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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

J774 cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Apoptosis (2) c-Kit (1) Caspase (1) COX (1) Farnesyl Transferase (1) Glutathione Peroxidase (1) Histamine Receptor (1) Interleukin Related (1) IRAK (1) Isocitrate Dehydrogenase (IDH) (1) NF-κB (1) NO Synthase (2) NOD-like Receptor (NLR) (2) P2X Receptor (1) p38 MAPK (1) Parasite (2) PERK (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) TNF Receptor (1) Virus Protease (1)
By Research Areas:	Cancer (2) Infection (2) Inflammation/Immunology (9) Metabolic Disease (2) Neurological Disease (1)

By Targets:

5-HT Receptor (1)

Apoptosis (2)

c-Kit (1)

Caspase (1)

COX (1)

Farnesyl Transferase (1)

Glutathione Peroxidase (1)

Histamine Receptor (1)

Interleukin Related (1)

IRAK (1)

Isocitrate Dehydrogenase (IDH) (1)

NF-κB (1)

NO Synthase (2)

NOD-like Receptor (NLR) (2)

P2X Receptor (1)

p38 MAPK (1)

Parasite (2)

PERK (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (1)

TNF Receptor (1)

Virus Protease (1)

By Research Areas:

Cancer (2)

Infection (2)

Inflammation/Immunology (9)

Metabolic Disease (2)

Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor Programmed Cell Death 4 (PDCD4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0577

Apiin 1 Publications Verification Apigenin 7-O-apiosylglucoside; Apigenin 7-(2-O-apiosylglucoside)	NO Synthase	Inflammation/Immunology
Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC₅₀ = 0.08 mg/mL) in-vitro and iNOS expression (IC₅₀ = 0.049 mg/ mL) in LPS-activated J774.A1 cells .

HY-129959

Aluminum phthalocyanine chloride AlClPc	Parasite	Infection
Aluminum phthalocyanine chloride is a photosensitizer that effectively inhibits the parasite Leishmania amazonensis (the causative agent of cutaneous leishmaniasis) by light-mediated cytolysis. Aluminum phthalocyanine chloride causes parasite morphology and cytolysis of isolated amasilians, while higher photosensitizer concentrations and light intensities are required to induce lysis of mammalian cells. Aluminum phthalocyanine chloride lyses parasites within infected J774 macrophages and can be used to further investigate the study of leishmaniasis .

HY-N0577R

Apiin (Standard) Apigenin 7-O-apiosylglucoside (Standard); Apigenin 7-(2-O-apiosylglucoside) (Standard)	Reference Standards NO Synthase	Inflammation/Immunology
Apiin (Standard) is the analytical standard of Apiin. This product is intended for research and analytical applications. Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC50 = 0.08 mg/mL) in-vitro and iNOS expression (IC50 = 0.049 mg/ mL) in LPS-activated J774.A1 cells .

HY-126489

Tetromycin B	Parasite	Infection
Tetromycin B is a cysteine protease inhibitor with Ki values of 0.62, 1.42, 32.5, and 1.59 μM for rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively. It inhibits the growth of T. brucei in vitro (IC₅₀=30.87 μM). Tetromycin B is also cytotoxic to HEK293T kidney cells and J774.1 macrophages (IC₅₀s=71.77 and 20.2 μM, respectively).

HY-B2097

Incadronate disodium YM 175; Bisphonal	Farnesyl Transferase	Metabolic Disease
Incadronate disodium (YM 175) is a bisphosphonate with strong inhibitory activity on bone resorption. Incadronate disodium indirectly stimulates renal 25-hydroxyvitamin D-1-hydroxylase by increasing circulating parathyroid hormone. Incadronate disodium, a cholesterol-lowering agent, is a potent inhibitor of rat liver microsomal squalene synthase (K_i=57 nM). Incadronate disodium inhibits sterol biosynthesis in mouse macrophage J774 cells (IC₅₀=64 μM). Incadronate disodium has the potential for malignant tumors research .

HY-149816

Anti-inflammatory agent 41	Interleukin Related TNF Receptor NF-κB	Inflammation/Immunology
Anti-inflammatory agent 41 (13a) significantly inhibit lipopolysaccharide (LPS)-induced expression of the proinflammatory cytokines IL-6 and TNF-α on J774A.1, THP-1 and LX-2 cells, and inhibits the activation of the NF-κB pathway .

HY-N12482

Callicarboric acid A	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-27 (compound 1) is an inhibitor of NLRP3 with an IC₅₀ value of 0.74 μM. NLRP3 reduces inflammasome-induced pyroptosis in J774A.1 cells. NLRP3-IN-27 can be isolated from Callicarpa arborea Rox .

HY-158111

NLRP3-IN-34	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-34 (Compound T10) is an inhibitor for NLRP3 inflammasome. NLRP3-IN-34 inhibits ROS production, NLRP3 inflammasome-dependent IL-1β production (IC₅₀ is 0.48 μM in cells J774A.1), and inhibits pyroptosis. NLRP3-IN-34 exhibits anti-inflammatory activity against DSS-induced peritonitis .

