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Results for "

MSI

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) ATM/ATR (1) Bacterial (4) Dengue Virus (1) DNA/RNA Synthesis (11) FAK (1) HBV (1) Phosphatase (4) Small Interfering RNA (siRNA) (7)
By Research Areas:	Cancer (14) Cardiovascular Disease (1) Endocrinology (2) Infection (4) Metabolic Disease (3) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (2) siRNAs (7)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-105088

Pexiganan MSI 78 free base	Bacterial	Infection
Pexiganan (MSI 78 free base) is a synthetic analog of magainin 2. Pexiganan is a potent and orally active broad-spectrum antimicrobial peptide. Pexiganan can be used in the research of infections, such as diabetic foot ulcer infections .

HY-12219B

MSI-1701	Others	Metabolic Disease
MSI-1701 is an analogue of MSI-1436 which can control weight gain and blood glucose level extracted from patent US 7410959 B1.

HY-12219

MSI-1436 Trodusquemine; Aminosterol-1436	Phosphatase	Endocrinology
MSI-1436 is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC₅₀ of appr 1 μM, 200-fold preference over TCPTP (IC₅₀, 224 μM).

HY-RS21378

Msi2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Msi2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Msi2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Msi2 Mouse Pre-designed siRNA Set A Msi2 Mouse Pre-designed siRNA Set A

HY-RS28764

Msi1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Msi1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Msi1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Msi1 Rat Pre-designed siRNA Set A Msi1 Rat Pre-designed siRNA Set A

HY-RS22242

Msi1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Msi1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Msi1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Msi1 Mouse Pre-designed siRNA Set A Msi1 Mouse Pre-designed siRNA Set A

HY-RS27897

Msi2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Msi2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Msi2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Msi2 Rat Pre-designed siRNA Set A Msi2 Rat Pre-designed siRNA Set A

HY-RS08715

MSI2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MSI2 Human Pre-designed siRNA Set A contains three designed siRNAs for MSI2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MSI2 Human Pre-designed siRNA Set A MSI2 Human Pre-designed siRNA Set A

HY-RS08714

MSI1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MSI1 Human Pre-designed siRNA Set A contains three designed siRNAs for MSI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MSI1 Human Pre-designed siRNA Set A MSI1 Human Pre-designed siRNA Set A

HY-105088A

Pexiganan acetate MSI 78	Bacterial	Infection
Pexiganan acetate (MSI 78) is the acetate salt form of Pexiganan (HY-105088). Pexiganan acetate is an orally active broad-spectrum antimicrobial peptide, which inhibits 99% gram-positive and Gram-negative aerobic bacteria through disruption of cell membrane/cells permeability. Pexiganan acetate can be used in the research of infections, such as diabetic foot ulcer infections .

HY-12219A

MSI-1436 lactate Maximum Cited Publications 6 Publications Verification Trodusquemine lactate; Aminosterol-1436 lactate	Phosphatase	Endocrinology
MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC₅₀ of 1 μM, 200-fold preference over TCPTP (IC₅₀ of 224 μM).

HY-16468

Squalamine MSI-1256	Bacterial HBV FAK Dengue Virus	Infection Neurological Disease Cancer
Squalamine (MSI-1256) is an aminosterol compound with broad-spectrum antiviral activity. Squalamine makes cells less conducive to certain viral replication by altering the electrostatic interactions in the inner membrane of host cells. Squalamine also has antibacterial and antitumor activities. Squalamine has broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria, fungi and protozoa. Squalamine inhibits tumor-related angiogenesis and the growth of human breast cancer cells. Squalamine restores the function of enteric nervous system in Parkinson ^,s disease mouse models .

HY-16467

Squalamine lactate MSI-1256F	Bacterial	Infection Cardiovascular Disease Cancer
Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

HY-163941

GSK_WRN2	DNA/RNA Synthesis	Cancer
GSK_WRN2 is a potent and selective covalent WRN helicase inhibitor that suppresses replication stress caused by DNA (TA)_n dinucleotide repeat expansions. GSK_WRN2 can be used to study microsatellite instability (MSI) cancers .

HY-163942

GSK_WRN4	DNA/RNA Synthesis	Cancer
GSK_WRN4 is a WRN helicase inhibitor (pIC₅₀=7.6) with anticancer activity. GSK_WRN4 selectively inhibits the growth of MSI tumor cells in vitro and in vivo by inducing DNA double-strand breaks, particularly at expanded TA repeats and DNA damage regions .

