K-12

By Targets:	Amino Acid Derivatives (1) Antibiotic (1) Apoptosis (1) Bacterial (6) Caspase (1) CDK (1) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Epigenetic Reader Domain (1) FLT3 (1) HDAC (2) Histone Methyltransferase (1) JNK (1) MAP3K (2) Molecular Glues (1) p38 MAPK (1) PAK (1) Small Interfering RNA (siRNA) (3) STK33 (1) Trk Receptor (1)
By Research Areas:	Cancer (4) Infection (7) Neurological Disease (3)
Oligonucleotides:	Human Pre-designed siRNA Sets (3) siRNAs (3)

Targets Recommended: URAT1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-163944

*LL-K12-18*	Molecular Glues CDK	Cancer
LL-K12-18 is a two-site molecular glue that enhances the protein-protein interaction of the *CDK12-DDB1* complex, stabilizing the *CDK12-DDB1* complex and promoting the degradation of cyclin K (EC₅₀=0.37 nM). LL-K12-18 exhibits strong gene transcription inhibition and anti-proliferation effects in tumor cells. LL-K12-18 can be used in cancer research .

HY-P10257

KR-12 (human)	Bacterial	Infection
KR-12 (human) is an active segment of LL-37 (HY-P4744). KR-12 (human) exhibits antimicrobial activity against gram-negative bacteria. KR-12 (human) inhibits E. coli K-12 with a MIC of 66 μM. KR-12 human can be used for the research of infection, such as E. coli infection .

HY-116788

Lipofermata 5+ Cited Publications	Bacterial	Infection
Lipofermata is a fatty acid transport protein 2 (FATP2) inhibitor. Lipofermata shows fatty acid transport inhibition with an IC₅₀ of 4.84 μM in Caco-2 cells. Lipofermata, an analog of spiro-indoline-thadiazole, shows zinc-specific suppression of antibacterial activity. Lipofermata perturbs zinc homeostasis in E. coli K-12 with a MIC of 16 μM .

HY-E70248

S-(3-Hydroxydodecanoate)-CoA	Endogenous Metabolite	Others
S-(3-Hydroxydodecanoate)-CoACoenzyme A, a Coenzyme A, is a metabolite that can be found or produced in E. coli (strain K12, MG1655) .

HY-N12320

Majoranaquinone	Antibiotic	Infection
Majoranaquinone exhibits a high antibacterial effect against 4 Staphylococcus, 1 Moraxella, and 1 Enterococcus strains. Majoranaquinone shows substantial efflux pump inhibitory activity in Escherichia coliATCC 25922 strain. Majoranaquinone is found to be an effective biofilm formation inhibitor on E.coli, ATCC 25922 and E. coli K-12 AG100 bacteria .

HY-135599

Lysine hydroxamate	Bacterial	Infection
Lysine hydroxamate is an amino acid hydroxamate that inhibits the growth of Escherichia coli K-12. Of the other amino acid hydroxamates tested, only L-lysine hydroxamate reduced the growth rate. The inhibition of growth by L-serine hydroxamate could be rapidly reversed by adding L-serine to the bacterial culture or by removing the analog by filtration. This reversal was specific for L-serine. L-alanine, glycine, or adenine had no effect on the inhibited culture. There was no evidence for active transport of the analog.

HY-RS08049

MAP3K12 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MAP3K12 Human Pre-designed siRNA Set A contains three designed siRNAs for MAP3K12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MAP3K12 Human Pre-designed siRNA Set A MAP3K12 Human Pre-designed siRNA Set A

HY-151357

MraY-IN-3	Bacterial	Infection
MraY-IN-3 (12a) is a potent bacterial translocase MraY inhibitor with an IC₅₀ value of 140 µM. MraY-IN-3 acts on E. coli K12, B. subtilis W23 and P. fluorescens Pf-5 with the MIC₅₀ values of 7 µg/mL, 12 µg/mL, and 46 µg/mL, respectively .

HY-W844796

2-Amino-5-methyl-5-hexenoic acid (S)-2-Amino-5-methylhex-5-enoic acid	Bacterial Amino Acid Derivatives	Infection
2-Amino-5-methyl-5-hexenoic acid ((S)-2-Amino-5-methylhex-5-enoic acid) is a Methionine analog that competes with methionine and resulting in inhibition of cell growth. 2-Amino-5-methyl-5-hexenoic acid inhibits protein synthesis but not DNA or RNA synthesis in S. typhimurium TA1535 and E. coli K-12 . X

HY-174211

JNK-IN-23	JNK	Cancer
JNK-IN-23 (Compound K12) is an inhibitor of JNK. JNK-IN-23 inhibits the proliferation of MDA-MB-231 (GIC₅₀: 30 nM). JNK-IN-23 blocks TNBC metastatic growth in vivo. JNK-IN-23 inhibits the growth of lung metastases by dual targeting of glutaminase-1 (GLS) and pyruvate dehydrogenase complex (PDHC) .