HY-170228

c-Kit-IN-9	c-Kit	Inflammation/Immunology
Kit-IN-9 (Compound D9) is an inhibitor of c-Kit. c-Kit-IN-9 inhibits the inflammatory responses in J774A.1, RAW264.7, MPMs cells and lung tissues by blocking the activation of the NF-κB pathway induced by LPS (HY-D1056). Meanwhile, c-Kit-IN-9 exhibits good anti-inflammatory activities in acute lung injury and sepsis mouse models. c-Kit-IN-9 can be used in the research of acute lung injury and related inflammatory diseases .

HY-158434

IRAK1-IN-1	IRAK	Inflammation/Immunology
IRAK1-IN-1 (compound B8) is an orally active IRAK1 inhibitor. IRAK1-IN-1 inhibits the release of IL-6 with the IC₅₀ values of 4.57 μM and 6.51 μM on mouse cells J774A. 1 and human cells THP-1, respectively. IRAK1-IN-1 alleviats LPS (HY-D1056)-induced acute lung injury (ALI) and DSS(HY-116282C)-induced colitis in mice .

HY-131521

Oxalomalic acid trisodium Oxalomalate trisodium	Isocitrate Dehydrogenase (IDH)	Cancer
Oxalomalic acid (Oxalomalate) trisodium is a aconitase and NADP-dependent isocitrate dehydrogenase inhibitor. Oxalomalic acid trisodium inhibits nitrite production and iNOS protein expression in lipopolysaccharide (HY-D1056)-activated J774 macrophages .

HY-B0388

Probucol 1 Publications Verification DH-581	Virus Protease Apoptosis Reactive Oxygen Species (ROS) Glutathione Peroxidase Caspase	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Probucol (DH-581) is an anti-hyperlipidemic agent. Probucol activates glutathione peroxidase. Probucol promotes low density lipoprotein (LDL) catabolism, inhibits ABCA1-dependent cholesterol efflux, and decreases HDL-C levels. Probucol also has anti-inflammatory, antioxidant and neuroprotective properties. Probucol can be used for researches on bone, cardiovascular, cancer, neurological, and metabolism-related diseases .

HY-123205

Oxatomide KW-4354	Histamine Receptor P2X Receptor 5-HT Receptor Apoptosis PERK p38 MAPK COX	Inflammation/Immunology
Oxatomide (KW-4354) is an orally active dual antagonist of the H1-histamine receptor and the P2X7 receptor, as well as an inhibitor of serotonin. Oxatomide possesses antihistaminic, antiallergic and anti-inflammatory activities. Oxatomide can be used in the research of allergic diseases .

Cat. No.	Product Name	Type

HY-129959

Aluminum phthalocyanine chloride AlClPc	Dyes
Aluminum phthalocyanine chloride is a photosensitizer that effectively inhibits the parasite Leishmania amazonensis (the causative agent of cutaneous leishmaniasis) by light-mediated cytolysis. Aluminum phthalocyanine chloride causes parasite morphology and cytolysis of isolated amasilians, while higher photosensitizer concentrations and light intensities are required to induce lysis of mammalian cells. Aluminum phthalocyanine chloride lyses parasites within infected J774 macrophages and can be used to further investigate the study of leishmaniasis .

Aluminum phthalocyanine chloride

AlClPc

Dyes

Aluminum phthalocyanine chloride is a photosensitizer that effectively inhibits the parasite Leishmania amazonensis (the causative agent of cutaneous leishmaniasis) by light-mediated cytolysis. Aluminum phthalocyanine chloride causes parasite morphology and cytolysis of isolated amasilians, while higher photosensitizer concentrations and light intensities are required to induce lysis of mammalian cells. Aluminum phthalocyanine chloride lyses parasites within infected J774 macrophages and can be used to further investigate the study of leishmaniasis .

Apiin 1 Publications Verification Apigenin 7-O-apiosylglucoside; Apigenin 7-(2-O-apiosylglucoside)	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Phenols Polyphenols Umbelliferae Plants Baccharis sarothroides A.Gray Inflammation/Immunology Disease Research Fields	NO Synthase
Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC₅₀ = 0.08 mg/mL) in-vitro and iNOS expression (IC₅₀ = 0.049 mg/ mL) in LPS-activated J774.A1 cells .

Apiin (Standard) Apigenin 7-O-apiosylglucoside (Standard); Apigenin 7-(2-O-apiosylglucoside) (Standard)	Structural Classification Flavonoids Flavones Source classification Phenols Polyphenols Umbelliferae Plants Baccharis sarothroides A.Gray	Reference Standards NO Synthase
Apiin (Standard) is the analytical standard of Apiin. This product is intended for research and analytical applications. Apiin, a major constituent of Apium graveolens leaves with anti-inflammatory properties. Apiin shows significant inhibitory activity on nitrite (NO) production (IC50 = 0.08 mg/mL) in-vitro and iNOS expression (IC50 = 0.049 mg/ mL) in LPS-activated J774.A1 cells .

Callicarboric acid A	Structural Classification Natural Products Labiatae Rudbeckia laciniata L. Source classification Plants	NOD-like Receptor (NLR)
NLRP3-IN-27 (compound 1) is an inhibitor of NLRP3 with an IC₅₀ value of 0.74 μM. NLRP3 reduces inflammasome-induced pyroptosis in J774A.1 cells. NLRP3-IN-27 can be isolated from Callicarpa arborea Rox .

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