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Results for "

KB 3.1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NF-κB (8) Adenosine Receptor (2) Akt (1) Antibiotic (1) Apoptosis (5) Autophagy (2) Bacterial (4) Endogenous Metabolite (1) ERK (1) Factor Xa (2) Fluorescent Dye (1) Fungal (3) Histone Demethylase (1) HSV (2) Interleukin Related (1) IRAK (2) Isotope-Labeled Compounds (1) JAK (1) Keap1-Nrf2 (1) Mitophagy (2) mTOR (1) Na+/K+ ATPase (2) NOD-like Receptor (NLR) (1) Opioid Receptor (2) P-glycoprotein (1) Parasite (1) PERK (1) Proteasome (2) Reference Standards (2) ROR (1) STAT (1) TNF Receptor (3)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Infection (7) Inflammation/Immunology (10) Metabolic Disease (1) Neurological Disease (4)

By Targets:

NF-κB (8)

Adenosine Receptor (2)

Akt (1)

Antibiotic (1)

Apoptosis (5)

Autophagy (2)

Bacterial (4)

Endogenous Metabolite (1)

ERK (1)

Factor Xa (2)

Fluorescent Dye (1)

Fungal (3)

Histone Demethylase (1)

HSV (2)

Interleukin Related (1)

IRAK (2)

Isotope-Labeled Compounds (1)

JAK (1)

Keap1-Nrf2 (1)

Mitophagy (2)

mTOR (1)

Na+/K+ ATPase (2)

NOD-like Receptor (NLR) (1)

Opioid Receptor (2)

P-glycoprotein (1)

Parasite (1)

PERK (1)

Proteasome (2)

Reference Standards (2)

ROR (1)

STAT (1)

TNF Receptor (3)

By Research Areas:

Cancer (7)

Cardiovascular Disease (1)

Infection (7)

Inflammation/Immunology (10)

Metabolic Disease (1)

Neurological Disease (4)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: NF-κB

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-137844

L-Leucine-7-amido-4-methylcoumarin hydrochloride Leu-AMC hydrochloride	Fluorescent Dye	Others
L-Leucine-7-amido-4-methylcoumarin (Leu-AMC) hydrochloride is a bright blue fluorogenic peptidyl substrate for LAP3 (leucine aminopeptidase). L-Leucine-7-amido-4-methylcoumarin hydrochloride can be used for leucine aminopeptidase inhibition assays in vitro .

HY-P1860

TNF-α (31-45), human 5+ Cited Publications	TNF Receptor NF-κB Apoptosis	Inflammation/Immunology Cancer
TNF-α (31-45), human is a potent *NF-kB* pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis .

HY-161849

LSD1-IN-31	Histone Demethylase	Metabolic Disease
LSD1-IN-31 (compound 11e) can directly bind to LSD1/CoREST complex to reduce LSD1 demethylation enzymatic activity. LSD1-IN-31 inhibits LSD1 demethylation activity and influences its downstream IκB/NF-κB signaling pathway. LSD1-IN-31 inhibits osteoclastic bone loss in vitro and in vivo. LSD1-IN-31 can be used for osteoporosis research .

HY-N15595

Curvulol	Bacterial Fungal	Infection
Curvulol is an antimicrobial agent with a polyketide structure. Curvulol can be isolated from Taxus baccata ( Chaetosphaeronema achilleae). Curvulol has a significant cytotoxicity against L929 and KB-3-1 cells, and strongly inhibits Staphylococcus aureus biofilm formation with a MIC of 64 μg/mL .

HY-N13196

Arcopilin A	Bacterial	Infection
Arcopilin A (compound Arcopilin A(1))is an antibacterial agent. Arcopilin A has weak inhibitory effects on fungal pathogens and Gram-positive bacteria, with IC₅₀ values of 8.9 μg/mL and 14 μg/mL for cells KB-3-1 and L929, but it can effectively destroy preformed biofilms of Staphylococcus aureus. Arcopilin A can enhance the activities of gentamicin (GM; HY-K1050) and vancomycin (Vac; HY-B0671) by 115 and 31 times, respectively .

