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Results for "

KY

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (1) ADC Linker (1) Antibiotic (2) Apoptosis (2) Autophagy (2) Bacterial (1) CD28 (1) CDK (1) DNA/RNA Synthesis (1) Drug Derivative (1) Fungal (1) GSK-3 (1) Histamine Receptor (1) MAP4K (1) Organoid (2) PAK (2) Phosphatase (1) PI3K (3) Polo-like Kinase (PLK) (2) PROTACs (1) Ras (1) Reference Standards (1) Small Interfering RNA (siRNA) (3) Wnt (8) β-catenin (4)
By Research Areas:	Cancer (12) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (5) Metabolic Disease (7) Neurological Disease (2)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124156A

KY-02327 acetate	Wnt	Metabolic Disease
KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 acetate shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation .

HY-124745

KY-05009 1 Publications Verification	MAP4K Wnt Apoptosis	Cancer
KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a K_i of 100 nM. KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells. KY-05009 exerts anti-cancer activity .

HY-120327

KY-226 2 Publications Verification	Phosphatase	Neurological Disease Metabolic Disease
KY-226 is a potent, selective, orally active and allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 0.25 μM, and without PPARγ agonist activity. KY-226 exerts anti-diabetic and anti-obesity effects by enhancing insulin and leptin signaling, respectively. KY-226 also protects neurons from cerebral ischemic injury .

HY-147084

KY371	ADC Linker	Metabolic Disease Cancer
KY371 is a click chemistry reagent containing an alkyne group. KY371 is a broad-range glycosidase inhibitor. KY371 can combine with proteomic analysis of targeted protein to study glycosidases .

HY-RS19855

Ky Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ky Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ky gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ky Mouse Pre-designed siRNA Set A Ky Mouse Pre-designed siRNA Set A

HY-124764

KY-04031	PAK	Cancer
KY-04031 is a potent PAK4 inhibitor with IC₅₀ of 0.79 μM. KY-04031 binds to the ATP-binding pocket of PAK4. KY-04031 blocks tumor cell growth and invasion .

HY-124156

KY-02327	Wnt	Metabolic Disease
KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl)-CXXC5 interaction inhibitor. KY-02327 shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation .

HY-167664

KY-455	Acyltransferase	Metabolic Disease
KY-455 is a novel inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT). KY-455 inhibita rabbit intestinal, hepatic, macrophage and adrenal ACAT with IC₅₀ values of 0.4, 0.9, 2.9 and 4.1 μmol/L, respectively.

HY-113680

KY1022	Apoptosis Ras β-catenin Wnt	Cancer
KY1022 is a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway. KY1022 can inhibit cellular EMT, metastasis and apoptosis. KY1022 can be used for the research of metastatic colorectal cancer .

HY-178227

KY19334	Wnt β-catenin CDK	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
KY19334 is a CXXC5-DVL inhibitor. KY19334 can activate the Wnt/β-catenin pathway by inhibiting CXXC5-Dvl interaction. KY19334 can inhibit cancer cells proliferation, migration, invasion and transformation by inhibiting CDK1. KY19334 can accelerate wound healing and exert regenerative effects. KY19334 can be used for the researches of cancer, inflammation, metabolic and neurological disease, such as cutaneous squamous cell carcinoma and diabetes .

HY-117218

KY-04045	PAK	Cancer
KY-04045 is a PAK4 specific inhibitor (IC₅₀=8.7 μM) that can be used for the development of anticancer drugs targeting PAK4 .

HY-13815

KY02111 5 Publications Verification	Wnt	Cardiovascular Disease
KY02111 is a canonical WNT signaling (β-catenin) inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration .

HY-117842

KY 234	Histamine Receptor	Inflammation/Immunology
KY 234 is an orally effective inhibitor that targets thromboxane A2 production, with an IC₅₀ of 5 μM. KY 234 significantly inhibits leukotriene D4 (LTD4), histamine, and antigen-induced bronchoconstriction in guinea pigs, with IC₅₀ values of 6.0 mg/kg, 2.5 mg/kg, and 6.3 mg/kg, respectively .

HY-U00148

KY-556 1 Publications Verification N556	Drug Derivative	Inflammation/Immunology
KY-556 is a promising and orally-active pro-agent of disodium cromoglycate (DSCG) against allergic diseases.

HY-P99431

KY-1044 Alomfilimab; SAR 445256	CD28	Inflammation/Immunology Cancer
KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOS ^high cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8 ⁺ T_Eff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response .

HY-156418

KY386	DNA/RNA Synthesis	Cancer
KY386 is a potent, selective inhibitor of DHX33 helicase, with the IC₅₀ of 19 nM. KY386 inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC₅₀ of 20 nM.and shows potent anti-cancer activity and moderate metabolic stability .

HY-131447

KY19382 4 Publications Verification A3051	GSK-3 Wnt β-catenin	Metabolic Disease
KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC₅₀s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases .

