cardiac diseases, including epilepsy, myopathies, pain and cardiac arrhythmias. Sodium channel blockers are used in the treatment of cardiac arrhythmia, pain and convulsion.

MCE offers a unique collection of 161 sodium channel blocker and antagonists, all of which have the identified inhibitory effect on sodium channels. MCE Sodium Channel Blocker Library can be used for neurological and cardiac diseases drug discovery and sodium channel research.

Cat. No.	Product Name	Target	Research Area

HY-P10811

Na2+ - Ca2+ Exchanger inhibitory peptide XIP	Na+/Ca2+ Exchanger	Neurological Disease
Na ⁺-Ca ²⁺ Exchanger inhibitory peptide (XIP) is a Na ⁺-Ca ²⁺ exchanger inhibitor with a K_i of 200 nM. Na ⁺-Ca ²⁺ Exchanger inhibitory peptide inhibits the Na ⁺-dependent Ca ²⁺ uptake and the Na ⁺-dependent Ca ²⁺ efflux of sarcolemmal vesicles in a noncompetitive manner .

HY-P1833

Egg Laying Hormone, aplysia	Peptides	Neurological Disease
Egg Laying Hormone, aplysia is a neuropeptide synthesized by the bag cell neurons, which contains 36 amino acids and can stimulate egglaying and ovulation in Aplysia via electrical discharge triggering of neurons. Egg-laying hormone of Aplysia induces a voltage-dependent slow inward current carried by Na' in an identified motoneuron .

HY-P10228

S-Thanatin	Fungal Bacterial	Infection
S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity. S-Thanatin can inhibit the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, without cytotoxicity. The antibacterial activity of S-Thanatin is not affected by PH value, but monovalent cations (Na ⁺/K ⁺) can reduce its antibacterial activity against Gram-negative bacteria in a dose-dependent manner .

HY-100838

cis-α-(Carboxycyclopropyl)glycine L-CCG III	EAAT	Neurological Disease
cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC₅₀: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na ⁺-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6745

Citreoviridin	Cardiovascular Disease Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Na+/K+ ATPase Apoptosis
Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na ⁺/K ⁺-ATPase whereas in microsomes, both Na ⁺/K ⁺-ATPase and Mg ²⁺-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .

HY-13295

Vinpocetine Maximum Cited Publications 8 Publications Verification Ethyl apovincamiNate	Cardiovascular Disease Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don Apocynaceae Alkaloids Piperidine Alkaloids Disease Research Fields Cancer	Sodium Channel IKK Phosphodiesterase (PDE)
Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits *NF-κB*-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-B1671

(+)-Kavain	Structural Classification Source classification Other Phenylpropanoids Piper methysticum G.Forst. Piperaceae Phenylpropanoids Plants	GABA Receptor Sodium Channel Calcium Channel
(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na ⁺ and Ca ²⁺ channels . (+)-Kavain is shown to bind at the α4β2δ GABA_A receptor and potentiate GABA efficacy . (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .

HY-N0492

α-Lipoic Acid 5+ Cited Publications Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits *NF-κB*-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0492A

α-Lipoic Acid sodium 5+ Cited Publications Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium	Infection Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits *NF-κB*-dependent HIV-1 LTR activation . α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-N0492R

α-Lipoic Acid (Standard) 5+ Cited Publications Thioctic acid (Standard); (±)-α-Lipoic acid (Standard); DL-α-Lipoic acid (Standard)	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Reference Standards NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (Standard) is the analytical standard of α-Lipoic Acid. This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits *NF-κB*-dependent HIV-1 LTR activation . α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells . α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1 .

HY-16928R

Cytochalasin B (Standard) Phomin (Standard)	Structural Classification Natural Products Microorganisms Source classification	Reference Standards Arp2/3 Complex
(R)-Duloxetine (Standard) is the analytical standard of (R)-Duloxetine. This product is intended for research and analytical applications. (R)-Duloxetine is a form of Duloxetine (HY-B0161) that causes tonic and usage-dependent impairment of neuronal Na+ channels. (R)-Duloxetine can be used in pain research .

