MDK

By Targets:	Akt (1) Apoptosis (2) mTOR (1) NF-κB (1) PI3K (2) Ser/Thr Protease (1) Small Interfering RNA (siRNA) (3) STAT (1)
By Research Areas:	Cancer (5)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18633

MDK83190	Apoptosis	Cancer
MDK83190 is a potent apoptosis activator, induces Apaf-1 oligomerization, increases procaspase-9 processing and subsequent caspase-3 activation in a cyto c-dependent Manner .

HY-110171

iMDK 3 Publications Verification	PI3K	Cancer
iMDK is a potent PI3K inhibitor and inhibits the growth factor *MDK* (also known as midkine or MK). iMDK suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice .

HY-110171A

iMDK quarterhydrate 3 Publications Verification	PI3K	Cancer
iMDK quarterhydrate is a potent PI3K inhibitor and inhibits the growth factor *MDK* (also known as midkine or MK). iMDK quarterhydrate suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice .

HY-119467

MDK0734	Ser/Thr Protease	Cancer
MDK0734 is a selective inhibitor that inhibits feline hepsin B endopeptidase and exopeptidase activities. MDK0734 demonstrated efficacy in a cell-based in vitro tumor invasion model, significantly attenuating the invasive ability of MCF-10A neoT cells. MDK0734 provides new potential inhibitors for the development of clinically useful compounds targeting the deleterious effects of feline hepsin B in cancer progression .

HY-RS08262

MDK Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MDK Human Pre-designed siRNA Set A contains three designed siRNAs for MDK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MDK Human Pre-designed siRNA Set A MDK Human Pre-designed siRNA Set A

HY-RS23165

Mdk Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mdk Rat Pre-designed siRNA Set A contains three designed siRNAs for Mdk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mdk Rat Pre-designed siRNA Set A Mdk Rat Pre-designed siRNA Set A

HY-RS16729

Mdk Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mdk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mdk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mdk Mouse Pre-designed siRNA Set A Mdk Mouse Pre-designed siRNA Set A

HY-178164

HBS-101	Apoptosis Akt mTOR STAT NF-κB	Cancer
HBS-101 is a selectively, orally active, brain-penetrant, Midkine (MDK) inhibitor (K_D = 38.4 nM). HBS-101 significantly reduces cell viability, clonogenic survival, and invasiveness and increases apoptosis. HBS-101 involves suppression of the Akt/mTOR, STAT3, and NF-κB pathways. HBS-101 can be used for the study of Triple-negative breast cancer (TNBC) .

Species:	Human (6) Mouse (6) Rat (1)
Tag:	His (11) Tag Free (2) Avi (2)
Source:	HEK293 (5) Sf9 insect cells (1) P. pastoris (1) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P701025

	MDK/Midkine Protein, Mouse (His) MK; ARAP; MDK; MEK; MK1; MKARAP; NEGF2	Mouse	E. coli
	Midkine (MDK) is a multifunctional cytokine and growth factor that signals through cell surface proteoglycan and non-proteoglycan receptors.It affects inflammatory responses, cell proliferation, adhesion, survival, tissue regeneration, differentiation and migration.MDK/Midkine Protein, Mouse (His) is the recombinant mouse-derived MDK/Midkine protein, expressed by E.coli , with N-His labeled tag.

HY-P700791

	MDK/Midkine Protein, Human (His-Avi) MK; ARAP; MDK; MEK; MK1; MKARAP; NEGF2	Human	E. coli
	Midkine (MDK) protein is a multifunctional cytokine and growth factor that signals through cell surface proteoglycan and non-proteoglycan receptors. MDK regulates inflammatory responses, cell proliferation, adhesion, growth, survival, tissue regeneration, differentiation, and migration and plays a crucial role in inflammation by recruiting neutrophils and macrophages. MDK/Midkine Protein, Human (His-Avi) is the recombinant human-derived MDK/Midkine protein, expressed by E. coli , with C-Avi, N-His labeled tag.

