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Results for "

LAG-3

" in MedChemExpress (MCE) Product Catalog:

35

Inhibitors & Agonists

2

Peptides

24

Inhibitory Antibodies

17

Recombinant Proteins

2

Antibodies

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-162811

    LAG-3 Cancer
    LAG-3 biner 1 (compound 3) is a small molecule ligand (Kd=1.23 μM) for the immune checkpoint lymphocyte activation gene 3 (LAG-3). LAG-3 biner 1 can be used in the research of cancer diagnosis targeting LAG-3 .
    LAG-3 biner 1
  • HY-P99141

    LAG-3 Inflammation/Immunology
    Anti-Mouse LAG-3 is an anti-mouse LAG-3 IgG1 antibody inhibitor derived from host Rat.
    Anti-Mouse LAG-3 Antibody (C9B7W)
  • HY-P99617

    REGN3767

    LAG-3 Inflammation/Immunology Cancer
    Fianlimab (REGN3767) is a human monoclonal antibody that targets the immune checkpoint receptor LAG-3 on T cells and has anti-tumour activity .
    Fianlimab
  • HY-P10835

    LAG-3 Cancer
    LAG-3 cyclic peptide inhibitor C25 is a LAG-3 inhibitor. LAG-3 cyclic peptide inhibitor C25 has a high affinity with human LAG-3 protein with a Kd value of 0.66 μM. LAG-3 cyclic peptide inhibitor C25 can block the interaction of LAG-3 with HLA-DR (MHC-II) and activate CD8 + T cells. LAG-3 cyclic peptide inhibitor C25 can be used in the study of cancer .
    LAG-3 cyclic peptide inhibitor C25
  • HY-P10837

    LAG-3 Inflammation/Immunology Cancer
    LAG-3 cyclic peptide inhibitor 12 (Cyclic peptide 12) is an inhibitor of LAG-3 with an IC50 value of 4.45 μM and a Ki value of 2.66 µM .
    LAG-3 cyclic peptide inhibitor 12
  • HY-RS16686

    Small Interfering RNA (siRNA) Others

    Lag3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lag3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Lag3 Mouse Pre-designed siRNA Set A
    Lag3 Mouse Pre-designed siRNA Set A
  • HY-RS07492

    Small Interfering RNA (siRNA) Others

    LAG3 Human Pre-designed siRNA Set A contains three designed siRNAs for LAG3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    LAG3 Human Pre-designed siRNA Set A
    LAG3 Human Pre-designed siRNA Set A
  • HY-RS23121

    Small Interfering RNA (siRNA) Others

    Lag3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lag3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Lag3 Rat Pre-designed siRNA Set A
    Lag3 Rat Pre-designed siRNA Set A
  • HY-P990204

    LAG-3 Others
    Anti-Mouse LAG-3 (D265A) Antibody (C9B7W) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to mouse LAG-3.
    Anti-Mouse LAG-3 (D265A) Antibody (C9B7W)
  • HY-P99736

    BI-754111

    LAG-3 Cancer
    Miptenalimab (BI-754111) is an anti-human LAG-3 antibody (KD: 88.6 nM for h LAG-3). Miptenalimab blocks the interaction of LAG-3 with its ligand MHC-II .
    Miptenalimab
  • HY-P99922

    LAG-3 Cancer
    Encelimab is an anti-LAG3 antibody. Encelimab blocks the interaction between LAG-3 and MHC II, and enhances T-cell activation. Encelimab alone or in combination with an anti-PD-1 antibody reduces tumor size in a lymphoma mice model (A20 cell xenograft) .
    Encelimab
  • HY-P99613

    MK-4280

    LAG-3 Cancer
    Favezelimab (MK-4280) is a humanized monoclonal antibody targeting LAG-3. Favezelimab blocks the interaction between LAG-3 and its ligand MHC class II. Favezelimab has the potential for colorectal cancer (CRC) research in combination with the PD-L1 inhibitor Pembrolizumab (HY-P9902). Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
    Favezelimab
  • HY-P99156

    BMS-986016

    LAG-3 Cancer
    Relatlimab (BMS-986016) is a human monoclonal antibody anti-LAG-3 antibody generated by immunization of transgenic mice bearing human immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with an IC50 value of 0.67 nM and LAG-3/FGL1 interaction with an IC50 value of 0.019 nM. Relatlimab can be used in research of cancer .
    Relatlimab
  • HY-P99027

    LAG525; IMP701

    LAG-3 Cancer
    Ieramilimab (LAG525; IMP701) is a humanized IgG4 monoclonal antibody that binds to LAG-3, resulting in inhibition of LAG-3 interaction with MHC-II molecules .
    Ieramilimab
  • HY-P990046

    Incagn-02385

    LAG-3 Inflammation/Immunology
    Tuparstobart (Incagn-02385) is an IgG1κ antibody targeting LAG-3. LAG-3 is an immune checkpoint receptor protein mainly expressed on activated T cells, NK cells, B cells and plasmacytoid dendritic cells .
    Tuparstobart
  • HY-P990740

    EMB-02; EMB-02

    PD-1/PD-L1 LAG-3 Inflammation/Immunology
    Fanastomig is an anti-PDCD1/LAG3 monoclonal antibody .
    Fanastomig
  • HY-P99573

    MGD-013

    LAG-3 Inflammation/Immunology Cancer
    Tebotelimab (MGD-013) is a humanized IgG4κ bispecific PD-1/LAG-3 dual-affinity re-targeting (DART) antibody. Tebotelimab binds cell-surface expressed PD-1 and LAG-3 with EC50s of 1.65 nM and 0.41 nM in NS0 cells, respectively. Tebotelimab blocks PD-1/PD-L1, PD-1/PD-L2 and LAG-3/HLA (MHC-II) interactions and PD-1 signaling. Tebotelimab restores exhausted T-cell responses and and enhances antitumour immunity [3].
    Tebotelimab
  • HY-P991299