HY-B1671R

(+)-Kavain (Standard)	Structural Classification Source classification Other Phenylpropanoids Piper methysticum G.Forst. Piperaceae Phenylpropanoids Plants	Reference Standards GABA Receptor Sodium Channel Calcium Channel
(+)-Kavain (Standard) is the analytical standard of (+)-Kavain. This product is intended for research and analytical applications. (+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels . (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy . (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .

HY-13295R

Vinpocetine (Standard) Ethyl apovincamiNate (Standard)	Apocynaceae Alkaloids Piperidine Alkaloids Structural Classification Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don	Reference Standards Sodium Channel IKK Phosphodiesterase (PDE)
Vinpocetine (Standard) is the analytical standard of Vinpocetine. This product is intended for research and analytical applications. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits *NF-κB*-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-N0492AR

α-Lipoic Acid sodium (Standard) Thioctic acid sodium (Standard); (±)-α-Lipoic acid sodium (Standard); DL-α-Lipoic acid sodium (Standard)	Natural Products Source classification Endogenous metabolite	Reference Standards NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
α-Lipoic Acid (sodium) (Standard) is the analytical standard of α-Lipoic Acid (sodium). This product is intended for research and analytical applications. α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4]. α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1[5].

Species:	Human (3)
Tag:	His (3) MBP (1) Fc (1) Flag (1)
Source:	HEK293 (1) E. coli Cell-free (1) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P704117

	SLC34A2 Protein, Human (HEK293, His, mFc) Sodium-dependent phosphate transport protein 2B; Sodium-phosphate transport protein 2B; Na(+)-dependent phosphate cotransporter 2B; Na(+)-dependent phosphate cotransporter 2B; NaPi3b; Sodium/phosphate cotransporter 2B (Na(+)/Pi cotransporter 2B; NaPi-2b); Solute carrier family 34 member 2; SLC34A2	Human	HEK293
	SLC34A2 Protein, Human (HEK293, His, mFc) is the recombinant human-derived SLC34A2 protein, expressed by HEK293, with N-10*His & C-mFc tag.

HY-P702027

	SLC17A3 Protein, Human (sf9, His, MBP, FLAG) SLC17A3; Sodium-dependent phosphate transport protein 4; Na(+)/PI cotransporter 4; Sodium/phosphate cotransporter 4; Solute carrier family 17 member 3	Human	Sf9 insect cells
	SLC17A3 is a voltage-driven organic anion transporter that plays a critical role in the renal proximal tubule. It actively promotes urate secretion and is essential for the elimination of the end products of purine metabolism. SLC17A3 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC17A3 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.

HY-P702435

	SLC23A2 Protein, Human (Cell-Free, His) Solute carrier family 23 member 2; Na(+)/L-ascorbic acid transporter 2; Nucleobase transporter-like 1 protein; Sodium-dependent vitamin C transporter 2; hSVCT2; Yolk sac permease-like molecule 2	Human	E. coli Cell-free
	The SLC23A2 protein is a sodium/ascorbic acid cotransporter that significantly promotes the electrical uptake of vitamin C, with a stoichiometry of 2 Na(+) ions per ascorbic acid molecule. Its role is critical in maintaining cellular vitamin C homeostasis, emphasizing its specific and efficient ascorbic acid transport. SLC23A2 Protein, Human (Cell-Free, His) is the recombinant human-derived SLC23A2 protein, expressed by E. coli Cell-free , with C-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B0575S

Triamterene-d5
Triamterene-d₅ is deuterium labeled Triamterene, which can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic.

HY-B0211S

Riluzole-13C,15N2
Riluzole- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Riluzole . Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM .

HY-W015912S

2-Acetylfuran-d3

2-Acetylfuran-d₃ is deuterated labeled Citreoviridin (HY-N6745). Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na ⁺/K ⁺-ATPase whereas in microsomes, both Na ⁺/K ⁺-ATPase and Mg ²⁺-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .

HY-B0211S1

Riluzole-13C6
Riluzole- ¹³C₆ (PK 26124- ¹³C₆) is ¹³C labeled Riluzole. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na ⁺ channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM.

HY-13295S

Vinpocetine-d5

Vinpocetine-d₅ is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P85302

	NPT1 Antibody (YA4994) SLC17A1; NPT1; Sodium-dependent phosphate transport protein 1; Na; +; /PI cotransporter 1; Na/Pi-4; ReNal Na; +; -dependent phosphate cotransporter 1; ReNal sodium-dependent phosphate transport protein 1; ReNal sodium-phosphate transport protei	WB, ELISA	Human
	NPT1 Antibody (YA4994) is a mouse-derived and non-conjugated monoclonal antibody, targeting to NPT1. It can be applicated for WB, ELISA assays, in the background of human.