HY-129914

Cefcanel daloxate KY-109 free base	Bacterial	Infection
Cefcanel daloxate (KY-109 (free base)) is an orally active cephalosporin prodrug against Gram-positive bacteria and *Haemophilus influenzae*. Cefcanel daloxate is promising for research of uremia .

HY-RS26355

Ky Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ky Rat Pre-designed siRNA Set A contains three designed siRNAs for Ky gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ky Rat Pre-designed siRNA Set A Ky Rat Pre-designed siRNA Set A

HY-RS07479

KY Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
KY Human Pre-designed siRNA Set A contains three designed siRNAs for KY gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

KY Human Pre-designed siRNA Set A KY Human Pre-designed siRNA Set A

HY-102028

KY1220 3 Publications Verification	Wnt β-catenin	Cancer
KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway, with an IC₅₀ of 2.1 μM in HEK293 reporter cells .

HY-10197

Wortmannin Maximum Cited Publications 150 Publications Verification SL-2052; KY-12420	Organoid PI3K Polo-like Kinase (PLK) Autophagy Antibiotic	Cancer
Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible PI3K inhibitor with an IC₅₀ of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC₅₀s of 5.8 and 48 nM, respectively .

HY-10197R

Wortmannin (Standard) SL-2052 (Standard); KY-12420 (Standard)	Organoid Reference Standards PI3K Polo-like Kinase (PLK) Autophagy Antibiotic	Cancer
Wortmannin (Standard) is the analytical standard of Wortmannin. This product is intended for research and analytical applications. Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible PI3K inhibitor with an IC50 of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC50s of 5.8 and 48 nM, respectively .

HY-W164451

N-(2-hydroxy-2-phenylethyl)acetamide	Fungal	Infection
N-(2-hydroxy-2-phenylethyl)acetamide is isolated from the solid rice cultures of the endophytic fungus Diaporthe eucalyptorum KY-9. N-(2-hydroxy-2-phenylethyl)acetamide exhibits antifungal activities against Alternaria solani .

HY-174461

PROTAC PI3Kα degrader-1	PROTACs PI3K	Cancer
PROTAC PI3Kα degrader-1 is a PI3Kα PROTAC degrader (DC₅₀ = 0.08 μM), demonstrating good selectivity for PI3Kα degradation over PI3Kβ, PI3Kγ, and PI3Kδ. PROTAC PI3Kα degrader-1 effectively degrades PI3Kα in a time- and concentration-dependent, over PI3Kβ, PI3Ky and PI3Kδ, and potently inhibited the phosphorylation of AKT at the Ser473site. PROTAC PI3Kα degrader-1 shows significant in vivo anticancer efficacy in HGC-27 and DOHH2 xenograft models. (Pink: PI3Kα ligand : (HY-174798), Blue: E3 ligase CRBN Ligand (HY-10984), Black: Linker, E3 ligase ligand-linker conjugate (HY-W940885)) .

Cat. No.	Product Name	Target	Research Area

HY-P99431

KY-1044 Alomfilimab; SAR 445256	CD28	Inflammation/Immunology Cancer
KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOS ^high cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8 ⁺ T_Eff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response .

HY-P99434

Amlitelimab KY1005; SAR445229	Inhibitory Antibodies	Inflammation/Immunology
Amlitelimab () is an anti-OX40 Ligand (OX40L) monoclonal antibody (mAb). Amlitelimab inhibits OX40-OX40L interaction, and can be used in the research of atopic dermatitis .

Wortmannin 145+ Cited Publications SL-2052; KY-12420	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Organoid PI3K Polo-like Kinase (PLK) Autophagy Antibiotic
Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible PI3K inhibitor with an IC₅₀ of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC₅₀s of 5.8 and 48 nM, respectively .

Wortmannin (Standard) SL-2052 (Standard); KY-12420 (Standard)	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Organoid Reference Standards PI3K Polo-like Kinase (PLK) Autophagy Antibiotic
Wortmannin (Standard) is the analytical standard of Wortmannin. This product is intended for research and analytical applications. Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible PI3K inhibitor with an IC50 of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC50s of 5.8 and 48 nM, respectively .

N-(2-hydroxy-2-phenylethyl)acetamide	Infection Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Fungal
N-(2-hydroxy-2-phenylethyl)acetamide is isolated from the solid rice cultures of the endophytic fungus Diaporthe eucalyptorum KY-9. N-(2-hydroxy-2-phenylethyl)acetamide exhibits antifungal activities against Alternaria solani .

Cat. No.	Product Name		Classification

HY-147084

KY371		Alkynes
KY371 is a click chemistry reagent containing an alkyne group. KY371 is a broad-range glycosidase inhibitor. KY371 can combine with proteomic analysis of targeted protein to study glycosidases .

Ky Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ky Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ky gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ky Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ky Rat Pre-designed siRNA Set A contains three designed siRNAs for Ky gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

KY Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
KY Human Pre-designed siRNA Set A contains three designed siRNAs for KY gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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