2. Epigenetics PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt
  3. AMPK JAK
  4. UCB9386

UCB9386 is the selective and brain penetrant inhibitor for Nuak1 with a pIC50 of 10.1. UCB9386 inhibits Nuak2 and Kak2 with an inhibition rate of ca. 50% at 10 nM.

For research use only. We do not sell to patients.

UCB9386 Chemical Structure

UCB9386 Chemical Structure

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Based on 1 publication(s) in Google Scholar

UCB9386 Related Antibodies

Top Publications Citing Use of Products

View All AMPK Isoform Specific Products:

View All Isoforms
NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

View All JAK Isoform Specific Products:

View All Isoforms
JAK1 JAK2 JAK3 Tyk2 JAK

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Description

UCB9386 is the selective and brain penetrant inhibitor for Nuak1 with a pIC50 of 10.1. UCB9386 inhibits Nuak2 and Kak2 with an inhibition rate of ca. 50% at 10 nM[1].

Molecular Weight

478.55

Formula

C27H26N8O
Appearance

Solid

Color

Light yellow to yellow

SMILES

C[C@H](C1=CC=CC=C1)N(C(C(N2CC3(CN(C)C3)C2)=N4)=O)C5=C4C=NC(C6=CN=C7C=CC=NN76)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (208.96 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0896 mL 10.4482 mL 20.8965 mL
5 mM 0.4179 mL 2.0896 mL 4.1793 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0896 mL 10.4482 mL 20.8965 mL 52.2411 mL
5 mM 0.4179 mL 2.0896 mL 4.1793 mL 10.4482 mL
10 mM 0.2090 mL 1.0448 mL 2.0896 mL 5.2241 mL
15 mM 0.1393 mL 0.6965 mL 1.3931 mL 3.4827 mL
20 mM 0.1045 mL 0.5224 mL 1.0448 mL 2.6121 mL
25 mM 0.0836 mL 0.4179 mL 0.8359 mL 2.0896 mL
30 mM 0.0697 mL 0.3483 mL 0.6965 mL 1.7414 mL
40 mM 0.0522 mL 0.2612 mL 0.5224 mL 1.3060 mL
50 mM 0.0418 mL 0.2090 mL 0.4179 mL 1.0448 mL
60 mM 0.0348 mL 0.1741 mL 0.3483 mL 0.8707 mL
80 mM 0.0261 mL 0.1306 mL 0.2612 mL 0.6530 mL
100 mM 0.0209 mL 0.1045 mL 0.2090 mL 0.5224 mL
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UCB9386 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UCB9386UCB 9386UCB-9386AMPKJAKAMP-activated protein kinaseJanus kinaseselectivebrain penetrantBALB/c mouseInhibitorinhibitorinhibit

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