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Results for "

Ku 70

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) DNA-PK (3) HIV (1) Reactive Oxygen Species (ROS) (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (5) Infection (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122727

STL127705 4 Publications Verification	DNA-PK Apoptosis	Cancer
STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor with an IC₅₀ of 3.5 μM. STL127705 interferes the binding of Ku70/80 to DNA and by inhibits the activation of the DNA-PKCS kinase. STL127705 shows antiproliferative and anticancer activity. STL127705 induces apoptosis .

HY-117078

Justicidin A	Apoptosis	Cancer
justicidin A is a nature product that could be isolated form Justicia procumbens. justicidin A decreases the level of Ku70 leading to translocation of Bax from the cytosol to mitochondria to induce apoptosis. justicidin A can be used in research of cancer .

HY-RS26253

Xrcc6 Rat Pre-designed siRNA Set A Ku70; G22p1; Kup70	Small Interfering RNA (siRNA)	Others
Xrcc6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Xrcc6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Xrcc6 Rat Pre-designed siRNA Set A Xrcc6 Rat Pre-designed siRNA Set A

HY-RS19756

Xrcc6 Mouse Pre-designed siRNA Set A Ku70; 70kDa; G22p1	Small Interfering RNA (siRNA)	Others
Xrcc6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Xrcc6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Xrcc6 Mouse Pre-designed siRNA Set A Xrcc6 Mouse Pre-designed siRNA Set A

HY-RS15901

XRCC6 Human Pre-designed siRNA Set A ML8; Ku70; TLAA; CTC75; CTCBF; G22P1	Small Interfering RNA (siRNA)	Others
XRCC6 Human Pre-designed siRNA Set A contains three designed siRNAs for XRCC6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

XRCC6 Human Pre-designed siRNA Set A XRCC6 Human Pre-designed siRNA Set A

HY-142944

DNA-PK-IN-2	DNA-PK	Cancer
DNA-PK-IN-2 is a potent inhibitor of DNA-PK. DNA-dependent protein kinase (DNA-PK) is a DNA-PK enzyme complex composed of Ku70/Ku80 heterodimer and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK-IN-2 has the potential for the research of cancer diseases (extracted from patent WO2021136462A1, compound 1) .

HY-142943

DNA-PK-IN-1	DNA-PK	Cancer
DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-dependent protein kinase (DNA-PK) is a DNA-PK enzyme complex composed of Ku70/Ku80 heterodimer and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK-IN-1 has the potential for the research of cancer diseases (extracted from patent WO2021136463A1, compound 1) .

HY-163177

HIV-1 inhibitor-63	HIV	Infection
HIV-1 inhibitor-63 (compound S17) is a potent HIV-1 inhibitor. HIV-1 inhibitor-63 inhibits integrase-Ku70 complex formation with an IC₅₀ value of 12 µM. HIV-1 inhibitor-63 inhibits HIV-1 post-integration DNA repair .

HY-146194

NHEJ inhibitor-1	Reactive Oxygen Species (ROS)	Cancer
NHEJ inhibitor-1 (Compound C2) is a trifunctional Pt(II) complex, alleviates the non-homologous end connection (NHEJ)/homologous recombination (HR)-related double strand breaks (DSBs) repairs to evade Cisplatin-resistance in non-small cell lung cancer (NSCLC). NHEJ inhibitor-1 inhibits the damage repair proteins Ku70 and Rad51 to make tumors re-sensitive to Cisplatin. NHEJ inhibitor-1 also induces ROS generation and MMP deduction .