HY-144728

MraY-IN-3 hydrochloride	Bacterial	Infection
MraY-IN-1 (compound 12a) is a potent MraY inhibitor with an IC₅₀ value of 140 μM. MraY-IN-1 has antimicrobial activity against Escherichia coli K12, Bacillus subtilis W23 and Pseudomonas fluorescens Pf-5 with MIC₅₀s of 7 µg/mL, 12 µg/mL and 46 µg/mL, respectively. MraY-IN-1 can be used for researching anti-bacteria .

HY-RS07435

KRT12 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
KRT12 Human Pre-designed siRNA Set A contains three designed siRNAs for KRT12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

KRT12 Human Pre-designed siRNA Set A KRT12 Human Pre-designed siRNA Set A

HY-RS12628

SECTM1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SECTM1 Human Pre-designed siRNA Set A contains three designed siRNAs for SECTM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SECTM1 Human Pre-designed siRNA Set A SECTM1 Human Pre-designed siRNA Set A

HY-117709

BRD6688	HDAC	Neurological Disease
BRD6688 is a selective HDAC2 inhibitor. BRD6688 increases H4K12 and H3K9 histone acetylation in primary mouse neuronal cells. BRD6688 crosses the blood brain barrier and rescues the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model .

HY-170484

KAI-11101	MAP3K p38 MAPK	Neurological Disease
KAI-11101 is the inhibitor for dual leucine zipper kinase (DLK, *MAP3K12) with a K_i* of 0.7 nM. KAI-11101 inhibits Paclitaxel (HY-B0015)-induced cJun phosphorylation (IC₅₀=95 nM) and thus inhibits the activation of MAPK pathway. KAI-11101 is blood brain barrier penetrable and can be further investigated for its neuroprotective property .

HY-114331

DLK-IN-1	MAP3K FLT3 PAK STK33 Trk Receptor	Neurological Disease
DLK-IN-1 (Compound 14) is an orally active, blood-brain barrier-penetrable and selective inhibitor of dual leucine zipper kinase (DLK, MAP3K12) with a K_i value of 3 nM. DLK-IN-1 inhibits Flt3, PAK4, STK33 and TrkA. DLK-IN-1 reduces p-c-Jun. DLK-IN-1 can be used in Alzheimer's disease research .

HY-174450

KMT9-IN-1	Epigenetic Reader Domain	Cancer
KMT9-IN-1 (Compound 8) is a KMT9 inhibitor and the ethyl ester prodrug of compound 7b. KMT9-IN-1 releases the active form 7b via esterases in cells. KMT9-IN-1 targets KMT9 in cells and reduces H4K12me1 levels. KMT9-IN-1 has antitumor activity against colon cancer. KMT9-IN-1 can be used in the research of prostate cancer and hepatocellular carcinoma .

HY-156096

HDAC3-IN-2	HDAC Histone Methyltransferase Caspase Apoptosis DNA/RNA Synthesis	Cancer
HDAC3-IN-2 (compound 4i) is a pyrazinyl hydrazide-based HDAC3 inhibitor (IC₅₀: 14 nM) that efficiently targets triple-negative breast cancer cells. HDAC3-IN-2 is cytotoxic with an IC₅₀ of 0.55 μM against 4T1 and an IC₅₀ of 0.74 μM against MDA-MB-231. HDAC3-IN-2 has anti-tumor efficacy in vivo in tumor-bearing mouse models, selectively increasing the acetylation levels of H3K9, H3K27 and H4K12, increasing the contents of apoptosis-related caspase-3, caspase-7 and cytochrome c, and reducing Proliferation-related Bcl-2, CD44, EGFR, and Ki-67 levels .

Cat. No.	Product Name	Target	Research Area

HY-P10257

KR-12 (human)	Bacterial	Infection
KR-12 (human) is an active segment of LL-37 (HY-P4744). KR-12 (human) exhibits antimicrobial activity against gram-negative bacteria. KR-12 (human) inhibits E. coli K-12 with a MIC of 66 μM. KR-12 human can be used for the research of infection, such as E. coli infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N12320

Majoranaquinone	Quinones Structural Classification Labiatae Source classification Plants Naphthalene Quinones Baccharis sarothroides A.Gray	Antibiotic
Majoranaquinone exhibits a high antibacterial effect against 4 Staphylococcus, 1 Moraxella, and 1 Enterococcus strains. Majoranaquinone shows substantial efflux pump inhibitory activity in Escherichia coliATCC 25922 strain. Majoranaquinone is found to be an effective biofilm formation inhibitor on E.coli, ATCC 25922 and E. coli K-12 AG100 bacteria .