HY-D0205AS1

Carbocisteine-13C3-1 Carbocysteine-¹³C3-1	Isotope-Labeled Compounds Keap1-Nrf2 NF-κB PERK Apoptosis	Infection Inflammation/Immunology
Carbocisteine- ¹³C₃-1 (Carbocysteine- ¹³C₃-1) is ¹³C labeled Carbocisteine. Carbocisteine is an orally active mucolytic agent. Carbocisteine attenuates the phosphorylation of NF-κB p65 and ERK1/2. Carbocisteine modulates Nrf2/HO-1 and NFκB interplay. Carbocisteine inhibits Apoptosis. Carbocisteine is used in chronic obstructive pulmonary disease (COPD) research .

HY-175522

P-gp-IN-31	P-glycoprotein Apoptosis	Cancer
P-gp-IN-31 is a P-glycoprotein (P-gp) inhibitor with IC₅₀ values of 0.42 μM for KB cells and 0.43 μM for MDR KBvin cells. P-gp-IN-31 can pass P-gp-mediated drug efflux mechanisms and shows collateral sensitivity via P-gp downregulation. P-gp-IN-31 inhibits cell proliferation, induces apoptosis and arrests the cell cycle at G2/M phase. P-gp-IN-31 can be used for the research of cancer, such as multidrug-resistant (MDR) malignancies .

HY-N16065

Prenylterphenyllin	Bacterial	Infection
Prenylterphenyllin (Compound 1) is an antibacterial agent. Prenylterphenyllin can be isolated from marine-derived fungus Aspergillus candidus IF10. Prenylterphenyllin has cytotoxic activity against KB3-1 cells with an IC₅₀ of 8.5 mg/mL. Prenylterphenyllin also has antibacterial activities against Xanthomonas oryzae and Erwinia amylovora with MICs of both 20 μg/mL .

HY-P1860A

TNF-α (31-45), human TFA	TNF Receptor NF-κB Apoptosis	Inflammation/Immunology
TNF-α (31-45), human TFA is a potent *NF-kB* pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis .

HY-176505

NOP antagonist 1	Opioid Receptor	Neurological Disease
NOP antagonist 1 (Compound (-)-31) is a nociceptin opioid peptide (NOP) antagonist with a *K_b* of 8.65  nM. NOP antagonist 1 can be used for neuropsychiatric disorders research .

HY-150587

Anti-inflammatory agent 31	ERK NF-κB	Inflammation/Immunology
Anti-inflammatory agent 31 (enone 17) is a kind of andrographolide derivatives, is a anti-inflammatory agent. Anti-inflammatory agent 31 inhibits *NF-κB* activation by upstream blockade of PI3K/Akt and ERK1/2 MAPK activation. Anti-inflammatory agent 31 shows recovery effective of the intracellular GSH levels and protective effect on liver .

HY-N15343

Albiducin A	Antibiotic Bacterial Fungal	Infection Cancer
Albiducin A is an antibiotic found in Hymenoscyphus albidus, exhibiting antibacterial and anticancer activities. The MIC range of Albiducin A against bacteria and fungi is 16.7-66.7 mg/mL. Its IC₅₀ values for mouse fibroblast cell line (L929) and human cervical carcinoma cell line (KB3-1) are 6.1 and 2.7 μg/mL, respectively. Albiducin A holds promise for research in the fields of infection and cancer diseases .

HY-N12606

Neodidymelliosides A	Fungal	Infection
Neodidymelliosides A (compound 1)It is a secondary metabolite of fungi and has a significant inhibitory effect on Staphylococcus aureus and Candida albicans biofilms. Neodidymelliosides AIt also has anti-cancer activity and can inhibit KB3.1 (cervix),PC-3 (prostate),MCF-7(breast),SKOV-3 (ovary),A431 (skin )and A549 (lung )Cell viability of cell lines .

HY-N8462

6-O-Nicotinoylscutebarbatine G Scutebatin C	Others	Cancer
6-O-Nicotinoylscutebarbatine G is an alkaloid that can be isolated from Scutellaria barbata.6-O-Nicotinoylscutebarbatine has cytotoxic activities against HONE-1, KB and HT29 cells with IC₅₀s of 3.1, 2.1 and 5.7 μM, respectively .