Species:	Human (2)
Tag:	His (2)
Source:	HEK293 (1) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P73846

	Ku70-Ku80 Heterodimer Protein, Human (sf9, His) XRCC5-XRCC6 Heterodimer Protein; X-ray repair cross-complementing protein	Human	Sf9 insect cells
	Ku70 is a single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA nonhomologous end joining (NHEJ) and is central to double-strand break repair and V(D)J recombination. As a DNA helicase II complex, it has a cell cycle-dependent preference for double-stranded DNA fork ends in the 3'-5' direction, recognizing and binding to broken DNA ends during NHEJ, protecting them from resection. Ku70-Ku80 Heterodimer Protein, Human (sf9, His) is a recombinant protein dimer complex containing human-derived Ku70-Ku80 Heterodimer protein, expressed by Sf9 insect cells , with N-His labeled tag. Ku70-Ku80 Heterodimer Protein, Human (sf9, His), has molecular weight of ~70 & 85 kDa, respectively.

HY-P7895

	Clusterin/APOJ Protein, Human (HEK293, His) rHuClusterin/APOJ, His ; Clusterin; Aging-Associated Gene 4 Protein; Apolipoprotein J; Apo-J; Complement Cytolysis Inhibitor; CLI; Complement-Associated Protein SP-40; Ku70-Binding Protein 1; NA1/NA2; Testosterone-Repressed Prostate Message 2; TRPM-2; CLU; APOJ; CLI; KuB1	Human	HEK293
	Clusterin/APOJ Protein, Human (HEK 293, His) expresses in HEK 293 cells with a His tag at the C-terminus. Clusterin (CLU) is a multifunctional glycoprotein that has been implicated in several physiological and pathological states, including Alzheimer’s disease (AD).

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80202

	Ku70 Antibody (YA715)	WB, IHC-P	Human, Mouse
	Ku70 Antibody (YA715) is a non-conjugated and Mouse origined monoclonal antibody about 70 kDa, targeting to Ku70. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse.

HY-P80736

	Ku70 Antibody (YA319) XRCC6; G22P1; X-ray repair cross-complementing protein 6; 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-	WB, IHC-F, IHC-P, ICC/IF	Human
	Ku70 Antibody (YA319) is a non-conjugated and Rabbit origined monoclonal antibody about 70 kDa, targeting to Ku70. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human.

HY-P85597

	Ku70/XRCC6 Antibody (YA5289) 5''-deoxyribose-5-phosphate lyase Ku70; 5''-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP dependent DNA helicase 2 subunit 1; ATP dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; CTCBF; DNA repair protein XRCC6; G22P1; Ku 70; Ku autoantigen 70kDa; Ku autoantigen p70 subunit; Ku autoantigen, 70kDa; Ku p70; Ku70; Ku70 DNA binding component of DNA-dependent proteinkinase complex; thyroid autoantigen 70 kDa; Kup70; Lupus Ku autoantigen protein p70; ML8; Thyroid autoantigen 70kD; Ku antigen; Thyroid autoantigen; Thyroid lupus autoantigen; Thyroid lupus autoantigen; Thyroid lupus autoantigen p70; Thyroid-lupus autoantigen; TLAA; TLAA; X ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 6; XRCC 6; XRCC6; XRCC6_HUMAN.	WB, ICC/IF, IP	Human, Monkey

HY-P85854

	Clusterin Antibody (YA5546) CLU; APOJ; CLI; KuB1; AAG4; Clusterin; Aging-associated gene 4 protein; Apolipoprotein J; Apo-J; Complement cytolysis inhibitor; CLI; Complement-associated protein SP-40; 40; Ku70-binding protein 1; NA1/NA2; Testosterone-repressed prostate m	WB, ICC/IF, ELISA	Human, Mouse, Rat,

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Xrcc6 Rat Pre-designed siRNA Set A Ku70; G22p1; Kup70		siRNAs Rat Pre-designed siRNA Sets
Xrcc6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Xrcc6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Xrcc6 Mouse Pre-designed siRNA Set A Ku70; 70kDa; G22p1		siRNAs Mouse Pre-designed siRNA Sets
Xrcc6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Xrcc6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

XRCC6 Human Pre-designed siRNA Set A ML8; Ku70; TLAA; CTC75; CTCBF; G22P1		siRNAs Human Pre-designed siRNA Sets
XRCC6 Human Pre-designed siRNA Set A contains three designed siRNAs for XRCC6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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