Species:	Human (5) Mouse (1) Cynomolgus (1) E.coli (2)
Tag:	GFP (1) His (7) Tag Free (1) Fc (1)
Source:	HEK293 (6) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P72032

	SECTM1 Protein, Human (HEK293, hFc) Protein K-12; K12	Human	HEK293
	SECTM1 Protein potentially influences thymocyte signaling, indicating a role in thymic regulatory mechanisms. Its interaction with CD7 suggests involvement in cellular processes, potentially influencing thymocyte-associated signaling pathways. SECTM1's significance in thymocyte function and interaction with CD7 hints at a role in modulating immune responses and cellular communication within the thymic microenvironment. SECTM1 Protein, Human (HEK293, hFc) is the recombinant human-derived SECTM1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P71281

	SECTM1 Protein, Human (HEK293, His) Secreted and Transmembrane Protein 1; Protein K-12; SECTM1; K12	Human	HEK293
	SECTM1 Protein potentially influences thymocyte signaling, indicating a role in thymic regulatory mechanisms. Its interaction with CD7 suggests involvement in cellular processes, potentially influencing thymocyte-associated signaling pathways. SECTM1's significance in thymocyte function and interaction with CD7 hints at a role in modulating immune responses and cellular communication within the thymic microenvironment. SECTM1 Protein, Human (HEK293, His) is the recombinant human-derived SECTM1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P78002

	C-MPL Protein, Human (HEK293, His) TPO-R; CD110; MPL; c-Mpl; MPLV; K12	Human	HEK293
	C-MPL Protein, the thrombopoietin receptor, is a pivotal regulator of megakaryopoiesis and platelet production, suggesting a specific role in TPO-R-dependent immune responses. Forming homodimers and interacting with ATXN2L, it contributes to its multifaceted role in hematopoiesis and immune modulation. C-MPL Protein, Human (HEK293, His) is the recombinant human-derived C-MPL protein, expressed by HEK293 , with C-His labeled tag.

HY-P78003

	C-MPL Protein, Mouse (HEK293, His) TPO-R; CD110; MPL; c-Mpl; MPLV; K12	Mouse	HEK293
	C-MPL Protein, the receptor for thrombopoietin (TPO), is a key regulator of megakaryopoiesis and platelet production.It plays a crucial role in TPO-R-dependent immune responses and inhibits thrombopoietin signaling by facilitating the down-regulation of the full-length isoform Mpl-fl.C-MPL Protein, Mouse (HEK293, His) is the recombinant mouse-derived C-MPL protein, expressed by HEK293 , with C-His labeled tag.

HY-P700977

	C-MPL Protein, Cynomolgus (HEK293, His) TPO-R; CD110; MPL; c-Mpl; MPLV; K12	Cynomolgus	HEK293
	C-MPL protein is a key member of the type I cytokine receptor family and is essential for mediating cellular responses to various cytokines. Its research enhances our understanding of cell signaling, providing potential applications for therapeutic intervention in hematopoietic disorders and immune disorders. C-MPL Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived C-MPL protein, expressed by HEK293 , with C-His labeled tag.

HY-P703455

	fimG Protein, E.coli (His) Protein FimG; fimG; Escherichia coli (strain K12)	E.coli	E. coli
	fimG Protein, E.coli (His) is the recombinant E.coli-derived fimG protein, expressed by E. coli, with His tag.

HY-P703429

	phoA Protein, E.coli Alkaline phosphatase; phoA; Escherichia coli (strain K12); APase; Hydrolase; 3.1.3.1	E.coli	E. coli
	phoA Protein, E.coli is the recombinant E.coli-derived phoA protein, expressed by E. coli, with tag free tag.

HY-P70921

	MBIP Protein, Human (His) MAP3K12-Binding Inhibitory Protein 1; MAPK Upstream Kinase-Binding Inhibitory Protein; MUK-Binding Inhibitory Protein; MBIP	Human	E. coli
	MBIP protein inhibits MAP3K12 activity and prevents activation of the JNK/SAPK pathway. It is an important component of the ATAC complex, a histone acetyltransferase complex targeting histones H3 and H4. MBIP Protein, Human (His) is the recombinant human-derived MBIP protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701835

	VKOR1 Protein, Human (HEK293, GFP, His) VKORC1; Vitamin K epoxide reductase complex subunit 1; Vitamin K1 2; 3-epoxide reductase subunit 1	Human	HEK293
	As the catalytic subunit of the VKOR complex, the VKOR1 protein is crucial in vitamin K metabolism and is essential for the reduction of inactive vitamin K 2,3-epoxide to the active form. This process is critical for γ-carboxylation of proteins and is particularly important for blood coagulation and the synthesis of coagulation factors. VKOR1 Protein, Human (HEK293, GFP, His) is the recombinant human-derived VKOR1 protein, expressed by HEK293 , with C-10*His, GFP labeled tag.

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HY-P83259

	Cytokeratin 12 Antibody (YA3004) K12; Keratin 12; KRT12; type I cytoskeletal 12	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Cytokeratin 12 Antibody (YA3004) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytokeratin 12.

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Cat. No.	Product Name		Classification

HY-RS08049

MAP3K12 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MAP3K12 Human Pre-designed siRNA Set A contains three designed siRNAs for MAP3K12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS07435

KRT12 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
KRT12 Human Pre-designed siRNA Set A contains three designed siRNAs for KRT12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS12628

SECTM1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SECTM1 Human Pre-designed siRNA Set A contains three designed siRNAs for SECTM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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