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Results for "

MTase

" in MedChemExpress (MCE) Product Catalog:

15

Inhibitors & Agonists

2

Natural
Products

2

Recombinant Proteins

1

Antibodies

1

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-131991
    Benzyl selenocyanate

    		DNA Methyltransferase Cancer
    Benzyl selenocyanate is a chemopreventive agent for various chemically induced tumors in animal models at both the initiation and postinitiation stages. Benzyl selenocyanate is an inhibitor of DNA (cytosine-5)-methyltransferase (Mtase), with an with an IC50 of 8.4 µM .
    Benzyl selenocyanate
  • HY-149362
    MTase-IN-1

    		SARS-CoV Infection
    MTase-IN-1 (compound 26) is a potent and selective inhibitor of coronavirus nsp14 N7-methyltransferases, with an IC50 of 0.72 nM. MTase-IN-1 impairs viral RNA translation and immune evasion .
    MTase-IN-1
  • HY-153719
    NSC111552

    		SARS-CoV Infection
    NSC111552 is a potent SARS-CoV-2 NSP14 MTase inhibitor. NSC111552 inhibits the FL-NAH binding to the SARS-CoV-2 NSP14 MTase with an IC50 of 5.1 μM .
    NSC111552
  • HY-124654
    SS148

    		SARS-CoV Metabolic Disease
    SS148 is a dual inhibitor of nsp14/nsp16 MTase. SS148 significant inhibits nsp10–nsp16 with an IC50 of 1.2 μM .
    SS148
  • HY-134309
    NSC 288387

    		Virus Protease Infection
    NSC 288387 is a pan-flavivirus MTase inhibitor. NSC 288387 binds to the SAM-binding pocket. NSC 288387 inhibits ZIKV with an IC50 of 0.2 μM. NSC 288387 also inhibits viral replication in cell culture .
    NSC 288387
  • HY-150680
    SARS-CoV-2 nsp14-IN-1

    		SARS-CoV Histone Methyltransferase DNA Methyltransferase Infection
    SARS-CoV-2 nsp14-IN-1 (Compound 3) is a prototypic bisubstrate inhibitor of SARS-CoV-2 Nsp14 MTase with an IC50 value of 0.061 μM. SARS-CoV-2 nsp14-IN-1 (Compound 3) has an excellent selectivity profile over a panel of human methyltransferases, can against apanel of 10 human MTases including histone lysine, proteinarginine, and DNA and RNA MTases .
    SARS-CoV-2 nsp14-IN-1
  • HY-N12612
    CNP0296775

    		DNA Methyltransferase Dengue Virus Infection
    CNP0296775 is an inhibitor of dengue virus methyltransferase (DENV MTase) that has the potential to disrupt the viral replication process .
    CNP0296775
  • HY-168441
    NCGC00537446

    		SARS-CoV Infection
    NCGC00537446 is a dual Nsp14 MTase/ExoN inhibitor. NCGC00537446 can be used for the research of SARS-CoV-2 replication and infection .
    NCGC00537446
  • HY-151448
    ZIKV-IN-5

    		Virus Protease Infection
    ZIKV-IN-5 (compound 5c) is a low-cytotoxicity and acid-stable anti-ZIKV agent (EC50=0.71 μM). ZIKV-IN-5 effectively inhibits the activity of ZIKV NS5 MTase .
    ZIKV-IN-5
  • HY-151447
    ZIKV-IN-4

    		Virus Protease Infection
    ZIKV-IN-4 (compound 5b) is a low-cytotoxicity and acid-stable anti-ZIKV agent (EC50=3.49 μM). ZIKV-IN-4 effectively inhibits the activity of ZIKV NS5 MTase .
    ZIKV-IN-4
  • HY-151445
    ZIKV-IN-2

    		DNA Methyltransferase Virus Protease Flavivirus Infection
    ZIKV-IN-2 (compound 3a) is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 38.86 μM. ZIKV-IN-2 inhibits ZIKV replication and infection. ZIKV-IN-2 can be used in research of Zika virus (ZIKV) .
    ZIKV-IN-2
  • HY-151446
    ZIKV-IN-3

    		DNA Methyltransferase Virus Protease Flavivirus Infection
    ZIKV-IN-3 (compound 5a), an andrographolide derivatives, is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 18.34 μM. ZIKV-IN-3 inhibits ZIKV replication and infection. ZIKV-IN-3 can be used in research of Zika virus (ZIKV) .
    ZIKV-IN-3
  • HY-159890
    MTI013

    		SARS-CoV Infection
    MTI013 is a selective SARS-CoV-2 nsp14 Mtase inhibitor (IC50: 2.98 μM) and an antiviral agent (IC50: 10.33 μM in HCoV-229E-infected Huh7 cells). MTI013 also shows a synergistic antiviral effect with the RdRp inhibitor SHEN26 (HY-155488) .
    MTI013
  • HY-RS03909
    Dnmt1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Dnmt1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dnmt1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Dnmt1 Mouse Pre-designed siRNA Set A
    Dnmt1 Mouse Pre-designed siRNA Set A
  • HY-W012078
    5-Methyl-2'-deoxycytidine
    3 Publications Verification

    5-Methyldeoxycytidine

    		 DNA Methyltransferase Endogenous Metabolite Others
    5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells .
    5-Methyl-2'-deoxycytidine

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