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Results for "

Lactic acidosis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (2) Apoptosis (2) Biochemical Assay Reagents (1) Endogenous Metabolite (1) Lactate Dehydrogenase (1) Mitochondrial Metabolism (3) Quinone Reductase (1)
By Research Areas:	Cancer (2) Endocrinology (1) Metabolic Disease (4)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16397

Phenformin 5+ Cited Publications Phenethylbiguanide	Mitochondrial Metabolism AMPK Apoptosis	Metabolic Disease Cancer
Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis .

HY-113383

2-Hydroxyvaleric acid	Endogenous Metabolite Lactate Dehydrogenase Biochemical Assay Reagents	Metabolic Disease Endocrinology
2-Hydroxyvaleric acid is a medium chain α-hydroxy fatty acid. 2-Hydroxyvaleric acid is an activator in fat metabolism of palmitic acid-1-C ^{14 ^{. 2-hydroxyvaleric acid is also used as a staining agent for measuring tissue-specific Lactate dehydrogenase activity and elevated levels of 2-hydroxyvaleric acid induces lactic acidosis .}}

HY-16397R

Phenformin (Standard)	Mitochondrial Metabolism AMPK Apoptosis	Metabolic Disease Cancer
Phenformin (Standard) is the analytical standard of Phenformin. This product is intended for research and analytical applications. Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis .

HY-128895A

KL1333 hydrochloride	Mitochondrial Metabolism Quinone Reductase	Metabolic Disease
KL1333 hydrochloride is an orally active NAD ⁺ modulator that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, leading to increased intracellular NAD ⁺ levels through NADH oxidation. Elevated NAD ⁺ levels trigger activation of SIRT1 and AMPK, and subsequently activate PGC-1α. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) fibroblasts. KL1333 hydrochloride protects against cisplatin-induced ototoxicity in mouse cochlear cultures .

Cat. No.	Product Name

HY-L204

Lactic Acid Metabolic Compound Library	452 compounds
Lactic acid metabolism is one of the key metabolic pathways within living organisms. It plays a crucial role not only in cellular energy conversion but is also closely related to a variety of physiological and pathological processes. The production and clearance of lactic acid are important indicators of cellular metabolic balance, and its abnormal regulation may lead to conditions such as lactic acidosis, muscle fatigue, and hereditary metabolic diseases. Moreover, lactic acid is closely related to the malignancy of tumors and is considered a biomarker for malignant tumors and poor prognosis. Lactic acid can serve as a metabolic substrate to support the metabolic needs of tumor cells under hypoxic conditions, and it can also cause acidification of the tumor microenvironment, suppress immune cell function to promote immune evasion, and induce drug resistance in tumor cells. Currently, targeting lactic acid-lactylation and its related metabolic pathways has become a new research avenue for cancer treatment. In-depth exploration of the molecular mechanisms of lactic acid metabolism can help in screening lead compounds that regulate the lactic acid metabolism. MCE contains 452 small molecule compounds targeting enzymes involved in lactic acid metabolism. This library is of significant value for researching the role of lactate metabolism in the mechanisms of diseases.

Lactic Acid Metabolic Compound Library

452 compounds

Lactic acid metabolism is one of the key metabolic pathways within living organisms. It plays a crucial role not only in cellular energy conversion but is also closely related to a variety of physiological and pathological processes. The production and clearance of lactic acid are important indicators of cellular metabolic balance, and its abnormal regulation may lead to conditions such as lactic acidosis, muscle fatigue, and hereditary metabolic diseases. Moreover, lactic acid is closely related to the malignancy of tumors and is considered a biomarker for malignant tumors and poor prognosis. Lactic acid can serve as a metabolic substrate to support the metabolic needs of tumor cells under hypoxic conditions, and it can also cause acidification of the tumor microenvironment, suppress immune cell function to promote immune evasion, and induce drug resistance in tumor cells. Currently, targeting lactic acid-lactylation and its related metabolic pathways has become a new research avenue for cancer treatment. In-depth exploration of the molecular mechanisms of lactic acid metabolism can help in screening lead compounds that regulate the lactic acid metabolism.

MCE contains 452 small molecule compounds targeting enzymes involved in lactic acid metabolism. This library is of significant value for researching the role of lactate metabolism in the mechanisms of diseases.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113383

2-Hydroxyvaleric acid	Source classification	Endogenous Metabolite Lactate Dehydrogenase Biochemical Assay Reagents
2-Hydroxyvaleric acid is a medium chain α-hydroxy fatty acid. 2-Hydroxyvaleric acid is an activator in fat metabolism of palmitic acid-1-C ^{14 ^{. 2-hydroxyvaleric acid is also used as a staining agent for measuring tissue-specific Lactate dehydrogenase activity and elevated levels of 2-hydroxyvaleric acid induces lactic acidosis .}}

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