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Isoforms Recommended: NUAK2
Results for "

NUAK2

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-156397
    HTH-02-006

    		AMPK YAP Cancer
    HTH-02-006 is a NUAK2 inhibitor, with an IC50 value of 126 nM. HTH-02-006 inhibits NUAK2-mediated signaling by reducing phosphorylation of its substrate MYPT1 at S445 and downstream MLC. HTH-02-006 shows growth inhibitory efficacy in YAP-high cancer cells (HuCCT-1, SNU475). HTH-02-006 significantly suppresses YAP-induced hepatomegaly (reduced liver/body weight ratio) in TetO-YAP S127A transgenic mice and demonstrates significant anti-tumor efficacy in mice bearing HMVP2 prostate cancer allografts. HTH-02-006 can be used for the study of liver cancer and prostate cancer [2].
    HTH-02-006
  • HY-15802
    WZ4003
    5+ Cited Publications

    		 AMPK Cancer
    WZ4003 is the first potent and highly specific NUAK kinase inhibitor with IC50 of 20 nM/100 nM for NUAK1 (ARK5)/NUAK2, without significant inhibition on other 139 kinases.
    WZ4003
  • HY-162708
    KHKI-01128

    		AMPK Cancer
    KHKI-01128 is a NUAK2 inhibitor, with an IC50 of 0.024 μM. KHKI-01128 exhibits potent anticancer activity against SW480 colorectal cancer cells .
    KHKI-01128
  • HY-170360
    UCB9386

    		AMPK JAK Cancer
    UCB9386 is the selective and brain penetrant inhibitor for Nuak1 with a pIC50 of 10.1. UCB9386 inhibits Nuak2 and Kak2 with an inhibition rate of ca. 50% at 10 nM .
    UCB9386
  • HY-12334
    HTH-01-015
    1 Publications Verification

    		 AMPK Cancer
    HTH-01-015 is a selective NUAK1/ARK5 inhibitor (IC50 is 100 nM). HTH-01-015 inhibits NUAK1 with >100-fold higher potency than NUAK2 (IC50 of >10 μM).
    HTH-01-015
  • HY-E70851
    Nuak2 Recombinant Human Active Protein Kinase

    		AMPK Cancer
    NUAK2 is a member of the SNF1/AMP kinase (AMPK) family (serine/threonine kinases) that is regulated by the putative tumor suppressor LKB1 (20-23) and also by death receptor signaling through NF-κB. Nuak2 Recombinant Human Active Protein Kinase is a recombinant Nuak2 protein that can be used to study Nuak2-related functions .
    Nuak2 Recombinant Human Active Protein Kinase
  • HY-RS09649
    Nuak2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Nuak2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nuak2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Nuak2 Rat Pre-designed siRNA Set A
    Nuak2 Rat Pre-designed siRNA Set A
  • HY-RS09647
    NUAK2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NUAK2 Human Pre-designed siRNA Set A contains three designed siRNAs for NUAK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NUAK2 Human Pre-designed siRNA Set A
    NUAK2 Human Pre-designed siRNA Set A
  • HY-RS09648
    Nuak2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Nuak2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nuak2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Nuak2 Mouse Pre-designed siRNA Set A
    Nuak2 Mouse Pre-designed siRNA Set A
  • HY-E70802
    Biotin-Nuak2 Recombinant Human Active Protein Kinase

    		AMPK Cancer
    NUAK2 is a member of the SNF1/AMP kinase (AMPK) family (serine/threonine kinases) that is regulated by the putative tumor suppressor LKB1 (20-23) and also by death receptor signaling through NF-κB. Biotin-Nuak2 Recombinant Human Active Protein Kinase is a recombinant Nuak2 protein that can be used to study Nuak2-related functions, and is biotinylated .
    Biotin-Nuak2 Recombinant Human Active Protein Kinase
  • HY-162709
    KHKI-01215

    		Apoptosis YAP Cancer
    KHKI-01215 is an inhibitor for NUAK2 with an IC50 of 0.052 μM. KHKI-01215 inhibits the proliferation of cancer cell SW480 with an IC50 of 3.16 μM, induces apoptosis in SW480. KHKI-01215 inhibits the YAP signaling pathway .
    KHKI-01215

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