HY-P73295

	MDK/Midkine Protein, Human (sf9) 1 Publications Verification Midkine; MK; ARAP; MDK; MK1; NEGF2	Human	Sf9 insect cells
	Midkine (MDK) protein is a multifunctional cytokine and growth factor that signals through cell surface proteoglycan and non-proteoglycan receptors. MDK regulates inflammatory responses, cell proliferation, adhesion, growth, survival, tissue regeneration, differentiation, and migration and plays a crucial role in inflammation by recruiting neutrophils and macrophages. MDK/Midkine Protein, Human (sf9) is the recombinant human-derived MDK protein, expressed by Sf9 insect cells , with tag free.

HY-P79419

	MDK/Midkine Protein, Mouse 1 Publications Verification Midkine; MDK; MK; Retanoic acid-responsive protein; Retinoic acid-induced differentiation factor	Mouse	E. coli
	Midkine (MDK) is a multifunctional cytokine and growth factor that signals through cell surface proteoglycan and non-proteoglycan receptors. It affects inflammatory responses, cell proliferation, adhesion, survival, tissue regeneration, differentiation and migration. MDK/Midkine Protein, Mouse is the recombinant mouse-derived Midkine protein, expressed by E. coli , with tag free.

HY-P700223AF

	Animal-Free Midkine Protein, Mouse (His) 1 Publications Verification Midkine; MDK; MK; Retanoic acid-responsive protein; Retinoic acid-induced differentiation factor	Mouse	E. coli
	Midkine (MDK) is a multifunctional cytokine and growth factor that signals through cell surface proteoglycan and non-proteoglycan receptors.It affects inflammatory responses, cell proliferation, adhesion, survival, tissue regeneration, differentiation and migration.Animal-Free Midkine Protein, Mouse (His) is the recombinant mouse-derived animal-FreeMidkine protein, expressed by E.coli , with C-His labeled tag.This product is for cell culture use only.

HY-P700138AF

	*Animal-Free MDK* Protein, Human (His)** 1 Publications Verification Amphiregulin associated protein; Amphiregulin-associated protein; ARAP; FLJ27379; MDK; Midgestation and kidney protein; Midkine; MK 1; MK; MK_HUMAN; MK1; NEGF 2; NEGF2; Neurite growth promoting factor 2; Neurite outgrowth promoting protein; Neurite outgrowth-promoting factor 2; Neurite outgrowth-promoting protein; Retinoic acid inducible factor	Human	E. coli
	Midkine (MDK) protein is a multifunctional cytokine and growth factor that signals through cell surface proteoglycan and non-proteoglycan receptors. MDK regulates inflammatory responses, cell proliferation, adhesion, growth, survival, tissue regeneration, differentiation, and migration and plays a crucial role in inflammation by recruiting neutrophils and macrophages. Animal-Free MDK Protein, Human (His) is the recombinant human-derived animal-FreeMDK protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P72273

	MUSK Protein, Human (P.pastoris, His) Muscle, skeletal receptor tyrosine-protein kinase; CMS9; FADS; MDK4; Muscle; MuSK;	Human	P. pastoris
	MUSK protein is a receptor tyrosine kinase that plays a crucial role in the formation and maintenance of the neuromuscular junction (NMJ). After LRP4 recruits AGRIN, MUSK phosphorylates and activates, affecting gene expression, coordinating actin cytoskeletal reorganization, and clustering acetylcholine receptors (AChR) in the postsynaptic membrane. MUSK Protein, Human (P.pastoris, His) is the recombinant human-derived MUSK protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P75746

	EphA7 Protein, Mouse (HEK293, His) Ephrin Type-A Receptor 7; MDK-1; EHK-3; EBK	Mouse	HEK293
	The EphA7 protein is a receptor tyrosine kinase that participates in bidirectional signaling with GPI-anchored ephrin-A ligands (especially EFNA5). It affects brain development by regulating intercellular adhesion and repulsion, contributing to axonal guidance of corticothalamic and retinal axons. EphA7 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphA7 protein, expressed by HEK293 , with C-His labeled tag.