HY-P87139

	VGLUT2 Antibody (YA6832) Differentiation associated BNPI antibody; Differentiation associated Na dependent inorganic phosphate cotransporter antibody; Differentiation associated Na(+) dependent inorganic phosphate cotransporter antibody; Differentiation-associated BNPI antibody; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter antibody; DNPI antibody; SLC17A6 antibody; Sodium dependent inorganic phosphate cotransporter antibody; Solute carrier family 17 (Sodium dependent inorganic phosphate cotransporter) member 6 antibody; Solute carrier family 17 member 6 antibody; Differentiation associated BNPI antibody; Differentiation associated Na dependent inorganic phosphate cotransporter antibody; Differentiation associated Na(+) dependent inorganic phosphate cotransporter antibody; Differentiation-associated BNPI antibody; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter antibody; DNPI antibody; SLC17A6 antibody; Sodium dependent inorganic phosphate cotransporter antibody; Solute carrier family 17 (Sodium dependent inorganic phosphate cotransporter) member 6 antibody; Solute carrier family 17 member 6 antibody; Vesicular glutamate transporter 2 antibody; Vesicular glutamate transporter type 2 antibody; VGLU2_HUMAN antibody; VGLUT 2 antibody; VGluT2 antibody	WB, IHC-F, IHC-P	Mouse, Rat

HY-P87140

	VGluT1 Antibody (YA6833) BNPI antibody; Brain specific Na (+) dependent inorganic phosphate cotransporter antibody; Brain specific Na dependent inorganic phosphate cotransporter antibody; Brain-specific Na(+)-dependent inorganic phosphate cotransporter antibody; Slc17a7 antibody; Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 antibody; Solute carrier family 17 member 7 antibody; Vesicular glutamate transporter 1 antibody; VGLU1_HUMAN antibody; VGLUT 1 antibody; BNPI antibody; Brain specific Na (+) dependent inorganic phosphate cotransporter antibody; Brain specific Na dependent inorganic phosphate cotransporter antibody; Brain-specific Na(+)-dependent inorganic phosphate cotransporter antibody; Slc17a7 antibody; Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 antibody; Solute carrier family 17 member 7 antibody; Vesicular glutamate transporter 1 antibody; VGLU1_HUMAN antibody; VGLUT 1 antibody; VGluT1 antibody	WB, IHC-P	Mouse, Rat

HY-P87141

	VGluT1 Antibody (YA6834) BNPI antibody; Brain specific Na (+) dependent inorganic phosphate cotransporter antibody; Brain specific Na dependent inorganic phosphate cotransporter antibody; Brain-specific Na(+)-dependent inorganic phosphate cotransporter antibody; Slc17a7 antibody; Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 antibody; Solute carrier family 17 member 7 antibody; Vesicular glutamate transporter 1 antibody; VGLU1_HUMAN antibody; VGLUT 1 antibody; BNPI antibody; Brain specific Na (+) dependent inorganic phosphate cotransporter antibody; Brain specific Na dependent inorganic phosphate cotransporter antibody; Brain-specific Na(+)-dependent inorganic phosphate cotransporter antibody; Slc17a7 antibody; Solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 antibody; Solute carrier family 17 member 7 antibody; Vesicular glutamate transporter 1 antibody; VGLU1_HUMAN antibody; VGLUT 1 antibody; VGluT1 antibody	IHC-F, IHC-P, WB	Mouse, Rat

HY-P81437

	SLC34A2 Antibody (YA1182) SLC34A2; Sodium-dependent phosphate transport protein 2B; Sodium-phosphate transport protein 2B; Na(+)-dependent phosphate cotransporter 2B; NaPi3b; Sodium/phosphate cotransporter 2B (Na(+)/Pi cotransporter 2B; NaPi-2b); Solute carrier family 34 member 2	IHC-P	Human
	SLC34A2 Antibody (YA1182) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1182), targeting SLC34A2. SLC34A2 Antibody (YA1182) can be used for IHC-P experiment in human background.