HY-162471

GSK_WRN3	DNA/RNA Synthesis ATM/ATR	Cancer
GSK_WRN3 is selective WRN helicase inhibitor (pIC₅₀ = 8.6). SK_WRN3 can selectively inhibit the growth of microsatellite unstable (MSI) cancer cells, induce DNA damage, and cause cell cycle arrest. GSK_WRN3 has anti-tumor activity .

HY-108466

Ro 08-2750 3 Publications Verification	Apoptosis	Neurological Disease Cancer
Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC₅₀ of ~ 1 μM. Ro 08-2750 inhibits NGF binding to p75 ^NTR selectively over TRKA . Ro 08-2750 is a selective _{MSI RNA-binding} activity inhibitor, with an IC₅₀ of 2.7 μM .

HY-121515A

DPM-1001 trihydrochloride	Phosphatase	Metabolic Disease
DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC₅₀ of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydrochloride has anti-diabetic property .

HY-121515

DPM-1001	Phosphatase	Metabolic Disease
DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC₅₀ of 100 nM. DPM-1001 is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 has anti-diabetic property .

HY-RS18892

Ebp Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ebp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ebp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ebp Mouse Pre-designed siRNA Set A Ebp Mouse Pre-designed siRNA Set A

HY-119734

Gossypolone	DNA/RNA Synthesis	Cancer
Gossypolone is an RNA-binding protein Musashi-1 inhibitor with a K_i of 12 nM. Gossypolone disrupts the Musashi-numb RNA interaction and directly binds to the RBD1 of MSI1 protein. Gossypolone can be used for the research of cancer .

HY-169422

GSK4418959 IDE275	DNA/RNA Synthesis	Cancer
GSK4418959 (IDE275) is a non-covalent, reversible, selective and orally active WRN helicase inhibitor. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer .

HY-161386

WRN inhibitor 7	DNA/RNA Synthesis	Cancer
WRN inhibitor 7 (Compound h6) is a WRN inhibitor. WRN inhibitor 7 effectively inhibits WRN's helicase and ATPase activity (IC₅₀: 9.8 μM and 15.8 μM respectively). WRN inhibitor 7 can be used for research of microsatellite instable (MSI) cancers .

HY-156581

WRN inhibitor 5	DNA/RNA Synthesis	Cancer
WRN inhibitor 5, a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor. WRN inhibitor 5 can be used for the research of cancer, including cancers characterized by microsatellite instability (MSI) and/or defective DNA mismatch repair system (dMMR) .

HY-174217

WRN-IN-19	DNA/RNA Synthesis	Cancer
WRN-IN-19 (Compound (S)-27) is a covalent WRN helicase inhibitor, with pIC50 (0 h/4 h) = 5.4/7.5 in the DNA-unwinding 5 endpoint assays. WRN-IN-19 shows synthetic lethality in MSI-H (high microsatellite instability) cancer cells .

HY-156784

ATX968 DHX9-IN-2	DNA/RNA Synthesis	Cancer
ATX968 (example 31) is an orally active, potent and selective inhibitor of ATP-dependent RNA helicase A (DHX9), with the EC₅₀ of 0.054 μM in circBRIP1. ATX968 results in robust and durable tumor growth inhibition or regression in mouse xenograft studies with MSI-H/dMMR colorectal cancer cell lines .

HY-168934

KWR137	DNA/RNA Synthesis	Cancer
KWR137 is a WRN degrader, with an IC₅₀ of 8 nM. KWR137 exhibits good anti-proliferative activity against MSI-H cells, with a GI₅₀ of 509 nM in SW48 cells and a GI₅₀ of 824 μM in HCT116 cells. It also demonstrates anti-tumor growth effects in xenograft mouse models. KWR137 can be used for cancer research .

HY-158116

VVD-214 RO7589831; VVD-133214	DNA/RNA Synthesis	Cancer
VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase with an IC₅₀ of 0.1316 µM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers .

Cat. No.	Product Name	Target	Research Area

HY-105088

Pexiganan MSI 78 free base	Bacterial	Infection
Pexiganan (MSI 78 free base) is a synthetic analog of magainin 2. Pexiganan is a potent and orally active broad-spectrum antimicrobial peptide. Pexiganan can be used in the research of infections, such as diabetic foot ulcer infections .

HY-105088A

Pexiganan acetate MSI 78	Bacterial	Infection
Pexiganan acetate (MSI 78) is the acetate salt form of Pexiganan (HY-105088). Pexiganan acetate is an orally active broad-spectrum antimicrobial peptide, which inhibits 99% gram-positive and Gram-negative aerobic bacteria through disruption of cell membrane/cells permeability. Pexiganan acetate can be used in the research of infections, such as diabetic foot ulcer infections .