HY-P75750

	EphB3 Protein, Rat (HEK293, His) Ephrin type-B receptor 3; MDK-5; Tyrosine-protein kinase receptor SEK-4; Sek4	Rat	HEK293
	The EphB3 protein is a receptor tyrosine kinase that binds to the transmembrane ephrin B ligand to initiate bidirectional signaling. The forward signal originates from the receptor, while the reverse signal originates from the ephrin ligand. EphB3 Protein, Rat (HEK293, His) is the recombinant rat-derived EphB3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P701024

	MDK/Midkine Protein, Human (Biotinylated, His-Avi) MK; ARAP; MDK; MEK; MK1; MKARAP; NEGF2	Human	E. coli
	Midkine (MDK) protein is a multifunctional cytokine and growth factor that signals through cell surface proteoglycan and non-proteoglycan receptors. MDK regulates inflammatory responses, cell proliferation, adhesion, growth, survival, tissue regeneration, differentiation, and migration and plays a crucial role in inflammation by recruiting neutrophils and macrophages. MDK/Midkine Protein, Human (Biotinylated, His-Avi) is the recombinant human-derived MDK/Midkine protein, expressed by E. coli , with C-Avi, N-His labeled tag.

HY-P75749

	EphB3 Protein, Mouse (508a.a, HEK293, His) Ephrin type-B receptor 3; MDK-5; Tyrosine-protein kinase receptor SEK-4; Sek4	Mouse	HEK293
	The EphB3 protein is a receptor tyrosine kinase that binds to the transmembrane ephrin B ligand to initiate bidirectional signaling. The forward signal originates from the receptor, while the reverse signal originates from the ephrin ligand. EphB3 Protein, Mouse (508a.a, HEK293, His) is the recombinant mouse-derived EphB3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77931

	EphB3 Protein, Human (HEK293, His) EK2; ETK2; HEK2; TYRO6; EPHB3; AW456895; Cek10; MDK5; Sek4; EC 2.7.10; EC 2.7.10.1	Human	HEK293
	The EphB3 protein is a receptor tyrosine kinase that performs bidirectional signaling with the transmembrane ephrin B ligand. It participates in forward signaling and reverse signaling, sharing functionality with EPHB2. EphB3 Protein, Human (HEK293, His) is the recombinant human-derived EphB3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P78294

	EphB3 Protein, Mouse (HEK293, His) EK2; ETK2; HEK2; TYRO6; EPHB3; AW456895; Cek10; MDK5; Sek4; EC 2.7.10; EC 2.7.10.1	Mouse	HEK293
	The EphB3 protein is a receptor tyrosine kinase that binds to the transmembrane ephrin B ligand to initiate bidirectional signaling. The forward signal originates from the receptor, while the reverse signal originates from the ephrin ligand. EphB3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphB3 protein, expressed by HEK293 , with C-His labeled tag.

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HY-P81837

	Midkine Antibody (YA1582) MDK; FLJ27379; MK1; NEGF2; Midkine; NEGF2; ARAP	WB, IP	Human
	Midkine Antibody (YA1582) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Midkine.

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Cat. No.	Product Name		Classification

HY-178164

HBS-101		Alkynes
HBS-101 is a selectively, orally active, brain-penetrant, Midkine (MDK) inhibitor (K_D = 38.4 nM). HBS-101 significantly reduces cell viability, clonogenic survival, and invasiveness and increases apoptosis. HBS-101 involves suppression of the Akt/mTOR, STAT3, and NF-κB pathways. HBS-101 can be used for the study of Triple-negative breast cancer (TNBC) .

Cat. No.	Product Name		Classification

HY-RS08262

MDK Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MDK Human Pre-designed siRNA Set A contains three designed siRNAs for MDK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23165

Mdk Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Mdk Rat Pre-designed siRNA Set A contains three designed siRNAs for Mdk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16729

Mdk Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Mdk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mdk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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