HY-136208

TAN-452	Opioid Receptor	Neurological Disease
TAN-452 is an orally active, selective peripherally acting δ-opioid receptor (DOR) antagonist with a K_i of 0.47 nM and a *K_b* of 0.21 nM. TAN-452 is an antagonist for μ-opioid receptor (MOR; K_i=36.56 nM and *K_b*=9.43 nM) and κ-opioid receptor (KOR; *K_i*=5.31 nM and *K_b*=7.18 nM). TAN-452, a derivative of Naltrindole, demonstrates low brain penetrability and attenuates morphine-induced side effects without affecting pain control .

HY-124543

MRS-1191 4 Publications Verification	Adenosine Receptor	Neurological Disease
MRS-1191 is a potent and selective A₃ adenosine receptor antagonist with a *K_B* value of 92 nM, a K_i value of 31.4 nM for human A₃ receptor and an IC₅₀ of 120 nM for CHO cells . MRS-1191 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-124543R

MRS-1191 (Standard)	Adenosine Receptor	Neurological Disease
MRS-1191 (Standard) is the analytical standard of MRS-1191. This product is intended for research and analytical applications. MRS-1191 is a potent and selective A3 adenosine receptor antagonist with a KB value of 92 nM, a Ki value of 31.4 nM for human A3 receptor and an IC50 of 120 nM for CHO cells . MRS-1191 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N0039

Ginsenoside Rb1 Maximum Cited Publications 11 Publications Verification Gypenoside III	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV	Inflammation/Immunology Cancer
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

HY-N1356

Reticuline 1 Publications Verification	JAK STAT NF-κB Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Reticuline shows anti-inflammatory effects through JAK2/STAT3 and *NF-κB* signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3 . Reticuline exhibits cardiovascular effects .

HY-N0039R

Ginsenoside Rb1 (Standard) Maximum Cited Publications 11 Publications Verification Gypenoside III (Standard)	Reference Standards Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV	Inflammation/Immunology Cancer
Ginsenoside Rb1 (Standard) is the analytical standard of Ginsenoside Rb1. This product is intended for research and analytical applications. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

HY-174382

ROR1-IN-3	Akt mTOR NF-κB ROR Apoptosis	Cancer
ROR1-IN-3 (Compound 24d) is a potent and highly selective ROR1 kinase inhibitor (IC₅₀ = 17.6 nM). ROR1-IN-3 demonstrates robust antitumor activity and inhibitory effect against ROR1 both in vitro and in vivo. ROR1-IN-3 has robust antiproliferative efficacy in vitro and in vivo. ROR1-IN-3 induces apoptosis in cancer cell lines. ROR1-IN-3 inhibits ROR1 downstream AKT/mTOR and *NF-κB* signaling pathway. ROR1-IN-3 can be studied in antitumor research .

HY-155751

HMGB1-IN-1	Interleukin Related TNF Receptor NOD-like Receptor (NLR)	Inflammation/Immunology
HMGB1-IN-1 (compound 6) displays strong NO inhibitory effect in RAW264.7 cells with IC₅₀ value of 15.9 ± 0.6 μM. HMGB1-IN-1 inhibit the HMGB1/NF-κB/NLRP3 pathway. HMGB1-IN-1 shows good anti-inflammatory activity and good anti-sepsis effects in kidney injury .

HY-B0385

Gabexate mesylate 4 Publications Verification FOY	Proteasome Factor Xa	Inflammation/Immunology
Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with K_is of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with K_is of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation .

HY-B0385R

Gabexate mesylate (Standard) FOY (Standard)	Reference Standards Proteasome Factor Xa	Inflammation/Immunology
Gabexate (mesylate) (Standard) is the analytical standard of Gabexate (mesylate). This product is intended for research and analytical applications. Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with Kis of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with Kis of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation .

HY-126914

Diacetylcercosporin	Parasite	Infection
Diacetylcercosporin is a perylenequinone produced by Cercospora and Septoria that has diverse biological activities. Diacetylcercosporin inhibits the growth of P. falciparum strains that are sensitive and resistant to chloroquine (IC₅₀s=2.75 and 1.94 μM for D6 and W2 clones, respectively) and L. donovani parasites (IC₅₀=3.1 μM) in vitro. Diacetylcercosporin exhibits cytotoxicity against SK-MEL, KB, BT549, and SKOV3 human cancer cell lines (IC₅₀s=4.8-8.7 μM). Diacetylcercosporin is also a phytotoxin that inhibits the growth of lettuce and bentgrass at a concentration of 1.62 mM.

Cat. No.	Product Name	Type