Pexiganan MSI 78 free base	Infection Structural Classification Natural Products Animals Classification of Application Fields Source classification Disease Research Fields	Bacterial
Pexiganan (MSI 78 free base) is a synthetic analog of magainin 2. Pexiganan is a potent and orally active broad-spectrum antimicrobial peptide. Pexiganan can be used in the research of infections, such as diabetic foot ulcer infections .

Squalamine MSI-1256	Infection Triterpenes Structural Classification Animals Classification of Application Fields Terpenoids Marine natural products Other marine organisms Disease Research Fields Cancer	Bacterial HBV FAK Dengue Virus
Squalamine (MSI-1256) is an aminosterol compound with broad-spectrum antiviral activity. Squalamine makes cells less conducive to certain viral replication by altering the electrostatic interactions in the inner membrane of host cells. Squalamine also has antibacterial and antitumor activities. Squalamine has broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria, fungi and protozoa. Squalamine inhibits tumor-related angiogenesis and the growth of human breast cancer cells. Squalamine restores the function of enteric nervous system in Parkinson ^,s disease mouse models .

Squalamine lactate MSI-1256F	Infection Cardiovascular Disease Triterpenes Structural Classification Animals Classification of Application Fields Terpenoids Marine natural products Other marine organisms Disease Research Fields	Bacterial
Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

Pexiganan acetate MSI 78	Structural Classification Natural Products Animals Source classification	Bacterial
Pexiganan acetate (MSI 78) is the acetate salt form of Pexiganan (HY-105088). Pexiganan acetate is an orally active broad-spectrum antimicrobial peptide, which inhibits 99% gram-positive and Gram-negative aerobic bacteria through disruption of cell membrane/cells permeability. Pexiganan acetate can be used in the research of infections, such as diabetic foot ulcer infections .

Cat. No.	Compare	Product Name	Species	Source

HY-P703385

	MSI2 Protein, Human (His, Strep) RNA-binding protein Musashi homolog 2; MSI2; Homo sapiens; Human; Musashi-2; RNA-binding	Human	E. coli
	MSI2 Protein, Human (His, Strep) is the recombinant human-derived MSI2, expressed by E. coli , with Strep, His labeled tag. ,

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HY-P84725

	Musashi 2 Antibody (YA4422) MSI2H; MGC3245; FLJ36569; MSI2	WB, IHC-P, ELISA	Human
	Musashi 2 Antibody (YA4422) is a mouse-derived and non-conjugated IgG1 antibody, targeting to MSI2. It can be applicated for WB, IHC-P, ELISA assays, in the background of human.

HY-P85563

	*Musashi 1/Msi1 Antibody (YA5255)* MSI1; Musashi-1; MSI 1; MSI1; MSI1H_HUMAN; Musashi homolog 1; Musashi-1; Musashi1; RNA binding protein Musashi homolog 1; RNA-binding protein Musashi homolog 1.	WB	Human, Mouse, Rat
	Musashi 1/Msi1 Antibody (YA5255) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Musashi-1. It can be applicated for WB assays, in the background of human, mouse, rat.

HY-P83070

	*Musashi 1/Msi1 Antibody (YA2815)* RNA-binding protein Musashi homolog 1; Musashi-1; MSI1	WB, IHC-P, ICC/IF, IP, FC	Human
	Musashi 1/Msi1 Antibody (YA2815) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2815), targeting Musashi 1, with a predicted molecular weight of 39 kDa (observed band size: 39 kDa). Musashi 1/Msi1 Antibody (YA2815) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human background.

HY-P85283

	*Musashi 1/Msi1 Antibody (YA4975)* MSI1; RNA-binding protein Musashi homolog 1; Musashi-1	WB, FC, ELISA	Human
	Musashi 1/Msi1 Antibody (YA4975) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Msi1. It can be applicated for WB, FC, ELISA assays, in the background of human.

HY-P83300

	Musashi 2 Antibody (YA3045) MSI2; RNA-binding protein Musashi homolog 2; Musashi-2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Musashi 2 Antibody (YA3045) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3045), targeting Musashi 2, with a predicted molecular weight of 35 kDa (observed band size: 35 kDa). Musashi 2 Antibody (YA3045) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

HY-P85284

	Musashi 2 Antibody (YA4976) MSI2; RNA-binding protein Musashi homolog 2; Musashi-2	WB, IHC-P, ICC/IF, ELISA	Human
	Musashi 2 Antibody (YA4976) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Msi2. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

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