LATS2

Isoforms Recommended:	LATS2

By Targets:	Biochemical Assay Reagents (1) PROTAC Linkers (1) Small Interfering RNA (siRNA) (6) YAP (5)
By Research Areas:	Cancer (6)
Click Chemistry:	PROTAC Synthesis (1) Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) siRNAs (6)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138489

TRULI Maximum Cited Publications 22 Publications Verification LATS-IN-1	YAP	Others
TRULI (Lats-IN-1) is a potent and ATP-competitive inhibitor of Lats1 and *Lats2* kinases. TRULI promotes Yap-dependent proliferation in postmitotic mammalian tissues .

HY-147165

VT02956	YAP	Cancer
VT02956 is a LATS inhibitor (IC₅₀: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids . VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-147082

GA-017 3 Publications Verification	YAP	Cancer
GA-017 is a potent and selective LATS1 and *LATS2* (large tumor suppressor kinase 1/2) inhibitor, with IC₅₀ values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids .

HY-RS07539

LATS2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LATS2 Human Pre-designed siRNA Set A contains three designed siRNAs for LATS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LATS2 Human Pre-designed siRNA Set A LATS2 Human Pre-designed siRNA Set A

HY-RS18181

Lats2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lats2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lats2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lats2 Mouse Pre-designed siRNA Set A Lats2 Mouse Pre-designed siRNA Set A

HY-RS24655

Lats2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lats2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lats2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lats2 Rat Pre-designed siRNA Set A Lats2 Rat Pre-designed siRNA Set A

HY-175649

LATS1/2-IN-1	YAP	Cancer
LATS1/2-IN-1 is a potent and selective LATS1 and *LATS2* inhibitor. LATS1/2-IN-1 exhibits potent inhibitory activity against LATS1 and *LATS2* with IC₅₀ values of 4.4 nM and 5.5 nM as determined via r ³³P functional assay. LATS1/2-IN-1 displays cellular IC₅₀ values of 136 nM for LATS1 and 36.0 nM for *LATS2* as determined via NanoBRET assay. LATS1/2-IN-1 reduces phosphorylation of YAP1 in mouse liver. LATS1/2-IN-1 demonstrates wound healing activity in HT-1080 scratch assay and in vivo SKH1 mouse punch biopsy model. LATS1/2-IN-1 can be used for the study of regenerative medicine indications such as wound healing .

HY-147165A

VT02956 hydrochloride	YAP	Cancer
VT02956 is a LATS inhibitor (IC₅₀: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids . VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-RS07537

LAT2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LAT2 Human Pre-designed siRNA Set A contains three designed siRNAs for LAT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LAT2 Human Pre-designed siRNA Set A LAT2 Human Pre-designed siRNA Set A

HY-RS21361

Lat2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lat2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lat2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lat2 Mouse Pre-designed siRNA Set A Lat2 Mouse Pre-designed siRNA Set A

HY-RS27880

Lat2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lat2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lat2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lat2 Rat Pre-designed siRNA Set A Lat2 Rat Pre-designed siRNA Set A

HY-130504

Propargyl-PEG1-acid 1 Publications Verification	PROTAC Linkers	Cancer
Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM . Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W087830

L-p-Boronophenylalanine	Biochemical Assay Reagents	Cancer
L-p-Boronophenylalanine is a boron-containing substrate for L-type amino acid transporters (L_AT1 and *L_AT2). L-p-Boronophenylalanine enters tumor cells by competing with natural amino acids for LAT, selectively accumulating boron in cancer cells. L-p-Boronophenylalanine can be used in boron neutron capture therapy (BNCT)*. When boron-10 captures thermal neutrons, a nuclear reaction occurs, producing high-energy alpha particles and lithium nuclei, which kill cancer cells at close range with little damage to surrounding tissues. L-p-Boronophenylalanine can be used in cancer research, especially glioblastoma and anaplastic astrocytoma ^[2].

Cat. No.	Product Name	Type

HY-W087830

L-p-Boronophenylalanine	Biochemical Assay Reagents
L-p-Boronophenylalanine is a boron-containing substrate for L-type amino acid transporters (L_AT1 and *L_AT2). L-p-Boronophenylalanine enters tumor cells by competing with natural amino acids for LAT, selectively accumulating boron in cancer cells. L-p-Boronophenylalanine can be used in boron neutron capture therapy (BNCT)*. When boron-10 captures thermal neutrons, a nuclear reaction occurs, producing high-energy alpha particles and lithium nuclei, which kill cancer cells at close range with little damage to surrounding tissues. L-p-Boronophenylalanine can be used in cancer research, especially glioblastoma and anaplastic astrocytoma ^[2].

L-p-Boronophenylalanine

Biochemical Assay Reagents

L-p-Boronophenylalanine is a boron-containing substrate for L-type amino acid transporters (L_AT1 and L_AT2). L-p-Boronophenylalanine enters tumor cells by competing with natural amino acids for LAT, selectively accumulating boron in cancer cells. L-p-Boronophenylalanine can be used in boron neutron capture therapy (BNCT). When boron-10 captures thermal neutrons, a nuclear reaction occurs, producing high-energy alpha particles and lithium nuclei, which kill cancer cells at close range with little damage to surrounding tissues. L-p-Boronophenylalanine can be used in cancer research, especially glioblastoma and anaplastic astrocytoma ^[2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81210

	*phospho-LATS1+LATS2* (Thr1079 +Thr1041) Antibody** LATS1 +LATS2 (phospho T1079 + T1041); Serine/threonine protein kinase LATS2; KPM; Large tumor supressor, homolog 1; LATS, large tumor suppressor, homolog 1 (Drosophila); LATS, large tumor suppressor, homolog 2 (Drosophila); LATS1 +LATS2 (phospho T1079 + T1041); p-LATS1 +LATS2(Thr1079 +Thr1041); RGD1564085; Serine/threonine protein kinase LATS1; WARTS; WARTS protein kinase; wts; 4932411G09Rik; AV277261; AW208599; AW228608; FLJ13161; LATS1_HUMAN.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse
	phospho-LATS1+LATS2 (Thr1079 +Thr1041) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to phospho-LATS1+LATS2 (Thr1079 +Thr1041).

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Cat. No.	Product Name		Classification

HY-130504

Propargyl-PEG1-acid 1 Publications Verification		Alkynes PROTAC Synthesis
Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM . Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-RS07539

LATS2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
LATS2 Human Pre-designed siRNA Set A contains three designed siRNAs for LATS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18181

Lats2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Lats2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lats2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24655

Lats2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Lats2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lats2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS07537

LAT2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
LAT2 Human Pre-designed siRNA Set A contains three designed siRNAs for LAT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS21361

Lat2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Lat2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lat2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS27880

Lat2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Lat2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lat2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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