    LAG-3 Cancer
    ENUM006 is a human monoclonal antibody (mAb) targeting CD223/LAG3 .
    ENUM006
  • HY-P991298

    LAG-3 Cancer
    DNV-3 is a human monoclonal antibody (mAb) targeting CD223/LAG3 .
    DNV-3
  • HY-164308

    LAG-3 Inflammation/Immunology
    SA-15-P inhibits LAG-3/MHCII and LAG-3/FGL1 interactions with IC50 values of 4.21 and 6.52 μM respectively. LAG-3/MHCII interaction is a target for immunotherapies .
    SA-15-P
  • HY-P991297

    Cancer
    AM0003 is a human monoclonal antibody (mAb) targeting CD223/LAG3. AM0003 can be used in the study of advanced solid tumors .
    AM0003
  • HY-P991303

    Sym022; S 95017

    Cancer
    TQB-2223 is a human monoclonal antibody (mAb) targeting CD223/LAG3. TQB-2223 can be used in the study of Hodgkin lymphoma .
    TQB-2223
  • HY-P991302

    LAG-3 Cancer
    KL-A289 is a human monoclonal antibody (mAb) targeting CD223/LAG3. KL-A289 can be used in the study of metastatic GC .
    KL-A289
  • HY-P99354

    Anti-Human CTLA4xLAG3

    LAG-3 Inflammation/Immunology Cancer
    Bavunalimab (Anti-Human CTLA4xLAG3) is a bispecific human anti-CTLA-4/LAG-3 monoclonal antibody. Bavunalimab activates T cells in NSG mice. Bavunalimab can be used for the research of cancer .
    Bavunalimab
  • HY-P990700

    RO-7247669; RG-6139

    PD-1/PD-L1 LAG-3 Inflammation/Immunology
    Tobemstomig is an anti-PDCD1/LAG3 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
    Tobemstomig
  • HY-P990912

    LAG-3 Inflammation/Immunology
    HY-P990912 is an PDCD1/LAG3-targeting IgG1κ-[scFv-heavy -κ]2 type chimeric human and humanized antibody .
    Cugrastomig
  • HY-P990968

    LAG-3 Inflammation/Immunology
    HY-P990968 is an LAG3-targeting IgG4κ type human antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
    Alcestobart
  • HY-P990976

    LAG-3 Inflammation/Immunology
    HY-P990976 is an LAG3-targeting IgG4κ type human antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
    Brivestobart
  • HY-P991300

    LAG-3 Cancer
    GSK2831781 is a human IgG1 monoclonal antibody (mAb) targeting CD223/LAG3. GSK2831781 can be used in the study of ulcerative colitis Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
    GSK2831781
  • HY-P991301

    LAG-3 Cancer
    IMP-761 is a human IgG4 monoclonal antibody (mAb) targeting CD223/LAG3. IMP-761 binds to D1 of human LAG32. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .
    IMP-761
  • HY-108691
    PF-06465469
    2 Publications Verification

    Itk Btk CXCR PD-1/PD-L1 LAG-3 Cancer
    PF-06465469 is a covalent inhibitor of ITK with an IC50 of 2 nM. PF-06465469 also inhibits BTK. PF-06465469 inhibits cell migration in response to CXCL12. PF-06465469 decreases PD-1 and LAG-3 expression. PF-06465469 can be used to study leukemia and T-cell lymphoma .
    PF-06465469
  • HY-P990750

    LAG-3 Inflammation/Immunology
    Negalstobart is an anti-LAG3 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Negalstobart
  • HY-149916

    Adenosine Receptor Cancer
    A2AR-antagonist-1 (compound 38) is an orally active adenosine A2A receptor (A2AR) antagonist (IC50=29 nM). A2AR-antagonist-1 exhibits anti-tumor activity and mouse liver microsomal metabolic stability (t1/2=86.1 min). A2AR-antagonist-1 is also a T cells activator, via inhibiting immunosuppressive molecules (LAG-3 and TIM-3) and enhancing effector molecules (GZMB, IFNG, and IL-2) .
    A2AR-antagonist-1
  • HY-145240

    Eukaryotic Initiation Factor (eIF) Infection Cancer
    eIF4E-IN-1 is a potent inhibitor of eIF4E. eIF4E-IN-1 inhibits immunosuppression components such as immune checkpoint proteins PD-1, PD-L1, LAG3, TIM3, and/or IDO, in order to inhibit or release immune suppression in certain diseases, such as cancer and infectious disease (extracted from patent WO2021003194A1, compound Y) .
    eIF4E-IN-1
  • HY-144088

    HPK1-IN-22

    MAP4K Inflammation/Immunology Cancer
    ZYF0033 is an orally active inhibitor of the hematopoietic progenitor cell kinase HPK1 with an IC50 of less than 10 nM based on the phosphorylation inhibition of MBP protein. ZYF0033 promotes anti-cancer immune responses and reduces phosphorylation of SLP76 (serine 376). ZYF0033 inhibits tumor growth in the 4T-1 syngeneic mouse model and leads to increased intratumoral infiltration of DCs, NK cells, and CD107a +CD8 + T cells, but not T cells, PD-1 +CD8 + T cells, TIM-3 +CD8 + Infiltration of T cells and LAG3 +CD8 + T cells was reduced .
    ZYF0033

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