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MTH1 Degrader

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-134725
    MTH1 degrader-1

    		DNA/RNA Synthesis Ligands for Target Protein for PROTAC Cancer
    MTH1 degrader-1, a MTH1 aTAG inhibitor, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). MTH1 degrader-1 can be used for synthesis PROTAC aTAG 4531 (HY-163168) .
    MTH1 degrader-1
  • HY-161162
    aTAG 2139

    CFT-2139

    		 DNA/RNA Synthesis Others
    aTAG 2139 (CFT-2139) is an aTAG-based MTH1 fusion protein degrader with a DC50 value of 1.1 nM. aTAG 2139 has a Ki value of 2.1 nM for MTH1 .
    aTAG 2139
  • HY-163168
    aTAG 4531

    CFT-4531

    		 PROTACs DNA/RNA Synthesis Cancer
    aTAG 4531 (CFT-4531) is a potent, selective, and onmechanism tool degrader of MTH1 with DC50 value of 0.28 nM and Ki value of 1.8 nM. The degradation activity is due to the intricate formation of the ternary complex between the MTH1 aTAG, CRBN E3 ligase, and aTAG tool degrader. Red: MTH1 aTAG inhibitor (HY-134725), Blue: CRBN ligand (HY-126457), Black: linker (HY-108374) .
    aTAG 4531
  • HY-161161
    aTAG 2139-NEG

    		DNA/RNA Synthesis Others
    aTAG 2139-NEG (Compound 23) binds to MTH1 and has no degradative activity with a Ki value of 2.0 nM. aTAG 2139-NEG serves as aTAG 2139 negative control .
    aTAG 2139-NEG
  • HY-172265
    FKBP12 PROTAC FM4

    		PROTACs Cancer
    FKBP12 PROTAC FM4 is a PROTAC degrader of MTH1, with a DC50 values of 0.09–0.22 nM. FKBP12 PROTAC FM4 is composed of PROTAC target protein ligand AP1867-3-(aminoethoxy) (HY-129363) (red part), E3 ligase ligand MTH1 ligand 1 (HY-134724) (blue part) and PROTAC Linker t-Boc-N-amido-PEG5-acetic acid (HY-W190962) (black part), among which the conjugate of PROTAC target protein ligand + Linker is FKBP12 Ligand-Linker Conjugate 2 (HY-172266) .
    FKBP12 PROTAC FM4

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